Karyopharm Therapeutics Inc.
KPTI- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001503802
In the last 90 days, Karyopharm Therapeutics Inc. insiders filed 0 open-market purchases and 2 sales; 96 institutions reported holding it in 13F filings for Q2 2026, worth $206.8M in total; no superinvestor holds it.
13F holders, Q2 2026
Institutional positions in Karyopharm Therapeutics Inc. as of Jun 30, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 96
- +19 vs. Q1 2026
- Shares held
- 21.2M
- +3.49M (+19.8%) vs. Q1 2026
- Total value
- $206.8M
- +$108.4M (+110.1%) vs. Q1 2026
- New holders
- 33
- 31 more added
- Sold out
- 14
- 14 more reduced
Compare with Q1 2026: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting KPTI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 96 | $206.8M |
| Q1 2026 | 77 | $98.4M |
| Q4 2025 | 68 | $69.6M |
| Q3 2025 | 52 | $19.5M |
| Q2 2025 | 50 | $19.0M |
| Q1 2025 | 50 | $13.7M |
| Q4 2024 | 87 | $41.2M |
| Q3 2024 | 91 | $49.2M |
| Q2 2024 | 114 | $58.6M |
| Q1 2024 | 114 | $113.0M |
| Q4 2023 | 120 | $63.5M |
| Q3 2023 | 120 | $102.8M |
| Q2 2023 | 138 | $145.0M |
| Q1 2023 | 132 | $340.1M |
| Q4 2022 | 155 | $334.4M |
| Q3 2022 | 147 | $364.1M |
| Q2 2022 | 150 | $302.8M |
| Q1 2022 | 139 | $501.8M |
| Q4 2021 | 143 | $347.5M |
| Q3 2021 | 134 | $334.4M |
| Q2 2021 | 154 | $608.7M |
| Q1 2021 | 171 | $637.1M |
Institutions, Q2 2026
Shares, value and share of portfolio for each institution holding Karyopharm Therapeutics Inc.; share changes are against Q1 2026.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Ra Capital Management, L.P. | 1,917,354 | $18.7M | 0.16% | 00.0% | Unchanged |
| Adage Capital Partners GP, L.L.C. | 1,521,322 | $14.9M | 0.02% | −285,000−15.8% | Reduced |
| Acorn Capital Advisors, LLC | 1,518,113 | $14.8M | 4.05% | +1,230,287+427.4% | Added |
| Goldman Sachs Group Inc | 1,424,658 | $13.9M | 0.00% | +477,079+50.3% | Added |
| BlackRock, Inc. | 1,418,799 | $13.9M | 0.00% | +1,173,900+479.3% | Added |
| Vanguard Capital Management LLC | 958,979 | $9.37M | 0.00% | +219,234+29.6% | Added |
| Catalio Capital Management, LP | 940,855 | $9.19M | 1.73% | +43,146+4.8% | Added |
| Avidity Partners Management LP | 924,487 | $9.03M | 1.45% | +460,746+99.4% | Added |
| T. Rowe Price Investment Management, Inc. | 786,309 | $7.68M | 0.01% | −755,781−49.0% | Reduced |
| Two Sigma Investments, LP | 695,264 | $6.79M | 0.01% | +544,032+359.7% | Added |
| Kalehua Capital Management LLC | 685,644 | $6.70M | 3.85% | +685,644 | New |
| NEA Management Company, LLC | 576,780 | $5.64M | 0.35% | +576,780 | New |
| Geode Capital Management, LLC | 531,231 | $5.19M | 0.00% | +325,098+157.7% | Added |
| Ghisallo Capital Management LLC | 500,000 | $4.88M | 0.10% | +500,000 | New |
| Soleus Capital Management, L.P. | 440,000 | $4.30M | 0.15% | 00.0% | Unchanged |
| UBS Group AG | 353,545 | $3.45M | 0.00% | +159,528+82.2% | Added |
| State Street Corp | 325,991 | $3.18M | 0.00% | +245,249+303.7% | Added |
| Affinity Asset Advisors, LLC | 312,500 | $3.05M | 0.15% | −187,500−37.5% | Reduced |
| Brevan Howard Capital Management LP | 309,817 | $3.03M | 0.04% | +97,450+45.9% | Added |
