Karyopharm Therapeutics Inc.
KPTI- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001503802
In the last 90 days, Karyopharm Therapeutics Inc. insiders filed 0 open-market purchases and 2 sales; 96 institutions reported holding it in 13F filings for Q2 2026, worth $206.8M in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Karyopharm Therapeutics Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 68
- +16 vs. Q3 2025
- Shares held
- 9.46M
- +6.48M (+217.7%) vs. Q3 2025
- Total value
- $69.6M
- +$50.1M (+257.6%) vs. Q3 2025
- New holders
- 26
- 19 more added
- Sold out
- 10
- 5 more reduced
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting KPTI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 96 | $206.8M |
| Q1 2026 | 77 | $98.4M |
| Q4 2025 | 68 | $69.6M |
| Q3 2025 | 52 | $19.5M |
| Q2 2025 | 50 | $19.0M |
| Q1 2025 | 50 | $13.7M |
| Q4 2024 | 87 | $41.2M |
| Q3 2024 | 91 | $49.2M |
| Q2 2024 | 114 | $58.6M |
| Q1 2024 | 114 | $113.0M |
| Q4 2023 | 120 | $63.5M |
| Q3 2023 | 120 | $102.8M |
| Q2 2023 | 138 | $145.0M |
| Q1 2023 | 132 | $340.1M |
| Q4 2022 | 155 | $334.4M |
| Q3 2022 | 147 | $364.1M |
| Q2 2022 | 150 | $302.8M |
| Q1 2022 | 139 | $501.8M |
| Q4 2021 | 143 | $347.5M |
| Q3 2021 | 134 | $334.4M |
| Q2 2021 | 154 | $608.7M |
| Q1 2021 | 171 | $637.1M |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Karyopharm Therapeutics Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Citigroup Inc | 1 | $7 | 0.00% | −512−99.8% | Reduced |
| CIBC Private Wealth Group, LLC | 3 | $22 | 0.00% | 00.0% | Unchanged |
| West Branch Capital LLC | 3 | $23 | 0.00% | 00.0% | Unchanged |
| Allworth Financial LP | 26 | $192 | 0.00% | 00.0% | Unchanged |
| Activest Wealth Management | 66 | $486 | 0.00% | 00.0% | Unchanged |
| SBI Securities Co., Ltd. | 74 | $545 | 0.00% | 00.0% | Unchanged |
| BNP Paribas Arbitrage, SA | 82 | $604 | 0.00% | 00.0% | Unchanged |
| Harbour Investments, Inc. | 85 | $626 | 0.00% | 00.0% | Unchanged |
| MB, Levis & Associates, LLC | 100 | $736 | 0.00% | 00.0% | Unchanged |
| Quent Capital, LLC | 235 | $1.73K | 0.00% | +4+1.7% | Added |
| Advisor Group Holdings, Inc. | 282 | $2.08K | 0.00% | −64−18.5% | Reduced |
| Aspect Partners, LLC | 391 | $2.88K | 0.00% | +391 | New |
| FMR LLC | 679 | $5.00K | 0.00% | 00.0% | Unchanged |
| Rockefeller Capital Management L.P. | 733 | $5.39K | 0.00% | +733 | New |
| JPMorgan Chase & Co | 1,741 | $12.8K | 0.00% | +1,191+216.5% | Added |
| TD Waterhouse Canada Inc. | 3,203 | $23.5K | 0.00% | 00.0% | Unchanged |
| Acadian Asset Management LLC | 3,726 | $27.0K | 0.00% | +3,726 | New |
| Barclays PLC | 4,109 | $30.2K | 0.00% | 00.0% | Unchanged |
| Morgan Stanley | 8,858 | $65.2K | 0.00% | −16,908−65.6% | Reduced |
| Price T Rowe Associates Inc | 10,886 | $81.0K | 0.00% | 00.0% | Unchanged |
| Bank of New York Mellon Corp | 11,087 | $81.6K | 0.00% | +10.0% | Added |
| XTX Topco Ltd | 11,904 | $87.6K | 0.00% | −2,498−17.3% | Reduced |
| Tudor Investment Corp Et Al | 12,922 | $95.1K | 0.00% | +12,922 | New |
| Persistent Asset Partners Ltd | 18,316 | $134.8K | 0.06% | +18,316 | New |
| Baird Financial Group, Inc. | 27,993 | $206.0K | 0.00% | +2,061+7.9% | Added |
| Prelude Capital Management, LLC | 28,723 | $211.4K | 0.02% | +28,723 | New |
| Northern Trust Corp | 29,023 | $213.6K | 0.00% | +10,147+53.8% | Added |
| Citadel Advisors LLC | 31,709 | $233.4K | 0.00% | +31,709 | New |
| Simplex Trading, LLC | 32,868 | $241.9K | 0.01% | +27,006+460.7% | Added |
| Jane Street Group, LLC | 35,533 | $261.5K | 0.00% | +35,533 | New |
| Silverback Asset Management LLC | 40,000 | $294.4K | 0.04% | 00.0% | Unchanged |
