Karyopharm Therapeutics Inc.
KPTI- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001503802
In the last 90 days, Karyopharm Therapeutics Inc. insiders filed 0 open-market purchases and 2 sales; 96 institutions reported holding it in 13F filings for Q2 2026, worth $206.8M in total; no superinvestor holds it.
13F holders, Q3 2024
Institutional positions in Karyopharm Therapeutics Inc. as of Sep 30, 2024. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 91
- −21 vs. Q2 2024
- Shares held
- 59.4M
- −3.98M (−6.3%) vs. Q2 2024
- Total value
- $49.2M
- −$5.79M (−10.5%) vs. Q2 2024
- New holders
- 10
- 21 more added
- Sold out
- 31
- 29 more reduced
2 institutions that held it in Q2 2024 haven't filed for Q3 2024 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q2 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting KPTI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 96 | $206.8M |
| Q1 2026 | 77 | $98.4M |
| Q4 2025 | 68 | $69.6M |
| Q3 2025 | 52 | $19.5M |
| Q2 2025 | 50 | $19.0M |
| Q1 2025 | 50 | $13.7M |
| Q4 2024 | 87 | $41.2M |
| Q3 2024 | 91 | $49.2M |
| Q2 2024 | 114 | $58.6M |
| Q1 2024 | 114 | $113.0M |
| Q4 2023 | 120 | $63.5M |
| Q3 2023 | 120 | $102.8M |
| Q2 2023 | 138 | $145.0M |
| Q1 2023 | 132 | $340.1M |
| Q4 2022 | 155 | $334.4M |
| Q3 2022 | 147 | $364.1M |
| Q2 2022 | 150 | $302.8M |
| Q1 2022 | 139 | $501.8M |
| Q4 2021 | 143 | $347.5M |
| Q3 2021 | 134 | $334.4M |
| Q2 2021 | 154 | $608.7M |
| Q1 2021 | 171 | $637.1M |
Institutions, Q3 2024
Shares, value and share of portfolio for each institution holding Karyopharm Therapeutics Inc.; share changes are against Q2 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| West Branch Capital LLC | 48 | $40 | 0.00% | 00.0% | Unchanged |
| CIBC Private Wealth Group, LLC | 50 | $42 | 0.00% | 00.0% | Unchanged |
| AdvisorNet Financial, Inc | 200 | $166 | 0.00% | 00.0% | Unchanged |
| Bruce G. Allen Investments, LLC | 338 | $281 | 0.00% | −169−33.3% | Reduced |
| Allworth Financial LP | 500 | $415 | 0.00% | 00.0% | Unchanged |
| SRS Capital Advisors, Inc. | 538 | $447 | 0.00% | 00.0% | Unchanged |
| Wells Fargo & Company | 666 | $553 | 0.00% | +652+4,657.1% | Added |
| Activest Wealth Management | 1,000 | $830 | 0.00% | 00.0% | Unchanged |
| Lazard Asset Management LLC | 1,570 | $1.00K | 0.00% | +1,570 | New |
| Harbour Investments, Inc. | 1,300 | $1.08K | 0.00% | 00.0% | Unchanged |
| MB, Levis & Associates, LLC | 1,500 | $1.25K | 0.00% | 00.0% | Unchanged |
| Golden State Equity Partners | 1,800 | $1.49K | 0.00% | +1,800 | New |
| Founders Capital Management | 2,000 | $1.66K | 0.00% | 00.0% | Unchanged |
| The PNC Financial Services Group, Inc. | 3,000 | $2.49K | 0.00% | 00.0% | Unchanged |
| Quent Capital, LLC | 3,489 | $2.90K | 0.00% | 00.0% | Unchanged |
| Advisor Group Holdings, Inc. | 4,390 | $3.64K | 0.00% | −2,823−39.1% | Reduced |
| Royal Bank of Canada | 7,950 | $6.00K | 0.00% | −48,407−85.9% | Reduced |
| Janney Montgomery Scott LLC | 10,000 | $8.00K | 0.00% | 00.0% | Unchanged |
| Avidian Wealth Solutions, LLC | 10,100 | $8.38K | 0.00% | +10,100 | New |
| BLB&B Advisors, LLC | 10,150 | $8.43K | 0.00% | −1,000−9.0% | Reduced |
