Karyopharm Therapeutics Inc.
KPTI- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001503802
In the last 90 days, Karyopharm Therapeutics Inc. insiders filed 0 open-market purchases and 2 sales; 96 institutions reported holding it in 13F filings for Q2 2026, worth $206.8M in total; no superinvestor holds it.
13F holders, Q1 2023
Institutional positions in Karyopharm Therapeutics Inc. as of Mar 31, 2023. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 132
- −23 vs. Q4 2022
- Shares held
- 87.5M
- −10.9M (−11.1%) vs. Q4 2022
- Total value
- $340.1M
- +$5.77M (+1.7%) vs. Q4 2022
- New holders
- 20
- 53 more added
- Sold out
- 43
- 30 more reduced
Compare with Q4 2022: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting KPTI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 96 | $206.8M |
| Q1 2026 | 77 | $98.4M |
| Q4 2025 | 68 | $69.6M |
| Q3 2025 | 52 | $19.5M |
| Q2 2025 | 50 | $19.0M |
| Q1 2025 | 50 | $13.7M |
| Q4 2024 | 87 | $41.2M |
| Q3 2024 | 91 | $49.2M |
| Q2 2024 | 114 | $58.6M |
| Q1 2024 | 114 | $113.0M |
| Q4 2023 | 120 | $63.5M |
| Q3 2023 | 120 | $102.8M |
| Q2 2023 | 138 | $145.0M |
| Q1 2023 | 132 | $340.1M |
| Q4 2022 | 155 | $334.4M |
| Q3 2022 | 147 | $364.1M |
| Q2 2022 | 150 | $302.8M |
| Q1 2022 | 139 | $501.8M |
| Q4 2021 | 143 | $347.5M |
| Q3 2021 | 134 | $334.4M |
| Q2 2021 | 154 | $608.7M |
| Q1 2021 | 171 | $637.1M |
Institutions, Q1 2023
Shares, value and share of portfolio for each institution holding Karyopharm Therapeutics Inc.; share changes are against Q4 2022.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| State Street Corp | 10,175,989 | $39.6M | 0.00% | +1,888,953+22.8% | Added |
| Avidity Partners Management LP | 9,633,911 | $37.5M | 1.24% | 00.0% | Unchanged |
| BlackRock Inc. | 9,072,188 | $35.3M | 0.00% | +563,951+6.6% | Added |
| Vanguard Group Inc | 7,503,836 | $29.2M | 0.00% | +2,306,334+44.4% | Added |
| Palo Alto Investors LP | 5,675,876 | $22.1M | 1.83% | +20,200+0.4% | Added |
| Rubric Capital Management LP | 4,441,056 | $17.3M | 0.69% | −3,853,565−46.5% | Reduced |
| Citadel Advisors LLC | 3,602,460 | $14.0M | 0.02% | −110,693−3.0% | Reduced |
| Barclays PLC | 2,847,389 | $11.1M | 0.01% | +1,800,677+172.0% | Added |
| Opaleye Management Inc. | 2,810,800 | $10.9M | 3.27% | +1,603,959+132.9% | Added |
| Bank of America Corp | 2,157,781 | $8.39M | 0.00% | +646,615+42.8% | Added |
| Marshall Wace, LLP | 1,984,906 | $7.72M | 0.02% | −225,317−10.2% | Reduced |
| Nuveen Asset Management, LLC | 1,778,532 | $6.92M | 0.00% | +184,822+11.6% | Added |
| Geode Capital Management, LLC | 1,771,733 | $6.89M | 0.00% | +394,605+28.7% | Added |
| Deutsche Bank AG | 1,644,934 | $6.40M | 0.00% | +1,050,608+176.8% | Added |
| Silverarc Capital Management, LLC | 1,541,426 | $6.00M | 2.69% | +1,541,426 | New |
| C WorldWide Group Holding A/S | 1,500,000 | $5.83M | 0.08% | 00.0% | Unchanged |
| Goldman Sachs Group Inc | 1,469,147 | $5.71M | 0.00% | +412,514+39.0% | Added |
| Candriam Luxembourg S.C.A. | 1,535,026 | $5.50M | 0.04% | 00.0% | Unchanged |
| Jacobs Levy Equity Management, Inc | 1,075,074 | $4.18M | 0.03% | −1,174,325−52.2% | Reduced |
| Rafferty Asset Management, LLC | 913,301 | $3.55M | 0.02% | +216,635+31.1% | Added |
