Karyopharm Therapeutics Inc.
KPTI- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001503802
In the last 90 days, Karyopharm Therapeutics Inc. insiders filed 0 open-market purchases and 2 sales; 96 institutions reported holding it in 13F filings for Q2 2026, worth $206.8M in total; no superinvestor holds it.
13F holders, Q3 2024
Institutional positions in Karyopharm Therapeutics Inc. as of Sep 30, 2024. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 91
- −21 vs. Q2 2024
- Shares held
- 59.4M
- −3.98M (−6.3%) vs. Q2 2024
- Total value
- $49.2M
- −$5.79M (−10.5%) vs. Q2 2024
- New holders
- 10
- 21 more added
- Sold out
- 31
- 29 more reduced
2 institutions that held it in Q2 2024 haven't filed for Q3 2024 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q2 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting KPTI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 96 | $206.8M |
| Q1 2026 | 77 | $98.4M |
| Q4 2025 | 68 | $69.6M |
| Q3 2025 | 52 | $19.5M |
| Q2 2025 | 50 | $19.0M |
| Q1 2025 | 50 | $13.7M |
| Q4 2024 | 87 | $41.2M |
| Q3 2024 | 91 | $49.2M |
| Q2 2024 | 114 | $58.6M |
| Q1 2024 | 114 | $113.0M |
| Q4 2023 | 120 | $63.5M |
| Q3 2023 | 120 | $102.8M |
| Q2 2023 | 138 | $145.0M |
| Q1 2023 | 132 | $340.1M |
| Q4 2022 | 155 | $334.4M |
| Q3 2022 | 147 | $364.1M |
| Q2 2022 | 150 | $302.8M |
| Q1 2022 | 139 | $501.8M |
| Q4 2021 | 143 | $347.5M |
| Q3 2021 | 134 | $334.4M |
| Q2 2021 | 154 | $608.7M |
| Q1 2021 | 171 | $637.1M |
Institutions, Q3 2024
Shares, value and share of portfolio for each institution holding Karyopharm Therapeutics Inc.; share changes are against Q2 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Vanguard Group Inc | 7,654,482 | $6.35M | 0.00% | 00.0% | Unchanged |
| Eversept Partners, LP | 5,547,880 | $4.60M | 0.35% | +560,700+11.2% | Added |
| Palo Alto Investors LP | 5,102,193 | $4.23M | 0.55% | 00.0% | Unchanged |
| Adage Capital Partners GP, L.L.C. | 4,319,842 | $3.59M | 0.01% | 00.0% | Unchanged |
| BlackRock, Inc. | 3,638,378 | $3.02M | 0.00% | +3,638,378 | New |
| Citadel Advisors LLC | 3,103,669 | $2.58M | 0.00% | +2,270+0.1% | Added |
| Marshall Wace, LLP | 2,082,226 | $1.73M | 0.00% | −498,637−19.3% | Reduced |
| Avidity Partners Management LP | 2,018,500 | $1.68M | 0.09% | 00.0% | Unchanged |
| BNP Paribas Arbitrage, SA | 1,982,354 | $1.65M | 0.00% | −291,841−12.8% | Reduced |
| Gsa Capital Partners LLP | 1,775,700 | $1.47M | 0.11% | +792,283+80.6% | Added |
| C WorldWide Group Holding A/S | 1,500,000 | $1.25M | 0.01% | 00.0% | Unchanged |
| JPMorgan Chase & Co | 1,385,724 | $1.15M | 0.00% | +109,865+8.6% | Added |
| Geode Capital Management, LLC | 1,355,392 | $1.13M | 0.00% | +43,856+3.3% | Added |
| Goldman Sachs Group Inc | 1,336,715 | $1.11M | 0.00% | −953,719−41.6% | Reduced |
| Deutsche Bank AG | 1,268,777 | $1.05M | 0.00% | 00.0% | Unchanged |
| Millennium Management LLC | 1,255,264 | $1.04M | 0.00% | −837,162−40.0% | Reduced |
| Renaissance Technologies LLC | 1,241,407 | $1.03M | 0.00% | +485,180+64.2% | Added |
| Kennedy Capital Management, Inc. | 1,204,009 | $999.3K | 0.02% | +7,217+0.6% | Added |
