Karyopharm Therapeutics Inc.
KPTI- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001503802
In the last 90 days, Karyopharm Therapeutics Inc. insiders filed 0 open-market purchases and 2 sales; 96 institutions reported holding it in 13F filings for Q2 2026, worth $206.8M in total; no superinvestor holds it.
13F holders, Q2 2023
Institutional positions in Karyopharm Therapeutics Inc. as of Jun 30, 2023. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 138
- +6 vs. Q1 2023
- Shares held
- 81.5M
- −5.97M (−6.8%) vs. Q1 2023
- Total value
- $145.0M
- −$195.1M (−57.4%) vs. Q1 2023
- New holders
- 30
- 43 more added
- Sold out
- 24
- 42 more reduced
Compare with Q1 2023: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting KPTI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 96 | $206.8M |
| Q1 2026 | 77 | $98.4M |
| Q4 2025 | 68 | $69.6M |
| Q3 2025 | 52 | $19.5M |
| Q2 2025 | 50 | $19.0M |
| Q1 2025 | 50 | $13.7M |
| Q4 2024 | 87 | $41.2M |
| Q3 2024 | 91 | $49.2M |
| Q2 2024 | 114 | $58.6M |
| Q1 2024 | 114 | $113.0M |
| Q4 2023 | 120 | $63.5M |
| Q3 2023 | 120 | $102.8M |
| Q2 2023 | 138 | $145.0M |
| Q1 2023 | 132 | $340.1M |
| Q4 2022 | 155 | $334.4M |
| Q3 2022 | 147 | $364.1M |
| Q2 2022 | 150 | $302.8M |
| Q1 2022 | 139 | $501.8M |
| Q4 2021 | 143 | $347.5M |
| Q3 2021 | 134 | $334.4M |
| Q2 2021 | 154 | $608.7M |
| Q1 2021 | 171 | $637.1M |
Institutions, Q2 2023
Shares, value and share of portfolio for each institution holding Karyopharm Therapeutics Inc.; share changes are against Q1 2023.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| BlackRock Inc. | 11,537,281 | $20.7M | 0.00% | +2,465,093+27.2% | Added |
| Vanguard Group Inc | 8,684,128 | $15.5M | 0.00% | +1,180,292+15.7% | Added |
| Avidity Partners Management LP | 8,370,100 | $15.0M | 0.52% | −1,263,811−13.1% | Reduced |
| Palo Alto Investors LP | 5,675,876 | $10.2M | 0.82% | 00.0% | Unchanged |
| Citadel Advisors LLC | 3,149,682 | $5.64M | 0.01% | −452,778−12.6% | Reduced |
| Marshall Wace, LLP | 2,443,997 | $4.37M | 0.01% | +459,091+23.1% | Added |
| ExodusPoint Capital Management, LP | 2,382,451 | $4.26M | 0.05% | +2,382,451 | New |
| State Street Corp | 2,212,367 | $3.96M | 0.00% | −7,963,622−78.3% | Reduced |
| Geode Capital Management, LLC | 2,137,094 | $3.83M | 0.00% | +365,361+20.6% | Added |
| Opaleye Management Inc. | 1,785,000 | $3.20M | 0.76% | −1,025,800−36.5% | Reduced |
| AIGH Capital Management LLC | 1,773,474 | $3.17M | 1.30% | +1,773,474 | New |
| Goldman Sachs Group Inc | 1,621,019 | $2.90M | 0.00% | +151,872+10.3% | Added |
| Deutsche Bank AG | 1,593,184 | $2.85M | 0.00% | −51,750−3.1% | Reduced |
| C WorldWide Group Holding A/S | 1,500,000 | $2.69M | 0.03% | 00.0% | Unchanged |
| Candriam Luxembourg S.C.A. | 1,435,694 | $2.57M | 0.02% | −99,332−6.5% | Reduced |
| Millennium Management LLC | 1,151,241 | $2.06M | 0.00% | +1,137,478+8,264.8% | Added |
| Tejara Capital Ltd | 1,143,991 | $2.05M | 1.01% | +642,429+128.1% | Added |
| Barclays PLC | 1,106,361 | $1.98M | 0.00% | −1,741,028−61.1% | Reduced |
| Northern Trust Corp | 1,069,094 | $1.91M | 0.00% | +244,345+29.6% | Added |
| Rubric Capital Management LP | 919,196 | $1.65M | 0.07% | −3,521,860−79.3% | Reduced |