| Northern Trust Corp | 824,749 | $3.21M | 0.00% | +79,016+10.6% | Added |
| Renaissance Technologies LLC | 735,700 | $2.86M | 0.00% | +546,400+288.6% | Added |
| Citigroup Inc | 730,027 | $2.84M | 0.00% | +221,434+43.5% | Added |
| Morgan Stanley | 726,690 | $2.83M | 0.00% | −562,747−43.6% | Reduced |
| UBS Oconnor LLC | 593,805 | $2.31M | 0.06% | +593,805 | New |
| D. E. Shaw & Co., Inc. | 549,607 | $2.14M | 0.00% | +241,648+78.5% | Added |
| Altium Capital Management LP | 505,781 | $1.97M | 1.18% | +505,781 | New |
| Tejara Capital Ltd | 501,562 | $1.95M | 1.00% | 00.0% | Unchanged |
| Alyeska Investment Group, L.P. | 481,696 | $1.87M | 0.02% | 00.0% | Unchanged |
| Affinity Asset Advisors, LLC | 460,979 | $1.79M | 0.69% | −200,285−30.3% | Reduced |
| Bank of New York Mellon Corp | 454,466 | $1.77M | 0.00% | +21,585+5.0% | Added |
| Two Sigma Advisers, LP | 401,500 | $1.56M | 0.00% | −301,700−42.9% | Reduced |
| Macquarie Group Ltd | 380,000 | $1.48M | 0.00% | 00.0% | Unchanged |
| BNP Paribas Arbitrage, SA | 369,605 | $1.44M | 0.00% | −54,015−12.8% | Reduced |
| Ikarian Capital, LLC | 300,000 | $1.17M | 0.48% | +300,000 | New |
| Susquehanna International Group, LLP | 295,184 | $1.15M | 0.00% | +39,991+15.7% | Added |
| Birchview Capital, LP | 291,332 | $1.13M | 0.89% | 00.0% | Unchanged |
| Ameriprise Financial Inc | 257,856 | $1.00M | 0.00% | +92,867+56.3% | Added |
| AlphaCentric Advisors LLC | 240,000 | $933.6K | 0.64% | +240,000 | New |
| Caxton Associates LP | 235,626 | $916.6K | 0.15% | +159,700+210.3% | Added |
| Wellington Management Group LLP | 234,049 | $910.5K | 0.00% | +5,430+2.4% | Added |
| Swiss National Bank | 231,550 | $900.7K | 0.00% | −27,600−10.7% | Reduced |
| Charles Schwab Investment Management Inc | 222,711 | $866.3K | 0.00% | +15,880+7.7% | Added |
| State of Wisconsin Investment Board | 197,433 | $768.0K | 0.00% | +187,385+1,864.9% | Added |
| DAFNA Capital Management LLC | 192,678 | $749.5K | 0.22% | 00.0% | Unchanged |
| JPMorgan Chase & Co | 190,668 | $742.0K | 0.00% | −1,291,496−87.1% | Reduced |
| Connor, Clark & Lunn Investment Management Ltd. | 187,450 | $729.2K | 0.00% | −244,828−56.6% | Reduced |
| Alliancebernstein L.P. | 177,830 | $691.8K | 0.00% | +19,800+12.5% | Added |
| Wells Fargo & Company | 167,641 | $652.1K | 0.00% | +167,519+137,310.7% | Added |
| Profund Advisors LLC | 167,517 | $651.6K | 0.04% | +167,517 | New |
| UBS Group AG | 162,441 | $631.9K | 0.00% | −360,818−69.0% | Reduced |
| Credit Suisse AG | 152,593 | $593.6K | 0.00% | +10,669+7.5% | Added |
| Tudor Investment Corp Et Al | 151,235 | $588.0K | 0.01% | +31,480+26.3% | Added |
| Hennion & Walsh Asset Management, Inc. | 139,574 | $543.0K | 0.03% | −4,779−3.3% | Reduced |
| Virginia Retirement Systems Et Al | 132,600 | $515.8K | 0.01% | +41,300+45.2% | Added |
| California State Teachers Retirement System | 123,207 | $479.3K | 0.00% | −1,099−0.9% | Reduced |
| Putnam Investments LLC | 120,768 | $469.8K | 0.00% | −121,852−50.2% | Reduced |
| FMR LLC | 114,987 | $447.3K | 0.00% | +4,066+3.7% | Added |
| Los Angeles Capital Management LLC | 113,724 | $442.4K | 0.00% | +11,807+11.6% | Added |
| Rhumbline Advisers | 104,291 | $406.0K | 0.00% | +5,551+5.6% | Added |