| UBS Oconnor LLC | 1,196,174 | $992.8K | 0.02% | +93,783+8.5% | Added |
| AlphaCentric Advisors LLC | 1,125,000 | $933.8K | 0.69% | 00.0% | Unchanged |
| D. E. Shaw & Co., Inc. | 1,047,396 | $869.3K | 0.00% | +203,284+24.1% | Added |
| Altium Capital Management LP | 740,000 | $614.2K | 0.18% | 00.0% | Unchanged |
| Silverarc Capital Management, LLC | 558,466 | $463.5K | 0.10% | 00.0% | Unchanged |
| Macquarie Group Ltd | 500,000 | $415.0K | 0.00% | −5,684−1.1% | Reduced |
| Cubist Systematic Strategies, LLC | 496,236 | $411.9K | 0.01% | −72,739−12.8% | Reduced |
| Birchview Capital, LP | 469,832 | $390.0K | 0.34% | 00.0% | Unchanged |
| State Street Corp | 409,510 | $339.9K | 0.00% | −44,300−9.8% | Reduced |
| Ikarian Capital, LLC | 409,355 | $339.8K | 0.11% | 00.0% | Unchanged |
| FMR LLC | 369,723 | $306.9K | 0.00% | +76,510+26.1% | Added |
| Acadian Asset Management LLC | 368,511 | $304.0K | 0.00% | +174,343+89.8% | Added |
| Susquehanna International Group, LLP | 302,548 | $251.1K | 0.00% | −140,926−31.8% | Reduced |
| Atom Investors LP | 259,824 | $215.7K | 0.02% | −2,023−0.8% | Reduced |
| Bridgeway Capital Management, LLC | 239,500 | $198.8K | 0.00% | −25,000−9.5% | Reduced |
| Northern Trust Corp | 229,668 | $190.6K | 0.00% | −640,499−73.6% | Reduced |
| Bank of America Corp | 228,941 | $190.0K | 0.00% | −69,744−23.4% | Reduced |
| Exchange Traded Concepts, LLC | 218,791 | $181.6K | 0.00% | +56,613+34.9% | Added |
| Jane Street Group, LLC | 204,750 | $169.9K | 0.00% | −1,345,226−86.8% | Reduced |
| DAFNA Capital Management LLC | 192,678 | $159.9K | 0.04% | 00.0% | Unchanged |
| Bank of New York Mellon Corp | 166,316 | $138.0K | 0.00% | +10.0% | Added |
| Price T Rowe Associates Inc | 134,700 | $112.0K | 0.00% | +37,600+38.7% | Added |
| UBS Group AG | 134,478 | $111.6K | 0.00% | −6,200−4.4% | Reduced |
| Woodline Partners LP | 134,112 | $111.3K | 0.00% | 00.0% | Unchanged |
| Morgan Stanley | 123,647 | $102.6K | 0.00% | −76,361−38.2% | Reduced |
| Citigroup Inc | 105,693 | $87.7K | 0.00% | −56,334−34.8% | Reduced |
| Barclays PLC | 95,767 | $79.5K | 0.00% | −777,507−89.0% | Reduced |
| Boothbay Fund Management, LLC | 91,091 | $75.6K | 0.00% | 00.0% | Unchanged |
| Two Sigma Investments, LP | 85,930 | $71.3K | 0.00% | +72,064+519.7% | Added |
| Point72 Asia (Singapore) Pte. Ltd. | 82,446 | $68.4K | 0.01% | −82,872−50.1% | Reduced |
| Prudential Financial Inc | 74,600 | $61.9K | 0.00% | +74,600 | New |
| Qube Research & Technologies Ltd | 62,026 | $51.5K | 0.00% | −44,444−41.7% | Reduced |
| Invesco Ltd. | 58,152 | $48.3K | 0.00% | +17,641+43.5% | Added |
| Cerity Partners LLC | 51,533 | $42.8K | 0.00% | +51,533 | New |
| Charles Schwab Investment Management Inc | 51,000 | $42.3K | 0.00% | 00.0% | Unchanged |
| Engineers Gate Manager LP | 48,133 | $40.0K | 0.00% | +19,433+67.7% | Added |
| Baird Financial Group, Inc. | 37,800 | $31.4K | 0.00% | +1,000+2.7% | Added |
| HSBC Holdings PLC | 40,301 | $31.0K | 0.00% | −12,790−24.1% | Reduced |
| Eqis Capital Management, Inc. | 37,201 | $30.9K | 0.00% | −1,125−2.9% | Reduced |
| Kennedy Investment Group | 35,000 | $29.1K | 0.01% | 00.0% | Unchanged |
