Karyopharm Therapeutics Inc.
KPTI- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001503802
In the last 90 days, Karyopharm Therapeutics Inc. insiders filed 0 open-market purchases and 2 sales; 96 institutions reported holding it in 13F filings for Q2 2026, worth $206.8M in total; no superinvestor holds it.
13F holders, Q2 2024
Institutional positions in Karyopharm Therapeutics Inc. as of Jun 30, 2024. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 114
- 0 vs. Q1 2024
- Shares held
- 67.6M
- −7.22M (−9.7%) vs. Q1 2024
- Total value
- $58.6M
- −$54.3M (−48.1%) vs. Q1 2024
- New holders
- 27
- 24 more added
- Sold out
- 27
- 33 more reduced
Compare with Q1 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting KPTI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 96 | $206.8M |
| Q1 2026 | 77 | $98.4M |
| Q4 2025 | 68 | $69.6M |
| Q3 2025 | 52 | $19.5M |
| Q2 2025 | 50 | $19.0M |
| Q1 2025 | 50 | $13.7M |
| Q4 2024 | 87 | $41.2M |
| Q3 2024 | 91 | $49.2M |
| Q2 2024 | 114 | $58.6M |
| Q1 2024 | 114 | $113.0M |
| Q4 2023 | 120 | $63.5M |
| Q3 2023 | 120 | $102.8M |
| Q2 2023 | 138 | $145.0M |
| Q1 2023 | 132 | $340.1M |
| Q4 2022 | 155 | $334.4M |
| Q3 2022 | 147 | $364.1M |
| Q2 2022 | 150 | $302.8M |
| Q1 2022 | 139 | $501.8M |
| Q4 2021 | 143 | $347.5M |
| Q3 2021 | 134 | $334.4M |
| Q2 2021 | 154 | $608.7M |
| Q1 2021 | 171 | $637.1M |
Institutions, Q2 2024
Shares, value and share of portfolio for each institution holding Karyopharm Therapeutics Inc.; share changes are against Q1 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Vanguard Group Inc | 7,654,482 | $6.64M | 0.00% | −683,919−8.2% | Reduced |
| Palo Alto Investors LP | 5,102,193 | $4.43M | 0.51% | 00.0% | Unchanged |
| Eversept Partners, LP | 4,987,180 | $4.33M | 0.33% | −29,140−0.6% | Reduced |
| Adage Capital Partners GP, L.L.C. | 4,319,842 | $3.75M | 0.01% | +819,842+23.4% | Added |
| BlackRock Inc. | 4,169,788 | $3.62M | 0.00% | −5,277,890−55.9% | Reduced |
| Citadel Advisors LLC | 3,101,399 | $2.69M | 0.00% | −3,670−0.1% | Reduced |
| Marshall Wace, LLP | 2,580,863 | $2.25M | 0.00% | −14,736−0.6% | Reduced |
| Goldman Sachs Group Inc | 2,290,434 | $1.99M | 0.00% | +782,172+51.9% | Added |
| BNP Paribas Arbitrage, SA | 2,274,195 | $1.97M | 0.00% | +500,437+28.2% | Added |
| Millennium Management LLC | 2,092,426 | $1.82M | 0.00% | +906,547+76.4% | Added |
| Avidity Partners Management LP | 2,018,500 | $1.75M | 0.07% | −6,280,070−75.7% | Reduced |
| Jane Street Group, LLC | 1,549,976 | $1.34M | 0.00% | +1,378,326+803.0% | Added |
| C WorldWide Group Holding A/S | 1,500,000 | $1.30M | 0.01% | 00.0% | Unchanged |
| Opaleye Management Inc. | 1,425,000 | $1.24M | 0.28% | +1,425,000 | New |
| Geode Capital Management, LLC | 1,311,536 | $1.14M | 0.00% | −1,208,569−48.0% | Reduced |
| JPMorgan Chase & Co | 1,275,859 | $1.11M | 0.00% | −101,725−7.4% | Reduced |
| Deutsche Bank AG | 1,268,777 | $1.10M | 0.00% | −56,200−4.2% | Reduced |
| Kennedy Capital Management, Inc. | 1,196,792 | $1.04M | 0.02% | +1,196,792 | New |
| AlphaCentric Advisors LLC | 1,125,000 | $976.0K | 0.72% | 00.0% | Unchanged |
