Karyopharm Therapeutics Inc.
KPTI- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001503802
In the last 90 days, Karyopharm Therapeutics Inc. insiders filed 0 open-market purchases and 2 sales; 96 institutions reported holding it in 13F filings for Q2 2026, worth $206.8M in total; no superinvestor holds it.
13F holders, Q1 2026
Institutional positions in Karyopharm Therapeutics Inc. as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 77
- +11 vs. Q4 2025
- Shares held
- 17.7M
- +8.77M (+98.6%) vs. Q4 2025
- Total value
- $98.4M
- +$32.9M (+50.3%) vs. Q4 2025
- New holders
- 25
- 32 more added
- Sold out
- 14
- 9 more reduced
2 institutions that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting KPTI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 96 | $206.8M |
| Q1 2026 | 77 | $98.4M |
| Q4 2025 | 68 | $69.6M |
| Q3 2025 | 52 | $19.5M |
| Q2 2025 | 50 | $19.0M |
| Q1 2025 | 50 | $13.7M |
| Q4 2024 | 87 | $41.2M |
| Q3 2024 | 91 | $49.2M |
| Q2 2024 | 114 | $58.6M |
| Q1 2024 | 114 | $113.0M |
| Q4 2023 | 120 | $63.5M |
| Q3 2023 | 120 | $102.8M |
| Q2 2023 | 138 | $145.0M |
| Q1 2023 | 132 | $340.1M |
| Q4 2022 | 155 | $334.4M |
| Q3 2022 | 147 | $364.1M |
| Q2 2022 | 150 | $302.8M |
| Q1 2022 | 139 | $501.8M |
| Q4 2021 | 143 | $347.5M |
| Q3 2021 | 134 | $334.4M |
| Q2 2021 | 154 | $608.7M |
| Q1 2021 | 171 | $637.1M |
Institutions, Q1 2026
Shares, value and share of portfolio for each institution holding Karyopharm Therapeutics Inc.; share changes are against Q4 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| PlanVest Financial, Inc | 1 | $6 | 0.00% | +1 | New |
| West Branch Capital LLC | 3 | $17 | 0.00% | 00.0% | Unchanged |
| Advisory Services Network, LLC | 12 | $67 | 0.00% | +12 | New |
| Allworth Financial LP | 26 | $145 | 0.00% | 00.0% | Unchanged |
| Activest Wealth Management | 66 | $368 | 0.00% | 00.0% | Unchanged |
| SBI Securities Co., Ltd. | 67 | $373 | 0.00% | −7−9.5% | Reduced |
| BNP Paribas Arbitrage, SA | 84 | $468 | 0.00% | +2+2.4% | Added |
| MB, Levis & Associates, LLC | 100 | $557 | 0.00% | 00.0% | Unchanged |
| Quent Capital, LLC | 235 | $1.31K | 0.00% | 00.0% | Unchanged |
| Harbour Investments, Inc. | 285 | $1.59K | 0.00% | +200+235.3% | Added |
| Advisor Group Holdings, Inc. | 402 | $2.24K | 0.00% | +120+42.6% | Added |
| JPMorgan Chase & Co | 471 | $2.50K | 0.00% | −1,270−72.9% | Reduced |
| FMR LLC | 665 | $3.70K | 0.00% | −14−2.1% | Reduced |
| Rockefeller Capital Management L.P. | 733 | $4.08K | 0.00% | 00.0% | Unchanged |
| TD Waterhouse Canada Inc. | 3,203 | $18.6K | 0.00% | 00.0% | Unchanged |
| Citigroup Inc | 4,941 | $27.5K | 0.00% | +4,940+494,000.0% | Added |
| Barclays PLC | 7,424 | $41.4K | 0.00% | +3,315+80.7% | Added |
| Vanguard Global Advisers, LLC | 8,207 | $45.7K | 0.00% | +8,207 | New |
| Price T Rowe Associates Inc | 10,886 | $61.0K | 0.00% | 00.0% | Unchanged |