| Two Sigma Advisers, LP | 31,200 | $25.9K | 0.00% | +31,200 | New |
| Monashee Investment Management LLC | 132,435 | $25.6K | 0.00% | +132,435 | New |
| Catalyst Funds Management Pty Ltd | 28,600 | $23.7K | 0.01% | 00.0% | Unchanged |
| XTX Topco Ltd | 25,905 | $21.5K | 0.00% | −114,671−81.6% | Reduced |
| Commonwealth Equity Services, LLC | 22,206 | $18.0K | 0.00% | −3,000−11.9% | Reduced |
| CI Private Wealth, LLC | 21,084 | $17.5K | 0.00% | +7,484+55.0% | Added |
| JustInvest LLC | 17,188 | $14.3K | 0.00% | +17,188 | New |
| ELCO Management Co., LLC | 16,177 | $13.4K | 0.01% | −3,485−17.7% | Reduced |
| Winthrop Advisory Group LLC | 15,000 | $12.4K | 0.00% | 00.0% | Unchanged |
| Victory Capital Management Inc | 14,496 | $12.0K | 0.00% | +503+3.6% | Added |
| AQR Capital Management LLC | 12,221 | $10.1K | 0.00% | −735,799−98.4% | Reduced |
| Wolverine Trading, LLC | 13,735 | $9.94K | 0.00% | +13,735 | New |
| Snowden Capital Advisors LLC | 11,000 | $9.13K | 0.00% | 00.0% | Unchanged |
| BLB&B Advisors, LLC | 10,150 | $8.43K | 0.00% | −1,000−9.0% | Reduced |
| Avidian Wealth Solutions, LLC | 10,100 | $8.38K | 0.00% | +10,100 | New |
| Janney Montgomery Scott LLC | 10,000 | $8.00K | 0.00% | 00.0% | Unchanged |
| Royal Bank of Canada | 7,950 | $6.00K | 0.00% | −48,407−85.9% | Reduced |
| Advisor Group Holdings, Inc. | 4,390 | $3.64K | 0.00% | −2,823−39.1% | Reduced |
| Quent Capital, LLC | 3,489 | $2.90K | 0.00% | 00.0% | Unchanged |
| The PNC Financial Services Group, Inc. | 3,000 | $2.49K | 0.00% | 00.0% | Unchanged |
| Founders Capital Management | 2,000 | $1.66K | 0.00% | 00.0% | Unchanged |
| Golden State Equity Partners | 1,800 | $1.49K | 0.00% | +1,800 | New |
| MB, Levis & Associates, LLC | 1,500 | $1.25K | 0.00% | 00.0% | Unchanged |
| Harbour Investments, Inc. | 1,300 | $1.08K | 0.00% | 00.0% | Unchanged |
| Lazard Asset Management LLC | 1,570 | $1.00K | 0.00% | +1,570 | New |
| Activest Wealth Management | 1,000 | $830 | 0.00% | 00.0% | Unchanged |
| Wells Fargo & Company | 666 | $553 | 0.00% | +652+4,657.1% | Added |
| SRS Capital Advisors, Inc. | 538 | $447 | 0.00% | 00.0% | Unchanged |
| Allworth Financial LP | 500 | $415 | 0.00% | 00.0% | Unchanged |
| Bruce G. Allen Investments, LLC | 338 | $281 | 0.00% | −169−33.3% | Reduced |
| AdvisorNet Financial, Inc | 200 | $166 | 0.00% | 00.0% | Unchanged |
| CIBC Private Wealth Group, LLC | 50 | $42 | 0.00% | 00.0% | Unchanged |
| West Branch Capital LLC | 48 | $40 | 0.00% | 00.0% | Unchanged |
| Opaleye Management Inc. | 0 | $0 | 0.00% | −1,425,000−100.0% | Sold out |
| Superstring Capital Management LP | 0 | $0 | 0.00% | −534,485−100.0% | Sold out |
| Y-Intercept (Hong Kong) Ltd | 0 | $0 | 0.00% | −410,954−100.0% | Sold out |
| Los Angeles Capital Management LLC | 0 | $0 | 0.00% | −354,020−100.0% | Sold out |
| Centiva Capital, LP | 0 | $0 | 0.00% | −203,600−100.0% | Sold out |
| HRT Financial LP | 0 | $0 | 0.00% | −147,536−100.0% | Sold out |
| State of Wyoming | 0 | $0 | 0.00% | −82,685−100.0% | Sold out |
| Verition Fund Management LLC | 0 | $0 | 0.00% | −68,932−100.0% | Sold out |
| Schonfeld Strategic Advisors LLC | 0 | $0 | 0.00% | −57,600−100.0% | Sold out |