| UBS Oconnor LLC | 1,102,391 | $956.9K | 0.03% | +380,064+52.6% | Added |
| Gsa Capital Partners LLP | 983,417 | $853.0K | 0.06% | −315,734−24.3% | Reduced |
| Barclays PLC | 873,274 | $757.7K | 0.00% | −19,541−2.2% | Reduced |
| Northern Trust Corp | 870,167 | $755.0K | 0.00% | −88,638−9.2% | Reduced |
| D. E. Shaw & Co., Inc. | 844,112 | $732.4K | 0.00% | −118,713−12.3% | Reduced |
| Renaissance Technologies LLC | 756,227 | $656.1K | 0.00% | −150,573−16.6% | Reduced |
| AQR Capital Management LLC | 748,020 | $649.0K | 0.00% | +622,194+494.5% | Added |
| Altium Capital Management LP | 740,000 | $642.0K | 0.27% | 00.0% | Unchanged |
| Cubist Systematic Strategies, LLC | 568,975 | $493.6K | 0.01% | +568,975 | New |
| Silverarc Capital Management, LLC | 558,466 | $484.5K | 0.12% | 00.0% | Unchanged |
| Superstring Capital Management LP | 534,485 | $463.7K | 0.58% | +534,485 | New |
| Macquarie Group Ltd | 505,684 | $438.9K | 0.00% | +5,684+1.1% | Added |
| Birchview Capital, LP | 469,832 | $407.6K | 0.38% | 00.0% | Unchanged |
| State Street Corp | 453,810 | $393.7K | 0.00% | −1,831,978−80.1% | Reduced |
| Susquehanna International Group, LLP | 443,474 | $384.8K | 0.00% | +366,875+479.0% | Added |
| Y-Intercept (Hong Kong) Ltd | 410,954 | $356.5K | 0.02% | +410,954 | New |
| Ikarian Capital, LLC | 409,355 | $355.2K | 0.11% | 00.0% | Unchanged |
| Los Angeles Capital Management LLC | 354,020 | $307.1K | 0.00% | −33,500−8.6% | Reduced |
| Bank of America Corp | 298,685 | $259.0K | 0.00% | +140,770+89.1% | Added |
| FMR LLC | 293,213 | $254.4K | 0.00% | +19,405+7.1% | Added |
| Bridgeway Capital Management, LLC | 264,500 | $229.5K | 0.01% | +75,000+39.6% | Added |
| Atom Investors LP | 261,847 | $227.2K | 0.02% | +17,450+7.1% | Added |
| Centiva Capital, LP | 203,600 | $176.6K | 0.01% | +203,600 | New |
| Morgan Stanley | 200,008 | $173.5K | 0.00% | −94,779−32.2% | Reduced |
| DAFNA Capital Management LLC | 192,678 | $167.2K | 0.04% | 00.0% | Unchanged |
| Acadian Asset Management LLC | 194,168 | $167.0K | 0.00% | +194,168 | New |
| Bank of New York Mellon Corp | 166,315 | $144.3K | 0.00% | −320,745−65.9% | Reduced |
| Point72 Asia (Singapore) Pte. Ltd. | 165,318 | $143.4K | 0.03% | +165,318 | New |
| Exchange Traded Concepts, LLC | 162,178 | $140.7K | 0.00% | −50,460−23.7% | Reduced |
| Citigroup Inc | 162,027 | $140.6K | 0.00% | +143,103+756.2% | Added |
| HRT Financial LP | 147,536 | $128.0K | 0.00% | +147,536 | New |
| UBS Group AG | 140,678 | $122.1K | 0.00% | −114,255−44.8% | Reduced |
| XTX Topco Ltd | 140,576 | $122.0K | 0.01% | −102,265−42.1% | Reduced |
| Woodline Partners LP | 134,112 | $116.4K | 0.00% | 00.0% | Unchanged |
| Qube Research & Technologies Ltd | 106,470 | $92.4K | 0.00% | +106,470 | New |
| Price T Rowe Associates Inc | 97,100 | $84.0K | 0.00% | +2,009+2.1% | Added |
| Boothbay Fund Management, LLC | 91,091 | $79.0K | 0.00% | 00.0% | Unchanged |
| State of Wyoming | 82,685 | $71.7K | 0.01% | +35,378+74.8% | Added |
| Verition Fund Management LLC | 68,932 | $59.8K | 0.00% | +68,932 | New |
| Schonfeld Strategic Advisors LLC | 57,600 | $50.0K | 0.00% | +57,600 | New |
