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Karyopharm Therapeutics Inc.

KPTI
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001503802

In the last 90 days, Karyopharm Therapeutics Inc. insiders filed 0 open-market purchases and 2 sales; 96 institutions reported holding it in 13F filings for Q2 2026, worth $206.8M in total; no superinvestor holds it.

13F holders, Q1 2025

Institutional positions in Karyopharm Therapeutics Inc. as of Mar 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
50
−37 vs. Q4 2024
Shares held
3.62M
−436.7K (−10.8%) vs. Q4 2024Converted for a 1-for-15 split
Total value
$13.7M
−$27.5M (−66.7%) vs. Q4 2024
New holders
5
8 more added
Sold out
42
21 more reduced

Compare with Q4 2024: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting KPTI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ1 2025: 50 institutions
Q1 2021: 171 institutionsQ2 2021: 154 institutionsQ3 2021: 134 institutionsQ4 2021: 143 institutionsQ1 2022: 139 institutionsQ2 2022: 150 institutionsQ3 2022: 147 institutionsQ4 2022: 155 institutionsQ1 2023: 132 institutionsQ2 2023: 138 institutionsQ3 2023: 120 institutionsQ4 2023: 120 institutionsQ1 2024: 114 institutionsQ2 2024: 114 institutionsQ3 2024: 91 institutionsQ4 2024: 87 institutionsQ1 2025: 50 institutionsQ2 2025: 50 institutionsQ3 2025: 52 institutionsQ4 2025: 68 institutionsQ1 2026: 77 institutionsQ2 2026: 96 institutions
Value heldQ1 2025: $13.7M
Q1 2021: $637.1MQ2 2021: $608.7MQ3 2021: $334.4MQ4 2021: $347.5MQ1 2022: $501.8MQ2 2022: $302.8MQ3 2022: $364.1MQ4 2022: $334.4MQ1 2023: $340.1MQ2 2023: $145.0MQ3 2023: $102.8MQ4 2023: $63.5MQ1 2024: $113.0MQ2 2024: $58.6MQ3 2024: $49.2MQ4 2024: $41.2MQ1 2025: $13.7MQ2 2025: $19.0MQ3 2025: $19.5MQ4 2025: $69.6MQ1 2026: $98.4MQ2 2026: $206.8M
Institutions holding KPTI and their total value by quarter
QuarterHoldersValue
Q2 202696$206.8M
Q1 202677$98.4M
Q4 202568$69.6M
Q3 202552$19.5M
Q2 202550$19.0M
Q1 202550$13.7M
Q4 202487$41.2M
Q3 202491$49.2M
Q2 2024114$58.6M
Q1 2024114$113.0M
Q4 2023120$63.5M
Q3 2023120$102.8M
Q2 2023138$145.0M
Q1 2023132$340.1M
Q4 2022155$334.4M
Q3 2022147$364.1M
Q2 2022150$302.8M
Q1 2022139$501.8M
Q4 2021143$347.5M
Q3 2021134$334.4M
Q2 2021154$608.7M
Q1 2021171$637.1M

Institutions, Q1 2025

Shares, value and share of portfolio for each institution holding Karyopharm Therapeutics Inc.; share changes are against Q4 2024.