| AlphaCentric Advisors LLC | 810,000 | $1.45M | 0.81% | +570,000+237.5% | Added |
| Altium Capital Management LP | 740,000 | $1.32M | 1.04% | +234,219+46.3% | Added |
| Qube Research & Technologies Ltd | 703,062 | $1.26M | 0.00% | +703,062 | New |
| Jacobs Levy Equity Management, Inc | 676,855 | $1.21M | 0.01% | −398,219−37.0% | Reduced |
| Renaissance Technologies LLC | 667,400 | $1.20M | 0.00% | −68,300−9.3% | Reduced |
| Jane Street Group, LLC | 662,363 | $1.19M | 0.00% | +662,363 | New |
| Bank of New York Mellon Corp | 660,616 | $1.18M | 0.00% | +206,150+45.4% | Added |
| UBS Oconnor LLC | 606,710 | $1.09M | 0.02% | +12,905+2.2% | Added |
| D. E. Shaw & Co., Inc. | 597,759 | $1.07M | 0.00% | +48,152+8.8% | Added |
| Wellington Management Group LLP | 561,799 | $1.01M | 0.00% | +327,750+140.0% | Added |
| J. Goldman & Co LP | 539,742 | $966.1K | 0.06% | +539,742 | New |
| Silverarc Capital Management, LLC | 518,985 | $929.0K | 0.31% | −1,022,441−66.3% | Reduced |
| Platinum Investment Management Ltd | 500,000 | $895.0K | 0.03% | +500,000 | New |
| Alyeska Investment Group, L.P. | 481,696 | $862.2K | 0.01% | 00.0% | Unchanged |
| Nuveen Asset Management, LLC | 463,534 | $829.7K | 0.00% | −1,314,998−73.9% | Reduced |
| BNP Paribas Arbitrage, SA | 461,096 | $825.4K | 0.00% | +91,491+24.8% | Added |
| Worth Venture Partners, LLC | 445,981 | $798.3K | 0.44% | +445,981 | New |
| UBS Group AG | 437,610 | $783.3K | 0.00% | +275,169+169.4% | Added |
| Morgan Stanley | 422,316 | $755.9K | 0.00% | −304,374−41.9% | Reduced |
| Ikarian Capital, LLC | 400,000 | $716.0K | 0.25% | +100,000+33.3% | Added |
| XTX Topco Ltd | 383,848 | $687.1K | 0.12% | +383,848 | New |
| Macquarie Group Ltd | 380,000 | $680.0K | 0.00% | 00.0% | Unchanged |
| Parkwood LLC | 1,000,000 | $669.0K | 0.12% | +1,000,000 | New |
| Ameriprise Financial Inc | 360,145 | $644.7K | 0.00% | +102,289+39.7% | Added |
| Two Sigma Investments, LP | 347,555 | $622.1K | 0.00% | +347,555 | New |
| Bank of America Corp | 336,439 | $602.2K | 0.00% | −1,821,342−84.4% | Reduced |
| Charles Schwab Investment Management Inc | 304,343 | $544.8K | 0.00% | +81,632+36.7% | Added |
| Birchview Capital, LP | 291,332 | $521.5K | 0.39% | 00.0% | Unchanged |
| FMR LLC | 266,091 | $476.3K | 0.00% | +151,104+131.4% | Added |
| Two Sigma Advisers, LP | 260,200 | $465.8K | 0.00% | −141,300−35.2% | Reduced |
| Ergoteles LLC | 237,400 | $424.9K | 0.02% | +237,400 | New |
| Alliancebernstein L.P. | 234,430 | $419.6K | 0.00% | +56,600+31.8% | Added |
| HRT Financial LP | 225,518 | $403.0K | 0.00% | +225,518 | New |
| Swiss National Bank | 223,350 | $399.8K | 0.00% | −8,200−3.5% | Reduced |
| UBS Asset Management Americas Inc | 91,628 | $356.4K | 0.00% | 00.0% | Unchanged |
| DAFNA Capital Management LLC | 192,678 | $344.9K | 0.09% | 00.0% | Unchanged |
| Atom Investors LP | 184,619 | $330.5K | 0.13% | +184,619 | New |
| AQR Capital Management LLC | 164,038 | $293.6K | 0.00% | +83,525+103.7% | Added |
| Cubist Systematic Strategies, LLC | 160,004 | $286.4K | 0.00% | +160,004 | New |
| Putnam Investments LLC | 147,803 | $264.6K | 0.00% | +27,035+22.4% | Added |
| Rhumbline Advisers | 134,585 | $240.9K | 0.00% | +30,294+29.0% | Added |
