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Karyopharm Therapeutics Inc.

KPTI
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001503802

In the last 90 days, Karyopharm Therapeutics Inc. insiders filed 0 open-market purchases and 2 sales; 96 institutions reported holding it in 13F filings for Q2 2026, worth $206.8M in total; no superinvestor holds it.

13F holders, Q2 2025

Institutional positions in Karyopharm Therapeutics Inc. as of Jun 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
50
0 vs. Q1 2025
Shares held
4.41M
+788.6K (+21.8%) vs. Q1 2025
Total value
$19.0M
+$5.28M (+38.4%) vs. Q1 2025
New holders
10
12 more added
Sold out
10
7 more reduced

Compare with Q1 2025: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting KPTI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ2 2025: 50 institutions
Q1 2021: 171 institutionsQ2 2021: 154 institutionsQ3 2021: 134 institutionsQ4 2021: 143 institutionsQ1 2022: 139 institutionsQ2 2022: 150 institutionsQ3 2022: 147 institutionsQ4 2022: 155 institutionsQ1 2023: 132 institutionsQ2 2023: 138 institutionsQ3 2023: 120 institutionsQ4 2023: 120 institutionsQ1 2024: 114 institutionsQ2 2024: 114 institutionsQ3 2024: 91 institutionsQ4 2024: 87 institutionsQ1 2025: 50 institutionsQ2 2025: 50 institutionsQ3 2025: 52 institutionsQ4 2025: 68 institutionsQ1 2026: 77 institutionsQ2 2026: 96 institutions
Value heldQ2 2025: $19.0M
Q1 2021: $637.1MQ2 2021: $608.7MQ3 2021: $334.4MQ4 2021: $347.5MQ1 2022: $501.8MQ2 2022: $302.8MQ3 2022: $364.1MQ4 2022: $334.4MQ1 2023: $340.1MQ2 2023: $145.0MQ3 2023: $102.8MQ4 2023: $63.5MQ1 2024: $113.0MQ2 2024: $58.6MQ3 2024: $49.2MQ4 2024: $41.2MQ1 2025: $13.7MQ2 2025: $19.0MQ3 2025: $19.5MQ4 2025: $69.6MQ1 2026: $98.4MQ2 2026: $206.8M
Institutions holding KPTI and their total value by quarter
QuarterHoldersValue
Q2 202696$206.8M
Q1 202677$98.4M
Q4 202568$69.6M
Q3 202552$19.5M
Q2 202550$19.0M
Q1 202550$13.7M
Q4 202487$41.2M
Q3 202491$49.2M
Q2 2024114$58.6M
Q1 2024114$113.0M
Q4 2023120$63.5M
Q3 2023120$102.8M
Q2 2023138$145.0M
Q1 2023132$340.1M
Q4 2022155$334.4M
Q3 2022147$364.1M
Q2 2022150$302.8M
Q1 2022139$501.8M
Q4 2021143$347.5M
Q3 2021134$334.4M
Q2 2021154$608.7M
Q1 2021171$637.1M

Institutions, Q2 2025

Shares, value and share of portfolio for each institution holding Karyopharm Therapeutics Inc.; share changes are against Q1 2025.

