Karyopharm Therapeutics Inc.
KPTI- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001503802
In the last 90 days, Karyopharm Therapeutics Inc. insiders filed 0 open-market purchases and 2 sales; 96 institutions reported holding it in 13F filings for Q2 2026, worth $206.8M in total; no superinvestor holds it.
13F holders, Q4 2023
Institutional positions in Karyopharm Therapeutics Inc. as of Dec 31, 2023. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 120
- 0 vs. Q3 2023
- Shares held
- 73.5M
- −3.74M (−4.8%) vs. Q3 2023
- Total value
- $63.5M
- −$39.3M (−38.2%) vs. Q3 2023
- New holders
- 23
- 24 more added
- Sold out
- 23
- 42 more reduced
Compare with Q3 2023: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting KPTI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 96 | $206.8M |
| Q1 2026 | 77 | $98.4M |
| Q4 2025 | 68 | $69.6M |
| Q3 2025 | 52 | $19.5M |
| Q2 2025 | 50 | $19.0M |
| Q1 2025 | 50 | $13.7M |
| Q4 2024 | 87 | $41.2M |
| Q3 2024 | 91 | $49.2M |
| Q2 2024 | 114 | $58.6M |
| Q1 2024 | 114 | $113.0M |
| Q4 2023 | 120 | $63.5M |
| Q3 2023 | 120 | $102.8M |
| Q2 2023 | 138 | $145.0M |
| Q1 2023 | 132 | $340.1M |
| Q4 2022 | 155 | $334.4M |
| Q3 2022 | 147 | $364.1M |
| Q2 2022 | 150 | $302.8M |
| Q1 2022 | 139 | $501.8M |
| Q4 2021 | 143 | $347.5M |
| Q3 2021 | 134 | $334.4M |
| Q2 2021 | 154 | $608.7M |
| Q1 2021 | 171 | $637.1M |
Institutions, Q4 2023
Shares, value and share of portfolio for each institution holding Karyopharm Therapeutics Inc.; share changes are against Q3 2023.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| BlackRock Inc. | 10,071,677 | $8.71M | 0.00% | −1,014,856−9.2% | Reduced |
| Vanguard Group Inc | 8,710,158 | $7.53M | 0.00% | −109,771−1.2% | Reduced |
| Avidity Partners Management LP | 8,298,570 | $7.18M | 0.27% | 00.0% | Unchanged |
| Palo Alto Investors LP | 5,102,193 | $4.41M | 0.40% | −573,683−10.1% | Reduced |
| Citadel Advisors LLC | 3,101,399 | $2.68M | 0.00% | −2,489−0.1% | Reduced |
| Geode Capital Management, LLC | 2,382,428 | $2.06M | 0.00% | +95,282+4.2% | Added |
| Gsa Capital Partners LLP | 2,337,985 | $2.02M | 0.17% | +1,769,687+311.4% | Added |
| State Street Corp | 2,053,773 | $1.78M | 0.00% | +10,768+0.5% | Added |
| Renaissance Technologies LLC | 1,964,377 | $1.70M | 0.00% | +1,233,977+168.9% | Added |
| Marshall Wace, LLP | 1,926,782 | $1.66M | 0.00% | −256,419−11.7% | Reduced |
| BNP Paribas Arbitrage, SA | 1,769,184 | $1.53M | 0.00% | +108,286+6.5% | Added |
| Adage Capital Partners GP, L.L.C. | 1,663,300 | $1.44M | 0.00% | +1,663,300 | New |
| Millennium Management LLC | 1,534,264 | $1.33M | 0.00% | +416,356+37.2% | Added |
| C WorldWide Group Holding A/S | 1,500,000 | $1.30M | 0.02% | 00.0% | Unchanged |
| Deutsche Bank AG | 1,327,008 | $1.15M | 0.00% | +1,268,777+2,178.9% | Added |
| Goldman Sachs Group Inc | 1,296,593 | $1.12M | 0.00% | −618,454−32.3% | Reduced |
| JPMorgan Chase & Co | 1,181,120 | $1.02M | 0.00% | +39,994+3.5% | Added |
| AlphaCentric Advisors LLC | 1,125,000 | $973.1K | 0.65% | 00.0% | Unchanged |
| Tejara Capital Ltd | 1,031,348 | $892.1K | 0.37% | −46,040−4.3% | Reduced |
| Northern Trust Corp | 996,147 | $861.7K | 0.00% | +10,415+1.1% | Added |
