Karyopharm Therapeutics Inc.
KPTI- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001503802
In the last 90 days, Karyopharm Therapeutics Inc. insiders filed 0 open-market purchases and 2 sales; 96 institutions reported holding it in 13F filings for Q2 2026, worth $206.8M in total; no superinvestor holds it.
13F holders, Q2 2021
Institutional positions in Karyopharm Therapeutics Inc. as of Jun 30, 2021. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 154
- −16 vs. Q1 2021
- Shares held
- 59.0M
- −1.17M (−1.9%) vs. Q1 2021
- Total value
- $608.7M
- −$28.3M (−4.4%) vs. Q1 2021
- New holders
- 21
- 54 more added
- Sold out
- 37
- 57 more reduced
1 institution that held it in Q1 2021 haven't filed for Q2 2021 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2021: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting KPTI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 96 | $206.8M |
| Q1 2026 | 77 | $98.4M |
| Q4 2025 | 68 | $69.6M |
| Q3 2025 | 52 | $19.5M |
| Q2 2025 | 50 | $19.0M |
| Q1 2025 | 50 | $13.7M |
| Q4 2024 | 87 | $41.2M |
| Q3 2024 | 91 | $49.2M |
| Q2 2024 | 114 | $58.6M |
| Q1 2024 | 114 | $113.0M |
| Q4 2023 | 120 | $63.5M |
| Q3 2023 | 120 | $102.8M |
| Q2 2023 | 138 | $145.0M |
| Q1 2023 | 132 | $340.1M |
| Q4 2022 | 155 | $334.4M |
| Q3 2022 | 147 | $364.1M |
| Q2 2022 | 150 | $302.8M |
| Q1 2022 | 139 | $501.8M |
| Q4 2021 | 143 | $347.5M |
| Q3 2021 | 134 | $334.4M |
| Q2 2021 | 154 | $608.7M |
| Q1 2021 | 171 | $637.1M |
Institutions, Q2 2021
Shares, value and share of portfolio for each institution holding Karyopharm Therapeutics Inc.; share changes are against Q1 2021.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| BlackRock Inc. | 8,781,248 | $90.6M | 0.00% | +1,031,491+13.3% | Added |
| State Street Corp | 5,816,549 | $60.0M | 0.00% | +484,269+9.1% | Added |
| Palo Alto Investors LP | 5,383,052 | $55.6M | 3.06% | +19,400+0.4% | Added |
| Rubric Capital Management LP | 4,253,212 | $43.9M | 2.77% | +4,253,212 | New |
| Vanguard Group Inc | 3,613,336 | $37.3M | 0.00% | +56,883+1.6% | Added |
| Alkeon Capital Management LLC | 2,663,177 | $27.5M | 0.10% | −5,022−0.2% | Reduced |
| Delphi Management Partners VIII, L.L.C. | 2,263,006 | $23.4M | 18.44% | 00.0% | Unchanged |
| Morgan Stanley | 1,642,681 | $17.0M | 0.00% | −55,792−3.3% | Reduced |
| Frontier Capital Management Co LLC | 1,488,939 | $15.4M | 0.11% | +267,312+21.9% | Added |
| Rice Hall James & Associates, LLC | 1,409,397 | $14.5M | 0.52% | −153,647−9.8% | Reduced |
| Lombard Odier Asset Management (Switzerland) SA | 1,376,372 | $14.2M | 0.72% | +546,691+65.9% | Added |
| C WorldWide Group Holding A/S | 1,200,000 | $12.4M | 0.13% | 00.0% | Unchanged |
| Geode Capital Management, LLC | 1,195,278 | $12.3M | 0.00% | +48,563+4.2% | Added |
| Nuveen Asset Management, LLC | 1,135,916 | $11.7M | 0.00% | +206,355+22.2% | Added |
| Goldman Sachs Group Inc | 1,005,721 | $10.4M | 0.00% | −206,250−17.0% | Reduced |
| J. Goldman & Co LP | 1,004,962 | $10.4M | 0.66% | −326,142−24.5% | Reduced |
| Two Sigma Advisers, LP | 982,400 | $10.1M | 0.03% | +72,200+7.9% | Added |
| Two Sigma Investments, LP | 846,118 | $8.73M | 0.02% | −646,524−43.3% | Reduced |
| Hood River Capital Management LLC | 802,246 | $8.28M | 0.25% | −46,461−5.5% | Reduced |
