Karyopharm Therapeutics Inc.
KPTI- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001503802
In the last 90 days, Karyopharm Therapeutics Inc. insiders filed 0 open-market purchases and 2 sales; 96 institutions reported holding it in 13F filings for Q2 2026, worth $206.8M in total; no superinvestor holds it.
13F holders, Q2 2022
Institutional positions in Karyopharm Therapeutics Inc. as of Jun 30, 2022. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 150
- +16 vs. Q1 2022
- Shares held
- 67.1M
- −737.9K (−1.1%) vs. Q1 2022
- Total value
- $302.8M
- −$195.8M (−39.3%) vs. Q1 2022
- New holders
- 28
- 40 more added
- Sold out
- 12
- 58 more reduced
5 institutions that held it in Q1 2022 haven't filed for Q2 2022 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2022: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting KPTI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 96 | $206.8M |
| Q1 2026 | 77 | $98.4M |
| Q4 2025 | 68 | $69.6M |
| Q3 2025 | 52 | $19.5M |
| Q2 2025 | 50 | $19.0M |
| Q1 2025 | 50 | $13.7M |
| Q4 2024 | 87 | $41.2M |
| Q3 2024 | 91 | $49.2M |
| Q2 2024 | 114 | $58.6M |
| Q1 2024 | 114 | $113.0M |
| Q4 2023 | 120 | $63.5M |
| Q3 2023 | 120 | $102.8M |
| Q2 2023 | 138 | $145.0M |
| Q1 2023 | 132 | $340.1M |
| Q4 2022 | 155 | $334.4M |
| Q3 2022 | 147 | $364.1M |
| Q2 2022 | 150 | $302.8M |
| Q1 2022 | 139 | $501.8M |
| Q4 2021 | 143 | $347.5M |
| Q3 2021 | 134 | $334.4M |
| Q2 2021 | 154 | $608.7M |
| Q1 2021 | 171 | $637.1M |
Institutions, Q2 2022
Shares, value and share of portfolio for each institution holding Karyopharm Therapeutics Inc.; share changes are against Q1 2022.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| State Street Corp | 10,362,009 | $46.7M | 0.00% | −604,692−5.5% | Reduced |
| BlackRock Inc. | 8,122,849 | $36.6M | 0.00% | +195,231+2.5% | Added |
| Palo Alto Investors LP | 5,621,533 | $25.4M | 2.21% | 00.0% | Unchanged |
| Rubric Capital Management LP | 4,400,000 | $19.8M | 1.04% | +792,557+22.0% | Added |
| Vanguard Group Inc | 4,221,980 | $19.0M | 0.00% | +261,272+6.6% | Added |
| Morgan Stanley | 2,386,698 | $10.8M | 0.00% | −425,865−15.1% | Reduced |
| Commodore Capital LP | 1,935,609 | $8.73M | 1.85% | −1,625,443−45.6% | Reduced |
| Nuveen Asset Management, LLC | 1,895,378 | $8.55M | 0.00% | +76,330+4.2% | Added |
| Walleye Capital LLC | 1,745,415 | $7.87M | 0.23% | +1,662,337+2,000.9% | Added |
| Jacobs Levy Equity Management, Inc | 1,527,040 | $6.89M | 0.05% | +863,528+130.1% | Added |
| C WorldWide Group Holding A/S | 1,500,000 | $6.76M | 0.08% | 00.0% | Unchanged |
| Goldman Sachs Group Inc | 1,446,402 | $6.52M | 0.00% | +547,496+60.9% | Added |
| Geode Capital Management, LLC | 1,326,319 | $5.98M | 0.00% | −11,569−0.9% | Reduced |
| Rice Hall James & Associates, LLC | 1,315,834 | $5.93M | 0.29% | −29,095−2.2% | Reduced |
| Candriam Luxembourg S.C.A. | 1,235,724 | $5.57M | 0.05% | −99,302−7.4% | Reduced |
| Iron Triangle Partners LP | 1,100,000 | $4.96M | 0.80% | −900,000−45.0% | Reduced |
| Two Sigma Investments, LP | 1,023,752 | $4.62M | 0.02% | −94,173−8.4% | Reduced |
| Two Sigma Advisers, LP | 986,000 | $4.45M | 0.01% | +210,700+27.2% | Added |
| Northern Trust Corp | 768,098 | $3.46M | 0.00% | +3,763+0.5% | Added |