| Barclays PLC | 970,062 | $839.1K | 0.00% | −182,236−15.8% | Reduced |
| Morgan Stanley | 845,151 | $731.1K | 0.00% | −199,320−19.1% | Reduced |
| UBS Oconnor LLC | 802,327 | $694.0K | 0.02% | −74,383−8.5% | Reduced |
| Altium Capital Management LP | 740,000 | $640.1K | 0.44% | 00.0% | Unchanged |
| D. E. Shaw & Co., Inc. | 617,216 | $533.9K | 0.00% | −5,639−0.9% | Reduced |
| AQR Capital Management LLC | 598,142 | $517.4K | 0.00% | +96,343+19.2% | Added |
| Silverarc Capital Management, LLC | 561,955 | $486.1K | 0.15% | 00.0% | Unchanged |
| Candriam Luxembourg S.C.A. | 530,694 | $459.1K | 0.00% | −610,000−53.5% | Reduced |
| Bank of New York Mellon Corp | 497,202 | $430.1K | 0.00% | −156,448−23.9% | Reduced |
| Birchview Capital, LP | 469,832 | $406.4K | 0.32% | −102,000−17.8% | Reduced |
| UBS Group AG | 457,185 | $395.5K | 0.00% | −449,460−49.6% | Reduced |
| Nuveen Asset Management, LLC | 454,302 | $393.0K | 0.00% | +1,896+0.4% | Added |
| Ikarian Capital, LLC | 400,000 | $346.0K | 0.09% | 00.0% | Unchanged |
| Los Angeles Capital Management LLC | 391,540 | $338.7K | 0.00% | +391,540 | New |
| Macquarie Group Ltd | 380,000 | $329.0K | 0.00% | 00.0% | Unchanged |
| Ameriprise Financial Inc | 309,967 | $268.1K | 0.00% | −47,011−13.2% | Reduced |
| Charles Schwab Investment Management Inc | 309,909 | $268.1K | 0.00% | +51,000+19.7% | Added |
| Bank of America Corp | 306,455 | $265.1K | 0.00% | −46,167−13.1% | Reduced |
| Bridgeway Capital Management, LLC | 289,500 | $250.4K | 0.01% | 00.0% | Unchanged |
| Jacobs Levy Equity Management, Inc | 284,457 | $246.1K | 0.00% | −2,069,071−87.9% | Reduced |
| Jane Street Group, LLC | 275,460 | $238.3K | 0.00% | +275,460 | New |
| Acadian Asset Management LLC | 275,059 | $237.0K | 0.00% | +275,059 | New |
| FMR LLC | 268,286 | $232.1K | 0.00% | +1,839+0.7% | Added |
| Panagora Asset Management Inc | 227,445 | $196.7K | 0.00% | +227,445 | New |
| Atom Investors LP | 216,690 | $187.4K | 0.03% | +25,865+13.6% | Added |
| Alliancebernstein L.P. | 192,810 | $166.8K | 0.00% | 00.0% | Unchanged |
| DAFNA Capital Management LLC | 192,678 | $166.7K | 0.04% | 00.0% | Unchanged |
| Two Sigma Investments, LP | 142,274 | $123.1K | 0.00% | +142,274 | New |
| Rhumbline Advisers | 138,107 | $119.5K | 0.00% | −500.0% | Reduced |
| Woodline Partners LP | 116,718 | $101.0K | 0.00% | −17,394−13.0% | Reduced |
| Exchange Traded Concepts, LLC | 115,864 | $100.2K | 0.00% | +29,380+34.0% | Added |
| Price T Rowe Associates Inc | 87,113 | $76.0K | 0.00% | 00.0% | Unchanged |
| Boothbay Fund Management, LLC | 81,736 | $70.7K | 0.00% | 00.0% | Unchanged |
| Susquehanna International Group, LLP | 78,596 | $68.0K | 0.00% | −59,213−43.0% | Reduced |
| Royal Bank of Canada | 76,320 | $66.0K | 0.00% | −961−1.2% | Reduced |
| SG Americas Securities, LLC | 73,430 | $64.0K | 0.00% | +54,839+295.0% | Added |
| Connor, Clark & Lunn Investment Management Ltd. | 71,224 | $61.6K | 0.00% | +35,945+101.9% | Added |
| Two Sigma Advisers, LP | 63,200 | $54.7K | 0.00% | +28,000+79.5% | Added |
| American International Group, Inc. | 56,295 | $48.7K | 0.00% | −228−0.4% | Reduced |