| Snowden Capital Advisors LLC | 11,000 | $9.13K | 0.00% | 00.0% | Unchanged |
| Wolverine Trading, LLC | 13,735 | $9.94K | 0.00% | +13,735 | New |
| AQR Capital Management LLC | 12,221 | $10.1K | 0.00% | −735,799−98.4% | Reduced |
| Victory Capital Management Inc | 14,496 | $12.0K | 0.00% | +503+3.6% | Added |
| Winthrop Advisory Group LLC | 15,000 | $12.4K | 0.00% | 00.0% | Unchanged |
| ELCO Management Co., LLC | 16,177 | $13.4K | 0.01% | −3,485−17.7% | Reduced |
| JustInvest LLC | 17,188 | $14.3K | 0.00% | +17,188 | New |
| CI Private Wealth, LLC | 21,084 | $17.5K | 0.00% | +7,484+55.0% | Added |
| Commonwealth Equity Services, LLC | 22,206 | $18.0K | 0.00% | −3,000−11.9% | Reduced |
| XTX Topco Ltd | 25,905 | $21.5K | 0.00% | −114,671−81.6% | Reduced |
| Catalyst Funds Management Pty Ltd | 28,600 | $23.7K | 0.01% | 00.0% | Unchanged |
| Monashee Investment Management LLC | 132,435 | $25.6K | 0.00% | +132,435 | New |
| Two Sigma Advisers, LP | 31,200 | $25.9K | 0.00% | +31,200 | New |
| Kennedy Investment Group | 35,000 | $29.1K | 0.01% | 00.0% | Unchanged |
| Eqis Capital Management, Inc. | 37,201 | $30.9K | 0.00% | −1,125−2.9% | Reduced |
| HSBC Holdings PLC | 40,301 | $31.0K | 0.00% | −12,790−24.1% | Reduced |
| Baird Financial Group, Inc. | 37,800 | $31.4K | 0.00% | +1,000+2.7% | Added |
| Engineers Gate Manager LP | 48,133 | $40.0K | 0.00% | +19,433+67.7% | Added |
| Charles Schwab Investment Management Inc | 51,000 | $42.3K | 0.00% | 00.0% | Unchanged |
| Cerity Partners LLC | 51,533 | $42.8K | 0.00% | +51,533 | New |
| Invesco Ltd. | 58,152 | $48.3K | 0.00% | +17,641+43.5% | Added |
| Qube Research & Technologies Ltd | 62,026 | $51.5K | 0.00% | −44,444−41.7% | Reduced |
| Prudential Financial Inc | 74,600 | $61.9K | 0.00% | +74,600 | New |
| Point72 Asia (Singapore) Pte. Ltd. | 82,446 | $68.4K | 0.01% | −82,872−50.1% | Reduced |
| Two Sigma Investments, LP | 85,930 | $71.3K | 0.00% | +72,064+519.7% | Added |
| Boothbay Fund Management, LLC | 91,091 | $75.6K | 0.00% | 00.0% | Unchanged |
| Barclays PLC | 95,767 | $79.5K | 0.00% | −777,507−89.0% | Reduced |
| Citigroup Inc | 105,693 | $87.7K | 0.00% | −56,334−34.8% | Reduced |
| Morgan Stanley | 123,647 | $102.6K | 0.00% | −76,361−38.2% | Reduced |
| Woodline Partners LP | 134,112 | $111.3K | 0.00% | 00.0% | Unchanged |
| UBS Group AG | 134,478 | $111.6K | 0.00% | −6,200−4.4% | Reduced |
| Price T Rowe Associates Inc | 134,700 | $112.0K | 0.00% | +37,600+38.7% | Added |
| Bank of New York Mellon Corp | 166,316 | $138.0K | 0.00% | +10.0% | Added |
| DAFNA Capital Management LLC | 192,678 | $159.9K | 0.04% | 00.0% | Unchanged |
| Jane Street Group, LLC | 204,750 | $169.9K | 0.00% | −1,345,226−86.8% | Reduced |
| Exchange Traded Concepts, LLC | 218,791 | $181.6K | 0.00% | +56,613+34.9% | Added |
| Bank of America Corp | 228,941 | $190.0K | 0.00% | −69,744−23.4% | Reduced |
| Northern Trust Corp | 229,668 | $190.6K | 0.00% | −640,499−73.6% | Reduced |
| Bridgeway Capital Management, LLC | 239,500 | $198.8K | 0.00% | −25,000−9.5% | Reduced |
| Atom Investors LP | 259,824 | $215.7K | 0.02% | −2,023−0.8% | Reduced |
