Karyopharm Therapeutics Inc.
KPTI- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001503802
In the last 90 days, Karyopharm Therapeutics Inc. insiders filed 0 open-market purchases and 2 sales; 96 institutions reported holding it in 13F filings for Q2 2026, worth $206.8M in total; no superinvestor holds it.
13F holders, Q3 2021
Institutional positions in Karyopharm Therapeutics Inc. as of Sep 30, 2021. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 134
- −20 vs. Q2 2021
- Shares held
- 57.4M
- −1.58M (−2.7%) vs. Q2 2021
- Total value
- $334.4M
- −$274.3M (−45.1%) vs. Q2 2021
- New holders
- 14
- 58 more added
- Sold out
- 34
- 34 more reduced
Compare with Q2 2021: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting KPTI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 96 | $206.8M |
| Q1 2026 | 77 | $98.4M |
| Q4 2025 | 68 | $69.6M |
| Q3 2025 | 52 | $19.5M |
| Q2 2025 | 50 | $19.0M |
| Q1 2025 | 50 | $13.7M |
| Q4 2024 | 87 | $41.2M |
| Q3 2024 | 91 | $49.2M |
| Q2 2024 | 114 | $58.6M |
| Q1 2024 | 114 | $113.0M |
| Q4 2023 | 120 | $63.5M |
| Q3 2023 | 120 | $102.8M |
| Q2 2023 | 138 | $145.0M |
| Q1 2023 | 132 | $340.1M |
| Q4 2022 | 155 | $334.4M |
| Q3 2022 | 147 | $364.1M |
| Q2 2022 | 150 | $302.8M |
| Q1 2022 | 139 | $501.8M |
| Q4 2021 | 143 | $347.5M |
| Q3 2021 | 134 | $334.4M |
| Q2 2021 | 154 | $608.7M |
| Q1 2021 | 171 | $637.1M |
Institutions, Q3 2021
Shares, value and share of portfolio for each institution holding Karyopharm Therapeutics Inc.; share changes are against Q2 2021.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Daiwa Securities Group Inc. | 138 | $1.00K | 0.00% | 00.0% | Unchanged |
| Allworth Financial LP | 100 | $1.00K | 0.00% | 00.0% | Unchanged |
| Quadrant Capital Group LLC | 90 | $1.00K | 0.00% | +65+260.0% | Added |
| Quantbot Technologies LP | 308 | $1.00K | 0.00% | +308 | New |
| Kelly Financial Services LLC | 250 | $1.46K | 0.00% | −2,330−90.3% | Reduced |
| Dark Forest Capital Management LP | 425 | $2.00K | 0.00% | +425 | New |
| Berman Capital Advisors, LLC | 641 | $3.00K | 0.00% | +641 | New |
| Glen Eagle Advisors, LLC | 600 | $3.49K | 0.00% | −100−14.3% | Reduced |
| O'Shaughnessy Asset Management, LLC | 753 | $4.00K | 0.00% | 00.0% | Unchanged |
| Nisa Investment Advisors, LLC | 800 | $5.00K | 0.00% | 00.0% | Unchanged |
| AdvisorNet Financial, Inc | 800 | $5.00K | 0.00% | 00.0% | Unchanged |
| American Portfolios Advisors | 1,000 | $5.82K | 0.00% | 00.0% | Unchanged |
| Private Capital Group, LLC | 1,000 | $6.00K | 0.00% | 00.0% | Unchanged |
| Captrust Financial Advisors | 1,125 | $7.00K | 0.00% | −3,311−74.6% | Reduced |
| Penserra Capital Management LLC | 1,725 | $10.0K | 0.00% | +15+0.9% | Added |
| Signaturefd, LLC | 1,897 | $11.0K | 0.00% | +346+22.3% | Added |
| US Bancorp | 2,112 | $13.0K | 0.00% | +941+80.4% | Added |
| Russell Investments Group, Ltd. | 2,510 | $14.0K | 0.00% | −50,159−95.2% | Reduced |
| Harbour Investments, Inc. | 2,805 | $16.0K | 0.00% | +300+12.0% | Added |
| Tarbox Family Office, Inc. | 3,000 | $17.0K | 0.00% | 00.0% | Unchanged |
| Founders Capital Management | 3,000 | $17.0K | 0.01% | +2,000+200.0% | Added |
