Karyopharm Therapeutics Inc.
KPTI- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001503802
In the last 90 days, Karyopharm Therapeutics Inc. insiders filed 0 open-market purchases and 2 sales; 96 institutions reported holding it in 13F filings for Q2 2026, worth $206.8M in total; no superinvestor holds it.
13F holders, Q1 2024
Institutional positions in Karyopharm Therapeutics Inc. as of Mar 31, 2024. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 114
- −4 vs. Q4 2023
- Shares held
- 74.8M
- +1.38M (+1.9%) vs. Q4 2023
- Total value
- $113.0M
- +$49.6M (+78.2%) vs. Q4 2023
- New holders
- 18
- 38 more added
- Sold out
- 22
- 31 more reduced
2 institutions that held it in Q4 2023 haven't filed for Q1 2024 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2023: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting KPTI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 96 | $206.8M |
| Q1 2026 | 77 | $98.4M |
| Q4 2025 | 68 | $69.6M |
| Q3 2025 | 52 | $19.5M |
| Q2 2025 | 50 | $19.0M |
| Q1 2025 | 50 | $13.7M |
| Q4 2024 | 87 | $41.2M |
| Q3 2024 | 91 | $49.2M |
| Q2 2024 | 114 | $58.6M |
| Q1 2024 | 114 | $113.0M |
| Q4 2023 | 120 | $63.5M |
| Q3 2023 | 120 | $102.8M |
| Q2 2023 | 138 | $145.0M |
| Q1 2023 | 132 | $340.1M |
| Q4 2022 | 155 | $334.4M |
| Q3 2022 | 147 | $364.1M |
| Q2 2022 | 150 | $302.8M |
| Q1 2022 | 139 | $501.8M |
| Q4 2021 | 143 | $347.5M |
| Q3 2021 | 134 | $334.4M |
| Q2 2021 | 154 | $608.7M |
| Q1 2021 | 171 | $637.1M |
Institutions, Q1 2024
Shares, value and share of portfolio for each institution holding Karyopharm Therapeutics Inc.; share changes are against Q4 2023.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| BlackRock Inc. | 9,447,678 | $14.3M | 0.00% | −623,999−6.2% | Reduced |
| Vanguard Group Inc | 8,338,401 | $12.6M | 0.00% | −371,757−4.3% | Reduced |
| Avidity Partners Management LP | 8,298,570 | $12.5M | 0.45% | 00.0% | Unchanged |
| Palo Alto Investors LP | 5,102,193 | $7.70M | 0.87% | 00.0% | Unchanged |
| Eversept Partners, LP | 5,016,320 | $7.57M | 0.57% | +5,016,320 | New |
| Adage Capital Partners GP, L.L.C. | 3,500,000 | $5.29M | 0.01% | +1,836,700+110.4% | Added |
| Citadel Advisors LLC | 3,105,069 | $4.69M | 0.00% | +3,670+0.1% | Added |
| Marshall Wace, LLP | 2,595,599 | $3.92M | 0.01% | +668,817+34.7% | Added |
| Geode Capital Management, LLC | 2,520,105 | $3.81M | 0.00% | +137,677+5.8% | Added |
| State Street Corp | 2,285,788 | $3.45M | 0.00% | +232,015+11.3% | Added |
| BNP Paribas Arbitrage, SA | 1,773,758 | $2.68M | 0.00% | +4,574+0.3% | Added |
| Goldman Sachs Group Inc | 1,508,262 | $2.28M | 0.00% | +211,669+16.3% | Added |
| C WorldWide Group Holding A/S | 1,500,000 | $2.27M | 0.03% | 00.0% | Unchanged |
| JPMorgan Chase & Co | 1,377,584 | $2.08M | 0.00% | +196,464+16.6% | Added |
| Deutsche Bank AG | 1,324,977 | $2.00M | 0.00% | −2,031−0.2% | Reduced |
| Gsa Capital Partners LLP | 1,299,151 | $1.96M | 0.16% | −1,038,834−44.4% | Reduced |
| Millennium Management LLC | 1,185,879 | $1.79M | 0.00% | −348,385−22.7% | Reduced |
| AlphaCentric Advisors LLC | 1,125,000 | $1.70M | 1.02% | 00.0% | Unchanged |
| D. E. Shaw & Co., Inc. | 962,825 | $1.45M | 0.00% | +345,609+56.0% | Added |
