Karyopharm Therapeutics Inc.
KPTI- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001503802
In the last 90 days, Karyopharm Therapeutics Inc. insiders filed 0 open-market purchases and 2 sales; 96 institutions reported holding it in 13F filings for Q2 2026, worth $206.8M in total; no superinvestor holds it.
13F holders, Q4 2021
Institutional positions in Karyopharm Therapeutics Inc. as of Dec 31, 2021. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 143
- +12 vs. Q3 2021
- Shares held
- 54.2M
- −955.4K (−1.7%) vs. Q3 2021
- Total value
- $347.5M
- +$26.3M (+8.2%) vs. Q3 2021
- New holders
- 29
- 51 more added
- Sold out
- 17
- 46 more reduced
3 institutions that held it in Q3 2021 haven't filed for Q4 2021 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2021: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting KPTI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 96 | $206.8M |
| Q1 2026 | 77 | $98.4M |
| Q4 2025 | 68 | $69.6M |
| Q3 2025 | 52 | $19.5M |
| Q2 2025 | 50 | $19.0M |
| Q1 2025 | 50 | $13.7M |
| Q4 2024 | 87 | $41.2M |
| Q3 2024 | 91 | $49.2M |
| Q2 2024 | 114 | $58.6M |
| Q1 2024 | 114 | $113.0M |
| Q4 2023 | 120 | $63.5M |
| Q3 2023 | 120 | $102.8M |
| Q2 2023 | 138 | $145.0M |
| Q1 2023 | 132 | $340.1M |
| Q4 2022 | 155 | $334.4M |
| Q3 2022 | 147 | $364.1M |
| Q2 2022 | 150 | $302.8M |
| Q1 2022 | 139 | $501.8M |
| Q4 2021 | 143 | $347.5M |
| Q3 2021 | 134 | $334.4M |
| Q2 2021 | 154 | $608.7M |
| Q1 2021 | 171 | $637.1M |
Institutions, Q4 2021
Shares, value and share of portfolio for each institution holding Karyopharm Therapeutics Inc.; share changes are against Q3 2021.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| BlackRock Inc. | 8,918,206 | $57.3M | 0.00% | +127,888+1.5% | Added |
| State Street Corp | 5,513,680 | $35.5M | 0.00% | −2,506,319−31.3% | Reduced |
| Palo Alto Investors LP | 5,470,452 | $35.2M | 2.25% | +87,400+1.6% | Added |
| Vanguard Group Inc | 3,358,807 | $21.6M | 0.00% | −283,892−7.8% | Reduced |
| Rubric Capital Management LP | 2,782,443 | $17.9M | 0.85% | −593,315−17.6% | Reduced |
| Alkeon Capital Management LLC | 1,961,588 | $12.6M | 0.04% | 00.0% | Unchanged |
| Frontier Capital Management Co LLC | 1,685,405 | $10.8M | 0.09% | +582,978+52.9% | Added |
| Lombard Odier Asset Management (Switzerland) SA | 1,658,047 | $10.7M | 0.68% | +140,243+9.2% | Added |
| Millennium Management LLC | 1,520,224 | $9.78M | 0.01% | +1,520,224 | New |
| C WorldWide Group Holding A/S | 1,500,000 | $9.64M | 0.09% | +300,000+25.0% | Added |
| Geode Capital Management, LLC | 1,442,731 | $9.28M | 0.00% | +35,574+2.5% | Added |
| Rice Hall James & Associates, LLC | 1,276,634 | $8.21M | 0.29% | −125,227−8.9% | Reduced |
| Morgan Stanley | 1,065,619 | $6.85M | 0.00% | −827,314−43.7% | Reduced |
| Nuveen Asset Management, LLC | 1,184,310 | $6.71M | 0.00% | +65,302+5.8% | Added |
| Goldman Sachs Group Inc | 1,028,882 | $6.62M | 0.00% | +43,500+4.4% | Added |
| Two Sigma Investments, LP | 989,031 | $6.36M | 0.02% | −107,652−9.8% | Reduced |
| Candriam Luxembourg S.C.A. | 877,668 | $5.64M | 0.04% | +160,000+22.3% | Added |
| Northern Trust Corp | 775,551 | $4.99M | 0.00% | +8,491+1.1% | Added |
| JPMorgan Chase & Co | 743,400 | $4.78M | 0.00% | +278,479+59.9% | Added |
