Karyopharm Therapeutics Inc.
KPTI- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001503802
In the last 90 days, Karyopharm Therapeutics Inc. insiders filed 0 open-market purchases and 2 sales; 96 institutions reported holding it in 13F filings for Q2 2026, worth $206.8M in total; no superinvestor holds it.
13F holders, Q3 2025
Institutional positions in Karyopharm Therapeutics Inc. as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 52
- +2 vs. Q2 2025
- Shares held
- 2.98M
- −1.44M (−32.6%) vs. Q2 2025
- Total value
- $19.5M
- +$444.0K (+2.3%) vs. Q2 2025
- New holders
- 7
- 7 more added
- Sold out
- 5
- 20 more reduced
Compare with Q2 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting KPTI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 96 | $206.8M |
| Q1 2026 | 77 | $98.4M |
| Q4 2025 | 68 | $69.6M |
| Q3 2025 | 52 | $19.5M |
| Q2 2025 | 50 | $19.0M |
| Q1 2025 | 50 | $13.7M |
| Q4 2024 | 87 | $41.2M |
| Q3 2024 | 91 | $49.2M |
| Q2 2024 | 114 | $58.6M |
| Q1 2024 | 114 | $113.0M |
| Q4 2023 | 120 | $63.5M |
| Q3 2023 | 120 | $102.8M |
| Q2 2023 | 138 | $145.0M |
| Q1 2023 | 132 | $340.1M |
| Q4 2022 | 155 | $334.4M |
| Q3 2022 | 147 | $364.1M |
| Q2 2022 | 150 | $302.8M |
| Q1 2022 | 139 | $501.8M |
| Q4 2021 | 143 | $347.5M |
| Q3 2021 | 134 | $334.4M |
| Q2 2021 | 154 | $608.7M |
| Q1 2021 | 171 | $637.1M |
Institutions, Q3 2025
Shares, value and share of portfolio for each institution holding Karyopharm Therapeutics Inc.; share changes are against Q2 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 700,992 | $4.58M | 0.00% | −27,774−3.8% | Reduced |
| Adage Capital Partners GP, L.L.C. | 421,322 | $2.76M | 0.00% | 00.0% | Unchanged |
| Vanguard Group Inc | 408,222 | $2.67M | 0.00% | −110,047−21.2% | Reduced |
| BlackRock, Inc. | 231,951 | $1.52M | 0.00% | −4,690−2.0% | Reduced |
| Catalio Capital Management, LP | 142,984 | $935.1K | 0.17% | −3,029−2.1% | Reduced |
| Avidity Partners Management LP | 134,566 | $880.1K | 0.20% | 00.0% | Unchanged |
| Marshall Wace, LLP | 128,451 | $840.1K | 0.00% | 00.0% | Unchanged |
| C WorldWide Group Holding A/S | 100,000 | $654.0K | 0.01% | 00.0% | Unchanged |
| Geode Capital Management, LLC | 93,289 | $610.3K | 0.00% | +1,448+1.6% | Added |
| Group One Trading, L.P. | 68,436 | $447.6K | 0.01% | −29,464−30.1% | Reduced |
| Renaissance Technologies LLC | 64,714 | $423.2K | 0.00% | −1,100−1.7% | Reduced |
| UBS Group AG | 59,685 | $390.3K | 0.00% | −102,215−63.1% | Reduced |
| State Street Corp | 46,342 | $303.1K | 0.00% | +13,047+39.2% | Added |
| Silverback Asset Management LLC | 40,000 | $261.6K | 0.03% | −30,000−42.9% | Reduced |
| Susquehanna International Group, LLP | 35,339 | $231.1K | 0.00% | +35,339 | New |
| Bridgeway Capital Management, LLC | 34,873 | $228.1K | 0.00% | −2,963−7.8% | Reduced |
| Birchview Capital, LP | 27,985 | $183.0K | 0.14% | 00.0% | Unchanged |