| Millennium Management LLC | 305,676 | $2.99M | 0.00% | −114,895−27.3% | Reduced |
| Boxer Capital Management, LLC | 302,536 | $2.96M | 0.22% | 00.0% | Unchanged |
| Davidson Kempner Capital Management LP | 300,000 | $2.93M | 0.05% | 00.0% | Unchanged |
| Acadian Asset Management LLC | 298,997 | $2.92M | 0.00% | +50,040+20.1% | Added |
| Silverarc Capital Management, LLC | 297,460 | $2.91M | 0.32% | +297,460 | New |
| Eversept Partners, LP | 276,174 | $2.70M | 0.15% | 00.0% | Unchanged |
| JPMorgan Chase & Co | 207,609 | $2.09M | 0.00% | +207,138+43,978.3% | Added |
| Morgan Stanley | 202,506 | $1.98M | 0.00% | +183,936+990.5% | Added |
| Trexquant Investment LP | 188,368 | $1.84M | 0.01% | −69,535−27.0% | Reduced |
| BNP Paribas Arbitrage, SA | 188,038 | $1.84M | 0.00% | +187,954+223,754.8% | Added |
| Barclays PLC | 165,904 | $1.62M | 0.00% | +158,480+2,134.7% | Added |
| Northern Trust Corp | 160,006 | $1.56M | 0.00% | +121,450+315.0% | Added |
| Vanguard Fiduciary Trust Co | 145,401 | $1.42M | 0.00% | +30,467+26.5% | Added |
| Vanguard Portfolio Management LLC | 134,818 | $1.32M | 0.00% | +134,818 | New |
| Marshall Wace, LLP | 128,451 | $1.25M | 0.00% | 00.0% | Unchanged |
| Renaissance Technologies LLC | 108,214 | $1.06M | 0.00% | +2,800+2.7% | Added |
| C WorldWide Group Holding A/S | 100,000 | $977.0K | 0.02% | 00.0% | Unchanged |
| Jump Financial, LLC | 94,000 | $918.4K | 0.01% | −168,146−64.1% | Reduced |
| Invesco Ltd. | 90,304 | $882.3K | 0.00% | +73,566+439.5% | Added |
| Connor, Clark & Lunn Investment Management Ltd. | 76,397 | $746.4K | 0.00% | −2,684−3.4% | Reduced |
| Bridgeway Capital Management, LLC | 71,873 | $702.2K | 0.01% | 00.0% | Unchanged |
| J. Goldman & Co LP | 67,500 | $659.5K | 0.02% | +67,500 | New |
| Squarepoint Ops LLC | 63,801 | $623.3K | 0.00% | +63,801 | New |
| Charles Schwab Investment Management Inc | 61,943 | $605.2K | 0.00% | +48,514+361.3% | Added |
| Royal Bank of Canada | 60,430 | $590.0K | 0.00% | +31+0.1% | Added |
| Bank of New York Mellon Corp | 57,262 | $559.4K | 0.00% | +45,863+402.3% | Added |
| Susquehanna Portfolio Strategies, LLC | 54,545 | $532.9K | 0.01% | +29,524+118.0% | Added |
| XTX Topco Ltd | 53,272 | $520.5K | 0.01% | −111,171−67.6% | Reduced |
| Citadel Advisors LLC | 52,069 | $508.7K | 0.00% | +52,069 | New |
| Bank of America Corp | 49,924 | $487.8K | 0.00% | +30,452+156.4% | Added |
| Birchview Capital, LP | 42,952 | $419.6K | 0.20% | −41,000−48.8% | Reduced |
| Citigroup Inc | 37,917 | $370.4K | 0.00% | +32,976+667.4% | Added |
| Nuveen, LLC | 37,868 | $370.0K | 0.00% | +37,868 | New |
| Engineers Gate Manager LP | 33,966 | $331.8K | 0.00% | −78,466−69.8% | Reduced |
| Nomura Asset Management International Inc. | 33,333 | $326.0K | 0.00% | +33,333 | New |
| Jane Street Group, LLC | 33,173 | $324.1K | 0.00% | −72,728−68.7% | Reduced |
| Toronto Dominion Bank | 30,930 | $302.2K | 0.00% | +30,930 | New |
| Silverback Asset Management LLC | 30,000 | $293.1K | 0.04% | −35,000−53.8% | Reduced |
| Baird Financial Group, Inc. | 29,791 | $291.1K | 0.00% | 00.0% | Unchanged |
