Karyopharm Therapeutics Inc.
KPTI- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001503802
In the last 90 days, Karyopharm Therapeutics Inc. insiders filed 0 open-market purchases and 2 sales; 96 institutions reported holding it in 13F filings for Q2 2026, worth $206.8M in total; no superinvestor holds it.
13F holders, Q1 2026
Institutional positions in Karyopharm Therapeutics Inc. as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 77
- +11 vs. Q4 2025
- Shares held
- 17.7M
- +8.77M (+98.6%) vs. Q4 2025
- Total value
- $98.4M
- +$32.9M (+50.3%) vs. Q4 2025
- New holders
- 25
- 32 more added
- Sold out
- 14
- 9 more reduced
2 institutions that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting KPTI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 96 | $206.8M |
| Q1 2026 | 77 | $98.4M |
| Q4 2025 | 68 | $69.6M |
| Q3 2025 | 52 | $19.5M |
| Q2 2025 | 50 | $19.0M |
| Q1 2025 | 50 | $13.7M |
| Q4 2024 | 87 | $41.2M |
| Q3 2024 | 91 | $49.2M |
| Q2 2024 | 114 | $58.6M |
| Q1 2024 | 114 | $113.0M |
| Q4 2023 | 120 | $63.5M |
| Q3 2023 | 120 | $102.8M |
| Q2 2023 | 138 | $145.0M |
| Q1 2023 | 132 | $340.1M |
| Q4 2022 | 155 | $334.4M |
| Q3 2022 | 147 | $364.1M |
| Q2 2022 | 150 | $302.8M |
| Q1 2022 | 139 | $501.8M |
| Q4 2021 | 143 | $347.5M |
| Q3 2021 | 134 | $334.4M |
| Q2 2021 | 154 | $608.7M |
| Q1 2021 | 171 | $637.1M |
Institutions, Q1 2026
Shares, value and share of portfolio for each institution holding Karyopharm Therapeutics Inc.; share changes are against Q4 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Commodore Capital LP | 1,950,000 | $10.9M | 0.63% | +1,950,000 | New |
| Ra Capital Management, L.P. | 1,917,354 | $10.7M | 0.11% | +1,917,354 | New |
| Adage Capital Partners GP, L.L.C. | 1,806,322 | $10.1M | 0.02% | +1,385,000+328.7% | Added |
| T. Rowe Price Investment Management, Inc. | 1,542,090 | $8.59M | 0.01% | +50,681+3.4% | Added |
| Goldman Sachs Group Inc | 947,579 | $5.28M | 0.00% | +947,579 | New |
| Catalio Capital Management, LP | 897,709 | $5.00M | 1.04% | +754,725+527.8% | Added |
| Vanguard Capital Management LLC | 739,745 | $4.12M | 0.00% | +739,745 | New |
| Ikarian Capital, LLC | 733,435 | $4.09M | 0.58% | +188,881+34.7% | Added |
| Affinity Asset Advisors, LLC | 500,000 | $2.79M | 0.16% | −389,575−43.8% | Reduced |
| Avidity Partners Management LP | 463,741 | $2.58M | 0.52% | +329,175+244.6% | Added |
| Soleus Capital Management, L.P. | 440,000 | $2.45M | 0.10% | 00.0% | Unchanged |
| Millennium Management LLC | 420,571 | $2.34M | 0.00% | +420,571 | New |
| Boxer Capital Management, LLC | 302,536 | $1.69M | 0.22% | +50,000+19.8% | Added |
| Davidson Kempner Capital Management LP | 300,000 | $1.67M | 0.03% | −10,020−3.2% | Reduced |
| Acorn Capital Advisors, LLC | 287,826 | $1.60M | 0.46% | +287,826 | New |
| Eversept Partners, LP | 276,174 | $1.54M | 0.10% | +276,174 | New |
