Karyopharm Therapeutics Inc.
KPTI- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001503802
In the last 90 days, Karyopharm Therapeutics Inc. insiders filed 0 open-market purchases and 2 sales; 96 institutions reported holding it in 13F filings for Q2 2026, worth $206.8M in total; no superinvestor holds it.
13F holders, Q3 2022
Institutional positions in Karyopharm Therapeutics Inc. as of Sep 30, 2022. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 147
- −3 vs. Q2 2022
- Shares held
- 66.7M
- −432.9K (−0.6%) vs. Q2 2022
- Total value
- $364.1M
- +$61.3M (+20.3%) vs. Q2 2022
- New holders
- 18
- 61 more added
- Sold out
- 21
- 43 more reduced
Compare with Q2 2022: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting KPTI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 96 | $206.8M |
| Q1 2026 | 77 | $98.4M |
| Q4 2025 | 68 | $69.6M |
| Q3 2025 | 52 | $19.5M |
| Q2 2025 | 50 | $19.0M |
| Q1 2025 | 50 | $13.7M |
| Q4 2024 | 87 | $41.2M |
| Q3 2024 | 91 | $49.2M |
| Q2 2024 | 114 | $58.6M |
| Q1 2024 | 114 | $113.0M |
| Q4 2023 | 120 | $63.5M |
| Q3 2023 | 120 | $102.8M |
| Q2 2023 | 138 | $145.0M |
| Q1 2023 | 132 | $340.1M |
| Q4 2022 | 155 | $334.4M |
| Q3 2022 | 147 | $364.1M |
| Q2 2022 | 150 | $302.8M |
| Q1 2022 | 139 | $501.8M |
| Q4 2021 | 143 | $347.5M |
| Q3 2021 | 134 | $334.4M |
| Q2 2021 | 154 | $608.7M |
| Q1 2021 | 171 | $637.1M |
Institutions, Q3 2022
Shares, value and share of portfolio for each institution holding Karyopharm Therapeutics Inc.; share changes are against Q2 2022.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Lindbrook Capital, LLC | 48 | $0 | 0.00% | −187−79.6% | Reduced |
| Quent Capital, LLC | 30 | $0 | 0.00% | 00.0% | Unchanged |
| Daiwa Securities Group Inc. | 138 | $1.00K | 0.00% | 00.0% | Unchanged |
| Allworth Financial LP | 100 | $1.00K | 0.00% | 00.0% | Unchanged |
| Key Financial Inc | 150 | $1.00K | 0.00% | +150 | New |
| Kelly Financial Services LLC | 250 | $1.36K | 0.00% | 00.0% | Unchanged |
| Cutler Group LP | 419 | $2.00K | 0.00% | −800−65.6% | Reduced |
| Signaturefd, LLC | 607 | $3.00K | 0.00% | +408+205.0% | Added |
| Money Concepts Capital Corp | 800 | $4.00K | 0.00% | 00.0% | Unchanged |
| Harbour Investments, Inc. | 800 | $4.00K | 0.00% | 00.0% | Unchanged |
| AdvisorNet Financial, Inc | 700 | $4.00K | 0.00% | 00.0% | Unchanged |
| Dark Forest Capital Management LP | 761 | $4.00K | 0.00% | +761 | New |
| China Universal Asset Management Co., Ltd. | 747 | $4.00K | 0.00% | +747 | New |
| Lazard Asset Management LLC | 1,000 | $5.00K | 0.00% | 00.0% | Unchanged |
| DT Investment Partners, LLC | 1,000 | $5.00K | 0.00% | +1,000 | New |
| TD Waterhouse Canada Inc. | 1,060 | $6.07K | 0.00% | 00.0% | Unchanged |
| Founders Capital Management | 2,000 | $11.0K | 0.01% | 00.0% | Unchanged |
| The PNC Financial Services Group, Inc. | 3,000 | $16.0K | 0.00% | 00.0% | Unchanged |
| Point72 Asset Management, L.P. | 3,500 | $19.0K | 0.00% | +3,500 | New |
| Advisor Group Holdings, Inc. | 3,801 | $21.0K | 0.00% | +157+4.3% | Added |
| US Bancorp | 3,989 | $22.0K | 0.00% | +2,563+179.7% | Added |
| Metropolitan Life Insurance Co | 4,622 | $25.2K | 0.00% | +1,964+73.9% | Added |
