Karyopharm Therapeutics Inc.
KPTI- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001503802
In the last 90 days, Karyopharm Therapeutics Inc. insiders filed 0 open-market purchases and 3 sales; 96 institutions reported holding it in 13F filings for Q2 2026, worth $206.8M in total; no superinvestor holds it.
13F holders, Q3 2022
Institutional positions in Karyopharm Therapeutics Inc. as of Sep 30, 2022. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 147
- −3 vs. Q2 2022
- Shares held
- 66.7M
- −432.9K (−0.6%) vs. Q2 2022
- Total value
- $364.1M
- +$61.3M (+20.3%) vs. Q2 2022
- New holders
- 18
- 61 more added
- Sold out
- 21
- 43 more reduced
Compare with Q2 2022: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting KPTI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 96 | $206.8M |
| Q1 2026 | 77 | $98.4M |
| Q4 2025 | 68 | $69.6M |
| Q3 2025 | 52 | $19.5M |
| Q2 2025 | 50 | $19.0M |
| Q1 2025 | 50 | $13.7M |
| Q4 2024 | 87 | $41.2M |
| Q3 2024 | 91 | $49.2M |
| Q2 2024 | 114 | $58.6M |
| Q1 2024 | 114 | $113.0M |
| Q4 2023 | 120 | $63.5M |
| Q3 2023 | 120 | $102.8M |
| Q2 2023 | 138 | $145.0M |
| Q1 2023 | 132 | $340.1M |
| Q4 2022 | 155 | $334.4M |
| Q3 2022 | 147 | $364.1M |
| Q2 2022 | 150 | $302.8M |
| Q1 2022 | 139 | $501.8M |
| Q4 2021 | 143 | $347.5M |
| Q3 2021 | 134 | $334.4M |
| Q2 2021 | 154 | $608.7M |
| Q1 2021 | 171 | $637.1M |
Institutions, Q3 2022
Shares, value and share of portfolio for each institution holding Karyopharm Therapeutics Inc.; share changes are against Q2 2022.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Mariner, LLC | 16,705 | $91.0K | 0.00% | +16,705 | New |
| SG Americas Securities, LLC | 15,214 | $83.0K | 0.00% | −76,019−83.3% | Reduced |
| ProShare Advisors LLC | 15,111 | $83.0K | 0.00% | +367+2.5% | Added |
| Jane Street Group, LLC | 14,768 | $81.0K | 0.00% | −193,829−92.9% | Reduced |
| Mackenzie Financial Corp | 13,806 | $75.0K | 0.00% | +1,884+15.8% | Added |
| Prelude Capital Management, LLC | 13,491 | $74.0K | 0.00% | +1,698+14.4% | Added |
| First Republic Investment Management, Inc. | 12,012 | $66.0K | 0.00% | −329−2.7% | Reduced |
| Janus Henderson Group PLC | 12,195 | $66.0K | 0.00% | −25−0.2% | Reduced |
| Snowden Capital Advisors LLC | 12,200 | $66.0K | 0.00% | 00.0% | Unchanged |
| Amalgamated Bank | 12,012 | $66.0K | 0.00% | +194+1.6% | Added |
| American Trust | 11,715 | $64.0K | 0.01% | −207−1.7% | Reduced |
| Creative Planning | 11,600 | $63.0K | 0.00% | 00.0% | Unchanged |
| Mercer Global Advisors Inc | 11,425 | $62.0K | 0.00% | +11,425 | New |
| Royal Bank of Canada | 11,175 | $61.0K | 0.00% | −2,146−16.1% | Reduced |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 10,390 | $57.0K | 0.00% | 00.0% | Unchanged |
| Y-Intercept (Hong Kong) Ltd | 10,364 | $56.6K | 0.01% | +10,364 | New |
| Commonwealth Equity Services, LLC | 10,165 | $55.0K | 0.00% | −2,825−21.7% | Reduced |
| Running Point Capital Advisors, LLC | 10,000 | $55.0K | 0.04% | 00.0% | Unchanged |
| Ameritas Investment Partners, Inc. | 6,194 | $33.0K | 0.00% | 00.0% | Unchanged |
| State of Wyoming | 5,914 | $32.0K | 0.02% | −4,692−44.2% | Reduced |
| Simplex Trading, LLC | 5,814 | $31.0K | 0.00% | −1,057−15.4% | Reduced |
| Wells Fargo & Company | 5,648 | $30.0K | 0.00% | −1,203−17.6% | Reduced |
