Karyopharm Therapeutics Inc.
KPTI- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001503802
In the last 90 days, Karyopharm Therapeutics Inc. insiders filed 0 open-market purchases and 2 sales; 96 institutions reported holding it in 13F filings for Q2 2026, worth $206.8M in total; no superinvestor holds it.
13F holders, Q3 2023
Institutional positions in Karyopharm Therapeutics Inc. as of Sep 30, 2023. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 120
- −18 vs. Q2 2023
- Shares held
- 77.2M
- −4.32M (−5.3%) vs. Q2 2023
- Total value
- $102.8M
- −$42.2M (−29.1%) vs. Q2 2023
- New holders
- 16
- 40 more added
- Sold out
- 34
- 30 more reduced
Compare with Q2 2023: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting KPTI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 96 | $206.8M |
| Q1 2026 | 77 | $98.4M |
| Q4 2025 | 68 | $69.6M |
| Q3 2025 | 52 | $19.5M |
| Q2 2025 | 50 | $19.0M |
| Q1 2025 | 50 | $13.7M |
| Q4 2024 | 87 | $41.2M |
| Q3 2024 | 91 | $49.2M |
| Q2 2024 | 114 | $58.6M |
| Q1 2024 | 114 | $113.0M |
| Q4 2023 | 120 | $63.5M |
| Q3 2023 | 120 | $102.8M |
| Q2 2023 | 138 | $145.0M |
| Q1 2023 | 132 | $340.1M |
| Q4 2022 | 155 | $334.4M |
| Q3 2022 | 147 | $364.1M |
| Q2 2022 | 150 | $302.8M |
| Q1 2022 | 139 | $501.8M |
| Q4 2021 | 143 | $347.5M |
| Q3 2021 | 134 | $334.4M |
| Q2 2021 | 154 | $608.7M |
| Q1 2021 | 171 | $637.1M |
Institutions, Q3 2023
Shares, value and share of portfolio for each institution holding Karyopharm Therapeutics Inc.; share changes are against Q2 2023.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| BlackRock Inc. | 11,086,533 | $14.9M | 0.00% | −450,748−3.9% | Reduced |
| Vanguard Group Inc | 8,819,929 | $11.8M | 0.00% | +135,801+1.6% | Added |
| Avidity Partners Management LP | 8,298,570 | $11.1M | 0.45% | −71,530−0.9% | Reduced |
| Palo Alto Investors LP | 5,675,876 | $7.61M | 0.72% | 00.0% | Unchanged |
| Citadel Advisors LLC | 3,103,888 | $4.16M | 0.00% | −45,794−1.5% | Reduced |
| Jacobs Levy Equity Management, Inc | 2,353,528 | $3.15M | 0.02% | +1,676,673+247.7% | Added |
| Geode Capital Management, LLC | 2,287,146 | $3.07M | 0.00% | +150,052+7.0% | Added |
| Marshall Wace, LLP | 2,183,201 | $2.93M | 0.01% | −260,796−10.7% | Reduced |
| State Street Corp | 2,043,005 | $2.74M | 0.00% | −169,362−7.7% | Reduced |
| Goldman Sachs Group Inc | 1,915,047 | $2.57M | 0.00% | +294,028+18.1% | Added |
| AIGH Capital Management LLC | 1,773,474 | $2.38M | 1.13% | 00.0% | Unchanged |
| BNP Paribas Arbitrage, SA | 1,660,898 | $2.23M | 0.00% | +1,199,802+260.2% | Added |
| C WorldWide Group Holding A/S | 1,500,000 | $2.01M | 0.03% | 00.0% | Unchanged |
| ExodusPoint Capital Management, LP | 1,397,543 | $1.87M | 0.02% | −984,908−41.3% | Reduced |
| Barclays PLC | 1,152,298 | $1.54M | 0.00% | +45,937+4.2% | Added |
| JPMorgan Chase & Co | 1,141,126 | $1.53M | 0.00% | +1,051,695+1,176.0% | Added |
| Candriam Luxembourg S.C.A. | 1,140,694 | $1.53M | 0.01% | −295,000−20.5% | Reduced |
| AlphaCentric Advisors LLC | 1,125,000 | $1.51M | 0.86% | +315,000+38.9% | Added |
| Millennium Management LLC | 1,117,908 | $1.50M | 0.00% | −33,333−2.9% | Reduced |