| Trexquant Investment LP | 41,733 | $307.2K | 0.00% | +41,733 | New |
| Bank of America Corp | 48,088 | $353.9K | 0.00% | +47,994+51,057.4% | Added |
| ADAR1 Capital Management, LLC | 50,000 | $368.0K | 0.03% | +25,000+100.0% | Added |
| DAFNA Capital Management LLC | 51,000 | $375.4K | 0.09% | +51,000 | New |
| Jump Financial, LLC | 53,816 | $396.1K | 0.00% | +53,816 | New |
| Connor, Clark & Lunn Investment Management Ltd. | 57,212 | $421.1K | 0.00% | +57,212 | New |
| Royal Bank of Canada | 58,000 | $427.0K | 0.00% | +51,266+761.3% | Added |
| State Street Corp | 58,942 | $433.8K | 0.00% | +12,600+27.2% | Added |
| Quadrature Capital Ltd | 59,708 | $439.5K | 0.00% | +59,708 | New |
| Renaissance Technologies LLC | 59,914 | $441.0K | 0.00% | −4,800−7.4% | Reduced |
| Context Capital Management, LLC | 62,995 | $463.6K | 0.01% | +62,995 | New |
| Bridgeway Capital Management, LLC | 65,873 | $484.8K | 0.01% | +31,000+88.9% | Added |
| UBS Group AG | 88,455 | $651.0K | 0.00% | +28,770+48.2% | Added |
| Two Sigma Advisers, LP | 89,729 | $660.4K | 0.00% | +89,729 | New |
| Walleye Capital LLC | 95,672 | $704.1K | 0.00% | +95,672 | New |
| C WorldWide Group Holding A/S | 100,000 | $736.0K | 0.01% | 00.0% | Unchanged |
| Group One Trading, L.P. | 102,419 | $753.8K | 0.02% | +33,983+49.7% | Added |
| Marshall Wace, LLP | 128,451 | $945.4K | 0.00% | 00.0% | Unchanged |
| Avidity Partners Management LP | 134,566 | $990.4K | 0.29% | 00.0% | Unchanged |
| Catalio Capital Management, LP | 142,984 | $1.05M | 0.19% | 00.0% | Unchanged |
| Boothbay Fund Management, LLC | 144,628 | $1.06M | 0.03% | +144,628 | New |
| Susquehanna International Group, LLP | 147,698 | $1.09M | 0.00% | +112,359+317.9% | Added |
| Two Sigma Investments, LP | 148,793 | $1.10M | 0.00% | +148,793 | New |
| Geode Capital Management, LLC | 187,734 | $1.38M | 0.00% | +94,445+101.2% | Added |
| BlackRock, Inc. | 247,558 | $1.82M | 0.00% | +15,607+6.7% | Added |
| Boxer Capital Management, LLC | 252,536 | $1.86M | 0.41% | +252,536 | New |
| Ameriprise Financial Inc | 276,881 | $2.04M | 0.00% | +276,881 | New |
| Exome Asset Management LLC | 295,541 | $2.18M | 1.07% | +295,541 | New |
| Braidwell LP | 303,370 | $2.23M | 0.07% | +303,370 | New |
| Davidson Kempner Capital Management LP | 310,020 | $2.28M | 0.03% | +310,020 | New |
| Adage Capital Partners GP, L.L.C. | 421,322 | $3.10M | 0.00% | 00.0% | Unchanged |
| Soleus Capital Management, L.P. | 440,000 | $3.24M | 0.14% | +440,000 | New |
| Ikarian Capital, LLC | 544,554 | $4.01M | 0.52% | +517,297+1,897.9% | Added |
| Vanguard Group Inc | 559,619 | $4.12M | 0.00% | +151,397+37.1% | Added |
| Affinity Asset Advisors, LLC | 889,575 | $6.55M | 0.47% | +889,575 | New |
| Opaleye Management Inc. | 930,000 | $6.84M | 0.90% | +930,000 | New |
| T. Rowe Price Investment Management, Inc. | 1,491,409 | $11.0M | 0.01% | +790,417+112.8% | Added |
| Birchview Capital, LP | 0 | $0 | 0.00% | −27,985−100.0% | Sold out |
| Goldman Sachs Group Inc | 0 | $0 | 0.00% | −24,885−100.0% | Sold out |
| Belvedere Trading LLC | 0 | $0 | 0.00% | −14,563−100.0% | Sold out |
| Gsa Capital Partners LLP | 0 | $0 | 0.00% | −14,076−100.0% | Sold out |
| Tower Research Capital LLC (TRC) | 0 | $0 | 0.00% | −1,089−100.0% | Sold out |
| Rise Advisors, LLC | 0 | $0 | 0.00% | −131−100.0% | Sold out |
| Fortitude Family Office, LLC | 0 | $0 | 0.00% | −81−100.0% | Sold out |
| Bruce G. Allen Investments, LLC | 0 | $0 | 0.00% | −22−100.0% | Sold out |
| Advisory Services Network, LLC | 0 | $0 | 0.00% | −12−100.0% | Sold out |
| Pittenger & Anderson Inc | 0 | $0 | 0.00% | −3−100.0% | Sold out |