| California State Teachers Retirement System | 127,890 | $228.9K | 0.00% | +4,683+3.8% | Added |
| Credit Suisse AG | 108,539 | $194.3K | 0.00% | −44,054−28.9% | Reduced |
| Acadian Asset Management LLC | 98,946 | $177.0K | 0.00% | +98,946 | New |
| Russell Investments Group, Ltd. | 95,455 | $170.9K | 0.00% | +1,075+1.1% | Added |
| Legal & General Group Plc | 93,279 | $167.0K | 0.00% | +44,768+92.3% | Added |
| Virginia Retirement Systems Et Al | 92,000 | $164.7K | 0.00% | −40,600−30.6% | Reduced |
| JPMorgan Chase & Co | 89,431 | $160.1K | 0.00% | −101,237−53.1% | Reduced |
| Susquehanna International Group, LLP | 89,007 | $159.3K | 0.00% | −206,177−69.8% | Reduced |
| Point72 Middle East FZE | 85,933 | $153.8K | 0.01% | +85,933 | New |
| Alps Advisors Inc | 83,803 | $150.0K | 0.00% | +83,803 | New |
| Boothbay Fund Management, LLC | 81,736 | $146.3K | 0.01% | +20,326+33.1% | Added |
| Royal Bank of Canada | 77,297 | $139.0K | 0.00% | +14,545+23.2% | Added |
| Price T Rowe Associates Inc | 68,108 | $122.0K | 0.00% | +7,642+12.6% | Added |
| Exchange Traded Concepts, LLC | 66,422 | $118.9K | 0.00% | +66,422 | New |
| Graham Capital Management, L.P. | 62,414 | $111.7K | 0.00% | +62,414 | New |
| MetLife Investment Management | 60,235 | $107.8K | 0.00% | +18,952+45.9% | Added |
| Laurion Capital Management LP | 57,146 | $102.3K | 0.00% | +57,146 | New |
| Invesco Ltd. | 54,541 | $97.6K | 0.00% | +11,312+26.2% | Added |
| American International Group, Inc. | 54,514 | $97.6K | 0.00% | +16,938+45.1% | Added |
| Quantbot Technologies LP | 54,397 | $97.4K | 0.01% | +6,200+12.9% | Added |
| Wells Fargo & Company | 47,217 | $84.5K | 0.00% | −120,424−71.8% | Reduced |
| Manufacturers Life Insurance Company, The | 47,088 | $84.3K | 0.00% | +18,328+63.7% | Added |
| Voya Investment Management LLC | 45,471 | $81.4K | 0.00% | +16,605+57.5% | Added |
| Citigroup Inc | 38,246 | $68.5K | 0.00% | −691,781−94.8% | Reduced |
| Janus Henderson Group PLC | 38,053 | $68.3K | 0.00% | −61−0.2% | Reduced |
| Connor, Clark & Lunn Investment Management Ltd. | 37,490 | $67.1K | 0.00% | −149,960−80.0% | Reduced |
| Weiss Multi-Strategy Advisers LLC | 35,559 | $64.0K | 0.00% | −3,753−9.5% | Reduced |
| Kennedy Investment Group | 35,000 | $62.6K | 0.04% | +15,000+75.0% | Added |
| Dark Forest Capital Management LP | 34,943 | $62.5K | 0.01% | +34,943 | New |
| Y-Intercept (Hong Kong) Ltd | 33,931 | $60.7K | 0.01% | +33,931 | New |
| Principal Financial Group Inc | 32,838 | $58.8K | 0.00% | −16,024−32.8% | Reduced |
| Redwood Wealth Management Group, LLC | 32,730 | $58.6K | 0.06% | 00.0% | Unchanged |
| Centiva Capital, LP | 32,700 | $58.5K | 0.00% | +32,700 | New |
| State Board of Administration of Florida Retirement System | 32,155 | $57.6K | 0.00% | +5,140+19.0% | Added |
| Arizona State Retirement System | 28,807 | $51.6K | 0.00% | −2,283−7.3% | Reduced |
| Teacher Retirement System of Texas | 27,840 | $50.0K | 0.00% | −5,214−15.8% | Reduced |
| Great West Life Assurance Co | 23,069 | $42.0K | 0.00% | −6,365−21.6% | Reduced |
| ProShare Advisors LLC | 22,107 | $39.6K | 0.00% | +5,086+29.9% | Added |
| Mariner, LLC | 19,984 | $35.8K | 0.00% | −8,072−28.8% | Reduced |