| Tejara Capital Ltd | 1,077,388 | $1.44M | 0.82% | −66,603−5.8% | Reduced |
| Morgan Stanley | 1,044,471 | $1.40M | 0.00% | +622,155+147.3% | Added |
| Northern Trust Corp | 985,732 | $1.32M | 0.00% | −83,362−7.8% | Reduced |
| UBS Group AG | 906,645 | $1.21M | 0.00% | +469,035+107.2% | Added |
| UBS Oconnor LLC | 876,710 | $1.17M | 0.02% | +270,000+44.5% | Added |
| Altium Capital Management LP | 740,000 | $991.6K | 0.57% | 00.0% | Unchanged |
| Renaissance Technologies LLC | 730,400 | $979.0K | 0.00% | +63,000+9.4% | Added |
| Bank of New York Mellon Corp | 653,650 | $875.9K | 0.00% | −6,966−1.1% | Reduced |
| D. E. Shaw & Co., Inc. | 622,855 | $834.6K | 0.00% | +25,096+4.2% | Added |
| Birchview Capital, LP | 571,832 | $766.3K | 0.65% | +280,500+96.3% | Added |
| Gsa Capital Partners LLP | 568,298 | $762.0K | 0.07% | +568,298 | New |
| Silverarc Capital Management, LLC | 561,955 | $753.0K | 0.28% | +42,970+8.3% | Added |
| AQR Capital Management LLC | 501,799 | $672.4K | 0.00% | +337,761+205.9% | Added |
| Parkwood LLC | 1,000,000 | $661.0K | 0.12% | 00.0% | Unchanged |
| Nuveen Asset Management, LLC | 452,406 | $606.2K | 0.00% | −11,128−2.4% | Reduced |
| Worth Venture Partners, LLC | 445,981 | $597.6K | 0.36% | 00.0% | Unchanged |
| Ikarian Capital, LLC | 400,000 | $536.0K | 0.20% | 00.0% | Unchanged |
| Macquarie Group Ltd | 380,000 | $509.0K | 0.00% | 00.0% | Unchanged |
| Ameriprise Financial Inc | 356,978 | $478.4K | 0.00% | −3,167−0.9% | Reduced |
| Bank of America Corp | 352,622 | $472.5K | 0.00% | +16,183+4.8% | Added |
| XTX Topco Ltd | 310,065 | $415.5K | 0.07% | −73,783−19.2% | Reduced |
| Bridgeway Capital Management, LLC | 289,500 | $387.9K | 0.01% | +289,500 | New |
| FMR LLC | 266,447 | $357.0K | 0.00% | +356+0.1% | Added |
| Charles Schwab Investment Management Inc | 258,909 | $346.9K | 0.00% | −45,434−14.9% | Reduced |
| Alliancebernstein L.P. | 192,810 | $258.4K | 0.00% | −41,620−17.8% | Reduced |
| DAFNA Capital Management LLC | 192,678 | $258.2K | 0.08% | 00.0% | Unchanged |
| Atom Investors LP | 190,825 | $255.7K | 0.06% | +6,206+3.4% | Added |
| Rhumbline Advisers | 138,157 | $185.1K | 0.00% | +3,572+2.7% | Added |
| Susquehanna International Group, LLP | 137,809 | $184.7K | 0.00% | +48,802+54.8% | Added |
| Woodline Partners LP | 134,112 | $179.7K | 0.00% | +134,112 | New |
| J. Goldman & Co LP | 120,000 | $160.8K | 0.01% | −419,742−77.8% | Reduced |
| Point72 Middle East FZE | 95,138 | $127.5K | 0.01% | +9,205+10.7% | Added |
| Russell Investments Group, Ltd. | 94,858 | $127.1K | 0.00% | −597−0.6% | Reduced |
| Price T Rowe Associates Inc | 87,113 | $117.0K | 0.00% | +19,005+27.9% | Added |
| Exchange Traded Concepts, LLC | 86,484 | $115.9K | 0.00% | +20,062+30.2% | Added |
| Alps Advisors Inc | 84,432 | $113.1K | 0.00% | +629+0.8% | Added |
| Graham Capital Management, L.P. | 82,309 | $110.3K | 0.00% | +19,895+31.9% | Added |
| Boothbay Fund Management, LLC | 81,736 | $109.5K | 0.00% | 00.0% | Unchanged |
| Royal Bank of Canada | 77,281 | $104.0K | 0.00% | −160.0% | Reduced |
| Invesco Ltd. | 63,812 | $85.5K | 0.00% | +9,271+17.0% | Added |
| MetLife Investment Management | 60,235 | $80.7K | 0.00% | 00.0% | Unchanged |