| Susquehanna International Group, LLP | 302,548 | $251.1K | 0.00% | −140,926−31.8% | Reduced |
| Acadian Asset Management LLC | 368,511 | $304.0K | 0.00% | +174,343+89.8% | Added |
| FMR LLC | 369,723 | $306.9K | 0.00% | +76,510+26.1% | Added |
| Ikarian Capital, LLC | 409,355 | $339.8K | 0.11% | 00.0% | Unchanged |
| State Street Corp | 409,510 | $339.9K | 0.00% | −44,300−9.8% | Reduced |
| Birchview Capital, LP | 469,832 | $390.0K | 0.34% | 00.0% | Unchanged |
| Cubist Systematic Strategies, LLC | 496,236 | $411.9K | 0.01% | −72,739−12.8% | Reduced |
| Macquarie Group Ltd | 500,000 | $415.0K | 0.00% | −5,684−1.1% | Reduced |
| Silverarc Capital Management, LLC | 558,466 | $463.5K | 0.10% | 00.0% | Unchanged |
| Altium Capital Management LP | 740,000 | $614.2K | 0.18% | 00.0% | Unchanged |
| D. E. Shaw & Co., Inc. | 1,047,396 | $869.3K | 0.00% | +203,284+24.1% | Added |
| AlphaCentric Advisors LLC | 1,125,000 | $933.8K | 0.69% | 00.0% | Unchanged |
| UBS Oconnor LLC | 1,196,174 | $992.8K | 0.02% | +93,783+8.5% | Added |
| Kennedy Capital Management, Inc. | 1,204,009 | $999.3K | 0.02% | +7,217+0.6% | Added |
| Renaissance Technologies LLC | 1,241,407 | $1.03M | 0.00% | +485,180+64.2% | Added |
| Millennium Management LLC | 1,255,264 | $1.04M | 0.00% | −837,162−40.0% | Reduced |
| Deutsche Bank AG | 1,268,777 | $1.05M | 0.00% | 00.0% | Unchanged |
| Goldman Sachs Group Inc | 1,336,715 | $1.11M | 0.00% | −953,719−41.6% | Reduced |
| Geode Capital Management, LLC | 1,355,392 | $1.13M | 0.00% | +43,856+3.3% | Added |
| JPMorgan Chase & Co | 1,385,724 | $1.15M | 0.00% | +109,865+8.6% | Added |
| C WorldWide Group Holding A/S | 1,500,000 | $1.25M | 0.01% | 00.0% | Unchanged |
| Gsa Capital Partners LLP | 1,775,700 | $1.47M | 0.11% | +792,283+80.6% | Added |
| BNP Paribas Arbitrage, SA | 1,982,354 | $1.65M | 0.00% | −291,841−12.8% | Reduced |
| Avidity Partners Management LP | 2,018,500 | $1.68M | 0.09% | 00.0% | Unchanged |
| Marshall Wace, LLP | 2,082,226 | $1.73M | 0.00% | −498,637−19.3% | Reduced |
| Citadel Advisors LLC | 3,103,669 | $2.58M | 0.00% | +2,270+0.1% | Added |
| BlackRock, Inc. | 3,638,378 | $3.02M | 0.00% | +3,638,378 | New |
| Adage Capital Partners GP, L.L.C. | 4,319,842 | $3.59M | 0.01% | 00.0% | Unchanged |
| Palo Alto Investors LP | 5,102,193 | $4.23M | 0.55% | 00.0% | Unchanged |
| Eversept Partners, LP | 5,547,880 | $4.60M | 0.35% | +560,700+11.2% | Added |
| Vanguard Group Inc | 7,654,482 | $6.35M | 0.00% | 00.0% | Unchanged |
| Opaleye Management Inc. | 0 | $0 | 0.00% | −1,425,000−100.0% | Sold out |
| Superstring Capital Management LP | 0 | $0 | 0.00% | −534,485−100.0% | Sold out |
| Y-Intercept (Hong Kong) Ltd | 0 | $0 | 0.00% | −410,954−100.0% | Sold out |
| Los Angeles Capital Management LLC | 0 | $0 | 0.00% | −354,020−100.0% | Sold out |
| Centiva Capital, LP | 0 | $0 | 0.00% | −203,600−100.0% | Sold out |
| HRT Financial LP | 0 | $0 | 0.00% | −147,536−100.0% | Sold out |
| State of Wyoming | 0 | $0 | 0.00% | −82,685−100.0% | Sold out |
| Verition Fund Management LLC | 0 | $0 | 0.00% | −68,932−100.0% | Sold out |
| Schonfeld Strategic Advisors LLC | 0 | $0 | 0.00% | −57,600−100.0% | Sold out |