| Northern Trust Corp | 958,805 | $1.45M | 0.00% | −37,342−3.7% | Reduced |
| Renaissance Technologies LLC | 906,800 | $1.37M | 0.00% | −1,057,577−53.8% | Reduced |
| Barclays PLC | 892,815 | $1.35M | 0.00% | −77,247−8.0% | Reduced |
| Altium Capital Management LP | 740,000 | $1.12M | 0.50% | 00.0% | Unchanged |
| UBS Oconnor LLC | 722,327 | $1.09M | 0.03% | −80,000−10.0% | Reduced |
| Silverarc Capital Management, LLC | 558,466 | $843.3K | 0.24% | −3,489−0.6% | Reduced |
| Macquarie Group Ltd | 500,000 | $755.0K | 0.00% | +120,000+31.6% | Added |
| Nuveen Asset Management, LLC | 492,365 | $743.5K | 0.00% | +38,063+8.4% | Added |
| Bank of New York Mellon Corp | 487,060 | $735.5K | 0.00% | −10,142−2.0% | Reduced |
| Birchview Capital, LP | 469,832 | $709.4K | 0.58% | 00.0% | Unchanged |
| Ikarian Capital, LLC | 409,355 | $618.1K | 0.17% | +9,355+2.3% | Added |
| Los Angeles Capital Management LLC | 387,520 | $585.2K | 0.00% | −4,020−1.0% | Reduced |
| Charles Schwab Investment Management Inc | 309,909 | $468.0K | 0.00% | 00.0% | Unchanged |
| Morgan Stanley | 294,787 | $445.1K | 0.00% | −550,364−65.1% | Reduced |
| FMR LLC | 273,808 | $413.4K | 0.00% | +5,522+2.1% | Added |
| UBS Group AG | 254,933 | $384.9K | 0.00% | −202,252−44.2% | Reduced |
| Atom Investors LP | 244,397 | $369.0K | 0.05% | +27,707+12.8% | Added |
| XTX Topco Ltd | 242,841 | $366.7K | 0.05% | +193,719+394.4% | Added |
| Panagora Asset Management Inc | 229,924 | $347.2K | 0.00% | +2,479+1.1% | Added |
| Exchange Traded Concepts, LLC | 212,638 | $321.1K | 0.01% | +96,774+83.5% | Added |
| Alliancebernstein L.P. | 192,810 | $291.1K | 0.00% | 00.0% | Unchanged |
| DAFNA Capital Management LLC | 192,678 | $290.9K | 0.07% | 00.0% | Unchanged |
| Bridgeway Capital Management, LLC | 189,500 | $286.1K | 0.01% | −100,000−34.5% | Reduced |
| Jane Street Group, LLC | 171,650 | $259.2K | 0.00% | −103,810−37.7% | Reduced |
| Bank of America Corp | 157,915 | $238.4K | 0.00% | −148,540−48.5% | Reduced |
| Rhumbline Advisers | 144,028 | $217.5K | 0.00% | +5,921+4.3% | Added |
| Royal Bank of Canada | 137,012 | $207.0K | 0.00% | +60,692+79.5% | Added |
| Woodline Partners LP | 134,112 | $202.5K | 0.00% | +17,394+14.9% | Added |
| AQR Capital Management LLC | 125,826 | $190.0K | 0.00% | −472,316−79.0% | Reduced |
| Price T Rowe Associates Inc | 95,091 | $144.0K | 0.00% | +7,978+9.2% | Added |
| Boothbay Fund Management, LLC | 91,091 | $137.5K | 0.00% | +9,355+11.4% | Added |
| Susquehanna International Group, LLP | 76,599 | $115.7K | 0.00% | −1,997−2.5% | Reduced |
| Connor, Clark & Lunn Investment Management Ltd. | 76,317 | $115.2K | 0.00% | +5,093+7.2% | Added |
| State Board of Administration of Florida Retirement System | 27,015 | $105.1K | 0.00% | −2,407−8.2% | Reduced |
| MetLife Investment Management | 60,551 | $91.4K | 0.00% | +60,551 | New |
| American International Group, Inc. | 55,816 | $84.3K | 0.00% | −479−0.9% | Reduced |
| Simplex Trading, LLC | 55,985 | $84.0K | 0.00% | +34,984+166.6% | Added |
| HSBC Holdings PLC | 53,563 | $80.9K | 0.00% | +8,273+18.3% | Added |
| State of Wyoming | 47,307 | $71.4K | 0.01% | +18,876+66.4% | Added |
| Bleakley Financial Group, LLC | 44,011 | $66.5K | 0.00% | +6,073+16.0% | Added |