| Banque Cantonale Vaudoise | 5,000 | $27.0K | 0.00% | 00.0% | Unchanged |
| Nisa Investment Advisors, LLC | 5,700 | $26.0K | 0.00% | +4,900+612.5% | Added |
| Metropolitan Life Insurance Co | 4,622 | $25.2K | 0.00% | +1,964+73.9% | Added |
| US Bancorp | 3,989 | $22.0K | 0.00% | +2,563+179.7% | Added |
| Advisor Group Holdings, Inc. | 3,801 | $21.0K | 0.00% | +157+4.3% | Added |
| Point72 Asset Management, L.P. | 3,500 | $19.0K | 0.00% | +3,500 | New |
| The PNC Financial Services Group, Inc. | 3,000 | $16.0K | 0.00% | 00.0% | Unchanged |
| Founders Capital Management | 2,000 | $11.0K | 0.01% | 00.0% | Unchanged |
| TD Waterhouse Canada Inc. | 1,060 | $6.07K | 0.00% | 00.0% | Unchanged |
| Lazard Asset Management LLC | 1,000 | $5.00K | 0.00% | 00.0% | Unchanged |
| DT Investment Partners, LLC | 1,000 | $5.00K | 0.00% | +1,000 | New |
| Money Concepts Capital Corp | 800 | $4.00K | 0.00% | 00.0% | Unchanged |
| Harbour Investments, Inc. | 800 | $4.00K | 0.00% | 00.0% | Unchanged |
| AdvisorNet Financial, Inc | 700 | $4.00K | 0.00% | 00.0% | Unchanged |
| Dark Forest Capital Management LP | 761 | $4.00K | 0.00% | +761 | New |
| China Universal Asset Management Co., Ltd. | 747 | $4.00K | 0.00% | +747 | New |
| Signaturefd, LLC | 607 | $3.00K | 0.00% | +408+205.0% | Added |
| Cutler Group LP | 419 | $2.00K | 0.00% | −800−65.6% | Reduced |
| Kelly Financial Services LLC | 250 | $1.36K | 0.00% | 00.0% | Unchanged |
| Daiwa Securities Group Inc. | 138 | $1.00K | 0.00% | 00.0% | Unchanged |
| Allworth Financial LP | 100 | $1.00K | 0.00% | 00.0% | Unchanged |
| Key Financial Inc | 150 | $1.00K | 0.00% | +150 | New |
| Lindbrook Capital, LLC | 48 | $0 | 0.00% | −187−79.6% | Reduced |
| Quent Capital, LLC | 30 | $0 | 0.00% | 00.0% | Unchanged |
| Sofos Investments, Inc. | 15 | – | – | +15 | New |
| Iron Triangle Partners LP | 0 | $0 | 0.00% | −1,100,000−100.0% | Sold out |
| Voloridge Investment Management, LLC | 0 | $0 | 0.00% | −389,164−100.0% | Sold out |
| HighVista Strategies LLC | 0 | $0 | 0.00% | −250,377−100.0% | Sold out |
| Qube Research & Technologies Ltd | 0 | $0 | 0.00% | −242,997−100.0% | Sold out |
| Jupiter Asset Management Ltd | 0 | $0 | 0.00% | −224,603−100.0% | Sold out |
| Allianz Asset Management GmbH | 0 | $0 | 0.00% | −179,225−100.0% | Sold out |
| HRT Financial LP | 0 | $0 | 0.00% | −49,034−100.0% | Sold out |
| Arrowstreet Capital, Limited Partnership | 0 | $0 | 0.00% | −44,753−100.0% | Sold out |
| DuPont Capital Management Corp | 0 | $0 | 0.00% | −36,455−100.0% | Sold out |
| Point72 Hong Kong Ltd | 0 | $0 | 0.00% | −29,111−100.0% | Sold out |
| Man Group plc | 0 | $0 | 0.00% | – | Sold out |
| Virtu Financial LLC | 0 | $0 | 0.00% | −13,137−100.0% | Sold out |
| Quantbot Technologies LP | 0 | $0 | 0.00% | −12,053−100.0% | Sold out |
| Jump Financial, LLC | 0 | $0 | 0.00% | −12,140−100.0% | Sold out |
| PDT Partners, LLC | 0 | $0 | 0.00% | −10,234−100.0% | Sold out |
| Federated Hermes, Inc. | 0 | $0 | 0.00% | −4,941−100.0% | Sold out |
| PEAK6 Investments LLC | 0 | $0 | 0.00% | −4,552−100.0% | Sold out |
| Captrust Financial Advisors | 0 | $0 | 0.00% | −1,000−100.0% | Sold out |
| Rockefeller Capital Management L.P. | 0 | $0 | 0.00% | −900−100.0% | Sold out |
| Ellevest, Inc. | 0 | $0 | 0.00% | −20−100.0% | Sold out |
| Quadrant Capital Group LLC | 0 | $0 | 0.00% | −90−100.0% | Sold out |