Karyopharm Therapeutics Inc.
KPTI- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001503802
In the last 90 days, Karyopharm Therapeutics Inc. insiders filed 0 open-market purchases and 2 sales; 96 institutions reported holding it in 13F filings for Q2 2026, worth $206.8M in total; no superinvestor holds it.
13F holders, Q4 2024
Institutional positions in Karyopharm Therapeutics Inc. as of Dec 31, 2024. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 87
- −4 vs. Q3 2024
- Shares held
- 60.9M
- +1.50M (+2.5%) vs. Q3 2024
- Total value
- $41.2M
- −$8.02M (−16.3%) vs. Q3 2024
- New holders
- 14
- 22 more added
- Sold out
- 18
- 23 more reduced
Compare with Q3 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting KPTI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 96 | $206.8M |
| Q1 2026 | 77 | $98.4M |
| Q4 2025 | 68 | $69.6M |
| Q3 2025 | 52 | $19.5M |
| Q2 2025 | 50 | $19.0M |
| Q1 2025 | 50 | $13.7M |
| Q4 2024 | 87 | $41.2M |
| Q3 2024 | 91 | $49.2M |
| Q2 2024 | 114 | $58.6M |
| Q1 2024 | 114 | $113.0M |
| Q4 2023 | 120 | $63.5M |
| Q3 2023 | 120 | $102.8M |
| Q2 2023 | 138 | $145.0M |
| Q1 2023 | 132 | $340.1M |
| Q4 2022 | 155 | $334.4M |
| Q3 2022 | 147 | $364.1M |
| Q2 2022 | 150 | $302.8M |
| Q1 2022 | 139 | $501.8M |
| Q4 2021 | 143 | $347.5M |
| Q3 2021 | 134 | $334.4M |
| Q2 2021 | 154 | $608.7M |
| Q1 2021 | 171 | $637.1M |
Institutions, Q4 2024
Shares, value and share of portfolio for each institution holding Karyopharm Therapeutics Inc.; share changes are against Q3 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Vanguard Group Inc | 7,654,482 | $5.17M | 0.00% | 00.0% | Unchanged |
| Adage Capital Partners GP, L.L.C. | 6,319,842 | $4.27M | 0.01% | +2,000,000+46.3% | Added |
| Palo Alto Investors LP | 4,907,001 | $3.32M | 0.51% | −195,192−3.8% | Reduced |
| BlackRock, Inc. | 3,768,875 | $2.55M | 0.00% | +130,497+3.6% | Added |
| Morgan Stanley | 3,513,188 | $2.38M | 0.00% | +3,389,541+2,741.3% | Added |
| Citadel Advisors LLC | 3,103,669 | $2.10M | 0.00% | 00.0% | Unchanged |
| Marshall Wace, LLP | 2,401,413 | $1.63M | 0.00% | +319,187+15.3% | Added |
| Catalio Capital Management, LP | 2,334,375 | $1.58M | 0.35% | +2,334,375 | New |
| Eversept Partners, LP | 2,088,757 | $1.41M | 0.15% | −3,459,123−62.4% | Reduced |
| Avidity Partners Management LP | 2,018,500 | $1.37M | 0.14% | 00.0% | Unchanged |
| Gsa Capital Partners LLP | 1,598,435 | $1.08M | 0.08% | −177,265−10.0% | Reduced |
| C WorldWide Group Holding A/S | 1,500,000 | $1.01M | 0.01% | 00.0% | Unchanged |
| UBS Oconnor LLC | 1,483,727 | $1.00M | 0.03% | +287,553+24.0% | Added |
| Geode Capital Management, LLC | 1,392,314 | $941.9K | 0.00% | +36,922+2.7% | Added |
| Goldman Sachs Group Inc | 1,335,771 | $903.4K | 0.00% | −944−0.1% | Reduced |
| BNP Paribas Arbitrage, SA | 1,313,893 | $888.6K | 0.00% | −668,461−33.7% | Reduced |
| Deutsche Bank AG | 1,268,777 | $862.8K | 0.00% | 00.0% | Unchanged |
| Renaissance Technologies LLC | 1,202,590 | $813.3K | 0.00% | −38,817−3.1% | Reduced |
| Kennedy Capital Management, Inc. | 1,195,293 | $808.4K | 0.02% | −8,716−0.7% | Reduced |