| Ikarian Capital, LLC | 27,257 | $178.3K | 0.04% | 00.0% | Unchanged |
| Baird Financial Group, Inc. | 25,932 | $169.6K | 0.00% | +15,400+146.2% | Added |
| Morgan Stanley | 25,766 | $168.5K | 0.00% | +675+2.7% | Added |
| ADAR1 Capital Management, LLC | 25,000 | $163.5K | 0.02% | +25,000 | New |
| Goldman Sachs Group Inc | 24,885 | $162.7K | 0.00% | −84,519−77.3% | Reduced |
| Northern Trust Corp | 18,876 | $123.4K | 0.00% | −34−0.2% | Reduced |
| Belvedere Trading LLC | 14,563 | $95.2K | 0.01% | +14,563 | New |
| XTX Topco Ltd | 14,402 | $94.2K | 0.00% | +1,346+10.3% | Added |
| Gsa Capital Partners LLP | 14,076 | $92.0K | 0.01% | +182+1.3% | Added |
| Bank of New York Mellon Corp | 11,086 | $72.5K | 0.00% | 00.0% | Unchanged |
| Price T Rowe Associates Inc | 10,886 | $72.0K | 0.00% | 00.0% | Unchanged |
| Royal Bank of Canada | 6,734 | $44.0K | 0.00% | −695−9.4% | Reduced |
| Simplex Trading, LLC | 5,862 | $38.0K | 0.00% | −2,371−28.8% | Reduced |
| Barclays PLC | 4,109 | $26.9K | 0.00% | −1,224−23.0% | Reduced |
| TD Waterhouse Canada Inc. | 3,203 | $19.9K | 0.00% | 00.0% | Unchanged |
| Tower Research Capital LLC (TRC) | 1,089 | $7.12K | 0.00% | +239+28.1% | Added |
| FMR LLC | 679 | $4.44K | 0.00% | −86−11.2% | Reduced |
| JPMorgan Chase & Co | 550 | $3.60K | 0.00% | −255,893−99.8% | Reduced |
| Citigroup Inc | 513 | $3.35K | 0.00% | −6,527−92.7% | Reduced |
| Advisor Group Holdings, Inc. | 346 | $2.41K | 0.00% | 00.0% | Unchanged |
| Quent Capital, LLC | 231 | $1.51K | 0.00% | +231 | New |
| Rise Advisors, LLC | 131 | $857 | 0.00% | +131 | New |
| MB, Levis & Associates, LLC | 100 | $654 | 0.00% | 00.0% | Unchanged |
| Bank of America Corp | 94 | $615 | 0.00% | −168,440−99.9% | Reduced |
| Harbour Investments, Inc. | 85 | $556 | 0.00% | 00.0% | Unchanged |
| BNP Paribas Arbitrage, SA | 82 | $536 | 0.00% | −29,555−99.7% | Reduced |
| Fortitude Family Office, LLC | 81 | $530 | 0.00% | 00.0% | Unchanged |
| SBI Securities Co., Ltd. | 74 | $484 | 0.00% | 00.0% | Unchanged |
| Activest Wealth Management | 66 | $432 | 0.00% | 00.0% | Unchanged |
| Allworth Financial LP | 26 | $171 | 0.00% | −6−18.8% | Reduced |
| Bruce G. Allen Investments, LLC | 22 | $144 | 0.00% | 00.0% | Unchanged |
| Advisory Services Network, LLC | 12 | $78 | 0.00% | +12 | New |
| CIBC Private Wealth Group, LLC | 3 | $20 | 0.00% | 00.0% | Unchanged |
| West Branch Capital LLC | 3 | $20 | 0.00% | 00.0% | Unchanged |
| Pittenger & Anderson Inc | 3 | $20 | 0.00% | +3 | New |
| Eversept Partners, LP | 0 | $0 | 0.00% | −257,154−100.0% | Sold out |
| Citadel Advisors LLC | 0 | $0 | 0.00% | −206,781−100.0% | Sold out |
| Palo Alto Investors LP | 0 | $0 | 0.00% | −187,911−100.0% | Sold out |
| Millennium Management LLC | 0 | $0 | 0.00% | −31,847−100.0% | Sold out |
| Raymond James Financial Inc | 0 | $0 | 0.00% | −90−100.0% | Sold out |