Karyopharm Therapeutics Inc.
KPTI- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001503802
In the last 90 days, Karyopharm Therapeutics Inc. insiders filed 0 open-market purchases and 2 sales; 96 institutions reported holding it in 13F filings for Q2 2026, worth $206.8M in total; no superinvestor holds it.
13F holders, Q3 2021
Institutional positions in Karyopharm Therapeutics Inc. as of Sep 30, 2021. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 134
- −20 vs. Q2 2021
- Shares held
- 57.4M
- −1.58M (−2.7%) vs. Q2 2021
- Total value
- $334.4M
- −$274.3M (−45.1%) vs. Q2 2021
- New holders
- 14
- 58 more added
- Sold out
- 34
- 34 more reduced
Compare with Q2 2021: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting KPTI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 96 | $206.8M |
| Q1 2026 | 77 | $98.4M |
| Q4 2025 | 68 | $69.6M |
| Q3 2025 | 52 | $19.5M |
| Q2 2025 | 50 | $19.0M |
| Q1 2025 | 50 | $13.7M |
| Q4 2024 | 87 | $41.2M |
| Q3 2024 | 91 | $49.2M |
| Q2 2024 | 114 | $58.6M |
| Q1 2024 | 114 | $113.0M |
| Q4 2023 | 120 | $63.5M |
| Q3 2023 | 120 | $102.8M |
| Q2 2023 | 138 | $145.0M |
| Q1 2023 | 132 | $340.1M |
| Q4 2022 | 155 | $334.4M |
| Q3 2022 | 147 | $364.1M |
| Q2 2022 | 150 | $302.8M |
| Q1 2022 | 139 | $501.8M |
| Q4 2021 | 143 | $347.5M |
| Q3 2021 | 134 | $334.4M |
| Q2 2021 | 154 | $608.7M |
| Q1 2021 | 171 | $637.1M |
Institutions, Q3 2021
Shares, value and share of portfolio for each institution holding Karyopharm Therapeutics Inc.; share changes are against Q2 2021.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| BlackRock Inc. | 8,790,318 | $51.2M | 0.00% | +9,070+0.1% | Added |
| State Street Corp | 8,019,999 | $46.7M | 0.00% | +2,203,450+37.9% | Added |
| Palo Alto Investors LP | 5,383,052 | $31.3M | 1.89% | 00.0% | Unchanged |
| Vanguard Group Inc | 3,642,699 | $21.2M | 0.00% | +29,363+0.8% | Added |
| Rubric Capital Management LP | 3,375,758 | $19.6M | 1.13% | −877,454−20.6% | Reduced |
| Delphi Management Partners VIII, L.L.C. | 2,263,006 | $13.2M | 9.51% | 00.0% | Unchanged |
| Alkeon Capital Management LLC | 1,961,588 | $11.4M | 0.04% | −701,589−26.3% | Reduced |
| Morgan Stanley | 1,892,933 | $11.0M | 0.00% | +250,252+15.2% | Added |
| Lombard Odier Asset Management (Switzerland) SA | 1,517,804 | $8.83M | 0.55% | +141,432+10.3% | Added |
| Geode Capital Management, LLC | 1,407,157 | $8.19M | 0.00% | +211,879+17.7% | Added |
| Rice Hall James & Associates, LLC | 1,401,861 | $8.16M | 0.30% | −7,536−0.5% | Reduced |
| C WorldWide Group Holding A/S | 1,200,000 | $6.98M | 0.07% | 00.0% | Unchanged |
| Nuveen Asset Management, LLC | 1,119,008 | $6.79M | 0.00% | −16,908−1.5% | Reduced |
| Frontier Capital Management Co LLC | 1,102,427 | $6.42M | 0.05% | −386,512−26.0% | Reduced |
| Two Sigma Investments, LP | 1,096,683 | $6.38M | 0.02% | +250,565+29.6% | Added |
| Two Sigma Advisers, LP | 1,082,000 | $6.30M | 0.02% | +99,600+10.1% | Added |
| Goldman Sachs Group Inc | 985,382 | $5.74M | 0.00% | −20,339−2.0% | Reduced |
| Northern Trust Corp | 767,060 | $4.46M | 0.00% | −18,222−2.3% | Reduced |
| Candriam Luxembourg S.C.A. | 717,668 | $4.18M | 0.03% | 00.0% | Unchanged |
| UBS Group AG | 608,485 | $3.54M | 0.00% | +314,950+107.3% | Added |