Institutions holding KPTI in Q1 2025
InstitutionSharesValue% of portfolioChange in sharesAction
Vanguard Group Inc510,294$1.91M0.00%00.0%UnchangedConverted for a 1-for-15 split
Adage Capital Partners GP, L.L.C.421,322$1.58M0.00%00.0%UnchangedConverted for a 1-for-15 split
Palo Alto Investors LP324,032$1.21M0.23%−3,101−0.9%ReducedConverted for a 1-for-15 split
Eversept Partners, LP257,154$961.8K0.11%+117,904+84.7%AddedConverted for a 1-for-15 split
BlackRock, Inc.242,742$907.9K0.00%−8,516−3.4%ReducedConverted for a 1-for-15 split
Citadel Advisors LLC206,909$773.8K0.00%00.0%UnchangedConverted for a 1-for-15 split
JPMorgan Chase & Co170,790$638.8K0.00%+152,376+827.5%AddedConverted for a 1-for-15 split
Catalio Capital Management, LP155,622$582.0K0.14%00.0%UnchangedConverted for a 1-for-15 split
T. Rowe Price Investment Management, Inc.139,646$523.0K0.00%+139,646New
Avidity Partners Management LP134,566$503.3K0.10%00.0%UnchangedConverted for a 1-for-15 split
Bank of America Corp132,908$497.1K0.00%+122,127+1,132.9%AddedConverted for a 1-for-15 split
Marshall Wace, LLP128,451$480.4K0.00%−31,643−19.8%ReducedConverted for a 1-for-15 split
C WorldWide Group Holding A/S100,000$374.0K0.00%00.0%UnchangedConverted for a 1-for-15 split
Geode Capital Management, LLC99,640$372.7K0.00%+6,819+7.3%AddedConverted for a 1-for-15 split
UBS Group AG93,612$350.1K0.00%+83,893+863.1%AddedConverted for a 1-for-15 split
Goldman Sachs Group Inc85,410$319.4K0.00%−3,641−4.1%ReducedConverted for a 1-for-15 split
Renaissance Technologies LLC61,214$228.9K0.00%−18,959−23.6%ReducedConverted for a 1-for-15 split
Millennium Management LLC55,367$207.1K0.00%−21,594−28.1%ReducedConverted for a 1-for-15 split
Silverback Asset Management LLC–$187.0K0.03%–New
Altium Capital Management LP49,333$184.5K0.54%00.0%UnchangedConverted for a 1-for-15 split
State Street Corp29,495$110.3K0.00%00.0%UnchangedConverted for a 1-for-15 split
BNP Paribas Arbitrage, SA28,961$108.3K0.00%−58,632−66.9%ReducedConverted for a 1-for-15 split
Birchview Capital, LP27,985$104.7K0.09%00.0%UnchangedConverted for a 1-for-15 split
Ikarian Capital, LLC27,257$101.9K0.03%00.0%UnchangedConverted for a 1-for-15 split
Shay Capital LLC25,417$95.1K0.03%+13,940+121.5%AddedConverted for a 1-for-15 split
UBS Oconnor LLC23,640$88.4K0.00%−75,275−76.1%ReducedConverted for a 1-for-15 split
Northern Trust Corp18,910$70.7K0.00%00.0%UnchangedConverted for a 1-for-15 split
Susquehanna International Group, LLP11,548$43.2K0.00%−32,728−73.9%ReducedConverted for a 1-for-15 split
Jane Street Group, LLC11,420$42.7K0.00%−38,467−77.1%ReducedConverted for a 1-for-15 split
Bank of New York Mellon Corp11,086$41.5K0.00%00.0%UnchangedConverted for a 1-for-15 split
Morgan Stanley10,423$39.0K0.00%−223,790−95.5%ReducedConverted for a 1-for-15 split
Leonteq Securities AG10,000$37.3K0.00%+10,000New
Citigroup Inc7,044$26.3K0.00%00.0%UnchangedConverted for a 1-for-15 split
Barclays PLC5,333$19.9K0.00%−1,041−16.3%ReducedConverted for a 1-for-15 split
TD Waterhouse Canada Inc.3,203$11.3K0.00%00.0%UnchangedConverted for a 1-for-15 split
Royal Bank of Canada1,459$5.00K0.00%+1,026+236.7%AddedConverted for a 1-for-15 split
FMR LLC527$1.97K0.00%−26,970−98.1%ReducedConverted for a 1-for-15 split
Advisor Group Holdings, Inc.346$1.29K0.00%−13−3.7%ReducedConverted for a 1-for-15 split
Coldstream Capital Management Inc331$1.24K0.00%+331New
Quent Capital, LLC231$8640.00%−2−0.7%ReducedConverted for a 1-for-15 split
VSM Wealth Advisory, LLC133$4970.00%00.0%UnchangedConverted for a 1-for-15 split
MB, Levis & Associates, LLC100$3740.00%00.0%UnchangedConverted for a 1-for-15 split
Harbour Investments, Inc.85$3180.00%−2−1.9%ReducedConverted for a 1-for-15 split
SBI Securities Co., Ltd.74$2770.00%+26+54.8%AddedConverted for a 1-for-15 split
Activest Wealth Management66$2470.00%−1−1.0%ReducedConverted for a 1-for-15 split
