Karyopharm Therapeutics Inc.
KPTI- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001503802
In the last 90 days, Karyopharm Therapeutics Inc. insiders filed 0 open-market purchases and 2 sales; 96 institutions reported holding it in 13F filings for Q2 2026, worth $206.8M in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Karyopharm Therapeutics Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 68
- +16 vs. Q3 2025
- Shares held
- 9.46M
- +6.48M (+217.7%) vs. Q3 2025
- Total value
- $69.6M
- +$50.1M (+257.6%) vs. Q3 2025
- New holders
- 26
- 19 more added
- Sold out
- 10
- 5 more reduced
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting KPTI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 96 | $206.8M |
| Q1 2026 | 77 | $98.4M |
| Q4 2025 | 68 | $69.6M |
| Q3 2025 | 52 | $19.5M |
| Q2 2025 | 50 | $19.0M |
| Q1 2025 | 50 | $13.7M |
| Q4 2024 | 87 | $41.2M |
| Q3 2024 | 91 | $49.2M |
| Q2 2024 | 114 | $58.6M |
| Q1 2024 | 114 | $113.0M |
| Q4 2023 | 120 | $63.5M |
| Q3 2023 | 120 | $102.8M |
| Q2 2023 | 138 | $145.0M |
| Q1 2023 | 132 | $340.1M |
| Q4 2022 | 155 | $334.4M |
| Q3 2022 | 147 | $364.1M |
| Q2 2022 | 150 | $302.8M |
| Q1 2022 | 139 | $501.8M |
| Q4 2021 | 143 | $347.5M |
| Q3 2021 | 134 | $334.4M |
| Q2 2021 | 154 | $608.7M |
| Q1 2021 | 171 | $637.1M |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Karyopharm Therapeutics Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 1,491,409 | $11.0M | 0.01% | +790,417+112.8% | Added |
| Opaleye Management Inc. | 930,000 | $6.84M | 0.90% | +930,000 | New |
| Affinity Asset Advisors, LLC | 889,575 | $6.55M | 0.47% | +889,575 | New |
| Vanguard Group Inc | 559,619 | $4.12M | 0.00% | +151,397+37.1% | Added |
| Ikarian Capital, LLC | 544,554 | $4.01M | 0.52% | +517,297+1,897.9% | Added |
| Soleus Capital Management, L.P. | 440,000 | $3.24M | 0.14% | +440,000 | New |
| Adage Capital Partners GP, L.L.C. | 421,322 | $3.10M | 0.00% | 00.0% | Unchanged |
| Davidson Kempner Capital Management LP | 310,020 | $2.28M | 0.03% | +310,020 | New |
| Braidwell LP | 303,370 | $2.23M | 0.07% | +303,370 | New |
| Exome Asset Management LLC | 295,541 | $2.18M | 1.07% | +295,541 | New |
| Ameriprise Financial Inc | 276,881 | $2.04M | 0.00% | +276,881 | New |
| Boxer Capital Management, LLC | 252,536 | $1.86M | 0.41% | +252,536 | New |
| BlackRock, Inc. | 247,558 | $1.82M | 0.00% | +15,607+6.7% | Added |
| Geode Capital Management, LLC | 187,734 | $1.38M | 0.00% | +94,445+101.2% | Added |
| Two Sigma Investments, LP | 148,793 | $1.10M | 0.00% | +148,793 | New |
| Susquehanna International Group, LLP | 147,698 | $1.09M | 0.00% | +112,359+317.9% | Added |
| Boothbay Fund Management, LLC | 144,628 | $1.06M | 0.03% | +144,628 | New |
| Catalio Capital Management, LP | 142,984 | $1.05M | 0.19% | 00.0% | Unchanged |
| Avidity Partners Management LP | 134,566 | $990.4K | 0.29% | 00.0% | Unchanged |
| Marshall Wace, LLP | 128,451 | $945.4K | 0.00% | 00.0% | Unchanged |
| Group One Trading, L.P. | 102,419 | $753.8K | 0.02% | +33,983+49.7% | Added |
| C WorldWide Group Holding A/S | 100,000 | $736.0K | 0.01% | 00.0% | Unchanged |
| Walleye Capital LLC | 95,672 | $704.1K | 0.00% | +95,672 | New |
| Two Sigma Advisers, LP | 89,729 | $660.4K | 0.00% | +89,729 | New |
| UBS Group AG | 88,455 | $651.0K | 0.00% | +28,770+48.2% | Added |
| Bridgeway Capital Management, LLC | 65,873 | $484.8K | 0.01% | +31,000+88.9% | Added |
| Context Capital Management, LLC | 62,995 | $463.6K | 0.01% | +62,995 | New |
| Renaissance Technologies LLC | 59,914 | $441.0K | 0.00% | −4,800−7.4% | Reduced |