| Nisa Investment Advisors, LLC | 5,700 | $26.0K | 0.00% | +4,900+612.5% | Added |
| Banque Cantonale Vaudoise | 5,000 | $27.0K | 0.00% | 00.0% | Unchanged |
| Wells Fargo & Company | 5,648 | $30.0K | 0.00% | −1,203−17.6% | Reduced |
| Simplex Trading, LLC | 5,814 | $31.0K | 0.00% | −1,057−15.4% | Reduced |
| State of Wyoming | 5,914 | $32.0K | 0.02% | −4,692−44.2% | Reduced |
| Ameritas Investment Partners, Inc. | 6,194 | $33.0K | 0.00% | 00.0% | Unchanged |
| Commonwealth Equity Services, LLC | 10,165 | $55.0K | 0.00% | −2,825−21.7% | Reduced |
| Running Point Capital Advisors, LLC | 10,000 | $55.0K | 0.04% | 00.0% | Unchanged |
| Y-Intercept (Hong Kong) Ltd | 10,364 | $56.6K | 0.01% | +10,364 | New |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 10,390 | $57.0K | 0.00% | 00.0% | Unchanged |
| Royal Bank of Canada | 11,175 | $61.0K | 0.00% | −2,146−16.1% | Reduced |
| Mercer Global Advisors Inc | 11,425 | $62.0K | 0.00% | +11,425 | New |
| Creative Planning | 11,600 | $63.0K | 0.00% | 00.0% | Unchanged |
| American Trust | 11,715 | $64.0K | 0.01% | −207−1.7% | Reduced |
| First Republic Investment Management, Inc. | 12,012 | $66.0K | 0.00% | −329−2.7% | Reduced |
| Janus Henderson Group PLC | 12,195 | $66.0K | 0.00% | −25−0.2% | Reduced |
| Snowden Capital Advisors LLC | 12,200 | $66.0K | 0.00% | 00.0% | Unchanged |
| Amalgamated Bank | 12,012 | $66.0K | 0.00% | +194+1.6% | Added |
| Prelude Capital Management, LLC | 13,491 | $74.0K | 0.00% | +1,698+14.4% | Added |
| Mackenzie Financial Corp | 13,806 | $75.0K | 0.00% | +1,884+15.8% | Added |
| Jane Street Group, LLC | 14,768 | $81.0K | 0.00% | −193,829−92.9% | Reduced |
| SG Americas Securities, LLC | 15,214 | $83.0K | 0.00% | −76,019−83.3% | Reduced |
| ProShare Advisors LLC | 15,111 | $83.0K | 0.00% | +367+2.5% | Added |
| Mariner, LLC | 16,705 | $91.0K | 0.00% | +16,705 | New |
| Great West Life Assurance Co | 17,855 | $97.0K | 0.00% | +14,838+491.8% | Added |
| Baird Financial Group, Inc. | 18,191 | $99.0K | 0.00% | +1,268+7.5% | Added |
| Qtron Investments LLC | 18,330 | $100.0K | 0.02% | +18,330 | New |
| Schonfeld Strategic Advisors LLC | 18,857 | $102.0K | 0.00% | +18,857 | New |
| Arizona State Retirement System | 19,423 | $106.0K | 0.00% | +949+5.1% | Added |
| Principal Financial Group Inc | 19,827 | $109.0K | 0.00% | −472−2.3% | Reduced |
| Franklin Resources Inc | 20,647 | $112.0K | 0.00% | +20,647 | New |
| Moors & Cabot, Inc. | 21,150 | $115.0K | 0.01% | 00.0% | Unchanged |
| Virginia Retirement Systems Et Al | 21,100 | $115.2K | 0.00% | +21,100 | New |
| Dynamic Technology Lab Private Ltd | 22,469 | $123.0K | 0.01% | −56,251−71.5% | Reduced |
| Teacher Retirement System of Texas | 23,373 | $128.0K | 0.00% | +12,516+115.3% | Added |
| Weiss Multi-Strategy Advisers LLC | 24,725 | $135.0K | 0.00% | −797−3.1% | Reduced |
| Manufacturers Life Insurance Company, The | 29,020 | $158.4K | 0.00% | −807−2.7% | Reduced |
| Engineers Gate Manager LP | 30,790 | $168.0K | 0.01% | −18,138−37.1% | Reduced |
| Prudential Financial Inc | 31,700 | $173.0K | 0.00% | −19,800−38.4% | Reduced |