| Jump Financial, LLC | 262,146 | $1.46M | 0.02% | +208,330+387.1% | Added |
| Trexquant Investment LP | 257,903 | $1.44M | 0.01% | +216,170+518.0% | Added |
| Acadian Asset Management LLC | 248,957 | $1.38M | 0.00% | +245,231+6,581.6% | Added |
| BlackRock, Inc. | 244,899 | $1.36M | 0.00% | −2,659−1.1% | Reduced |
| Boothbay Fund Management, LLC | 213,810 | $1.19M | 0.03% | +69,182+47.8% | Added |
| Brevan Howard Capital Management LP | 212,367 | $1.18M | 0.01% | +212,367 | New |
| Geode Capital Management, LLC | 206,133 | $1.15M | 0.00% | +18,399+9.8% | Added |
| UBS Group AG | 194,017 | $1.08M | 0.00% | +105,562+119.3% | Added |
| Group One Trading, L.P. | 191,527 | $1.07M | 0.04% | +89,108+87.0% | Added |
| XTX Topco Ltd | 164,443 | $915.9K | 0.02% | +152,539+1,281.4% | Added |
| Two Sigma Investments, LP | 151,232 | $842.4K | 0.00% | +2,439+1.6% | Added |
| ADAR1 Capital Management, LLC | 136,736 | $761.6K | 0.05% | +86,736+173.5% | Added |
| Marshall Wace, LLP | 128,451 | $715.5K | 0.00% | 00.0% | Unchanged |
| Vanguard Fiduciary Trust Co | 114,934 | $640.2K | 0.00% | +114,934 | New |
| Engineers Gate Manager LP | 112,432 | $626.2K | 0.01% | +112,432 | New |
| Jane Street Group, LLC | 105,901 | $589.9K | 0.00% | +70,368+198.0% | Added |
| Renaissance Technologies LLC | 105,414 | $587.2K | 0.00% | +45,500+75.9% | Added |
| C WorldWide Group Holding A/S | 100,000 | $557.0K | 0.01% | 00.0% | Unchanged |
| Birchview Capital, LP | 83,952 | $467.6K | 0.27% | +83,952 | New |
| State Street Corp | 80,742 | $449.7K | 0.00% | +21,800+37.0% | Added |
| Connor, Clark & Lunn Investment Management Ltd. | 79,081 | $440.5K | 0.00% | +21,869+38.2% | Added |
| Bridgeway Capital Management, LLC | 71,873 | $400.3K | 0.01% | +6,000+9.1% | Added |
| Balyasny Asset Management LLC | 70,748 | $394.1K | 0.00% | +70,748 | New |
| Silverback Asset Management LLC | 65,000 | $362.1K | 0.07% | +25,000+62.5% | Added |
| Royal Bank of Canada | 60,399 | $336.0K | 0.00% | +2,399+4.1% | Added |
| Polygon Management Ltd. | 52,984 | $295.1K | 0.06% | +52,984 | New |
| DAFNA Capital Management LLC | 45,800 | $255.1K | 0.06% | −5,200−10.2% | Reduced |
| Northern Trust Corp | 38,556 | $214.8K | 0.00% | +9,533+32.8% | Added |
| Zimmer Partners, LP | 37,500 | $208.9K | 0.01% | +37,500 | New |
| Centiva Capital, LP | 30,210 | $168.3K | 0.01% | +30,210 | New |
| China Universal Asset Management Co., Ltd. | 30,000 | $167.1K | 0.01% | +30,000 | New |
| Baird Financial Group, Inc. | 29,791 | $165.9K | 0.00% | +1,798+6.4% | Added |
| Susquehanna Portfolio Strategies, LLC | 25,021 | $139.4K | 0.00% | +25,021 | New |
| Susquehanna International Group, LLP | 24,138 | $134.4K | 0.00% | −123,560−83.7% | Reduced |
| Bank of America Corp | 19,472 | $108.5K | 0.00% | −28,616−59.5% | Reduced |
| Omers Administration Corp | 19,400 | $108.1K | 0.00% | +19,400 | New |
