Karyopharm Therapeutics Inc.
KPTI- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001503802
In the last 90 days, Karyopharm Therapeutics Inc. insiders filed 0 open-market purchases and 2 sales; 96 institutions reported holding it in 13F filings for Q2 2026, worth $206.8M in total; no superinvestor holds it.
13F holders, Q3 2022
Institutional positions in Karyopharm Therapeutics Inc. as of Sep 30, 2022. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 147
- −3 vs. Q2 2022
- Shares held
- 66.7M
- −432.9K (−0.6%) vs. Q2 2022
- Total value
- $364.1M
- +$61.3M (+20.3%) vs. Q2 2022
- New holders
- 18
- 61 more added
- Sold out
- 21
- 43 more reduced
Compare with Q2 2022: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting KPTI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 96 | $206.8M |
| Q1 2026 | 77 | $98.4M |
| Q4 2025 | 68 | $69.6M |
| Q3 2025 | 52 | $19.5M |
| Q2 2025 | 50 | $19.0M |
| Q1 2025 | 50 | $13.7M |
| Q4 2024 | 87 | $41.2M |
| Q3 2024 | 91 | $49.2M |
| Q2 2024 | 114 | $58.6M |
| Q1 2024 | 114 | $113.0M |
| Q4 2023 | 120 | $63.5M |
| Q3 2023 | 120 | $102.8M |
| Q2 2023 | 138 | $145.0M |
| Q1 2023 | 132 | $340.1M |
| Q4 2022 | 155 | $334.4M |
| Q3 2022 | 147 | $364.1M |
| Q2 2022 | 150 | $302.8M |
| Q1 2022 | 139 | $501.8M |
| Q4 2021 | 143 | $347.5M |
| Q3 2021 | 134 | $334.4M |
| Q2 2021 | 154 | $608.7M |
| Q1 2021 | 171 | $637.1M |
Institutions, Q3 2022
Shares, value and share of portfolio for each institution holding Karyopharm Therapeutics Inc.; share changes are against Q2 2022.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| State Street Corp | 9,010,339 | $49.2M | 0.00% | −1,351,670−13.0% | Reduced |
| BlackRock Inc. | 7,912,954 | $43.2M | 0.00% | −209,895−2.6% | Reduced |
| Palo Alto Investors LP | 5,621,533 | $30.7M | 2.43% | 00.0% | Unchanged |
| Vanguard Group Inc | 4,813,399 | $26.3M | 0.00% | +591,419+14.0% | Added |
| Rubric Capital Management LP | 3,990,126 | $21.8M | 1.10% | −409,874−9.3% | Reduced |
| Nuveen Asset Management, LLC | 1,971,048 | $10.8M | 0.00% | +75,670+4.0% | Added |
| Commodore Capital LP | 1,935,609 | $10.6M | 1.70% | 00.0% | Unchanged |
| Citadel Advisors LLC | 1,809,646 | $9.88M | 0.01% | +1,401,297+343.2% | Added |
| Jacobs Levy Equity Management, Inc | 1,582,524 | $8.64M | 0.07% | +55,484+3.6% | Added |
| Ally Bridge Group (NY) LLC | 1,528,580 | $8.35M | 5.51% | +1,528,580 | New |
| Woodline Partners LP | 1,513,259 | $8.26M | 0.12% | +1,513,259 | New |
| C WorldWide Group Holding A/S | 1,500,000 | $8.19M | 0.11% | 00.0% | Unchanged |
| Goldman Sachs Group Inc | 1,355,176 | $7.40M | 0.00% | −91,226−6.3% | Reduced |
| Candriam Luxembourg S.C.A. | 1,335,026 | $7.29M | 0.05% | +99,302+8.0% | Added |
| Geode Capital Management, LLC | 1,330,435 | $7.26M | 0.00% | +4,116+0.3% | Added |
| Morgan Stanley | 1,079,881 | $5.90M | 0.00% | −1,306,817−54.8% | Reduced |
| Rice Hall James & Associates, LLC | 909,083 | $4.96M | 0.29% | −406,751−30.9% | Reduced |
| Acadian Asset Management LLC | 850,576 | $4.64M | 0.03% | +665,280+359.0% | Added |
| Two Sigma Advisers, LP | 831,300 | $4.54M | 0.01% | −154,700−15.7% | Reduced |
| BNP Paribas Arbitrage, SA | 762,520 | $4.16M | 0.01% | +178,232+30.5% | Added |
| Northern Trust Corp | 753,779 | $4.12M | 0.00% | −14,319−1.9% | Reduced |
