Karyopharm Therapeutics Inc.
KPTI- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001503802
In the last 90 days, Karyopharm Therapeutics Inc. insiders filed 0 open-market purchases and 2 sales; 96 institutions reported holding it in 13F filings for Q2 2026, worth $206.8M in total; no superinvestor holds it.
13F holders, Q1 2023
Institutional positions in Karyopharm Therapeutics Inc. as of Mar 31, 2023. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 132
- −23 vs. Q4 2022
- Shares held
- 87.5M
- −10.9M (−11.1%) vs. Q4 2022
- Total value
- $340.1M
- +$5.77M (+1.7%) vs. Q4 2022
- New holders
- 20
- 53 more added
- Sold out
- 43
- 30 more reduced
Compare with Q4 2022: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting KPTI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 96 | $206.8M |
| Q1 2026 | 77 | $98.4M |
| Q4 2025 | 68 | $69.6M |
| Q3 2025 | 52 | $19.5M |
| Q2 2025 | 50 | $19.0M |
| Q1 2025 | 50 | $13.7M |
| Q4 2024 | 87 | $41.2M |
| Q3 2024 | 91 | $49.2M |
| Q2 2024 | 114 | $58.6M |
| Q1 2024 | 114 | $113.0M |
| Q4 2023 | 120 | $63.5M |
| Q3 2023 | 120 | $102.8M |
| Q2 2023 | 138 | $145.0M |
| Q1 2023 | 132 | $340.1M |
| Q4 2022 | 155 | $334.4M |
| Q3 2022 | 147 | $364.1M |
| Q2 2022 | 150 | $302.8M |
| Q1 2022 | 139 | $501.8M |
| Q4 2021 | 143 | $347.5M |
| Q3 2021 | 134 | $334.4M |
| Q2 2021 | 154 | $608.7M |
| Q1 2021 | 171 | $637.1M |
Institutions, Q1 2023
Shares, value and share of portfolio for each institution holding Karyopharm Therapeutics Inc.; share changes are against Q4 2022.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Proequities, Inc. | 1 | $3 | 0.00% | +1 | New |
| Sofos Investments, Inc. | 4 | $8 | 0.00% | +1+33.3% | Added |
| Kelly Financial Services LLC | 250 | $973 | 0.00% | 00.0% | Unchanged |
| Daiwa Securities Group Inc. | 138 | $1.00K | 0.00% | 00.0% | Unchanged |
| Quent Capital, LLC | 386 | $1.50K | 0.00% | 00.0% | Unchanged |
| Lindbrook Capital, LLC | 399 | $1.55K | 0.00% | +399 | New |
| Allworth Financial LP | 500 | $1.95K | 0.00% | 00.0% | Unchanged |
| Advisory Services Network, LLC | 600 | $2.33K | 0.00% | 00.0% | Unchanged |
| AdvisorNet Financial, Inc | 700 | $2.72K | 0.00% | 00.0% | Unchanged |
| Nisa Investment Advisors, LLC | 860 | $3.00K | 0.00% | +60+7.5% | Added |
| Lazard Asset Management LLC | 1,000 | $3.00K | 0.00% | 00.0% | Unchanged |
| Harbour Investments, Inc. | 800 | $3.11K | 0.00% | 00.0% | Unchanged |
| Belpointe Asset Management LLC | 1,000 | $3.89K | 0.00% | 00.0% | Unchanged |
| TD Waterhouse Canada Inc. | 1,060 | $4.22K | 0.00% | 00.0% | Unchanged |
| MB, Levis & Associates, LLC | 1,500 | $5.83K | 0.00% | 00.0% | Unchanged |
| China Universal Asset Management Co., Ltd. | 1,536 | $5.97K | 0.00% | +711+86.2% | Added |
| Founders Capital Management | 2,000 | $8.00K | 0.01% | 00.0% | Unchanged |
| The PNC Financial Services Group, Inc. | 3,000 | $11.7K | 0.00% | 00.0% | Unchanged |
| Group One Trading, L.P. | 3,110 | $12.1K | 0.00% | +3,110 | New |
| Metropolitan Life Insurance Co | 4,270 | $16.6K | 0.00% | −352−7.6% | Reduced |
| Ameritas Investment Partners, Inc. | 6,194 | $24.1K | 0.00% | 00.0% | Unchanged |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 8,321 | $32.4K | 0.00% | −3,697−30.8% | Reduced |
