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Karyopharm Therapeutics Inc.

KPTI
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001503802

In the last 90 days, Karyopharm Therapeutics Inc. insiders filed 0 open-market purchases and 2 sales; 96 institutions reported holding it in 13F filings for Q2 2026, worth $206.8M in total; no superinvestor holds it.

13F holders, Q1 2021

Institutional positions in Karyopharm Therapeutics Inc. as of Mar 31, 2021. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
171
No complete 13F data for Q4 2020
Shares held
60.2M
No complete 13F data for Q4 2020
Total value
$637.1M
No complete 13F data for Q4 2020

Holders and value by quarter

Institutions reporting KPTI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ1 2021: 171 institutions
Q1 2021: 171 institutionsQ2 2021: 154 institutionsQ3 2021: 134 institutionsQ4 2021: 143 institutionsQ1 2022: 139 institutionsQ2 2022: 150 institutionsQ3 2022: 147 institutionsQ4 2022: 155 institutionsQ1 2023: 132 institutionsQ2 2023: 138 institutionsQ3 2023: 120 institutionsQ4 2023: 120 institutionsQ1 2024: 114 institutionsQ2 2024: 114 institutionsQ3 2024: 91 institutionsQ4 2024: 87 institutionsQ1 2025: 50 institutionsQ2 2025: 50 institutionsQ3 2025: 52 institutionsQ4 2025: 68 institutionsQ1 2026: 77 institutionsQ2 2026: 96 institutions
Value heldQ1 2021: $637.1M
Q1 2021: $637.1MQ2 2021: $608.7MQ3 2021: $334.4MQ4 2021: $347.5MQ1 2022: $501.8MQ2 2022: $302.8MQ3 2022: $364.1MQ4 2022: $334.4MQ1 2023: $340.1MQ2 2023: $145.0MQ3 2023: $102.8MQ4 2023: $63.5MQ1 2024: $113.0MQ2 2024: $58.6MQ3 2024: $49.2MQ4 2024: $41.2MQ1 2025: $13.7MQ2 2025: $19.0MQ3 2025: $19.5MQ4 2025: $69.6MQ1 2026: $98.4MQ2 2026: $206.8M
Institutions holding KPTI and their total value by quarter
QuarterHoldersValue
Q2 202696$206.8M
Q1 202677$98.4M
Q4 202568$69.6M
Q3 202552$19.5M
Q2 202550$19.0M
Q1 202550$13.7M
Q4 202487$41.2M
Q3 202491$49.2M
Q2 2024114$58.6M
Q1 2024114$113.0M
Q4 2023120$63.5M
Q3 2023120$102.8M
Q2 2023138$145.0M
Q1 2023132$340.1M
Q4 2022155$334.4M
Q3 2022147$364.1M
Q2 2022150$302.8M
Q1 2022139$501.8M
Q4 2021143$347.5M
Q3 2021134$334.4M
Q2 2021154$608.7M
Q1 2021171$637.1M

Institutions, Q1 2021

Shares, value and share of portfolio for each institution holding Karyopharm Therapeutics Inc..

Livermore's 13F data starts with Q1 2021, so Q1 2021 has no change from the previous quarter.

