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Karyopharm Therapeutics Inc.

KPTI
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001503802

In the last 90 days, Karyopharm Therapeutics Inc. insiders filed 0 open-market purchases and 2 sales; 96 institutions reported holding it in 13F filings for Q2 2026, worth $206.8M in total; no superinvestor holds it.

13F holders, Q1 2021

Institutional positions in Karyopharm Therapeutics Inc. as of Mar 31, 2021. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
171
No complete 13F data for Q4 2020
Shares held
60.2M
No complete 13F data for Q4 2020
Total value
$637.1M
No complete 13F data for Q4 2020

Holders and value by quarter

Institutions reporting KPTI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ1 2021: 171 institutions
Q1 2021: 171 institutionsQ2 2021: 154 institutionsQ3 2021: 134 institutionsQ4 2021: 143 institutionsQ1 2022: 139 institutionsQ2 2022: 150 institutionsQ3 2022: 147 institutionsQ4 2022: 155 institutionsQ1 2023: 132 institutionsQ2 2023: 138 institutionsQ3 2023: 120 institutionsQ4 2023: 120 institutionsQ1 2024: 114 institutionsQ2 2024: 114 institutionsQ3 2024: 91 institutionsQ4 2024: 87 institutionsQ1 2025: 50 institutionsQ2 2025: 50 institutionsQ3 2025: 52 institutionsQ4 2025: 68 institutionsQ1 2026: 77 institutionsQ2 2026: 96 institutions
Value heldQ1 2021: $637.1M
Q1 2021: $637.1MQ2 2021: $608.7MQ3 2021: $334.4MQ4 2021: $347.5MQ1 2022: $501.8MQ2 2022: $302.8MQ3 2022: $364.1MQ4 2022: $334.4MQ1 2023: $340.1MQ2 2023: $145.0MQ3 2023: $102.8MQ4 2023: $63.5MQ1 2024: $113.0MQ2 2024: $58.6MQ3 2024: $49.2MQ4 2024: $41.2MQ1 2025: $13.7MQ2 2025: $19.0MQ3 2025: $19.5MQ4 2025: $69.6MQ1 2026: $98.4MQ2 2026: $206.8M
Institutions holding KPTI and their total value by quarter
QuarterHoldersValue
Q2 202696$206.8M
Q1 202677$98.4M
Q4 202568$69.6M
Q3 202552$19.5M
Q2 202550$19.0M
Q1 202550$13.7M
Q4 202487$41.2M
Q3 202491$49.2M
Q2 2024114$58.6M
Q1 2024114$113.0M
Q4 2023120$63.5M
Q3 2023120$102.8M
Q2 2023138$145.0M
Q1 2023132$340.1M
Q4 2022155$334.4M
Q3 2022147$364.1M
Q2 2022150$302.8M
Q1 2022139$501.8M
Q4 2021143$347.5M
Q3 2021134$334.4M
Q2 2021154$608.7M
Q1 2021171$637.1M

Institutions, Q1 2021

Shares, value and share of portfolio for each institution holding Karyopharm Therapeutics Inc..

Livermore's 13F data starts with Q1 2021, so Q1 2021 has no change from the previous quarter.