| XTX Topco Ltd | 49,122 | $42.5K | 0.01% | −260,943−84.2% | Reduced |
| Voya Investment Management LLC | 45,471 | $39.3K | 0.00% | 00.0% | Unchanged |
| Wade G W & Inc | 45,140 | $39.0K | 0.00% | 00.0% | Unchanged |
| HSBC Holdings PLC | 45,290 | $38.9K | 0.00% | +362+0.8% | Added |
| Monashee Investment Management LLC | 132,435 | $34.9K | 0.01% | +132,435 | New |
| Sawtooth Solutions, LLC | 37,938 | $32.8K | 0.00% | +37,938 | New |
| Bleakley Financial Group, LLC | 37,938 | $32.8K | 0.00% | +37,938 | New |
| Kennedy Investment Group | 35,000 | $30.3K | 0.02% | 00.0% | Unchanged |
| Principal Financial Group Inc | 31,442 | $27.2K | 0.00% | −1,396−4.3% | Reduced |
| Group One Trading, L.P. | 30,473 | $26.4K | 0.00% | −24,040−44.1% | Reduced |
| Redwood Wealth Management Group, LLC | 29,730 | $25.7K | 0.03% | −3,000−9.2% | Reduced |
| State Board of Administration of Florida Retirement System | 29,422 | $25.4K | 0.00% | +29,422 | New |
| Wells Fargo & Company | 29,365 | $25.4K | 0.00% | +6,682+29.5% | Added |
| Engineers Gate Manager LP | 28,700 | $24.8K | 0.00% | −10,262−26.3% | Reduced |
| Invesco Ltd. | 28,471 | $24.6K | 0.00% | −35,341−55.4% | Reduced |
| State of Wyoming | 28,431 | $24.6K | 0.00% | −12,310−30.2% | Reduced |
| Wexford Capital LP | 27,280 | $23.6K | 0.01% | +27,280 | New |
| Weiss Multi-Strategy Advisers LLC | 27,043 | $23.0K | 0.00% | −4,771−15.0% | Reduced |
| Banque Cantonale Vaudoise | 25,000 | $22.0K | 0.00% | +10,000+66.7% | Added |
| Prudential Financial Inc | 24,815 | $21.5K | 0.00% | +5,400+27.8% | Added |
| ELCO Management Co., LLC | 22,561 | $19.5K | 0.01% | 00.0% | Unchanged |
| Point72 Middle East FZE | 22,028 | $19.1K | 0.00% | −73,110−76.8% | Reduced |
| Simplex Trading, LLC | 21,001 | $18.0K | 0.00% | −505−2.3% | Reduced |
| Two Sigma Securities, LLC | 19,586 | $16.9K | 0.00% | +19,586 | New |
| New York State Common Retirement Fund | 19,373 | $16.8K | 0.00% | −290−1.5% | Reduced |
| ProShare Advisors LLC | 18,746 | $16.2K | 0.00% | −3,445−15.5% | Reduced |
| California State Teachers Retirement System | 18,642 | $16.1K | 0.00% | −6,348−25.4% | Reduced |
| Diversified Trust Co | 18,580 | $16.1K | 0.00% | +18,580 | New |
| Citigroup Inc | 16,432 | $14.2K | 0.00% | +14,827+923.8% | Added |
| Amalgamated Bank | 14,694 | $13.0K | 0.00% | −737−4.8% | Reduced |
| CI Private Wealth, LLC | 14,000 | $12.1K | 0.00% | +14,000 | New |
| Baird Financial Group, Inc. | 13,800 | $11.9K | 0.00% | 00.0% | Unchanged |
| Legal & General Group Plc | 13,735 | $11.9K | 0.00% | 00.0% | Unchanged |
| Neuberger Berman Group LLC | 13,317 | $11.5K | 0.00% | +2,083+18.5% | Added |
| Brinker Capital Investments, LLC | 10,965 | $10.1K | 0.00% | −2,074−15.9% | Reduced |
| Orion Portfolio Solutions, LLC | 10,965 | $10.1K | 0.00% | −2,074−15.9% | Reduced |
| Tower Research Capital LLC (TRC) | 11,616 | $10.0K | 0.00% | −10,528−47.5% | Reduced |
| Creative Planning | 11,600 | $10.0K | 0.00% | 00.0% | Unchanged |
| Bayesian Capital Management, LP | 11,100 | $9.60K | 0.00% | +11,100 | New |
| Snowden Capital Advisors LLC | 11,000 | $9.52K | 0.00% | +11,000 | New |
| Janney Montgomery Scott LLC | 10,000 | $9.00K | 0.00% | 00.0% | Unchanged |