| Millennium Management LLC | 1,154,414 | $780.7K | 0.00% | −100,850−8.0% | Reduced |
| Jane Street Group, LLC | 748,306 | $506.1K | 0.00% | +543,556+265.5% | Added |
| Altium Capital Management LP | 740,000 | $500.5K | 0.16% | 00.0% | Unchanged |
| Susquehanna International Group, LLP | 664,145 | $449.2K | 0.00% | +361,597+119.5% | Added |
| Silverarc Capital Management, LLC | 595,990 | $403.1K | 0.09% | +37,524+6.7% | Added |
| Macquarie Group Ltd | 500,000 | $338.0K | 0.00% | 00.0% | Unchanged |
| State Street Corp | 442,510 | $299.3K | 0.00% | +33,000+8.1% | Added |
| Birchview Capital, LP | 419,832 | $283.9K | 0.23% | −50,000−10.6% | Reduced |
| FMR LLC | 412,456 | $278.9K | 0.00% | +42,733+11.6% | Added |
| Ikarian Capital, LLC | 408,899 | $276.5K | 0.08% | −456−0.1% | Reduced |
| Acadian Asset Management LLC | 342,847 | $230.0K | 0.00% | −25,664−7.0% | Reduced |
| Cubist Systematic Strategies, LLC | 328,807 | $222.4K | 0.00% | −167,429−33.7% | Reduced |
| Northern Trust Corp | 283,729 | $191.9K | 0.00% | +54,061+23.5% | Added |
| JPMorgan Chase & Co | 276,208 | $186.8K | 0.00% | −1,109,516−80.1% | Reduced |
| Atom Investors LP | 259,824 | $175.7K | 0.02% | 00.0% | Unchanged |
| Bridgeway Capital Management, LLC | 239,500 | $162.0K | 0.00% | 00.0% | Unchanged |
| D. E. Shaw & Co., Inc. | 229,685 | $155.3K | 0.00% | −817,711−78.1% | Reduced |
| Exchange Traded Concepts, LLC | 218,791 | $148.0K | 0.00% | 00.0% | Unchanged |
| Shay Capital LLC | 172,153 | $116.4K | 0.03% | +172,153 | New |
| Bank of New York Mellon Corp | 166,317 | $112.5K | 0.00% | +10.0% | Added |
| Bank of America Corp | 161,708 | $109.3K | 0.00% | −67,233−29.4% | Reduced |
| UBS Group AG | 145,791 | $98.6K | 0.00% | +11,313+8.4% | Added |
| Two Sigma Investments, LP | 137,786 | $93.2K | 0.00% | +51,856+60.3% | Added |
| Woodline Partners LP | 134,112 | $90.7K | 0.00% | 00.0% | Unchanged |
| Opti Capital Management, LP | 125,000 | $84.5K | 0.00% | +125,000 | New |
| Citigroup Inc | 105,679 | $71.5K | 0.00% | −140.0% | Reduced |
| Barclays PLC | 95,611 | $64.7K | 0.00% | −156−0.2% | Reduced |
| Boothbay Fund Management, LLC | 90,635 | $61.3K | 0.00% | −456−0.5% | Reduced |
| Point72 Asia (Singapore) Pte. Ltd. | 84,698 | $57.3K | 0.02% | +2,252+2.7% | Added |
| Two Sigma Advisers, LP | 76,600 | $51.8K | 0.00% | +45,400+145.5% | Added |
| Prudential Financial Inc | 74,600 | $50.5K | 0.00% | 00.0% | Unchanged |
| Price T Rowe Associates Inc | 64,300 | $44.0K | 0.00% | −70,400−52.3% | Reduced |
| Charles Schwab Investment Management Inc | 51,173 | $34.6K | 0.00% | +173+0.3% | Added |
| TD Waterhouse Canada Inc. | 48,049 | $32.2K | 0.00% | +48,049 | New |
| Colony Group, LLC | 45,818 | $31.0K | 0.00% | +45,818 | New |
| Baird Financial Group, Inc. | 44,800 | $30.3K | 0.00% | +7,000+18.5% | Added |
| Velan Capital Investment Management LP | 40,000 | $27.1K | 0.02% | +40,000 | New |
| HSBC Holdings PLC | 40,301 | $26.5K | 0.00% | 00.0% | Unchanged |
| Eqis Capital Management, Inc. | 38,684 | $26.2K | 0.00% | +1,483+4.0% | Added |