Allworth Financial LP32$1920.00%−1−4.0%ReducedConverted for a 1-for-15 split
Bruce G. Allen Investments, LLC22$820.00%−1−2.4%ReducedConverted for a 1-for-15 split
CIBC Private Wealth Group, LLC3$120.00%−0−10.0%ReducedConverted for a 1-for-15 split
West Branch Capital LLC3$120.00%−0−6.3%ReducedConverted for a 1-for-15 split
Danske Bank A/S3$110.00%+3New
Gsa Capital Partners LLP0$00.00%−106,562−100.0%Sold outConverted for a 1-for-15 split
Deutsche Bank AG0$00.00%−84,585−100.0%Sold outConverted for a 1-for-15 split
Kennedy Capital Management, Inc.0$00.00%−79,686−100.0%Sold outConverted for a 1-for-15 split
Silverarc Capital Management, LLC0$00.00%−39,733−100.0%Sold outConverted for a 1-for-15 split
Macquarie Group Ltd0$00.00%−33,333−100.0%Sold outConverted for a 1-for-15 split
Acadian Asset Management LLC0$00.00%−22,856−100.0%Sold outConverted for a 1-for-15 split
Cubist Systematic Strategies, LLC0$00.00%−21,920−100.0%Sold outConverted for a 1-for-15 split
Atom Investors LP0$00.00%−17,322−100.0%Sold outConverted for a 1-for-15 split
Bridgeway Capital Management, LLC0$00.00%−15,967−100.0%Sold outConverted for a 1-for-15 split
D. E. Shaw & Co., Inc.0$00.00%−15,312−100.0%Sold outConverted for a 1-for-15 split
Exchange Traded Concepts, LLC0$00.00%−14,586−100.0%Sold outConverted for a 1-for-15 split
Two Sigma Investments, LP0$00.00%−9,186−100.0%Sold outConverted for a 1-for-15 split
Woodline Partners LP0$00.00%−8,941−100.0%Sold outConverted for a 1-for-15 split
Opti Capital Management, LP0$00.00%−8,333−100.0%Sold outConverted for a 1-for-15 split
Boothbay Fund Management, LLC0$00.00%−6,042−100.0%Sold outConverted for a 1-for-15 split
Point72 Asia (Singapore) Pte. Ltd.0$00.00%−5,647−100.0%Sold outConverted for a 1-for-15 split
Two Sigma Advisers, LP0$00.00%−5,107−100.0%Sold outConverted for a 1-for-15 split
Prudential Financial Inc0$00.00%−4,973−100.0%Sold outConverted for a 1-for-15 split
Price T Rowe Associates Inc0$00.00%−4,287−100.0%Sold outConverted for a 1-for-15 split
Charles Schwab Investment Management Inc0$00.00%−3,412−100.0%Sold outConverted for a 1-for-15 split
Colony Group, LLC0$00.00%−3,055−100.0%Sold outConverted for a 1-for-15 split
Baird Financial Group, Inc.0$00.00%−2,987−100.0%Sold outConverted for a 1-for-15 split
Velan Capital Investment Management LP0$00.00%−2,667−100.0%Sold outConverted for a 1-for-15 split
HSBC Holdings PLC0$00.00%−2,687−100.0%Sold outConverted for a 1-for-15 split
Eqis Capital Management, Inc.0$00.00%−2,579−100.0%Sold outConverted for a 1-for-15 split
Kennedy Investment Group0$00.00%−2,333−100.0%Sold outConverted for a 1-for-15 split
R Squared Ltd0$00.00%−1,978−100.0%Sold outConverted for a 1-for-15 split
Engineers Gate Manager LP0$00.00%−1,913−100.0%Sold outConverted for a 1-for-15 split
Commonwealth Equity Services, LLC0$00.00%−1,486−100.0%Sold outConverted for a 1-for-15 split
Squarepoint Ops LLC0$00.00%−1,386−100.0%Sold outConverted for a 1-for-15 split
CI Private Wealth, LLC0$00.00%−1,367−100.0%Sold outConverted for a 1-for-15 split
ADAR1 Capital Management, LLC0$00.00%−1,333−100.0%Sold outConverted for a 1-for-15 split
ELCO Management Co., LLC0$00.00%−1,078−100.0%Sold outConverted for a 1-for-15 split
Winthrop Advisory Group LLC0$00.00%−1,000−100.0%Sold outConverted for a 1-for-15 split
CAPROCK Group, Inc.0$00.00%−773−100.0%Sold outConverted for a 1-for-15 split
Snowden Capital Advisors LLC0$00.00%−733−100.0%Sold outConverted for a 1-for-15 split
Wolverine Trading, LLC0$00.00%−685−100.0%Sold outConverted for a 1-for-15 split
Walleye Capital LLC0$00.00%−697−100.0%Sold outConverted for a 1-for-15 split
Janney Montgomery Scott LLC0$00.00%−667−100.0%Sold outConverted for a 1-for-15 split
BLB&B Advisors, LLC0$00.00%−677−100.0%Sold outConverted for a 1-for-15 split
Tower Research Capital LLC (TRC)0$00.00%−513−100.0%Sold outConverted for a 1-for-15 split
Wells Fargo & Company0$00.00%−44−100.0%Sold outConverted for a 1-for-15 split