| Susquehanna International Group, LLP | 602,826 | $3.88M | 0.01% | +62,433+11.6% | Added |
| Cubist Systematic Strategies, LLC | 563,530 | $3.62M | 0.03% | +467,536+487.0% | Added |
| Two Sigma Advisers, LP | 427,600 | $2.75M | 0.01% | −654,400−60.5% | Reduced |
| Hennion & Walsh Asset Management, Inc. | 393,692 | $2.53M | 0.12% | −13,782−3.4% | Reduced |
| Macquarie Group Ltd | 382,041 | $2.46M | 0.00% | 00.0% | Unchanged |
| Rafferty Asset Management, LLC | 380,568 | $2.45M | 0.01% | +9,585+2.6% | Added |
| Citigroup Inc | 304,098 | $1.96M | 0.00% | +60,850+25.0% | Added |
| Bank of New York Mellon Corp | 297,541 | $1.91M | 0.00% | −4,960−1.6% | Reduced |
| Parametric Portfolio Associates LLC | 277,519 | $1.78M | 0.00% | −15,611−5.3% | Reduced |
| J. Goldman & Co LP | 274,243 | $1.76M | 0.16% | +216,517+375.1% | Added |
| Jennison Associates LLC | 270,757 | $1.74M | 0.00% | +665+0.2% | Added |
| UBS Group AG | 266,995 | $1.72M | 0.00% | −341,490−56.1% | Reduced |
| Bank of America Corp | 254,868 | $1.64M | 0.00% | +18,953+8.0% | Added |
| HRT Financial LP | 248,332 | $1.60M | 0.01% | +248,332 | New |
| Birchview Capital, LP | 246,000 | $1.58M | 1.02% | 00.0% | Unchanged |
| Citadel Advisors LLC | 228,883 | $1.47M | 0.00% | +8,106+3.7% | Added |
| Trexquant Investment LP | 220,875 | $1.42M | 0.09% | +184,674+510.1% | Added |
| Tudor Investment Corp Et Al | 208,526 | $1.34M | 0.03% | +15,595+8.1% | Added |
| Jane Street Group, LLC | 207,143 | $1.33M | 0.00% | +178,815+631.2% | Added |
| Wellington Management Group LLP | 201,550 | $1.30M | 0.00% | +201,550 | New |
| Voloridge Investment Management, LLC | 197,391 | $1.27M | 0.01% | +197,391 | New |
| Gsa Capital Partners LLP | 191,976 | $1.23M | 0.16% | +14,980+8.5% | Added |
| Allianz Asset Management GmbH | 187,101 | $1.21M | 0.00% | +54,153+40.7% | Added |
| Charles Schwab Investment Management Inc | 188,149 | $1.21M | 0.00% | 00.0% | Unchanged |
| Barclays PLC | 181,752 | $1.17M | 0.00% | +49,363+37.3% | Added |
| D. E. Shaw & Co., Inc. | 176,051 | $1.13M | 0.00% | +176,051 | New |
| Swiss National Bank | 149,450 | $961.0K | 0.00% | +17,800+13.5% | Added |
| AlphaCentric Advisors LLC | 140,000 | $900.0K | 0.26% | +4,000+2.9% | Added |
| Squarepoint Ops LLC | 124,274 | $799.0K | 0.00% | +124,274 | New |
| Group One Trading, L.P. | 120,114 | $772.0K | 0.01% | +73,460+157.5% | Added |
| Alliancebernstein L.P. | 115,830 | $745.0K | 0.00% | 00.0% | Unchanged |
| ExodusPoint Capital Management, LP | 108,896 | $700.0K | 0.01% | +78,976+264.0% | Added |
| California State Teachers Retirement System | 96,698 | $622.0K | 0.00% | +8,747+9.9% | Added |
| State of Wisconsin Investment Board | 95,800 | $616.0K | 0.00% | +400+0.4% | Added |
| Rhumbline Advisers | 94,710 | $609.0K | 0.00% | −1,481−1.5% | Reduced |
| UBS Asset Management Americas Inc | 91,721 | $589.8K | 0.00% | +7,328+8.7% | Added |
| Renaissance Technologies LLC | 85,900 | $552.0K | 0.00% | −409,500−82.7% | Reduced |
| Jump Financial, LLC | 85,615 | $551.0K | 0.03% | +85,615 | New |
| Algert Global LLC | 78,239 | $503.0K | 0.06% | −9,300−10.6% | Reduced |
| Wells Fargo & Company | 65,868 | $424.0K | 0.00% | +40,478+159.4% | Added |
| Susquehanna Fundamental Investments, LLC | 62,544 | $402.0K | 0.01% | −81,726−56.6% | Reduced |