| Advisor Group Holdings, Inc. | 8,906 | $34.6K | 0.00% | 00.0% | Unchanged |
| Janney Montgomery Scott LLC | 10,000 | $39.0K | 0.00% | 00.0% | Unchanged |
| Amalgamated Bank | 10,571 | $41.0K | 0.00% | −1,441−12.0% | Reduced |
| Creative Planning | 11,600 | $45.1K | 0.00% | 00.0% | Unchanged |
| Victory Capital Management Inc | 11,684 | $45.5K | 0.00% | +11,684 | New |
| Bayesian Capital Management, LP | 11,880 | $46.2K | 0.01% | −31,758−72.8% | Reduced |
| HSBC Holdings PLC | 12,279 | $46.8K | 0.00% | +12,279 | New |
| Moors & Cabot, Inc. | 12,200 | $47.5K | 0.00% | 00.0% | Unchanged |
| Squarepoint Ops LLC | 12,553 | $48.8K | 0.00% | −39,730−76.0% | Reduced |
| Millennium Management LLC | 13,763 | $54.0K | 0.00% | −337,780−96.1% | Reduced |
| Banque Cantonale Vaudoise | 15,000 | $58.0K | 0.00% | +10,000+200.0% | Added |
| PEAK6 Investments LLC | 15,000 | $58.4K | 0.00% | +15,000 | New |
| Ashton Thomas Private Wealth, LLC | 16,000 | $62.2K | 0.01% | +1,500+10.3% | Added |
| Snowden Capital Advisors LLC | 16,200 | $63.0K | 0.00% | +1,967+13.8% | Added |
| ProShare Advisors LLC | 17,021 | $66.2K | 0.00% | +291+1.7% | Added |
| New York State Common Retirement Fund | 19,074 | $74.2K | 0.00% | −30,000−61.1% | Reduced |
| Tower Research Capital LLC (TRC) | 19,343 | $75.0K | 0.00% | −779−3.9% | Reduced |
| Kennedy Investment Group | 20,000 | $77.8K | 0.05% | +20,000 | New |
| Allspring Global Investments Holdings, LLC | 24,593 | $95.7K | 0.00% | −2,006−7.5% | Reduced |
| Baird Financial Group, Inc. | 26,975 | $104.9K | 0.00% | +7,874+41.2% | Added |
| State Board of Administration of Florida Retirement System | 27,015 | $105.1K | 0.00% | 00.0% | Unchanged |
| Mariner, LLC | 28,056 | $109.0K | 0.00% | +28,056 | New |
| Manufacturers Life Insurance Company, The | 28,760 | $111.9K | 0.00% | 00.0% | Unchanged |
| Voya Investment Management LLC | 28,866 | $112.3K | 0.00% | 00.0% | Unchanged |
| Great West Life Assurance Co | 29,434 | $114.0K | 0.00% | +26,417+875.6% | Added |
| Arizona State Retirement System | 31,090 | $120.9K | 0.00% | +10,823+53.4% | Added |
| Redwood Wealth Management Group, LLC | 32,730 | $127.3K | 0.14% | −500−1.5% | Reduced |
| Teacher Retirement System of Texas | 33,054 | $129.0K | 0.00% | +4,457+15.6% | Added |
| SG Americas Securities, LLC | 35,864 | $140.0K | 0.00% | +35,864 | New |
| Mirae Asset Global Investments Co., Ltd. | 37,398 | $145.5K | 0.00% | +37,398 | New |
| American International Group, Inc. | 37,576 | $146.2K | 0.00% | +748+2.0% | Added |
| Janus Henderson Group PLC | 38,114 | $148.1K | 0.00% | +25,920+212.6% | Added |
| Weiss Multi-Strategy Advisers LLC | 39,312 | $153.0K | 0.00% | +15,183+62.9% | Added |
| MetLife Investment Management | 41,283 | $160.6K | 0.00% | +11,889+40.4% | Added |
| Prelude Capital Management, LLC | 42,427 | $165.0K | 0.01% | −16,107−27.5% | Reduced |
| Invesco Ltd. | 43,229 | $168.2K | 0.00% | +7,103+19.7% | Added |
| Man Group plc | – | $173.5K | 0.00% | – | New |
| Quantbot Technologies LP | 48,197 | $187.5K | 0.01% | +48,197 | New |
| Legal & General Group Plc | 48,511 | $188.6K | 0.00% | +2,692+5.9% | Added |