Institutions holding KPTI in Q1 2021
InstitutionSharesValue% of portfolioChange in sharesAction
BlackRock Inc.7,749,757$81.5M0.00%––
Palo Alto Investors LP5,363,652$56.4M3.21%––
State Street Corp5,332,280$56.1M0.00%––
Vanguard Group Inc3,556,453$37.4M0.00%––
Alkeon Capital Management LLC2,668,199$28.1M0.11%––
Delphi Management Partners VIII, L.L.C.2,263,006$23.8M16.44%––
Wellington Management Group LLP1,917,768$20.2M0.00%––
Morgan Stanley1,698,473$17.9M0.00%––
Rice Hall James & Associates, LLC1,563,044$16.4M0.54%––
Two Sigma Investments, LP1,492,642$15.7M0.05%––
Adage Capital Partners GP, L.L.C.1,349,800$14.2M0.03%––
Candriam Luxembourg S.C.A.951,574$14.1M0.12%––
J. Goldman & Co LP1,331,104$14.0M0.84%––
Frontier Capital Management Co LLC1,221,627$12.9M0.10%––
Goldman Sachs Group Inc1,211,971$12.8M0.00%––
C WorldWide Group Holding A/S1,200,000$12.6M0.12%––
Geode Capital Management, LLC1,146,715$12.1M0.00%––
Laurion Capital Management LP980,464$10.3M0.14%––
Nuveen Asset Management, LLC929,561$9.78M0.00%––
Two Sigma Advisers, LP910,200$9.57M0.03%––
Hood River Capital Management LLC848,707$8.93M0.29%––
Lombard Odier Asset Management (Switzerland) SA829,681$8.73M0.58%––
Compagnie Lombard Odier SCmA829,681$8.73M0.19%––
Citadel Advisors LLC822,516$8.65M0.01%––
Northern Trust Corp745,036$7.84M0.00%––
Millennium Management LLC739,714$7.78M0.01%––
Granahan Investment Management Inc690,410$7.26M0.15%––
Ami Asset Management Corp501,172$5.27M0.28%––
Price T Rowe Associates Inc492,955$5.19M0.00%––
Charles Schwab Investment Management Inc452,244$4.76M0.00%––
Macquarie Group Ltd381,059$4.01M0.01%––
JPMorgan Chase & Co339,747$3.58M0.00%––
Citigroup Inc336,065$3.54M0.00%––
Bank of New York Mellon Corp319,758$3.37M0.00%––
Susquehanna International Group, LLP305,458$3.21M0.00%––
Balyasny Asset Management LLC291,187$3.06M0.02%––
Deutsche Bank AG288,553$3.04M0.00%––
Barclays PLC274,374$2.89M0.00%––
Rafferty Asset Management, LLC270,663$2.85M0.02%––
Hennion & Walsh Asset Management, Inc.266,968$2.81M0.17%––
Birchview Capital, LP230,000$2.42M1.44%––
Bank of America Corp225,283$2.37M0.00%––
Schonfeld Strategic Advisors LLC178,704$1.88M0.02%––
Allianz Asset Management GmbH175,789$1.85M0.00%––
Junson Asset Management (Hong Kong) Ltd150,000$1.57M0.66%––
Dimensional Fund Advisors LP146,603$1.54M0.00%––
Qube Research & Technologies Ltd146,442$1.54M0.03%––
UBS Group AG146,021$1.54M0.00%––
California Public Employees Retirement System143,000$1.50M0.00%––
Phocas Financial Corp.135,816$1.43M0.19%––
Alliancebernstein L.P.129,730$1.36M0.00%––
Mutual of America Capital Management LLC128,243$1.35M0.01%––
Rhumbline Advisers120,927$1.27M0.00%––
Swiss National Bank117,750$1.24M0.00%––
California State Teachers Retirement System105,734$1.11M0.00%––
Wells Fargo & Company104,578$1.10M0.00%––
State of Wisconsin Investment Board95,400$1.00M0.00%––
Credit Suisse AG89,865$945.0K0.00%––
Parametric Portfolio Associates LLC88,111$927.0K0.00%––
Parametrica Management Ltd92,888$925.0K0.44%––
Jennison Associates LLC86,381$909.0K0.00%––
Tudor Investment Corp Et Al83,372$877.0K0.02%––
FMR LLC79,210$833.0K0.00%––
New York State Common Retirement Fund74,875$788.0K0.00%––
Jane Street Group, LLC73,325$771.0K0.00%––
Knights of Columbus Asset Advisors LLC72,343$761.0K0.07%––
PDT Partners, LLC71,026$747.0K0.05%––
Seven Eight Capital, LP46,600$721.0K0.17%––
Engineers Gate Manager LP68,312$719.0K0.04%––
Jump Financial, LLC62,500$658.0K0.06%––
Dynamic Technology Lab Private Ltd61,002$642.0K0.07%––
First Trust Advisors LP58,053$611.0K0.00%––
UBS Asset Management Americas Inc55,625$585.2K0.00%––
Group One Trading, L.P.53,249$560.0K0.01%––
AlphaCentric Advisors LLC52,000$547.0K0.18%––
Integral Health Asset Management, LLC50,000$526.0K0.15%––
Virtu Financial LLC47,054$495.0K0.04%––
Teachers Retirement System of the State of Kentucky46,472$489.0K0.00%––
Emerald Advisers, LLC46,470$489.0K0.02%––
Russell Investments Group, Ltd.43,425$456.0K0.00%––
American International Group, Inc.41,315$435.0K0.00%––
D.A. Davidson & Co.41,000$431.0K0.01%––
Manufacturers Life Insurance Company, The40,832$430.0K0.00%––
Virtus ETF Advisers LLC40,187$423.0K0.18%––
Bridgefront Capital, LLC37,381$393.0K0.12%––
Creative Planning34,792$366.0K0.00%––
Trexquant Investment LP34,151$359.0K0.03%––
DekaBank Deutsche Girozentrale36,200$355.0K0.00%––
SEI Investments Co33,299$350.0K0.00%––
Weiss Multi-Strategy Advisers LLC32,143$338.0K0.01%––
Principal Financial Group Inc31,953$336.0K0.00%––
Voya Investment Management LLC31,850$335.0K0.00%––
Gsa Capital Partners LLP30,592$322.0K0.05%––
Tower Research Capital LLC (TRC)30,032$316.0K0.01%––
Vontobel Holding Ltd.30,000$316.0K0.00%––
Cubist Systematic Strategies, LLC29,982$315.0K0.00%––
ProShare Advisors LLC29,268$308.0K0.00%––
Insight Advisors, LLC32,765$306.0K0.10%––
Bayesian Capital Management, LP27,000$284.0K0.07%––
Spearhead Capital Advisors, LLC27,023$284.0K0.04%––