Institutions holding KPTI in Q2 2025
InstitutionSharesValue% of portfolioChange in sharesAction
T. Rowe Price Investment Management, Inc.728,766$3.14M0.00%+589,120+421.9%Added
Vanguard Group Inc518,269$2.23M0.00%+7,975+1.6%Added
Adage Capital Partners GP, L.L.C.421,322$1.82M0.00%00.0%Unchanged
Eversept Partners, LP257,154$1.11M0.11%00.0%Unchanged
JPMorgan Chase & Co256,443$1.11M0.00%+85,653+50.2%Added
BlackRock, Inc.236,641$1.02M0.00%−6,101−2.5%Reduced
Citadel Advisors LLC206,781$891.2K0.00%−128−0.1%Reduced
Palo Alto Investors LP187,911$809.9K0.17%−136,121−42.0%Reduced
Bank of America Corp168,534$726.4K0.00%+35,626+26.8%Added
UBS Group AG161,900$697.8K0.00%+68,288+72.9%Added
Catalio Capital Management, LP146,013$629.3K0.13%−9,609−6.2%Reduced
Avidity Partners Management LP134,566$580.0K0.12%00.0%Unchanged
Marshall Wace, LLP128,451$553.6K0.00%00.0%Unchanged
Goldman Sachs Group Inc109,404$471.5K0.00%+23,994+28.1%Added
C WorldWide Group Holding A/S100,000$431.0K0.01%00.0%Unchanged
Group One Trading, L.P.97,900$421.9K0.01%+97,900New
Geode Capital Management, LLC91,841$395.9K0.00%−7,799−7.8%Reduced
Silverback Asset Management LLC70,000$301.7K0.05%––
Renaissance Technologies LLC65,814$283.7K0.00%+4,600+7.5%Added
Bridgeway Capital Management, LLC37,836$163.1K0.00%+37,836New
State Street Corp33,295$143.5K0.00%+3,800+12.9%Added
Millennium Management LLC31,847$137.3K0.00%−23,520−42.5%Reduced
BNP Paribas Arbitrage, SA29,637$127.7K0.00%+676+2.3%Added
Birchview Capital, LP27,985$120.6K0.12%00.0%Unchanged
Ikarian Capital, LLC27,257$117.5K0.04%00.0%Unchanged
Morgan Stanley25,091$108.1K0.00%+14,668+140.7%Added
Northern Trust Corp18,910$81.5K0.00%00.0%Unchanged
Gsa Capital Partners LLP13,894$60.0K0.00%+13,894New
XTX Topco Ltd13,056$56.3K0.00%+13,056New
Bank of New York Mellon Corp11,086$47.8K0.00%00.0%Unchanged
Price T Rowe Associates Inc10,886$47.0K0.00%+10,886New
Baird Financial Group, Inc.10,532$45.4K0.00%+10,532New
Simplex Trading, LLC8,233$35.0K0.00%+8,233New
Royal Bank of Canada7,429$32.0K0.00%+5,970+409.2%Added
Citigroup Inc7,040$30.3K0.00%−4−0.1%Reduced
Barclays PLC5,333$23.0K0.00%00.0%Unchanged
TD Waterhouse Canada Inc.3,203$14.0K0.00%00.0%Unchanged
Tower Research Capital LLC (TRC)850$3.66K0.00%+850New
FMR LLC765$3.30K0.00%+238+45.2%Added
Advisor Group Holdings, Inc.346$1.49K0.00%00.0%Unchanged
MB, Levis & Associates, LLC100$4310.00%00.0%Unchanged
Raymond James Financial Inc90$3880.00%+90New
Harbour Investments, Inc.85$3660.00%00.0%Unchanged
Fortitude Family Office, LLC81$3490.00%+81New
SBI Securities Co., Ltd.74$3190.00%00.0%Unchanged
Activest Wealth Management66$2840.00%00.0%Unchanged
Allworth Financial LP32$1380.00%00.0%Unchanged
Bruce G. Allen Investments, LLC22$950.00%00.0%Unchanged
CIBC Private Wealth Group, LLC3$130.00%00.0%Unchanged
West Branch Capital LLC3$130.00%00.0%Unchanged
Altium Capital Management LP0$00.00%−49,333−100.0%Sold out
Shay Capital LLC0$00.00%−25,417−100.0%Sold out
UBS Oconnor LLC0$00.00%−23,640−100.0%Sold out
Susquehanna International Group, LLP0$00.00%−11,548−100.0%Sold out
Jane Street Group, LLC0$00.00%−11,420−100.0%Sold out
Leonteq Securities AG0$00.00%−10,000−100.0%Sold out
Coldstream Capital Management Inc0$00.00%−331−100.0%Sold out
Quent Capital, LLC0$00.00%−231−100.0%Sold out
VSM Wealth Advisory, LLC0$00.00%−133−100.0%Sold out
Danske Bank A/S0$00.00%−3−100.0%Sold out