| Great West Life Assurance Co | 3,017 | $18.0K | 0.00% | 00.0% | Unchanged |
| Atlas Private Wealth Advisors | 3,500 | $20.0K | 0.01% | −2,000−36.4% | Reduced |
| Rockefeller Capital Management L.P. | 3,700 | $21.0K | 0.00% | +300+8.8% | Added |
| The PNC Financial Services Group, Inc. | 3,800 | $22.0K | 0.00% | 00.0% | Unchanged |
| Patriot Financial Group Insurance Agency, LLC | 4,000 | $23.0K | 0.00% | +600+17.6% | Added |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 5,977 | $35.0K | 0.00% | 00.0% | Unchanged |
| Ameritas Investment Partners, Inc. | 6,194 | $36.0K | 0.00% | 00.0% | Unchanged |
| MetLife Investment Management | 9,555 | $55.6K | 0.00% | −14,158−59.7% | Reduced |
| Cambridge Investment Research Advisors, Inc. | 10,431 | $61.0K | 0.00% | 00.0% | Unchanged |
| Handelsbanken Fonder AB | 10,400 | $61.0K | 0.00% | 00.0% | Unchanged |
| Point72 Hong Kong Ltd | 10,774 | $63.0K | 0.00% | +10,774 | New |
| Metropolitan Life Insurance Co | 11,535 | $67.1K | 0.00% | −10,712−48.2% | Reduced |
| Commonwealth Equity Services, LLC | 12,740 | $74.0K | 0.00% | +12,740 | New |
| Amalgamated Bank | 13,061 | $76.0K | 0.00% | −535−3.9% | Reduced |
| First Mercantile Trust Co | 13,414 | $78.0K | 0.01% | +3,562+36.2% | Added |
| State of Wyoming | 13,502 | $79.0K | 0.05% | −901−6.3% | Reduced |
| ACT Capital Management, LLC | 14,000 | $81.0K | 0.04% | 00.0% | Unchanged |
| Creative Planning | 16,100 | $94.0K | 0.00% | 00.0% | Unchanged |
| Arizona State Retirement System | 16,364 | $95.0K | 0.00% | +134+0.8% | Added |
| XTX Topco Ltd | 16,272 | $95.0K | 0.03% | +16,272 | New |
| First Republic Investment Management, Inc. | 17,314 | $101.0K | 0.00% | −5,137−22.9% | Reduced |
| Schonfeld Strategic Advisors LLC | 17,613 | $102.0K | 0.00% | +17,613 | New |
| Baird Financial Group, Inc. | 17,680 | $103.0K | 0.00% | +714+4.2% | Added |
| E Fund Management Co., Ltd. | 20,522 | $119.0K | 0.00% | +20,522 | New |
| Prelude Capital Management, LLC | 21,000 | $122.0K | 0.01% | 00.0% | Unchanged |
| Bridgefront Capital, LLC | 20,946 | $122.0K | 0.13% | +20,946 | New |
| Moors & Cabot, Inc. | 21,150 | $123.0K | 0.01% | +2,500+13.4% | Added |
| Advisor Group Holdings, Inc. | 21,235 | $124.0K | 0.00% | +8,530+67.1% | Added |
| Dimensional Fund Advisors LP | 23,570 | $137.0K | 0.00% | −514−2.1% | Reduced |
| SG3 Management, LLC | 25,000 | $146.0K | 0.05% | +25,000 | New |
| ProShare Advisors LLC | 25,345 | $148.0K | 0.00% | −6,827−21.2% | Reduced |
| Wells Fargo & Company | 25,390 | $148.0K | 0.00% | −5,266−17.2% | Reduced |
| Tower Research Capital LLC (TRC) | 26,001 | $152.0K | 0.00% | +20,624+383.6% | Added |
| Royal Bank of Canada | 26,679 | $155.0K | 0.00% | +4,979+22.9% | Added |
| Jane Street Group, LLC | 28,328 | $165.0K | 0.00% | +1,386+5.1% | Added |
| Voya Investment Management LLC | 29,620 | $172.0K | 0.00% | +170+0.6% | Added |
| ExodusPoint Capital Management, LP | 29,920 | $174.0K | 0.00% | +2,800+10.3% | Added |
| Golden State Equity Partners | 29,953 | $174.0K | 0.07% | +7,850+35.5% | Added |
| Vontobel Holding Ltd. | 30,000 | $175.0K | 0.00% | 00.0% | Unchanged |
| Legal & General Group Plc | 30,049 | $175.0K | 0.00% | +11,715+63.9% | Added |