| Simplicity Wealth,LLC | 44,011 | $66.5K | 0.00% | +44,011 | New |
| SEI Investments Co | 40,000 | $60.4K | 0.00% | +40,000 | New |
| Voya Investment Management LLC | 38,802 | $58.6K | 0.00% | −6,669−14.7% | Reduced |
| Group One Trading, L.P. | 37,132 | $56.1K | 0.00% | +6,659+21.9% | Added |
| Manufacturers Life Insurance Company, The | 35,868 | $54.2K | 0.00% | +35,868 | New |
| Kennedy Investment Group | 35,000 | $52.9K | 0.03% | 00.0% | Unchanged |
| Wells Fargo & Company | 33,898 | $51.2K | 0.00% | +4,533+15.4% | Added |
| Principal Financial Group Inc | 33,165 | $50.1K | 0.00% | +1,723+5.5% | Added |
| Colony Group, LLC | 45,930 | $50.0K | 0.00% | +45,930 | New |
| ELCO Management Co., LLC | 31,901 | $48.2K | 0.03% | +9,340+41.4% | Added |
| Eqis Capital Management, Inc. | 29,197 | $44.1K | 0.00% | +29,197 | New |
| Engineers Gate Manager LP | 28,700 | $43.3K | 0.00% | 00.0% | Unchanged |
| Invesco Ltd. | 27,969 | $42.2K | 0.00% | −502−1.8% | Reduced |
| Banque Cantonale Vaudoise | 25,000 | $38.0K | 0.00% | 00.0% | Unchanged |
| Commonwealth Equity Services, LLC | 25,406 | $38.0K | 0.00% | +25,406 | New |
| Prelude Capital Management, LLC | 23,500 | $35.5K | 0.00% | +23,500 | New |
| New York State Common Retirement Fund | 21,150 | $31.9K | 0.00% | +1,777+9.2% | Added |
| Baird Financial Group, Inc. | 20,800 | $31.4K | 0.00% | +7,000+50.7% | Added |
| ProShare Advisors LLC | 20,348 | $30.7K | 0.00% | +1,602+8.5% | Added |
| Prudential Financial Inc | 19,615 | $29.6K | 0.00% | −5,200−21.0% | Reduced |
| Citigroup Inc | 18,924 | $28.6K | 0.00% | +2,492+15.2% | Added |
| Diversified Trust Co | 18,580 | $28.1K | 0.00% | 00.0% | Unchanged |
| Winthrop Advisory Group LLC | 15,000 | $22.6K | 0.00% | +15,000 | New |
| CI Private Wealth, LLC | 13,900 | $21.0K | 0.00% | −100−0.7% | Reduced |
| Legal & General Group Plc | 13,735 | $20.7K | 0.00% | 00.0% | Unchanged |
| Two Sigma Investments, LP | 13,691 | $20.7K | 0.00% | −128,583−90.4% | Reduced |
| California State Teachers Retirement System | 11,387 | $17.2K | 0.00% | −7,255−38.9% | Reduced |
| Snowden Capital Advisors LLC | 11,000 | $16.6K | 0.00% | 00.0% | Unchanged |
| Two Sigma Securities, LLC | 10,208 | $15.4K | 0.00% | −9,378−47.9% | Reduced |
| Janney Montgomery Scott LLC | 10,000 | $15.0K | 0.00% | 00.0% | Unchanged |
| Advisor Group Holdings, Inc. | 8,595 | $13.0K | 0.00% | +2,151+33.4% | Added |
| Metropolitan Life Insurance Co | 6,231 | $9.41K | 0.00% | +6,231 | New |
| Ameritas Investment Partners, Inc. | 6,194 | $9.35K | 0.00% | 00.0% | Unchanged |
| The PNC Financial Services Group, Inc. | 3,000 | $4.53K | 0.00% | 00.0% | Unchanged |
| Amalgamated Bank | 2,478 | $4.00K | 0.00% | −12,216−83.1% | Reduced |
| Founders Capital Management | 2,000 | $3.02K | 0.00% | 00.0% | Unchanged |
| Tower Research Capital LLC (TRC) | 1,637 | $2.47K | 0.00% | −9,979−85.9% | Reduced |
| MB, Levis & Associates, LLC | 1,500 | $2.27K | 0.00% | 00.0% | Unchanged |
| ADAR1 Capital Management, LLC | 1,479 | $2.23K | 0.00% | +1,479 | New |
| Harbour Investments, Inc. | 1,300 | $1.96K | 0.00% | 00.0% | Unchanged |
| Headlands Technologies LLC | 1,242 | $1.88K | 0.00% | +1,242 | New |