| Altium Capital Management LP | 750,000 | $4.09M | 1.54% | +50,000+7.1% | Added |
| Bank of America Corp | 731,864 | $4.00M | 0.00% | +252,446+52.7% | Added |
| ExodusPoint Capital Management, LP | 707,280 | $3.86M | 0.05% | +61,295+9.5% | Added |
| Walleye Capital LLC | 673,672 | $3.68M | 0.08% | −1,071,743−61.4% | Reduced |
| Rafferty Asset Management, LLC | 668,004 | $3.65M | 0.04% | +208,595+45.4% | Added |
| Frontier Capital Management Co LLC | 629,154 | $3.44M | 0.04% | −3,352−0.5% | Reduced |
| Citigroup Inc | 607,396 | $3.32M | 0.00% | +138,377+29.5% | Added |
| Balyasny Asset Management LLC | 595,558 | $3.25M | 0.01% | +509,499+592.0% | Added |
| Deutsche Bank AG | 593,817 | $3.24M | 0.00% | −671−0.1% | Reduced |
| Lombard Odier Asset Management (Switzerland) SA | 479,124 | $2.62M | 0.22% | −34,678−6.7% | Reduced |
| Barclays PLC | 455,464 | $2.49M | 0.00% | +373,539+456.0% | Added |
| Susquehanna International Group, LLP | 391,917 | $2.14M | 0.00% | +109,981+39.0% | Added |
| Macquarie Group Ltd | 381,465 | $2.09M | 0.00% | −576−0.2% | Reduced |
| Renaissance Technologies LLC | 308,300 | $1.68M | 0.00% | −146,500−32.2% | Reduced |
| Bank of New York Mellon Corp | 298,991 | $1.63M | 0.00% | +12,610+4.4% | Added |
| Hennion & Walsh Asset Management, Inc. | 276,422 | $1.51M | 0.10% | −10,237−3.6% | Reduced |
| UBS Oconnor LLC | 271,219 | $1.48M | 0.02% | +43,620+19.2% | Added |
| Birchview Capital, LP | 269,332 | $1.47M | 1.04% | 00.0% | Unchanged |
| Millennium Management LLC | 262,686 | $1.43M | 0.00% | −342,697−56.6% | Reduced |
| Wellington Management Group LLP | 245,134 | $1.34M | 0.00% | +48,792+24.9% | Added |
| Two Sigma Investments, LP | 228,335 | $1.25M | 0.00% | −795,417−77.7% | Reduced |
| Charles Schwab Investment Management Inc | 200,501 | $1.09M | 0.00% | +524+0.3% | Added |
| JPMorgan Chase & Co | 179,227 | $978.0K | 0.00% | −4,938−2.7% | Reduced |
| Voya Investment Management LLC | 171,621 | $937.0K | 0.00% | +142,755+494.5% | Added |
| Ameriprise Financial Inc | 170,029 | $929.0K | 0.00% | +170,029 | New |
| Swiss National Bank | 169,450 | $925.0K | 0.00% | +8,700+5.4% | Added |
| Marshall Wace, LLP | 159,137 | $868.0K | 0.00% | +136,137+591.9% | Added |
| Connor, Clark & Lunn Investment Management Ltd. | 155,433 | $849.0K | 0.01% | +109,455+238.1% | Added |
| D. E. Shaw & Co., Inc. | 143,806 | $785.0K | 0.00% | +85,306+145.8% | Added |
| Credit Suisse AG | 139,141 | $760.0K | 0.00% | +445+0.3% | Added |
| Alliancebernstein L.P. | 138,130 | $754.0K | 0.00% | +20,100+17.0% | Added |
| Russell Investments Group, Ltd. | 129,415 | $705.0K | 0.00% | +20,320+18.6% | Added |
| Trexquant Investment LP | 119,526 | $653.0K | 0.02% | +23,395+24.3% | Added |
| AQR Capital Management LLC | 112,676 | $615.0K | 0.00% | +90,054+398.1% | Added |
| UBS Group AG | 112,546 | $614.0K | 0.00% | −204,989−64.6% | Reduced |
| FMR LLC | 112,094 | $612.0K | 0.00% | −423−0.4% | Reduced |
| Jefferies Group LLC | 101,700 | $555.3K | 0.02% | +101,700 | New |
| Rhumbline Advisers | 99,742 | $545.0K | 0.00% | +8,312+9.1% | Added |
| Algert Global LLC | 95,958 | $524.0K | 0.03% | −45,632−32.2% | Reduced |
| California State Teachers Retirement System | 91,580 | $500.0K | 0.00% | +1,098+1.2% | Added |