| Deutsche Bank AG | 58,231 | $78.0K | 0.00% | −1,534,953−96.3% | Reduced |
| American International Group, Inc. | 56,523 | $75.7K | 0.00% | +2,009+3.7% | Added |
| Group One Trading, L.P. | 54,513 | $73.0K | 0.00% | +53,020+3,551.2% | Added |
| Manufacturers Life Insurance Company, The | 47,088 | $63.1K | 0.00% | 00.0% | Unchanged |
| Centiva Capital, LP | 45,790 | $61.4K | 0.00% | +13,090+40.0% | Added |
| Voya Investment Management LLC | 45,471 | $60.9K | 0.00% | 00.0% | Unchanged |
| HSBC Holdings PLC | 44,928 | $60.4K | 0.00% | +32,649+265.9% | Added |
| Wade G W & Inc | 45,140 | $60.0K | 0.00% | +45,140 | New |
| State of Wyoming | 40,741 | $54.6K | 0.01% | +40,741 | New |
| Engineers Gate Manager LP | 38,962 | $52.2K | 0.00% | +25,037+179.8% | Added |
| Connor, Clark & Lunn Investment Management Ltd. | 35,279 | $47.3K | 0.00% | −2,211−5.9% | Reduced |
| Two Sigma Advisers, LP | 35,200 | $47.2K | 0.00% | −225,000−86.5% | Reduced |
| Kennedy Investment Group | 35,000 | $46.9K | 0.03% | 00.0% | Unchanged |
| Squarepoint Ops LLC | 34,154 | $45.8K | 0.00% | +34,154 | New |
| Principal Financial Group Inc | 32,838 | $44.0K | 0.00% | 00.0% | Unchanged |
| Redwood Wealth Management Group, LLC | 32,730 | $43.9K | 0.05% | 00.0% | Unchanged |
| Weiss Multi-Strategy Advisers LLC | 31,814 | $43.0K | 0.00% | −3,745−10.5% | Reduced |
| California State Teachers Retirement System | 24,990 | $33.5K | 0.00% | −102,900−80.5% | Reduced |
| Brevan Howard Capital Management LP | 22,824 | $30.6K | 0.01% | +22,824 | New |
| Wells Fargo & Company | 22,683 | $30.4K | 0.00% | −24,534−52.0% | Reduced |
| ELCO Management Co., LLC | 22,561 | $30.2K | 0.02% | +9,087+67.4% | Added |
| ProShare Advisors LLC | 22,191 | $29.7K | 0.00% | +84+0.4% | Added |
| Tower Research Capital LLC (TRC) | 22,144 | $29.7K | 0.00% | +4,678+26.8% | Added |
| Quantbot Technologies LP | 21,699 | $29.1K | 0.00% | −32,698−60.1% | Reduced |
| Simplex Trading, LLC | 21,506 | $28.0K | 0.00% | +21,506 | New |
| New York State Common Retirement Fund | 19,663 | $26.3K | 0.00% | +704+3.7% | Added |
| Nomura Holdings Inc | 19,433 | $26.0K | 0.00% | +19,433 | New |
| Prudential Financial Inc | 19,415 | $26.0K | 0.00% | +19,415 | New |
| SG Americas Securities, LLC | 18,591 | $25.0K | 0.00% | +3,723+25.0% | Added |
| Amalgamated Bank | 15,431 | $21.0K | 0.00% | 00.0% | Unchanged |
| Allspring Global Investments Holdings, LLC | 14,964 | $20.1K | 0.00% | +14,964 | New |
| Banque Cantonale Vaudoise | 15,000 | $20.0K | 0.00% | 00.0% | Unchanged |
| Headlands Technologies LLC | 13,817 | $18.5K | 0.01% | +13,817 | New |
| Baird Financial Group, Inc. | 13,800 | $18.5K | 0.00% | 00.0% | Unchanged |
| Legal & General Group Plc | 13,735 | $18.4K | 0.00% | −79,544−85.3% | Reduced |
| Brinker Capital Investments, LLC | 13,039 | $17.5K | 0.00% | +13,039 | New |
| Orion Portfolio Solutions, LLC | 13,039 | $17.5K | 0.00% | +13,039 | New |
| Creative Planning | 11,600 | $15.5K | 0.00% | 00.0% | Unchanged |
| Victory Capital Management Inc | 11,436 | $15.3K | 0.00% | +18+0.2% | Added |
| Neuberger Berman Group LLC | 11,234 | $15.1K | 0.00% | +11,234 | New |