| Northern Trust Corp | 785,282 | $8.11M | 0.00% | +40,246+5.4% | Added |
| Granahan Investment Management Inc | 731,558 | $7.55M | 0.14% | +41,148+6.0% | Added |
| Candriam Luxembourg S.C.A. | 717,668 | $7.41M | 0.05% | −233,906−24.6% | Reduced |
| Wellington Management Group LLP | 596,000 | $6.15M | 0.00% | −1,321,768−68.9% | Reduced |
| Ami Asset Management Corp | 514,101 | $5.31M | 0.27% | +12,929+2.6% | Added |
| JPMorgan Chase & Co | 483,222 | $4.99M | 0.00% | +143,475+42.2% | Added |
| Charles Schwab Investment Management Inc | 465,058 | $4.80M | 0.00% | +12,814+2.8% | Added |
| Price T Rowe Associates Inc | 399,099 | $4.12M | 0.00% | −93,856−19.0% | Reduced |
| BNP Paribas Arbitrage, SA | 392,732 | $4.05M | 0.01% | +383,908+4,350.7% | Added |
| Citigroup Inc | 389,026 | $4.01M | 0.00% | +52,961+15.8% | Added |
| Macquarie Group Ltd | 382,041 | $3.94M | 0.00% | +982+0.3% | Added |
| Hennion & Walsh Asset Management, Inc. | 375,798 | $3.88M | 0.21% | +108,830+40.8% | Added |
| Susquehanna International Group, LLP | 323,105 | $3.33M | 0.00% | +17,647+5.8% | Added |
| UBS Group AG | 293,535 | $3.03M | 0.00% | +147,514+101.0% | Added |
| Bank of New York Mellon Corp | 289,056 | $2.98M | 0.00% | −30,702−9.6% | Reduced |
| Rafferty Asset Management, LLC | 252,764 | $2.61M | 0.02% | −17,899−6.6% | Reduced |
| Bank of America Corp | 235,428 | $2.43M | 0.00% | +10,145+4.5% | Added |
| Birchview Capital, LP | 230,000 | $2.37M | 1.42% | 00.0% | Unchanged |
| Deutsche Bank AG | 226,743 | $2.34M | 0.00% | −61,810−21.4% | Reduced |
| Mutual of America Capital Management LLC | 218,516 | $2.25M | 0.02% | +90,273+70.4% | Added |
| Citadel Advisors LLC | 211,094 | $2.18M | 0.00% | −611,422−74.3% | Reduced |
| Barclays PLC | 198,775 | $2.05M | 0.00% | −75,599−27.6% | Reduced |
| Parametric Portfolio Associates LLC | 172,474 | $1.78M | 0.00% | +84,363+95.7% | Added |
| Integral Health Asset Management, LLC | 150,000 | $1.55M | 0.43% | +100,000+200.0% | Added |
| Jennison Associates LLC | 134,230 | $1.39M | 0.00% | +47,849+55.4% | Added |
| Swiss National Bank | 131,650 | $1.36M | 0.00% | +13,900+11.8% | Added |
| Rhumbline Advisers | 125,687 | $1.30M | 0.00% | +4,760+3.9% | Added |
| Allianz Asset Management GmbH | 117,934 | $1.22M | 0.00% | −57,855−32.9% | Reduced |
| Alliancebernstein L.P. | 115,830 | $1.20M | 0.00% | −13,900−10.7% | Reduced |
| Millennium Management LLC | 115,013 | $1.19M | 0.00% | −624,701−84.5% | Reduced |
| California State Teachers Retirement System | 99,284 | $1.02M | 0.00% | −6,450−6.1% | Reduced |
| State of Wisconsin Investment Board | 95,400 | $985.0K | 0.00% | 00.0% | Unchanged |
| UBS Asset Management Americas Inc | 84,393 | $870.9K | 0.00% | +28,768+51.7% | Added |
| Credit Suisse AG | 83,964 | $866.0K | 0.00% | −5,901−6.6% | Reduced |
| Susquehanna Fundamental Investments, LLC | 81,726 | $843.0K | 0.02% | +63,144+339.8% | Added |
| AlphaCentric Advisors LLC | 81,500 | $841.0K | 0.23% | +29,500+56.7% | Added |
| Jacobs Levy Equity Management, Inc | 81,257 | $839.0K | 0.01% | +81,257 | New |
| Tudor Investment Corp Et Al | 80,772 | $834.0K | 0.02% | −2,600−3.1% | Reduced |
| Jump Financial, LLC | 70,285 | $725.0K | 0.07% | +7,785+12.5% | Added |
| Laurion Capital Management LP | 60,786 | $627.0K | 0.01% | −919,678−93.8% | Reduced |