| Mirae Asset Global ETFs Holdings Ltd. | 56,945 | $49.4K | 0.00% | +56,945 | New |
| HSBC Holdings PLC | 53,091 | $48.1K | 0.00% | −472−0.9% | Reduced |
| Royal Bank of Canada | 56,357 | $48.0K | 0.00% | −80,655−58.9% | Reduced |
| Charles Schwab Investment Management Inc | 51,000 | $44.2K | 0.00% | −258,909−83.5% | Reduced |
| Colony Group, LLC | 45,930 | $44.0K | 0.00% | 00.0% | Unchanged |
| Simplicity Wealth,LLC | 49,160 | $42.7K | 0.00% | +5,149+11.7% | Added |
| Bleakley Financial Group, LLC | 49,160 | $42.7K | 0.00% | +5,149+11.7% | Added |
| Invesco Ltd. | 40,511 | $35.1K | 0.00% | +12,542+44.8% | Added |
| SEI Investments Co | 40,000 | $34.7K | 0.00% | 00.0% | Unchanged |
| Eqis Capital Management, Inc. | 38,326 | $33.3K | 0.00% | +9,129+31.3% | Added |
| Baird Financial Group, Inc. | 36,800 | $31.9K | 0.00% | +16,000+76.9% | Added |
| Point72 (DIFC) Ltd | 35,939 | $31.2K | 0.00% | +35,939 | New |
| Tower Research Capital LLC (TRC) | 35,184 | $30.5K | 0.00% | +33,547+2,049.3% | Added |
| Kennedy Investment Group | 35,000 | $30.4K | 0.02% | 00.0% | Unchanged |
| Redwood Wealth Management Group, LLC | 34,030 | $29.5K | 0.02% | +34,030 | New |
| Engineers Gate Manager LP | 28,700 | $24.9K | 0.00% | 00.0% | Unchanged |
| Catalyst Funds Management Pty Ltd | 28,600 | $24.8K | 0.01% | +28,600 | New |
| Jump Financial, LLC | 26,798 | $23.3K | 0.00% | +26,798 | New |
| Commonwealth Equity Services, LLC | 25,206 | $22.0K | 0.00% | −200−0.8% | Reduced |
| Banque Cantonale Vaudoise | 25,000 | $22.0K | 0.00% | 00.0% | Unchanged |
| Neuberger Berman Group LLC | 22,951 | $19.9K | 0.00% | +22,951 | New |
| Balyasny Asset Management LLC | 22,562 | $19.6K | 0.00% | +22,562 | New |
| O'Shaughnessy Asset Management, LLC | 21,941 | $19.0K | 0.00% | +21,941 | New |
| ELCO Management Co., LLC | 19,662 | $17.1K | 0.01% | −12,239−38.4% | Reduced |
| Rhumbline Advisers | 16,431 | $14.3K | 0.00% | −127,597−88.6% | Reduced |
| Paloma Partners Management Co | 15,435 | $13.4K | 0.00% | +15,435 | New |
| ProShare Advisors LLC | 15,170 | $13.2K | 0.00% | −5,178−25.4% | Reduced |
| Winthrop Advisory Group LLC | 15,000 | $13.0K | 0.00% | 00.0% | Unchanged |
| Victory Capital Management Inc | 13,993 | $12.1K | 0.00% | +13,993 | New |
| Two Sigma Investments, LP | 13,866 | $12.0K | 0.00% | +175+1.3% | Added |
| CI Private Wealth, LLC | 13,600 | $11.8K | 0.00% | −300−2.2% | Reduced |
| BLB&B Advisors, LLC | 11,150 | $9.67K | 0.00% | +11,150 | New |
| Snowden Capital Advisors LLC | 11,000 | $9.54K | 0.00% | 00.0% | Unchanged |
| Scientech Research LLC | 10,950 | $9.50K | 0.00% | +10,950 | New |
| Janney Montgomery Scott LLC | 10,000 | $9.00K | 0.00% | 00.0% | Unchanged |
| Advisor Group Holdings, Inc. | 7,213 | $6.27K | 0.00% | −1,382−16.1% | Reduced |
| CWM, LLC | 6,248 | $5.00K | 0.00% | +6,236+51,966.7% | Added |
| Quent Capital, LLC | 3,489 | $3.03K | 0.00% | +3,489 | New |
| The PNC Financial Services Group, Inc. | 3,000 | $2.60K | 0.00% | 00.0% | Unchanged |
| Founders Capital Management | 2,000 | $1.74K | 0.00% | 00.0% | Unchanged |
| MB, Levis & Associates, LLC | 1,500 | $1.30K | 0.00% | 00.0% | Unchanged |