| Quadrature Capital Ltd | 59,708 | $439.5K | 0.00% | +59,708 | New |
| State Street Corp | 58,942 | $433.8K | 0.00% | +12,600+27.2% | Added |
| Royal Bank of Canada | 58,000 | $427.0K | 0.00% | +51,266+761.3% | Added |
| Connor, Clark & Lunn Investment Management Ltd. | 57,212 | $421.1K | 0.00% | +57,212 | New |
| Jump Financial, LLC | 53,816 | $396.1K | 0.00% | +53,816 | New |
| DAFNA Capital Management LLC | 51,000 | $375.4K | 0.09% | +51,000 | New |
| ADAR1 Capital Management, LLC | 50,000 | $368.0K | 0.03% | +25,000+100.0% | Added |
| Bank of America Corp | 48,088 | $353.9K | 0.00% | +47,994+51,057.4% | Added |
| Trexquant Investment LP | 41,733 | $307.2K | 0.00% | +41,733 | New |
| Silverback Asset Management LLC | 40,000 | $294.4K | 0.04% | 00.0% | Unchanged |
| Jane Street Group, LLC | 35,533 | $261.5K | 0.00% | +35,533 | New |
| Simplex Trading, LLC | 32,868 | $241.9K | 0.01% | +27,006+460.7% | Added |
| Citadel Advisors LLC | 31,709 | $233.4K | 0.00% | +31,709 | New |
| Northern Trust Corp | 29,023 | $213.6K | 0.00% | +10,147+53.8% | Added |
| Prelude Capital Management, LLC | 28,723 | $211.4K | 0.02% | +28,723 | New |
| Baird Financial Group, Inc. | 27,993 | $206.0K | 0.00% | +2,061+7.9% | Added |
| Persistent Asset Partners Ltd | 18,316 | $134.8K | 0.06% | +18,316 | New |
| Tudor Investment Corp Et Al | 12,922 | $95.1K | 0.00% | +12,922 | New |
| XTX Topco Ltd | 11,904 | $87.6K | 0.00% | −2,498−17.3% | Reduced |
| Bank of New York Mellon Corp | 11,087 | $81.6K | 0.00% | +10.0% | Added |
| Price T Rowe Associates Inc | 10,886 | $81.0K | 0.00% | 00.0% | Unchanged |
| Morgan Stanley | 8,858 | $65.2K | 0.00% | −16,908−65.6% | Reduced |
| Barclays PLC | 4,109 | $30.2K | 0.00% | 00.0% | Unchanged |
| Acadian Asset Management LLC | 3,726 | $27.0K | 0.00% | +3,726 | New |
| TD Waterhouse Canada Inc. | 3,203 | $23.5K | 0.00% | 00.0% | Unchanged |
| JPMorgan Chase & Co | 1,741 | $12.8K | 0.00% | +1,191+216.5% | Added |
| Rockefeller Capital Management L.P. | 733 | $5.39K | 0.00% | +733 | New |
| FMR LLC | 679 | $5.00K | 0.00% | 00.0% | Unchanged |
| Aspect Partners, LLC | 391 | $2.88K | 0.00% | +391 | New |
| Advisor Group Holdings, Inc. | 282 | $2.08K | 0.00% | −64−18.5% | Reduced |
| Quent Capital, LLC | 235 | $1.73K | 0.00% | +4+1.7% | Added |
| MB, Levis & Associates, LLC | 100 | $736 | 0.00% | 00.0% | Unchanged |
| Harbour Investments, Inc. | 85 | $626 | 0.00% | 00.0% | Unchanged |
| BNP Paribas Arbitrage, SA | 82 | $604 | 0.00% | 00.0% | Unchanged |
| SBI Securities Co., Ltd. | 74 | $545 | 0.00% | 00.0% | Unchanged |
| Activest Wealth Management | 66 | $486 | 0.00% | 00.0% | Unchanged |
| Allworth Financial LP | 26 | $192 | 0.00% | 00.0% | Unchanged |
| West Branch Capital LLC | 3 | $23 | 0.00% | 00.0% | Unchanged |
| CIBC Private Wealth Group, LLC | 3 | $22 | 0.00% | 00.0% | Unchanged |
| Citigroup Inc | 1 | $7 | 0.00% | −512−99.8% | Reduced |
| Birchview Capital, LP | 0 | $0 | 0.00% | −27,985−100.0% | Sold out |
| Goldman Sachs Group Inc | 0 | $0 | 0.00% | −24,885−100.0% | Sold out |
| Belvedere Trading LLC | 0 | $0 | 0.00% | −14,563−100.0% | Sold out |
| Gsa Capital Partners LLP | 0 | $0 | 0.00% | −14,076−100.0% | Sold out |
| Tower Research Capital LLC (TRC) | 0 | $0 | 0.00% | −1,089−100.0% | Sold out |
| Rise Advisors, LLC | 0 | $0 | 0.00% | −131−100.0% | Sold out |
| Fortitude Family Office, LLC | 0 | $0 | 0.00% | −81−100.0% | Sold out |
| Bruce G. Allen Investments, LLC | 0 | $0 | 0.00% | −22−100.0% | Sold out |
| Advisory Services Network, LLC | 0 | $0 | 0.00% | −12−100.0% | Sold out |
| Pittenger & Anderson Inc | 0 | $0 | 0.00% | −3−100.0% | Sold out |