| Susquehanna International Group, LLP | 540,393 | $3.15M | 0.00% | +217,288+67.2% | Added |
| Renaissance Technologies LLC | 495,400 | $2.88M | 0.00% | +476,928+2,581.9% | Added |
| BNP Paribas Arbitrage, SA | 468,241 | $2.73M | 0.01% | +75,509+19.2% | Added |
| JPMorgan Chase & Co | 464,921 | $2.71M | 0.00% | −18,301−3.8% | Reduced |
| Hennion & Walsh Asset Management, Inc. | 407,474 | $2.37M | 0.12% | +31,676+8.4% | Added |
| Macquarie Group Ltd | 382,041 | $2.22M | 0.00% | 00.0% | Unchanged |
| Rafferty Asset Management, LLC | 370,983 | $2.16M | 0.01% | +118,219+46.8% | Added |
| Bank of New York Mellon Corp | 302,501 | $1.76M | 0.00% | +13,445+4.7% | Added |
| Parametric Portfolio Associates LLC | 293,130 | $1.71M | 0.00% | +120,656+70.0% | Added |
| Jennison Associates LLC | 270,092 | $1.57M | 0.00% | +135,862+101.2% | Added |
| Birchview Capital, LP | 246,000 | $1.43M | 0.97% | +16,000+7.0% | Added |
| Citigroup Inc | 243,248 | $1.42M | 0.00% | −145,778−37.5% | Reduced |
| Bank of America Corp | 235,915 | $1.37M | 0.00% | +487+0.2% | Added |
| Deutsche Bank AG | 224,636 | $1.31M | 0.00% | −2,107−0.9% | Reduced |
| Citadel Advisors LLC | 220,777 | $1.28M | 0.00% | +9,683+4.6% | Added |
| Balyasny Asset Management LLC | 200,412 | $1.17M | 0.01% | +150,763+303.7% | Added |
| Tudor Investment Corp Et Al | 192,931 | $1.12M | 0.02% | +112,159+138.9% | Added |
| Charles Schwab Investment Management Inc | 188,149 | $1.10M | 0.00% | −276,909−59.5% | Reduced |
| Gsa Capital Partners LLP | 176,996 | $1.03M | 0.10% | +147,858+507.4% | Added |
| Susquehanna Fundamental Investments, LLC | 144,270 | $840.0K | 0.02% | +62,544+76.5% | Added |
| AlphaCentric Advisors LLC | 136,000 | $792.0K | 0.20% | +54,500+66.9% | Added |
| Allianz Asset Management GmbH | 132,948 | $774.0K | 0.00% | +15,014+12.7% | Added |
| Barclays PLC | 132,389 | $770.0K | 0.00% | −66,386−33.4% | Reduced |
| Swiss National Bank | 131,650 | $766.0K | 0.00% | 00.0% | Unchanged |
| Virginia Retirement Systems Et Al | 122,300 | $712.0K | 0.01% | +98,800+420.4% | Added |
| Alliancebernstein L.P. | 115,830 | $674.0K | 0.00% | 00.0% | Unchanged |
| Rhumbline Advisers | 96,191 | $560.0K | 0.00% | −29,496−23.5% | Reduced |
| Cubist Systematic Strategies, LLC | 95,994 | $559.0K | 0.01% | +48,981+104.2% | Added |
| State of Wisconsin Investment Board | 95,400 | $555.0K | 0.00% | 00.0% | Unchanged |
| California State Teachers Retirement System | 87,951 | $512.0K | 0.00% | −11,333−11.4% | Reduced |
| Algert Global LLC | 87,539 | $509.0K | 0.07% | +51,219+141.0% | Added |
| Credit Suisse AG | 85,614 | $498.0K | 0.00% | +1,650+2.0% | Added |
| UBS Asset Management Americas Inc | 84,393 | $491.2K | 0.00% | 00.0% | Unchanged |
| DuPont Capital Management Corp | 73,295 | $427.0K | 0.01% | +73,295 | New |
| Engineers Gate Manager LP | 60,799 | $354.0K | 0.02% | +45,819+305.9% | Added |
| J. Goldman & Co LP | 57,726 | $336.0K | 0.03% | −947,236−94.3% | Reduced |
| State Board of Administration of Florida Retirement System | 53,091 | $309.0K | 0.00% | +19,920+60.1% | Added |
| GFG Capital, LLC | 53,150 | $309.0K | 0.10% | +53,150 | New |
| Banque Cantonale Vaudoise | 50,000 | $291.0K | 0.01% | +50,000 | New |