| M&G Investment Management Ltd | 62,183 | $622.0K | 0.00% | +62,183 | New |
| New York State Common Retirement Fund | 59,300 | $612.0K | 0.00% | −15,575−20.8% | Reduced |
| Russell Investments Group, Ltd. | 52,669 | $542.0K | 0.00% | +9,244+21.3% | Added |
| Balyasny Asset Management LLC | 49,649 | $512.0K | 0.00% | −241,538−82.9% | Reduced |
| Virtus ETF Advisers LLC | 48,428 | $500.0K | 0.21% | +8,241+20.5% | Added |
| Cubist Systematic Strategies, LLC | 47,013 | $485.0K | 0.01% | +17,031+56.8% | Added |
| American International Group, Inc. | 40,342 | $416.0K | 0.00% | −973−2.4% | Reduced |
| Manufacturers Life Insurance Company, The | 40,167 | $415.0K | 0.00% | −665−1.6% | Reduced |
| Algert Global LLC | 36,320 | $375.0K | 0.13% | +36,320 | New |
| DekaBank Deutsche Girozentrale | 36,200 | $364.0K | 0.00% | 00.0% | Unchanged |
| Squarepoint Ops LLC | 34,409 | $355.0K | 0.00% | +34,409 | New |
| Spearhead Capital Advisors, LLC | 34,029 | $351.0K | 0.05% | +7,006+25.9% | Added |
| Weiss Multi-Strategy Advisers LLC | 33,337 | $344.0K | 0.01% | +1,194+3.7% | Added |
| State Board of Administration of Florida Retirement System | 33,171 | $342.0K | 0.00% | +6,825+25.9% | Added |
| ProShare Advisors LLC | 32,172 | $332.0K | 0.00% | +2,904+9.9% | Added |
| Wells Fargo & Company | 30,656 | $316.0K | 0.00% | −73,922−70.7% | Reduced |
| SEI Investments Co | 30,807 | $314.0K | 0.00% | −2,492−7.5% | Reduced |
| Vontobel Holding Ltd. | 30,000 | $310.0K | 0.00% | 00.0% | Unchanged |
| Voya Investment Management LLC | 29,450 | $304.0K | 0.00% | −2,400−7.5% | Reduced |
| Gsa Capital Partners LLP | 29,138 | $301.0K | 0.03% | −1,454−4.8% | Reduced |
| Principal Financial Group Inc | 28,742 | $297.0K | 0.00% | −3,211−10.0% | Reduced |
| Invesco Ltd. | 28,606 | $295.0K | 0.00% | +10,426+57.3% | Added |
| ExodusPoint Capital Management, LP | 27,120 | $280.0K | 0.00% | +1,209+4.7% | Added |
| Jane Street Group, LLC | 26,942 | $278.0K | 0.00% | −46,383−63.3% | Reduced |
| Trexquant Investment LP | 24,542 | $253.0K | 0.02% | −9,609−28.1% | Reduced |
| Dimensional Fund Advisors LP | 24,084 | $249.0K | 0.00% | −122,519−83.6% | Reduced |
| MetLife Investment Management | 23,713 | $244.7K | 0.00% | 00.0% | Unchanged |
| Virginia Retirement Systems Et Al | 23,500 | $243.0K | 0.00% | +23,500 | New |
| Boothbay Fund Management, LLC | 23,067 | $238.0K | 0.01% | +23,067 | New |
| First Republic Investment Management, Inc. | 22,451 | $232.0K | 0.00% | +4,800+27.2% | Added |
| Metropolitan Life Insurance Co | 22,247 | $229.6K | 0.00% | +2,881+14.9% | Added |
| Golden State Equity Partners | 22,103 | $228.0K | 0.09% | +11,406+106.6% | Added |
| Symons Capital Management Inc | 21,766 | $225.0K | 0.13% | −112−0.5% | Reduced |
| Royal Bank of Canada | 21,700 | $224.0K | 0.00% | +10,356+91.3% | Added |
| Prelude Capital Management, LLC | 21,000 | $217.0K | 0.01% | 00.0% | Unchanged |
| Centiva Capital, LP | 20,405 | $211.0K | 0.02% | +20,405 | New |
| Moors & Cabot, Inc. | 18,650 | $192.0K | 0.01% | −300−1.6% | Reduced |
| Renaissance Technologies LLC | 18,472 | $191.0K | 0.00% | +18,472 | New |
| Legal & General Group Plc | 18,334 | $190.0K | 0.00% | −829−4.3% | Reduced |
| Virtu Financial LLC | 18,229 | $188.0K | 0.02% | −28,825−61.3% | Reduced |
| Baird Financial Group, Inc. | 16,966 | $175.0K | 0.00% | +1,348+8.6% | Added |