| Altium Capital Management LP | 700,000 | $3.16M | 1.34% | +55,000+8.5% | Added |
| ExodusPoint Capital Management, LP | 645,985 | $2.91M | 0.04% | +626,498+3,215.0% | Added |
| Frontier Capital Management Co LLC | 632,506 | $2.85M | 0.03% | −646,789−50.6% | Reduced |
| Millennium Management LLC | 605,383 | $2.73M | 0.00% | −647,490−51.7% | Reduced |
| Deutsche Bank AG | 594,488 | $2.68M | 0.00% | −4,948−0.8% | Reduced |
| BNP Paribas Arbitrage, SA | 584,288 | $2.64M | 0.01% | +575,738+6,733.8% | Added |
| Lombard Odier Asset Management (Switzerland) SA | 513,802 | $2.32M | 0.20% | −262,251−33.8% | Reduced |
| Bank of America Corp | 479,418 | $2.16M | 0.00% | −636,812−57.1% | Reduced |
| Citigroup Inc | 469,019 | $2.12M | 0.00% | +341,239+267.1% | Added |
| Rafferty Asset Management, LLC | 459,409 | $2.07M | 0.02% | −349,530−43.2% | Reduced |
| Renaissance Technologies LLC | 454,800 | $2.05M | 0.00% | +239,700+111.4% | Added |
| Citadel Advisors LLC | 408,349 | $1.84M | 0.00% | −446,168−52.2% | Reduced |
| Voloridge Investment Management, LLC | 389,164 | $1.75M | 0.01% | −287,670−42.5% | Reduced |
| Macquarie Group Ltd | 382,041 | $1.72M | 0.00% | 00.0% | Unchanged |
| UBS Group AG | 317,535 | $1.43M | 0.00% | −200,925−38.8% | Reduced |
| Hennion & Walsh Asset Management, Inc. | 286,659 | $1.29M | 0.08% | −99,178−25.7% | Reduced |
| Bank of New York Mellon Corp | 286,381 | $1.29M | 0.00% | −10,519−3.5% | Reduced |
| Susquehanna International Group, LLP | 281,936 | $1.27M | 0.00% | +807+0.3% | Added |
| Birchview Capital, LP | 269,332 | $1.22M | 0.88% | 00.0% | Unchanged |
| HighVista Strategies LLC | 250,377 | $1.13M | 0.68% | +250,377 | New |
| Qube Research & Technologies Ltd | 242,997 | $1.10M | 0.01% | +242,997 | New |
| UBS Oconnor LLC | 227,599 | $1.03M | 0.01% | +227,599 | New |
| Jupiter Asset Management Ltd | 224,603 | $1.01M | 0.01% | +224,603 | New |
| Jane Street Group, LLC | 208,597 | $941.0K | 0.00% | −208,246−50.0% | Reduced |
| Charles Schwab Investment Management Inc | 199,977 | $902.0K | 0.00% | +5,780+3.0% | Added |
| Wellington Management Group LLP | 196,342 | $886.0K | 0.00% | 00.0% | Unchanged |
| Cubist Systematic Strategies, LLC | 190,479 | $859.0K | 0.01% | +28,996+18.0% | Added |
| Acadian Asset Management LLC | 185,296 | $836.0K | 0.00% | −313,626−62.9% | Reduced |
| JPMorgan Chase & Co | 184,165 | $830.0K | 0.00% | −534,475−74.4% | Reduced |
| Allianz Asset Management GmbH | 179,225 | $808.0K | 0.00% | +15,240+9.3% | Added |
| Swiss National Bank | 160,750 | $725.0K | 0.00% | 00.0% | Unchanged |
| Algert Global LLC | 141,590 | $639.0K | 0.05% | +141,590 | New |
| Credit Suisse AG | 138,696 | $626.0K | 0.00% | +538+0.4% | Added |
| Alliancebernstein L.P. | 118,030 | $532.0K | 0.00% | +2,000+1.7% | Added |
| FMR LLC | 112,517 | $507.0K | 0.00% | −1,455−1.3% | Reduced |
| Russell Investments Group, Ltd. | 109,095 | $491.0K | 0.00% | +48,349+79.6% | Added |
| Trexquant Investment LP | 96,131 | $434.0K | 0.02% | +67,023+230.3% | Added |
| Rhumbline Advisers | 91,430 | $412.0K | 0.00% | +12,307+15.6% | Added |
| SG Americas Securities, LLC | 91,233 | $411.0K | 0.01% | +91,233 | New |
| California State Teachers Retirement System | 90,482 | $408.0K | 0.00% | +741+0.8% | Added |