| Group One Trading, L.P. | 46,654 | $272.0K | 0.01% | +41,871+875.4% | Added |
| Price T Rowe Associates Inc | 44,912 | $261.0K | 0.00% | −354,187−88.7% | Reduced |
| Virtus ETF Advisers LLC | 44,364 | $258.0K | 0.11% | −4,064−8.4% | Reduced |
| New York State Common Retirement Fund | 42,760 | $249.0K | 0.00% | −16,540−27.9% | Reduced |
| SG Americas Securities, LLC | 42,199 | $246.0K | 0.00% | +42,199 | New |
| Boothbay Fund Management, LLC | 39,622 | $231.0K | 0.01% | +16,555+71.8% | Added |
| American International Group, Inc. | 39,406 | $229.0K | 0.00% | −936−2.3% | Reduced |
| Manufacturers Life Insurance Company, The | 39,173 | $228.0K | 0.00% | −994−2.5% | Reduced |
| DekaBank Deutsche Girozentrale | 36,200 | $211.0K | 0.00% | 00.0% | Unchanged |
| Trexquant Investment LP | 36,201 | $211.0K | 0.02% | +11,659+47.5% | Added |
| Invesco Ltd. | 34,157 | $199.0K | 0.00% | +5,551+19.4% | Added |
| Weiss Multi-Strategy Advisers LLC | 34,099 | $198.0K | 0.00% | +762+2.3% | Added |
| Spearhead Capital Advisors, LLC | 33,658 | $196.0K | 0.03% | −371−1.1% | Reduced |
| Principal Financial Group Inc | 30,365 | $176.0K | 0.00% | +1,623+5.6% | Added |
| Vontobel Holding Ltd. | 30,000 | $175.0K | 0.00% | 00.0% | Unchanged |
| Legal & General Group Plc | 30,049 | $175.0K | 0.00% | +11,715+63.9% | Added |
| ExodusPoint Capital Management, LP | 29,920 | $174.0K | 0.00% | +2,800+10.3% | Added |
| Golden State Equity Partners | 29,953 | $174.0K | 0.07% | +7,850+35.5% | Added |
| Voya Investment Management LLC | 29,620 | $172.0K | 0.00% | +170+0.6% | Added |
| Jane Street Group, LLC | 28,328 | $165.0K | 0.00% | +1,386+5.1% | Added |
| Royal Bank of Canada | 26,679 | $155.0K | 0.00% | +4,979+22.9% | Added |
| Tower Research Capital LLC (TRC) | 26,001 | $152.0K | 0.00% | +20,624+383.6% | Added |
| ProShare Advisors LLC | 25,345 | $148.0K | 0.00% | −6,827−21.2% | Reduced |
| Wells Fargo & Company | 25,390 | $148.0K | 0.00% | −5,266−17.2% | Reduced |
| SG3 Management, LLC | 25,000 | $146.0K | 0.05% | +25,000 | New |
| Dimensional Fund Advisors LP | 23,570 | $137.0K | 0.00% | −514−2.1% | Reduced |
| Advisor Group Holdings, Inc. | 21,235 | $124.0K | 0.00% | +8,530+67.1% | Added |
| Moors & Cabot, Inc. | 21,150 | $123.0K | 0.01% | +2,500+13.4% | Added |
| Prelude Capital Management, LLC | 21,000 | $122.0K | 0.01% | 00.0% | Unchanged |
| Bridgefront Capital, LLC | 20,946 | $122.0K | 0.13% | +20,946 | New |
| E Fund Management Co., Ltd. | 20,522 | $119.0K | 0.00% | +20,522 | New |
| Baird Financial Group, Inc. | 17,680 | $103.0K | 0.00% | +714+4.2% | Added |
| Schonfeld Strategic Advisors LLC | 17,613 | $102.0K | 0.00% | +17,613 | New |
| First Republic Investment Management, Inc. | 17,314 | $101.0K | 0.00% | −5,137−22.9% | Reduced |
| Arizona State Retirement System | 16,364 | $95.0K | 0.00% | +134+0.8% | Added |
| XTX Topco Ltd | 16,272 | $95.0K | 0.03% | +16,272 | New |
| Creative Planning | 16,100 | $94.0K | 0.00% | 00.0% | Unchanged |
| ACT Capital Management, LLC | 14,000 | $81.0K | 0.04% | 00.0% | Unchanged |
| State of Wyoming | 13,502 | $79.0K | 0.05% | −901−6.3% | Reduced |
| First Mercantile Trust Co | 13,414 | $78.0K | 0.01% | +3,562+36.2% | Added |
| Amalgamated Bank | 13,061 | $76.0K | 0.00% | −535−3.9% | Reduced |