| Mirae Asset Global Investments Co., Ltd. | 32,197 | $176.0K | 0.00% | +9,656+42.8% | Added |
| CSS LLC | 33,128 | $181.0K | 0.01% | +7,400+28.8% | Added |
| Tower Research Capital LLC (TRC) | 34,397 | $188.0K | 0.00% | +5,301+18.2% | Added |
| Invesco Ltd. | 34,901 | $191.0K | 0.00% | +3,806+12.2% | Added |
| American International Group, Inc. | 36,171 | $197.0K | 0.00% | +511+1.4% | Added |
| Allspring Global Investments Holdings, LLC | 36,529 | $199.0K | 0.00% | +11,413+45.4% | Added |
| Legal & General Group Plc | 37,819 | $207.0K | 0.00% | +4,244+12.6% | Added |
| XTX Topco Ltd | 40,541 | $221.0K | 0.05% | −11,065−21.4% | Reduced |
| GFG Capital, LLC | 41,400 | $226.0K | 0.07% | 00.0% | Unchanged |
| MetLife Investment Management | 41,409 | $226.1K | 0.00% | +18,196+78.4% | Added |
| Ensign Peak Advisors, Inc | 43,380 | $237.0K | 0.00% | 00.0% | Unchanged |
| Aquatic Capital Management LLC | 45,100 | $246.0K | 0.02% | +29,000+180.1% | Added |
| E Fund Management Co., Ltd. | 45,924 | $251.0K | 0.02% | −6,747−12.8% | Reduced |
| Price T Rowe Associates Inc | 52,532 | $287.0K | 0.00% | +14,862+39.5% | Added |
| State Board of Administration of Florida Retirement System | 53,075 | $290.0K | 0.00% | 00.0% | Unchanged |
| Walleye Trading LLC | 59,480 | $325.0K | 0.01% | +59,480 | New |
| Tudor Investment Corp Et Al | 60,064 | $328.0K | 0.01% | +5,551+10.2% | Added |
| New York State Common Retirement Fund | 67,406 | $368.0K | 0.00% | +18,532+37.9% | Added |
| New York Life Investment Management LLC | 68,293 | $373.0K | 0.00% | +5,018+7.9% | Added |
| State of Wisconsin Investment Board | 69,730 | $381.0K | 0.00% | −3,114−4.3% | Reduced |
| Caxton Associates LP | 71,903 | $393.0K | 0.07% | +20,910+41.0% | Added |
| UBS Asset Management Americas Inc | 72,022 | $393.2K | 0.00% | +751+1.1% | Added |
| Los Angeles Capital Management LLC | 78,657 | $429.0K | 0.00% | +59,977+321.1% | Added |
| Cubist Systematic Strategies, LLC | 88,364 | $482.0K | 0.00% | −102,115−53.6% | Reduced |
| California State Teachers Retirement System | 91,580 | $500.0K | 0.00% | +1,098+1.2% | Added |
| Algert Global LLC | 95,958 | $524.0K | 0.03% | −45,632−32.2% | Reduced |
| Rhumbline Advisers | 99,742 | $545.0K | 0.00% | +8,312+9.1% | Added |
| Jefferies Group LLC | 101,700 | $555.3K | 0.02% | +101,700 | New |
| FMR LLC | 112,094 | $612.0K | 0.00% | −423−0.4% | Reduced |
| UBS Group AG | 112,546 | $614.0K | 0.00% | −204,989−64.6% | Reduced |
| AQR Capital Management LLC | 112,676 | $615.0K | 0.00% | +90,054+398.1% | Added |
| Trexquant Investment LP | 119,526 | $653.0K | 0.02% | +23,395+24.3% | Added |
| Russell Investments Group, Ltd. | 129,415 | $705.0K | 0.00% | +20,320+18.6% | Added |
| Alliancebernstein L.P. | 138,130 | $754.0K | 0.00% | +20,100+17.0% | Added |
| Credit Suisse AG | 139,141 | $760.0K | 0.00% | +445+0.3% | Added |
| D. E. Shaw & Co., Inc. | 143,806 | $785.0K | 0.00% | +85,306+145.8% | Added |
| Connor, Clark & Lunn Investment Management Ltd. | 155,433 | $849.0K | 0.01% | +109,455+238.1% | Added |
| Marshall Wace, LLP | 159,137 | $868.0K | 0.00% | +136,137+591.9% | Added |
| Swiss National Bank | 169,450 | $925.0K | 0.00% | +8,700+5.4% | Added |