| Credit Suisse AG | 62,143 | $398.0K | 0.00% | −23,471−27.4% | Reduced |
| Dynamic Technology Lab Private Ltd | 61,045 | $392.0K | 0.04% | +61,045 | New |
| Simplex Trading, LLC | 58,733 | $377.0K | 0.01% | +58,733 | New |
| State Board of Administration of Florida Retirement System | 53,075 | $341.0K | 0.00% | −160.0% | Reduced |
| DuPont Capital Management Corp | 52,402 | $337.0K | 0.01% | −20,893−28.5% | Reduced |
| Deutsche Bank AG | 47,966 | $308.0K | 0.00% | −176,670−78.6% | Reduced |
| Ensign Peak Advisors, Inc | 43,380 | $279.0K | 0.00% | +43,380 | New |
| Virginia Retirement Systems Et Al | 43,100 | $277.0K | 0.00% | −79,200−64.8% | Reduced |
| New York State Common Retirement Fund | 42,594 | $274.0K | 0.00% | −166−0.4% | Reduced |
| Golden State Equity Partners | 41,850 | $269.0K | 0.14% | +11,897+39.7% | Added |
| GFG Capital, LLC | 41,400 | $266.0K | 0.08% | −11,750−22.1% | Reduced |
| Patriot Financial Group Insurance Agency, LLC | 38,750 | $249.0K | 0.04% | +34,750+868.8% | Added |
| Allspring Global Investments Holdings, LLC | 38,544 | $247.0K | 0.00% | +38,544 | New |
| American International Group, Inc. | 38,262 | $246.0K | 0.00% | −1,144−2.9% | Reduced |
| Manufacturers Life Insurance Company, The | 38,301 | $246.0K | 0.00% | −872−2.2% | Reduced |
| Spearhead Capital Advisors, LLC | 34,459 | $222.0K | 0.03% | +801+2.4% | Added |
| Legal & General Group Plc | 31,845 | $205.0K | 0.00% | +1,796+6.0% | Added |
| Invesco Ltd. | 31,568 | $203.0K | 0.00% | −2,589−7.6% | Reduced |
| Lazard Asset Management LLC | 31,543 | $202.0K | 0.00% | +31,543 | New |
| Royal Bank of Canada | 31,077 | $200.0K | 0.00% | +4,398+16.5% | Added |
| Weiss Multi-Strategy Advisers LLC | 29,883 | $192.0K | 0.00% | −4,216−12.4% | Reduced |
| Voya Investment Management LLC | 28,866 | $186.0K | 0.00% | −754−2.5% | Reduced |
| Engineers Gate Manager LP | 28,200 | $181.0K | 0.01% | −32,599−53.6% | Reduced |
| MetLife Investment Management | 27,007 | $173.7K | 0.00% | +17,452+182.6% | Added |
| ProShare Advisors LLC | 26,371 | $170.0K | 0.00% | +1,026+4.0% | Added |
| Bridgefront Capital, LLC | 24,396 | $157.0K | 0.15% | +3,450+16.5% | Added |
| SG Americas Securities, LLC | 23,716 | $152.0K | 0.00% | −18,483−43.8% | Reduced |
| Dimensional Fund Advisors LP | 23,570 | $152.0K | 0.00% | 00.0% | Unchanged |
| Moors & Cabot, Inc. | 21,550 | $139.0K | 0.01% | +400+1.9% | Added |
| Prelude Capital Management, LLC | 21,000 | $135.0K | 0.01% | 00.0% | Unchanged |
| Price T Rowe Associates Inc | 20,412 | $131.0K | 0.00% | −24,500−54.6% | Reduced |
| North Star Investment Management Corp. | 20,000 | $129.0K | 0.01% | +20,000 | New |
| Tower Research Capital LLC (TRC) | 19,738 | $127.0K | 0.00% | −6,263−24.1% | Reduced |
| Baird Financial Group, Inc. | 19,817 | $127.0K | 0.00% | +2,137+12.1% | Added |
| Assenagon Asset Management S.A. | 19,366 | $125.0K | 0.00% | +19,366 | New |
| Arizona State Retirement System | 18,288 | $118.0K | 0.00% | +1,924+11.8% | Added |
| First Republic Investment Management, Inc. | 16,684 | $107.0K | 0.00% | −630−3.6% | Reduced |
| Fox Run Management, L.L.C. | 15,443 | $99.0K | 0.06% | +15,443 | New |
| State of Wyoming | 14,427 | $93.0K | 0.04% | +925+6.9% | Added |
| BNP Paribas Arbitrage, SA | 14,424 | $92.7K | 0.00% | −453,817−96.9% | Reduced |