| Russell Investments Group, Ltd. | 94,380 | $367.1K | 0.00% | −51,780−35.4% | Reduced |
| UBS Asset Management Americas Inc | 91,628 | $356.4K | 0.00% | +8,753+10.6% | Added |
| Algert Global LLC | 86,813 | $337.7K | 0.02% | +4,145+5.0% | Added |
| AQR Capital Management LLC | 80,513 | $313.2K | 0.00% | +18,866+30.6% | Added |
| Fred Alger Management, LLC | 69,420 | $270.0K | 0.00% | +69,420 | New |
| Royal Bank of Canada | 62,752 | $244.0K | 0.00% | −1,477−2.3% | Reduced |
| Boothbay Fund Management, LLC | 61,410 | $238.9K | 0.01% | +61,410 | New |
| Price T Rowe Associates Inc | 60,466 | $236.0K | 0.00% | +2,511+4.3% | Added |
| Walleye Capital LLC | 56,700 | $220.6K | 0.00% | −103,407−64.6% | Reduced |
| E Fund Management Co., Ltd. | 51,849 | $202.0K | 0.01% | +15,345+42.0% | Added |
| Principal Financial Group Inc | 48,862 | $190.1K | 0.00% | −7,943−14.0% | Reduced |
| Legal & General Group Plc | 48,511 | $188.6K | 0.00% | +2,692+5.9% | Added |
| Quantbot Technologies LP | 48,197 | $187.5K | 0.01% | +48,197 | New |
| Man Group plc | – | $173.5K | 0.00% | – | New |
| Invesco Ltd. | 43,229 | $168.2K | 0.00% | +7,103+19.7% | Added |
| Prelude Capital Management, LLC | 42,427 | $165.0K | 0.01% | −16,107−27.5% | Reduced |
| MetLife Investment Management | 41,283 | $160.6K | 0.00% | +11,889+40.4% | Added |
| Weiss Multi-Strategy Advisers LLC | 39,312 | $153.0K | 0.00% | +15,183+62.9% | Added |
| Janus Henderson Group PLC | 38,114 | $148.1K | 0.00% | +25,920+212.6% | Added |
| American International Group, Inc. | 37,576 | $146.2K | 0.00% | +748+2.0% | Added |
| Mirae Asset Global Investments Co., Ltd. | 37,398 | $145.5K | 0.00% | +37,398 | New |
| SG Americas Securities, LLC | 35,864 | $140.0K | 0.00% | +35,864 | New |
| Teacher Retirement System of Texas | 33,054 | $129.0K | 0.00% | +4,457+15.6% | Added |
| Redwood Wealth Management Group, LLC | 32,730 | $127.3K | 0.14% | −500−1.5% | Reduced |
| Arizona State Retirement System | 31,090 | $120.9K | 0.00% | +10,823+53.4% | Added |
| Great West Life Assurance Co | 29,434 | $114.0K | 0.00% | +26,417+875.6% | Added |
| Voya Investment Management LLC | 28,866 | $112.3K | 0.00% | 00.0% | Unchanged |
| Manufacturers Life Insurance Company, The | 28,760 | $111.9K | 0.00% | 00.0% | Unchanged |
| Mariner, LLC | 28,056 | $109.0K | 0.00% | +28,056 | New |
| State Board of Administration of Florida Retirement System | 27,015 | $105.1K | 0.00% | 00.0% | Unchanged |
| Baird Financial Group, Inc. | 26,975 | $104.9K | 0.00% | +7,874+41.2% | Added |
| Allspring Global Investments Holdings, LLC | 24,593 | $95.7K | 0.00% | −2,006−7.5% | Reduced |
| Kennedy Investment Group | 20,000 | $77.8K | 0.05% | +20,000 | New |
| Tower Research Capital LLC (TRC) | 19,343 | $75.0K | 0.00% | −779−3.9% | Reduced |
| New York State Common Retirement Fund | 19,074 | $74.2K | 0.00% | −30,000−61.1% | Reduced |
| ProShare Advisors LLC | 17,021 | $66.2K | 0.00% | +291+1.7% | Added |
| Snowden Capital Advisors LLC | 16,200 | $63.0K | 0.00% | +1,967+13.8% | Added |
| Ashton Thomas Private Wealth, LLC | 16,000 | $62.2K | 0.01% | +1,500+10.3% | Added |
| PEAK6 Investments LLC | 15,000 | $58.4K | 0.00% | +15,000 | New |
| Banque Cantonale Vaudoise | 15,000 | $58.0K | 0.00% | +10,000+200.0% | Added |