| Bank of New York Mellon Corp | 11,399 | $63.5K | 0.00% | +312+2.8% | Added |
| HSBC Holdings PLC | 11,495 | $65.6K | 0.00% | +11,495 | New |
| Charles Schwab Investment Management Inc | 13,429 | $74.8K | 0.00% | +13,429 | New |
| Velan Capital Investment Management LP | 15,000 | $83.5K | 0.05% | +15,000 | New |
| Invesco Ltd. | 16,738 | $93.2K | 0.00% | +16,738 | New |
| Morgan Stanley | 18,570 | $103.4K | 0.00% | +9,712+109.6% | Added |
| Omers Administration Corp | 19,400 | $108.1K | 0.00% | +19,400 | New |
| Bank of America Corp | 19,472 | $108.5K | 0.00% | −28,616−59.5% | Reduced |
| Susquehanna International Group, LLP | 24,138 | $134.4K | 0.00% | −123,560−83.7% | Reduced |
| Susquehanna Portfolio Strategies, LLC | 25,021 | $139.4K | 0.00% | +25,021 | New |
| Baird Financial Group, Inc. | 29,791 | $165.9K | 0.00% | +1,798+6.4% | Added |
| China Universal Asset Management Co., Ltd. | 30,000 | $167.1K | 0.01% | +30,000 | New |
| Centiva Capital, LP | 30,210 | $168.3K | 0.01% | +30,210 | New |
| Zimmer Partners, LP | 37,500 | $208.9K | 0.01% | +37,500 | New |
| Northern Trust Corp | 38,556 | $214.8K | 0.00% | +9,533+32.8% | Added |
| DAFNA Capital Management LLC | 45,800 | $255.1K | 0.06% | −5,200−10.2% | Reduced |
| Polygon Management Ltd. | 52,984 | $295.1K | 0.06% | +52,984 | New |
| Royal Bank of Canada | 60,399 | $336.0K | 0.00% | +2,399+4.1% | Added |
| Silverback Asset Management LLC | 65,000 | $362.1K | 0.07% | +25,000+62.5% | Added |
| Balyasny Asset Management LLC | 70,748 | $394.1K | 0.00% | +70,748 | New |
| Bridgeway Capital Management, LLC | 71,873 | $400.3K | 0.01% | +6,000+9.1% | Added |
| Connor, Clark & Lunn Investment Management Ltd. | 79,081 | $440.5K | 0.00% | +21,869+38.2% | Added |
| State Street Corp | 80,742 | $449.7K | 0.00% | +21,800+37.0% | Added |
| Birchview Capital, LP | 83,952 | $467.6K | 0.27% | +83,952 | New |
| C WorldWide Group Holding A/S | 100,000 | $557.0K | 0.01% | 00.0% | Unchanged |
| Renaissance Technologies LLC | 105,414 | $587.2K | 0.00% | +45,500+75.9% | Added |
| Jane Street Group, LLC | 105,901 | $589.9K | 0.00% | +70,368+198.0% | Added |
| Engineers Gate Manager LP | 112,432 | $626.2K | 0.01% | +112,432 | New |
| Vanguard Fiduciary Trust Co | 114,934 | $640.2K | 0.00% | +114,934 | New |
| Marshall Wace, LLP | 128,451 | $715.5K | 0.00% | 00.0% | Unchanged |
| ADAR1 Capital Management, LLC | 136,736 | $761.6K | 0.05% | +86,736+173.5% | Added |
| Two Sigma Investments, LP | 151,232 | $842.4K | 0.00% | +2,439+1.6% | Added |
| XTX Topco Ltd | 164,443 | $915.9K | 0.02% | +152,539+1,281.4% | Added |
| Group One Trading, L.P. | 191,527 | $1.07M | 0.04% | +89,108+87.0% | Added |
| UBS Group AG | 194,017 | $1.08M | 0.00% | +105,562+119.3% | Added |
| Geode Capital Management, LLC | 206,133 | $1.15M | 0.00% | +18,399+9.8% | Added |
| Brevan Howard Capital Management LP | 212,367 | $1.18M | 0.01% | +212,367 | New |