| Principal Financial Group Inc | 30,365 | $176.0K | 0.00% | +1,623+5.6% | Added |
| Spearhead Capital Advisors, LLC | 33,658 | $196.0K | 0.03% | −371−1.1% | Reduced |
| Weiss Multi-Strategy Advisers LLC | 34,099 | $198.0K | 0.00% | +762+2.3% | Added |
| Invesco Ltd. | 34,157 | $199.0K | 0.00% | +5,551+19.4% | Added |
| DekaBank Deutsche Girozentrale | 36,200 | $211.0K | 0.00% | 00.0% | Unchanged |
| Trexquant Investment LP | 36,201 | $211.0K | 0.02% | +11,659+47.5% | Added |
| Manufacturers Life Insurance Company, The | 39,173 | $228.0K | 0.00% | −994−2.5% | Reduced |
| American International Group, Inc. | 39,406 | $229.0K | 0.00% | −936−2.3% | Reduced |
| Boothbay Fund Management, LLC | 39,622 | $231.0K | 0.01% | +16,555+71.8% | Added |
| SG Americas Securities, LLC | 42,199 | $246.0K | 0.00% | +42,199 | New |
| New York State Common Retirement Fund | 42,760 | $249.0K | 0.00% | −16,540−27.9% | Reduced |
| Virtus ETF Advisers LLC | 44,364 | $258.0K | 0.11% | −4,064−8.4% | Reduced |
| Price T Rowe Associates Inc | 44,912 | $261.0K | 0.00% | −354,187−88.7% | Reduced |
| Group One Trading, L.P. | 46,654 | $272.0K | 0.01% | +41,871+875.4% | Added |
| Banque Cantonale Vaudoise | 50,000 | $291.0K | 0.01% | +50,000 | New |
| State Board of Administration of Florida Retirement System | 53,091 | $309.0K | 0.00% | +19,920+60.1% | Added |
| GFG Capital, LLC | 53,150 | $309.0K | 0.10% | +53,150 | New |
| J. Goldman & Co LP | 57,726 | $336.0K | 0.03% | −947,236−94.3% | Reduced |
| Engineers Gate Manager LP | 60,799 | $354.0K | 0.02% | +45,819+305.9% | Added |
| DuPont Capital Management Corp | 73,295 | $427.0K | 0.01% | +73,295 | New |
| UBS Asset Management Americas Inc | 84,393 | $491.2K | 0.00% | 00.0% | Unchanged |
| Credit Suisse AG | 85,614 | $498.0K | 0.00% | +1,650+2.0% | Added |
| Algert Global LLC | 87,539 | $509.0K | 0.07% | +51,219+141.0% | Added |
| California State Teachers Retirement System | 87,951 | $512.0K | 0.00% | −11,333−11.4% | Reduced |
| State of Wisconsin Investment Board | 95,400 | $555.0K | 0.00% | 00.0% | Unchanged |
| Cubist Systematic Strategies, LLC | 95,994 | $559.0K | 0.01% | +48,981+104.2% | Added |
| Rhumbline Advisers | 96,191 | $560.0K | 0.00% | −29,496−23.5% | Reduced |
| Alliancebernstein L.P. | 115,830 | $674.0K | 0.00% | 00.0% | Unchanged |
| Virginia Retirement Systems Et Al | 122,300 | $712.0K | 0.01% | +98,800+420.4% | Added |
| Swiss National Bank | 131,650 | $766.0K | 0.00% | 00.0% | Unchanged |
| Barclays PLC | 132,389 | $770.0K | 0.00% | −66,386−33.4% | Reduced |
| Allianz Asset Management GmbH | 132,948 | $774.0K | 0.00% | +15,014+12.7% | Added |
| AlphaCentric Advisors LLC | 136,000 | $792.0K | 0.20% | +54,500+66.9% | Added |
| Susquehanna Fundamental Investments, LLC | 144,270 | $840.0K | 0.02% | +62,544+76.5% | Added |
| Gsa Capital Partners LLP | 176,996 | $1.03M | 0.10% | +147,858+507.4% | Added |
| Charles Schwab Investment Management Inc | 188,149 | $1.10M | 0.00% | −276,909−59.5% | Reduced |
| Tudor Investment Corp Et Al | 192,931 | $1.12M | 0.02% | +112,159+138.9% | Added |
| Balyasny Asset Management LLC | 200,412 | $1.17M | 0.01% | +150,763+303.7% | Added |
| Citadel Advisors LLC | 220,777 | $1.28M | 0.00% | +9,683+4.6% | Added |