| Morgan Stanley | 18,570 | $103.4K | 0.00% | +9,712+109.6% | Added |
| Invesco Ltd. | 16,738 | $93.2K | 0.00% | +16,738 | New |
| Velan Capital Investment Management LP | 15,000 | $83.5K | 0.05% | +15,000 | New |
| Charles Schwab Investment Management Inc | 13,429 | $74.8K | 0.00% | +13,429 | New |
| HSBC Holdings PLC | 11,495 | $65.6K | 0.00% | +11,495 | New |
| Bank of New York Mellon Corp | 11,399 | $63.5K | 0.00% | +312+2.8% | Added |
| Price T Rowe Associates Inc | 10,886 | $61.0K | 0.00% | 00.0% | Unchanged |
| Vanguard Global Advisers, LLC | 8,207 | $45.7K | 0.00% | +8,207 | New |
| Barclays PLC | 7,424 | $41.4K | 0.00% | +3,315+80.7% | Added |
| Citigroup Inc | 4,941 | $27.5K | 0.00% | +4,940+494,000.0% | Added |
| TD Waterhouse Canada Inc. | 3,203 | $18.6K | 0.00% | 00.0% | Unchanged |
| Rockefeller Capital Management L.P. | 733 | $4.08K | 0.00% | 00.0% | Unchanged |
| FMR LLC | 665 | $3.70K | 0.00% | −14−2.1% | Reduced |
| JPMorgan Chase & Co | 471 | $2.50K | 0.00% | −1,270−72.9% | Reduced |
| Advisor Group Holdings, Inc. | 402 | $2.24K | 0.00% | +120+42.6% | Added |
| Harbour Investments, Inc. | 285 | $1.59K | 0.00% | +200+235.3% | Added |
| Quent Capital, LLC | 235 | $1.31K | 0.00% | 00.0% | Unchanged |
| MB, Levis & Associates, LLC | 100 | $557 | 0.00% | 00.0% | Unchanged |
| BNP Paribas Arbitrage, SA | 84 | $468 | 0.00% | +2+2.4% | Added |
| SBI Securities Co., Ltd. | 67 | $373 | 0.00% | −7−9.5% | Reduced |
| Activest Wealth Management | 66 | $368 | 0.00% | 00.0% | Unchanged |
| Allworth Financial LP | 26 | $145 | 0.00% | 00.0% | Unchanged |
| Advisory Services Network, LLC | 12 | $67 | 0.00% | +12 | New |
| West Branch Capital LLC | 3 | $17 | 0.00% | 00.0% | Unchanged |
| PlanVest Financial, Inc | 1 | $6 | 0.00% | +1 | New |
| Opaleye Management Inc. | 0 | $0 | 0.00% | −930,000−100.0% | Sold out |
| Braidwell LP | 0 | $0 | 0.00% | −303,370−100.0% | Sold out |
| Exome Asset Management LLC | 0 | $0 | 0.00% | −295,541−100.0% | Sold out |
| Ameriprise Financial Inc | 0 | $0 | 0.00% | −276,881−100.0% | Sold out |
| Walleye Capital LLC | 0 | $0 | 0.00% | −95,672−100.0% | Sold out |
| Two Sigma Advisers, LP | 0 | $0 | 0.00% | −89,729−100.0% | Sold out |
| Context Capital Management, LLC | 0 | $0 | 0.00% | −62,995−100.0% | Sold out |
| Quadrature Capital Ltd | 0 | $0 | 0.00% | −59,708−100.0% | Sold out |
| Simplex Trading, LLC | 0 | $0 | 0.00% | −32,868−100.0% | Sold out |
| Citadel Advisors LLC | 0 | $0 | 0.00% | −31,709−100.0% | Sold out |
| Prelude Capital Management, LLC | 0 | $0 | 0.00% | −28,723−100.0% | Sold out |
| Persistent Asset Partners Ltd | 0 | $0 | 0.00% | −18,316−100.0% | Sold out |
| Tudor Investment Corp Et Al | 0 | $0 | 0.00% | −12,922−100.0% | Sold out |
| Aspect Partners, LLC | 0 | $0 | 0.00% | −391−100.0% | Sold out |
| Vanguard Group Inc | – | – | – | – | Not filed |
| CIBC Private Wealth Group, LLC | – | – | – | – | Not filed |