| Kennedy Investment Group | 35,000 | $23.7K | 0.01% | 00.0% | Unchanged |
| R Squared Ltd | 29,670 | $20.1K | 0.02% | +29,670 | New |
| Engineers Gate Manager LP | 28,699 | $19.4K | 0.00% | −19,434−40.4% | Reduced |
| Commonwealth Equity Services, LLC | 22,288 | $15.0K | 0.00% | +82+0.4% | Added |
| Squarepoint Ops LLC | 20,786 | $14.1K | 0.00% | +20,786 | New |
| CI Private Wealth, LLC | 20,500 | $13.9K | 0.00% | −584−2.8% | Reduced |
| ADAR1 Capital Management, LLC | 20,000 | $13.5K | 0.00% | +20,000 | New |
| ELCO Management Co., LLC | 16,177 | $10.9K | 0.01% | 00.0% | Unchanged |
| Winthrop Advisory Group LLC | 15,000 | $10.1K | 0.00% | 00.0% | Unchanged |
| CAPROCK Group, Inc. | 11,600 | $7.84K | 0.00% | +11,600 | New |
| Snowden Capital Advisors LLC | 11,000 | $7.44K | 0.00% | 00.0% | Unchanged |
| Wolverine Trading, LLC | 10,273 | $7.19K | 0.00% | −3,462−25.2% | Reduced |
| Walleye Capital LLC | 10,451 | $7.07K | 0.00% | +10,451 | New |
| Janney Montgomery Scott LLC | 10,000 | $7.00K | 0.00% | 00.0% | Unchanged |
| BLB&B Advisors, LLC | 10,150 | $6.86K | 0.00% | 00.0% | Unchanged |
| Tower Research Capital LLC (TRC) | 7,696 | $5.20K | 0.00% | +7,696 | New |
| Royal Bank of Canada | 6,500 | $4.00K | 0.00% | −1,450−18.2% | Reduced |
| Advisor Group Holdings, Inc. | 5,390 | $3.66K | 0.00% | +1,000+22.8% | Added |
| Quent Capital, LLC | 3,489 | $2.36K | 0.00% | 00.0% | Unchanged |
| VSM Wealth Advisory, LLC | 2,000 | $1.35K | 0.00% | +2,000 | New |
| MB, Levis & Associates, LLC | 1,500 | $1.01K | 0.00% | 00.0% | Unchanged |
| Harbour Investments, Inc. | 1,300 | $879 | 0.00% | 00.0% | Unchanged |
| Activest Wealth Management | 1,000 | $676 | 0.00% | 00.0% | Unchanged |
| SBI Securities Co., Ltd. | 717 | $485 | 0.00% | +717 | New |
| Wells Fargo & Company | 666 | $450 | 0.00% | 00.0% | Unchanged |
| Allworth Financial LP | 500 | $334 | 0.00% | 00.0% | Unchanged |
| Bruce G. Allen Investments, LLC | 338 | $229 | 0.00% | 00.0% | Unchanged |
| CIBC Private Wealth Group, LLC | 50 | $36 | 0.00% | 00.0% | Unchanged |
| West Branch Capital LLC | 48 | $33 | 0.00% | 00.0% | Unchanged |
| AlphaCentric Advisors LLC | 0 | $0 | 0.00% | −1,125,000−100.0% | Sold out |
| DAFNA Capital Management LLC | 0 | $0 | 0.00% | −192,678−100.0% | Sold out |
| Qube Research & Technologies Ltd | 0 | $0 | 0.00% | −62,026−100.0% | Sold out |
| Invesco Ltd. | 0 | $0 | 0.00% | −58,152−100.0% | Sold out |
| Cerity Partners LLC | 0 | $0 | 0.00% | −51,533−100.0% | Sold out |
| Monashee Investment Management LLC | 0 | $0 | 0.00% | −132,435−100.0% | Sold out |
| Catalyst Funds Management Pty Ltd | 0 | $0 | 0.00% | −28,600−100.0% | Sold out |
| XTX Topco Ltd | 0 | $0 | 0.00% | −25,905−100.0% | Sold out |
| JustInvest LLC | 0 | $0 | 0.00% | −17,188−100.0% | Sold out |
| Victory Capital Management Inc | 0 | $0 | 0.00% | −14,496−100.0% | Sold out |
| AQR Capital Management LLC | 0 | $0 | 0.00% | −12,221−100.0% | Sold out |
| Avidian Wealth Solutions, LLC | 0 | $0 | 0.00% | −10,100−100.0% | Sold out |
| The PNC Financial Services Group, Inc. | 0 | $0 | 0.00% | −3,000−100.0% | Sold out |