Institutions holding KPTI in Q1 2021
InstitutionSharesValue% of portfolioChange in sharesAction
Simplex Trading, LLC3,110$00.00%––
Daiwa Securities Group Inc.138$1.00K0.00%––
Gemmer Asset Management LLC140$1.00K0.00%––
Cypress Capital Management LLC (WY)50$1.00K0.00%––
Parallel Advisors, LLC102$1.00K0.00%––
Certified Advisory Corp95$1.00K0.00%––
US Bancorp177$2.00K0.00%––
International Assets Investment Management, LLC100$2.00K0.00%––
Kelly Financial Services LLC250$2.63K0.00%––
Point72 Hong Kong Ltd299$3.00K0.00%––
Allworth Financial LP430$5.00K0.00%––
Sargent Bickham Lagudis LLC606$6.00K0.00%––
AdvisorNet Financial, Inc800$8.00K0.00%––
O'Shaughnessy Asset Management, LLC753$8.00K0.00%––
Glen Eagle Advisors, LLC810$8.52K0.00%––
Ikarian Capital, LLC791$9.00K0.00%––
Sowell Financial Services LLC1,255$10.0K0.00%––
Private Capital Group, LLC1,000$11.0K0.00%––
Trust Co of Vermont1,400$15.0K0.00%––
Signaturefd, LLC1,454$15.0K0.00%––
Thomas J. Herzfeld Advisors, Inc.1,500$16.0K0.01%––
Penserra Capital Management LLC1,695$17.0K0.00%––
Bank of Montreal2,034$21.0K0.00%––
Valeo Financial Advisors, LLC2,107$22.0K0.00%––
Tortoise Investment Management, LLC2,200$23.0K0.01%––
Patriot Financial Group Insurance Agency, LLC2,200$23.0K0.01%––
Great West Life Assurance Co3,017$32.0K0.00%––
Rockefeller Capital Management L.P.3,400$35.0K0.00%––
Captrust Financial Advisors3,500$37.0K0.00%––
Nisa Investment Advisors, LLC4,050$43.0K0.00%––
Harbour Investments, Inc.5,105$54.0K0.00%––
Zurcher Kantonalbank (Zurich Cantonalbank)5,977$63.0K0.00%––
Ameritas Investment Partners, Inc.6,194$65.0K0.00%––
Pacer Advisors, Inc.6,328$67.0K0.00%––
Lazard Asset Management LLC7,456$78.0K0.00%––
BNP Paribas Arbitrage, SA8,824$92.8K0.00%––
Amalgamated Bank10,074$106.0K0.00%––
CSS LLC10,127$106.0K0.01%––
Golden State Equity Partners10,697$113.0K0.06%––
Private Advisor Group, LLC11,070$116.0K0.00%––
Emerald Mutual Fund Advisers Trust11,145$117.0K0.00%––
E Fund Management Co., Ltd.11,264$118.0K0.01%––
Royal Bank of Canada11,344$119.0K0.00%––
Victory Capital Management Inc11,432$120.0K0.00%––
Silvant Capital Management LLC11,386$120.0K0.02%––
Man Group plc11,646$122.0K0.00%––
Altfest L J & Co Inc12,213$128.0K0.03%––
Advisor Group Holdings, Inc.13,251$139.0K0.00%––
Handelsbanken Fonder AB13,400$141.0K0.00%––
Atlas Private Wealth Advisors13,780$145.0K0.08%––
HSBC Holdings PLC14,239$149.0K0.00%––
D. E. Shaw & Co., Inc.14,865$156.0K0.00%––
Arizona State Retirement System14,998$158.0K0.00%––
Baird Financial Group, Inc.15,618$164.0K0.00%––
Twinbeech Capital LP15,988$168.0K0.02%––
First Mercantile Trust Co16,096$169.0K0.02%––
SG Americas Securities, LLC16,269$171.0K0.00%––
The PNC Financial Services Group, Inc.17,010$179.0K0.00%––
First Republic Investment Management, Inc.17,651$186.0K0.00%––
Invesco Ltd.18,180$191.0K0.00%––
Susquehanna Fundamental Investments, LLC18,582$195.0K0.00%––
Moors & Cabot, Inc.18,950$199.0K0.02%––
Legal & General Group Plc19,163$202.0K0.00%––
Metropolitan Life Insurance Co19,366$203.7K0.00%––
Prelude Capital Management, LLC21,000$221.0K0.02%––
Mesirow Financial Investment Management, Inc.21,712$228.0K0.62%––
Symons Capital Management Inc21,878$230.0K0.12%––
MetLife Investment Management23,713$249.5K0.00%––
ExodusPoint Capital Management, LP25,911$273.0K0.01%––
AlphaCrest Capital Management LLC26,000$274.0K0.02%––
State Board of Administration of Florida Retirement System26,346$277.0K0.00%––
Bayesian Capital Management, LP27,000$284.0K0.07%––
Spearhead Capital Advisors, LLC27,023$284.0K0.04%––
Insight Advisors, LLC32,765$306.0K0.10%––
ProShare Advisors LLC29,268$308.0K0.00%––
Cubist Systematic Strategies, LLC29,982$315.0K0.00%––
Tower Research Capital LLC (TRC)30,032$316.0K0.01%––
Vontobel Holding Ltd.30,000$316.0K0.00%––
Gsa Capital Partners LLP30,592$322.0K0.05%––
Voya Investment Management LLC31,850$335.0K0.00%––
Principal Financial Group Inc31,953$336.0K0.00%––
Weiss Multi-Strategy Advisers LLC32,143$338.0K0.01%––
SEI Investments Co33,299$350.0K0.00%––
DekaBank Deutsche Girozentrale36,200$355.0K0.00%––
Trexquant Investment LP34,151$359.0K0.03%––
Creative Planning34,792$366.0K0.00%––
Bridgefront Capital, LLC37,381$393.0K0.12%––
Virtus ETF Advisers LLC40,187$423.0K0.18%––
Manufacturers Life Insurance Company, The40,832$430.0K0.00%––
D.A. Davidson & Co.41,000$431.0K0.01%––
American International Group, Inc.41,315$435.0K0.00%––
Russell Investments Group, Ltd.43,425$456.0K0.00%––
Teachers Retirement System of the State of Kentucky46,472$489.0K0.00%––
Emerald Advisers, LLC46,470$489.0K0.02%––
Virtu Financial LLC47,054$495.0K0.04%––
Integral Health Asset Management, LLC50,000$526.0K0.15%––
AlphaCentric Advisors LLC52,000$547.0K0.18%––
Group One Trading, L.P.53,249$560.0K0.01%––
UBS Asset Management Americas Inc55,625$585.2K0.00%––
First Trust Advisors LP58,053$611.0K0.00%––