| Balyasny Asset Management LLC | 86,059 | $388.0K | 0.00% | −256,425−74.9% | Reduced |
| Barclays PLC | 81,925 | $369.0K | 0.00% | −5,799−6.6% | Reduced |
| Dynamic Technology Lab Private Ltd | 78,720 | $355.0K | 0.04% | +78,720 | New |
| State of Wisconsin Investment Board | 72,844 | $329.0K | 0.00% | −22,956−24.0% | Reduced |
| UBS Asset Management Americas Inc | 71,271 | $321.4K | 0.00% | +9,151+14.7% | Added |
| New York Life Investment Management LLC | 63,275 | $285.0K | 0.00% | +63,275 | New |
| D. E. Shaw & Co., Inc. | 58,500 | $264.0K | 0.00% | +24,387+71.5% | Added |
| Tudor Investment Corp Et Al | 54,513 | $246.0K | 0.01% | +54,513 | New |
| State Board of Administration of Florida Retirement System | 53,075 | $239.0K | 0.00% | 00.0% | Unchanged |
| E Fund Management Co., Ltd. | 52,671 | $238.0K | 0.02% | +12,089+29.8% | Added |
| XTX Topco Ltd | 51,606 | $233.0K | 0.10% | +37,177+257.7% | Added |
| Prudential Financial Inc | 51,500 | $232.0K | 0.00% | +51,500 | New |
| Caxton Associates LP | 50,993 | $230.0K | 0.03% | +50,993 | New |
| HRT Financial LP | 49,034 | $221.0K | 0.00% | +49,034 | New |
| Engineers Gate Manager LP | 48,928 | $221.0K | 0.01% | +48,928 | New |
| New York State Common Retirement Fund | 48,874 | $220.0K | 0.00% | −3,551−6.8% | Reduced |
| Connor, Clark & Lunn Investment Management Ltd. | 45,978 | $207.0K | 0.00% | +45,978 | New |
| Arrowstreet Capital, Limited Partnership | 44,753 | $202.0K | 0.00% | +44,753 | New |
| Ensign Peak Advisors, Inc | 43,380 | $196.0K | 0.00% | 00.0% | Unchanged |
| GFG Capital, LLC | 41,400 | $187.0K | 0.06% | 00.0% | Unchanged |
| Price T Rowe Associates Inc | 37,670 | $170.0K | 0.00% | +11,372+43.2% | Added |
| DuPont Capital Management Corp | 36,455 | $164.0K | 0.01% | +13,728+60.4% | Added |
| American International Group, Inc. | 35,660 | $161.0K | 0.00% | −85−0.2% | Reduced |
| Legal & General Group Plc | 33,575 | $151.0K | 0.00% | +1,730+5.4% | Added |
| Invesco Ltd. | 31,095 | $141.0K | 0.00% | −451−1.4% | Reduced |
| Manufacturers Life Insurance Company, The | 29,827 | $134.5K | 0.00% | +329+1.1% | Added |
| Tower Research Capital LLC (TRC) | 29,096 | $131.0K | 0.00% | +22,576+346.3% | Added |
| Point72 Hong Kong Ltd | 29,111 | $131.0K | 0.01% | +28,640+6,080.7% | Added |
| Voya Investment Management LLC | 28,866 | $130.0K | 0.00% | −1,897−6.2% | Reduced |
| CSS LLC | 25,728 | $116.0K | 0.01% | +2,300+9.8% | Added |
| Weiss Multi-Strategy Advisers LLC | 25,522 | $115.0K | 0.00% | −2,356−8.5% | Reduced |
| Allspring Global Investments Holdings, LLC | 25,116 | $113.0K | 0.00% | −23,602−48.4% | Reduced |
| MetLife Investment Management | 23,213 | $104.7K | 0.00% | −18,559−44.4% | Reduced |
| Marshall Wace, LLP | 23,000 | $103.0K | 0.00% | +23,000 | New |
| AQR Capital Management LLC | 22,622 | $102.0K | 0.00% | −5,208−18.7% | Reduced |
| Mirae Asset Global Investments Co., Ltd. | 22,541 | $102.0K | 0.00% | +22,541 | New |
| Moors & Cabot, Inc. | 21,150 | $95.0K | 0.01% | −400−1.9% | Reduced |
| Principal Financial Group Inc | 20,299 | $91.0K | 0.00% | +7,195+54.9% | Added |
| Man Group plc | – | $85.0K | 0.00% | – | – |
| Los Angeles Capital Management LLC | 18,680 | $84.0K | 0.00% | 00.0% | Unchanged |
| Arizona State Retirement System | 18,474 | $83.0K | 0.00% | +95+0.5% | Added |