| Cubist Systematic Strategies, LLC | 88,364 | $482.0K | 0.00% | −102,115−53.6% | Reduced |
| Los Angeles Capital Management LLC | 78,657 | $429.0K | 0.00% | +59,977+321.1% | Added |
| UBS Asset Management Americas Inc | 72,022 | $393.2K | 0.00% | +751+1.1% | Added |
| Caxton Associates LP | 71,903 | $393.0K | 0.07% | +20,910+41.0% | Added |
| State of Wisconsin Investment Board | 69,730 | $381.0K | 0.00% | −3,114−4.3% | Reduced |
| New York Life Investment Management LLC | 68,293 | $373.0K | 0.00% | +5,018+7.9% | Added |
| New York State Common Retirement Fund | 67,406 | $368.0K | 0.00% | +18,532+37.9% | Added |
| Tudor Investment Corp Et Al | 60,064 | $328.0K | 0.01% | +5,551+10.2% | Added |
| Walleye Trading LLC | 59,480 | $325.0K | 0.01% | +59,480 | New |
| State Board of Administration of Florida Retirement System | 53,075 | $290.0K | 0.00% | 00.0% | Unchanged |
| Price T Rowe Associates Inc | 52,532 | $287.0K | 0.00% | +14,862+39.5% | Added |
| E Fund Management Co., Ltd. | 45,924 | $251.0K | 0.02% | −6,747−12.8% | Reduced |
| Aquatic Capital Management LLC | 45,100 | $246.0K | 0.02% | +29,000+180.1% | Added |
| Ensign Peak Advisors, Inc | 43,380 | $237.0K | 0.00% | 00.0% | Unchanged |
| MetLife Investment Management | 41,409 | $226.1K | 0.00% | +18,196+78.4% | Added |
| GFG Capital, LLC | 41,400 | $226.0K | 0.07% | 00.0% | Unchanged |
| XTX Topco Ltd | 40,541 | $221.0K | 0.05% | −11,065−21.4% | Reduced |
| Legal & General Group Plc | 37,819 | $207.0K | 0.00% | +4,244+12.6% | Added |
| Allspring Global Investments Holdings, LLC | 36,529 | $199.0K | 0.00% | +11,413+45.4% | Added |
| American International Group, Inc. | 36,171 | $197.0K | 0.00% | +511+1.4% | Added |
| Invesco Ltd. | 34,901 | $191.0K | 0.00% | +3,806+12.2% | Added |
| Tower Research Capital LLC (TRC) | 34,397 | $188.0K | 0.00% | +5,301+18.2% | Added |
| CSS LLC | 33,128 | $181.0K | 0.01% | +7,400+28.8% | Added |
| Mirae Asset Global Investments Co., Ltd. | 32,197 | $176.0K | 0.00% | +9,656+42.8% | Added |
| Prudential Financial Inc | 31,700 | $173.0K | 0.00% | −19,800−38.4% | Reduced |
| Engineers Gate Manager LP | 30,790 | $168.0K | 0.01% | −18,138−37.1% | Reduced |
| Manufacturers Life Insurance Company, The | 29,020 | $158.4K | 0.00% | −807−2.7% | Reduced |
| Weiss Multi-Strategy Advisers LLC | 24,725 | $135.0K | 0.00% | −797−3.1% | Reduced |
| Teacher Retirement System of Texas | 23,373 | $128.0K | 0.00% | +12,516+115.3% | Added |
| Dynamic Technology Lab Private Ltd | 22,469 | $123.0K | 0.01% | −56,251−71.5% | Reduced |
| Virginia Retirement Systems Et Al | 21,100 | $115.2K | 0.00% | +21,100 | New |
| Moors & Cabot, Inc. | 21,150 | $115.0K | 0.01% | 00.0% | Unchanged |
| Franklin Resources Inc | 20,647 | $112.0K | 0.00% | +20,647 | New |
| Principal Financial Group Inc | 19,827 | $109.0K | 0.00% | −472−2.3% | Reduced |
| Arizona State Retirement System | 19,423 | $106.0K | 0.00% | +949+5.1% | Added |
| Schonfeld Strategic Advisors LLC | 18,857 | $102.0K | 0.00% | +18,857 | New |
| Qtron Investments LLC | 18,330 | $100.0K | 0.02% | +18,330 | New |
| Baird Financial Group, Inc. | 18,191 | $99.0K | 0.00% | +1,268+7.5% | Added |
| Great West Life Assurance Co | 17,855 | $97.0K | 0.00% | +14,838+491.8% | Added |