| Principal Financial Group Inc | 48,862 | $190.1K | 0.00% | −7,943−14.0% | Reduced |
| E Fund Management Co., Ltd. | 51,849 | $202.0K | 0.01% | +15,345+42.0% | Added |
| Walleye Capital LLC | 56,700 | $220.6K | 0.00% | −103,407−64.6% | Reduced |
| Price T Rowe Associates Inc | 60,466 | $236.0K | 0.00% | +2,511+4.3% | Added |
| Boothbay Fund Management, LLC | 61,410 | $238.9K | 0.01% | +61,410 | New |
| Royal Bank of Canada | 62,752 | $244.0K | 0.00% | −1,477−2.3% | Reduced |
| Fred Alger Management, LLC | 69,420 | $270.0K | 0.00% | +69,420 | New |
| AQR Capital Management LLC | 80,513 | $313.2K | 0.00% | +18,866+30.6% | Added |
| Algert Global LLC | 86,813 | $337.7K | 0.02% | +4,145+5.0% | Added |
| UBS Asset Management Americas Inc | 91,628 | $356.4K | 0.00% | +8,753+10.6% | Added |
| Russell Investments Group, Ltd. | 94,380 | $367.1K | 0.00% | −51,780−35.4% | Reduced |
| Rhumbline Advisers | 104,291 | $406.0K | 0.00% | +5,551+5.6% | Added |
| Los Angeles Capital Management LLC | 113,724 | $442.4K | 0.00% | +11,807+11.6% | Added |
| FMR LLC | 114,987 | $447.3K | 0.00% | +4,066+3.7% | Added |
| Putnam Investments LLC | 120,768 | $469.8K | 0.00% | −121,852−50.2% | Reduced |
| California State Teachers Retirement System | 123,207 | $479.3K | 0.00% | −1,099−0.9% | Reduced |
| Virginia Retirement Systems Et Al | 132,600 | $515.8K | 0.01% | +41,300+45.2% | Added |
| Hennion & Walsh Asset Management, Inc. | 139,574 | $543.0K | 0.03% | −4,779−3.3% | Reduced |
| Tudor Investment Corp Et Al | 151,235 | $588.0K | 0.01% | +31,480+26.3% | Added |
| Credit Suisse AG | 152,593 | $593.6K | 0.00% | +10,669+7.5% | Added |
| UBS Group AG | 162,441 | $631.9K | 0.00% | −360,818−69.0% | Reduced |
| Profund Advisors LLC | 167,517 | $651.6K | 0.04% | +167,517 | New |
| Wells Fargo & Company | 167,641 | $652.1K | 0.00% | +167,519+137,310.7% | Added |
| Alliancebernstein L.P. | 177,830 | $691.8K | 0.00% | +19,800+12.5% | Added |
| Connor, Clark & Lunn Investment Management Ltd. | 187,450 | $729.2K | 0.00% | −244,828−56.6% | Reduced |
| JPMorgan Chase & Co | 190,668 | $742.0K | 0.00% | −1,291,496−87.1% | Reduced |
| DAFNA Capital Management LLC | 192,678 | $749.5K | 0.22% | 00.0% | Unchanged |
| State of Wisconsin Investment Board | 197,433 | $768.0K | 0.00% | +187,385+1,864.9% | Added |
| Charles Schwab Investment Management Inc | 222,711 | $866.3K | 0.00% | +15,880+7.7% | Added |
| Swiss National Bank | 231,550 | $900.7K | 0.00% | −27,600−10.7% | Reduced |
| Wellington Management Group LLP | 234,049 | $910.5K | 0.00% | +5,430+2.4% | Added |
| Caxton Associates LP | 235,626 | $916.6K | 0.15% | +159,700+210.3% | Added |
| AlphaCentric Advisors LLC | 240,000 | $933.6K | 0.64% | +240,000 | New |
| Ameriprise Financial Inc | 257,856 | $1.00M | 0.00% | +92,867+56.3% | Added |
| Birchview Capital, LP | 291,332 | $1.13M | 0.89% | 00.0% | Unchanged |
| Susquehanna International Group, LLP | 295,184 | $1.15M | 0.00% | +39,991+15.7% | Added |
| Ikarian Capital, LLC | 300,000 | $1.17M | 0.48% | +300,000 | New |
| BNP Paribas Arbitrage, SA | 369,605 | $1.44M | 0.00% | −54,015−12.8% | Reduced |
| Macquarie Group Ltd | 380,000 | $1.48M | 0.00% | 00.0% | Unchanged |