| Boothbay Fund Management, LLC | 213,810 | $1.19M | 0.03% | +69,182+47.8% | Added |
| BlackRock, Inc. | 244,899 | $1.36M | 0.00% | −2,659−1.1% | Reduced |
| Acadian Asset Management LLC | 248,957 | $1.38M | 0.00% | +245,231+6,581.6% | Added |
| Trexquant Investment LP | 257,903 | $1.44M | 0.01% | +216,170+518.0% | Added |
| Jump Financial, LLC | 262,146 | $1.46M | 0.02% | +208,330+387.1% | Added |
| Eversept Partners, LP | 276,174 | $1.54M | 0.10% | +276,174 | New |
| Acorn Capital Advisors, LLC | 287,826 | $1.60M | 0.46% | +287,826 | New |
| Davidson Kempner Capital Management LP | 300,000 | $1.67M | 0.03% | −10,020−3.2% | Reduced |
| Boxer Capital Management, LLC | 302,536 | $1.69M | 0.22% | +50,000+19.8% | Added |
| Millennium Management LLC | 420,571 | $2.34M | 0.00% | +420,571 | New |
| Soleus Capital Management, L.P. | 440,000 | $2.45M | 0.10% | 00.0% | Unchanged |
| Avidity Partners Management LP | 463,741 | $2.58M | 0.52% | +329,175+244.6% | Added |
| Affinity Asset Advisors, LLC | 500,000 | $2.79M | 0.16% | −389,575−43.8% | Reduced |
| Ikarian Capital, LLC | 733,435 | $4.09M | 0.58% | +188,881+34.7% | Added |
| Vanguard Capital Management LLC | 739,745 | $4.12M | 0.00% | +739,745 | New |
| Catalio Capital Management, LP | 897,709 | $5.00M | 1.04% | +754,725+527.8% | Added |
| Goldman Sachs Group Inc | 947,579 | $5.28M | 0.00% | +947,579 | New |
| T. Rowe Price Investment Management, Inc. | 1,542,090 | $8.59M | 0.01% | +50,681+3.4% | Added |
| Adage Capital Partners GP, L.L.C. | 1,806,322 | $10.1M | 0.02% | +1,385,000+328.7% | Added |
| Ra Capital Management, L.P. | 1,917,354 | $10.7M | 0.11% | +1,917,354 | New |
| Commodore Capital LP | 1,950,000 | $10.9M | 0.63% | +1,950,000 | New |
| Opaleye Management Inc. | 0 | $0 | 0.00% | −930,000−100.0% | Sold out |
| Braidwell LP | 0 | $0 | 0.00% | −303,370−100.0% | Sold out |
| Exome Asset Management LLC | 0 | $0 | 0.00% | −295,541−100.0% | Sold out |
| Ameriprise Financial Inc | 0 | $0 | 0.00% | −276,881−100.0% | Sold out |
| Walleye Capital LLC | 0 | $0 | 0.00% | −95,672−100.0% | Sold out |
| Two Sigma Advisers, LP | 0 | $0 | 0.00% | −89,729−100.0% | Sold out |
| Context Capital Management, LLC | 0 | $0 | 0.00% | −62,995−100.0% | Sold out |
| Quadrature Capital Ltd | 0 | $0 | 0.00% | −59,708−100.0% | Sold out |
| Simplex Trading, LLC | 0 | $0 | 0.00% | −32,868−100.0% | Sold out |
| Citadel Advisors LLC | 0 | $0 | 0.00% | −31,709−100.0% | Sold out |
| Prelude Capital Management, LLC | 0 | $0 | 0.00% | −28,723−100.0% | Sold out |
| Persistent Asset Partners Ltd | 0 | $0 | 0.00% | −18,316−100.0% | Sold out |
| Tudor Investment Corp Et Al | 0 | $0 | 0.00% | −12,922−100.0% | Sold out |
| Aspect Partners, LLC | 0 | $0 | 0.00% | −391−100.0% | Sold out |
| Vanguard Group Inc | – | – | – | – | Not filed |
| CIBC Private Wealth Group, LLC | – | – | – | – | Not filed |