| Price T Rowe Associates Inc | 27,225 | $266.0K | 0.00% | +16,339+150.1% | Added |
| ExodusPoint Capital Management, LP | 26,582 | $259.7K | 0.00% | +26,582 | New |
| China Universal Asset Management Co., Ltd. | 25,000 | $244.3K | 0.01% | −5,000−16.7% | Reduced |
| Simplex Trading, LLC | 24,086 | $235.3K | 0.01% | +24,086 | New |
| Rhumbline Advisers | 23,467 | $229.3K | 0.00% | +23,467 | New |
| Susquehanna Fundamental Investments, LLC | 23,265 | $227.3K | 0.00% | +23,265 | New |
| Velan Capital Investment Management LP | 20,000 | $195.4K | 0.12% | +5,000+33.3% | Added |
| Deutsche Bank AG | 19,425 | $189.8K | 0.00% | +19,425 | New |
| Wells Fargo & Company | 16,903 | $165.1K | 0.00% | +16,903 | New |
| SEI Investments Co | 15,083 | $147.4K | 0.00% | +15,083 | New |
| HSBC Holdings PLC | 13,750 | $137.4K | 0.00% | +2,255+19.6% | Added |
| Headlands Technologies LLC | 12,113 | $118.3K | 0.01% | +12,113 | New |
| MetLife Investment Management | 12,017 | $117.4K | 0.00% | +12,017 | New |
| Virtu Financial LLC | 10,728 | $105.0K | 0.00% | +10,728 | New |
| Y-Intercept (Hong Kong) Ltd | 10,375 | $101.4K | 0.00% | +10,375 | New |
| Quadrature Capital Ltd | 10,296 | $100.6K | 0.00% | +10,296 | New |
| Mirae Asset Global ETFs Holdings Ltd. | 9,171 | $89.6K | 0.00% | +9,171 | New |
| FMR LLC | 8,936 | $87.3K | 0.00% | +8,271+1,243.8% | Added |
| Vanguard Global Advisers, LLC | 8,207 | $80.2K | 0.00% | 00.0% | Unchanged |
| Police & Firemen's Retirement System of New Jersey | 5,874 | $57.4K | 0.00% | +5,874 | New |
| New York State Common Retirement Fund | 5,600 | $54.7K | 0.00% | +5,600 | New |
| TD Waterhouse Canada Inc. | 5,707 | $54.5K | 0.00% | +2,504+78.2% | Added |
| Legal & General Group Plc | 1,935 | $18.9K | 0.00% | +1,935 | New |
| Ameritas Investment Partners, Inc. | 1,808 | $17.7K | 0.00% | +1,808 | New |
| Russell Investments Group, Ltd. | 1,592 | $15.6K | 0.00% | +1,592 | New |
| Tower Research Capital LLC (TRC) | 1,259 | $12.3K | 0.00% | +1,259 | New |
| Advisor Group Holdings, Inc. | 402 | $3.93K | 0.00% | 00.0% | Unchanged |
| Sterling Capital Management LLC | 352 | $3.44K | 0.00% | +352 | New |
| Harbour Investments, Inc. | 285 | $2.78K | 0.00% | 00.0% | Unchanged |
| California State Teachers Retirement System | 274 | $2.68K | 0.00% | +274 | New |
| Quent Capital, LLC | 166 | $1.62K | 0.00% | −69−29.4% | Reduced |
| MB, Levis & Associates, LLC | 100 | $977 | 0.00% | 00.0% | Unchanged |
| SBI Securities Co., Ltd. | 67 | $655 | 0.00% | 00.0% | Unchanged |
| Activest Wealth Management | 66 | $645 | 0.00% | 00.0% | Unchanged |
| Allworth Financial LP | 26 | $255 | 0.00% | 00.0% | Unchanged |
| Caitong International Asset Management Co., Ltd | 14 | $137 | 0.00% | +14 | New |
| West Branch Capital LLC | 3 | $30 | 0.00% | 00.0% | Unchanged |
| PlanVest Financial, Inc | 1 | $10 | 0.00% | 00.0% | Unchanged |
| Commodore Capital LP | 0 | $0 | 0.00% | −1,950,000−100.0% | Sold out |
| Ikarian Capital, LLC | 0 | $0 | 0.00% | −733,435−100.0% | Sold out |
| Boothbay Fund Management, LLC | 0 | $0 | 0.00% | −213,810−100.0% | Sold out |
| Group One Trading, L.P. | 0 | $0 | 0.00% | −191,527−100.0% | Sold out |