Karyopharm Therapeutics Inc.
KPTI- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001503802
In the last 90 days, Karyopharm Therapeutics Inc. insiders filed 0 open-market purchases and 2 sales; 96 institutions reported holding it in 13F filings for Q2 2026, worth $206.8M in total; no superinvestor holds it.
13F holders, Q2 2021
Institutional positions in Karyopharm Therapeutics Inc. as of Jun 30, 2021. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 154
- −16 vs. Q1 2021
- Shares held
- 59.0M
- −1.17M (−1.9%) vs. Q1 2021
- Total value
- $608.7M
- −$28.3M (−4.4%) vs. Q1 2021
- New holders
- 21
- 54 more added
- Sold out
- 37
- 57 more reduced
1 institution that held it in Q1 2021 haven't filed for Q2 2021 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2021: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting KPTI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 96 | $206.8M |
| Q1 2026 | 77 | $98.4M |
| Q4 2025 | 68 | $69.6M |
| Q3 2025 | 52 | $19.5M |
| Q2 2025 | 50 | $19.0M |
| Q1 2025 | 50 | $13.7M |
| Q4 2024 | 87 | $41.2M |
| Q3 2024 | 91 | $49.2M |
| Q2 2024 | 114 | $58.6M |
| Q1 2024 | 114 | $113.0M |
| Q4 2023 | 120 | $63.5M |
| Q3 2023 | 120 | $102.8M |
| Q2 2023 | 138 | $145.0M |
| Q1 2023 | 132 | $340.1M |
| Q4 2022 | 155 | $334.4M |
| Q3 2022 | 147 | $364.1M |
| Q2 2022 | 150 | $302.8M |
| Q1 2022 | 139 | $501.8M |
| Q4 2021 | 143 | $347.5M |
| Q3 2021 | 134 | $334.4M |
| Q2 2021 | 154 | $608.7M |
| Q1 2021 | 171 | $637.1M |
Institutions, Q2 2021
Shares, value and share of portfolio for each institution holding Karyopharm Therapeutics Inc.; share changes are against Q1 2021.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| FMR LLC | 2 | $0 | 0.00% | −79,208−100.0% | Reduced |
| Quadrant Capital Group LLC | 25 | $0 | 0.00% | +25 | New |
| Kelly Financial Services LLC | 2,580 | $250 | 0.01% | +2,330+932.0% | Added |
| Allworth Financial LP | 100 | $1.00K | 0.00% | −330−76.7% | Reduced |
| Daiwa Securities Group Inc. | 138 | $1.00K | 0.00% | 00.0% | Unchanged |
| Gemmer Asset Management LLC | 140 | $1.00K | 0.00% | 00.0% | Unchanged |
| Cypress Capital Management LLC (WY) | 50 | $1.00K | 0.00% | 00.0% | Unchanged |
| Simplex Trading, LLC | 284 | $2.00K | 0.00% | −2,826−90.9% | Reduced |
| TCI Wealth Advisors, Inc. | 298 | $3.00K | 0.00% | +298 | New |
| Trust Co of Vermont | 400 | $4.00K | 0.00% | −1,000−71.4% | Reduced |
| Bank of Montreal | 536 | $6.00K | 0.00% | −1,498−73.6% | Reduced |
| Sargent Bickham Lagudis LLC | 606 | $6.00K | 0.00% | 00.0% | Unchanged |
| Lindbrook Capital, LLC | 575 | $6.00K | 0.00% | +575 | New |
| Glen Eagle Advisors, LLC | 700 | $7.22K | 0.00% | −110−13.6% | Reduced |
| Nisa Investment Advisors, LLC | 800 | $8.00K | 0.00% | −3,250−80.2% | Reduced |
| AdvisorNet Financial, Inc | 800 | $8.00K | 0.00% | 00.0% | Unchanged |
| O'Shaughnessy Asset Management, LLC | 753 | $8.00K | 0.00% | 00.0% | Unchanged |
| Advisory Services Network, LLC | 900 | $9.00K | 0.00% | +900 | New |
| Private Capital Group, LLC | 1,000 | $10.0K | 0.00% | 00.0% | Unchanged |
| Founders Capital Management | 1,000 | $10.0K | 0.01% | +1,000 | New |
| American Portfolios Advisors | 1,000 | $10.3K | 0.00% | +1,000 | New |
| US Bancorp | 1,171 | $12.0K | 0.00% | +994+561.6% | Added |
| Thomas J. Herzfeld Advisors, Inc. | 1,500 | $15.0K | 0.01% | 00.0% | Unchanged |
| Signaturefd, LLC | 1,551 | $16.0K | 0.00% | +97+6.7% | Added |
| Penserra Capital Management LLC | 1,710 | $17.0K | 0.00% | +15+0.9% | Added |
| Tortoise Investment Management, LLC | 2,200 | $23.0K | 0.00% | 00.0% | Unchanged |
| Harbour Investments, Inc. | 2,505 | $26.0K | 0.00% | −2,600−50.9% | Reduced |
| Great West Life Assurance Co | 3,017 | $31.0K | 0.00% | 00.0% | Unchanged |
| Tarbox Family Office, Inc. | 3,000 | $31.0K | 0.01% | +3,000 | New |
| Rockefeller Capital Management L.P. | 3,400 | $35.0K | 0.00% | 00.0% | Unchanged |
| Patriot Financial Group Insurance Agency, LLC | 3,400 | $35.0K | 0.01% | +1,200+54.5% | Added |
| The PNC Financial Services Group, Inc. | 3,800 | $39.0K | 0.00% | −13,210−77.7% | Reduced |
| Captrust Financial Advisors | 4,436 | $46.0K | 0.00% | +936+26.7% | Added |
| Group One Trading, L.P. | 4,783 | $49.0K | 0.00% | −48,466−91.0% | Reduced |
| Tower Research Capital LLC (TRC) | 5,377 | $55.0K | 0.00% | −24,655−82.1% | Reduced |
| Atlas Private Wealth Advisors | 5,500 | $57.0K | 0.03% | −8,280−60.1% | Reduced |
| Lazard Asset Management LLC | 5,726 | $59.0K | 0.00% | −1,730−23.2% | Reduced |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 5,977 | $62.0K | 0.00% | 00.0% | Unchanged |
| Ameritas Investment Partners, Inc. | 6,194 | $64.0K | 0.00% | 00.0% | Unchanged |
| Altshuler Shaham Ltd | 9,739 | $101.0K | 0.00% | +9,739 | New |
| First Mercantile Trust Co | 9,852 | $102.0K | 0.01% | −6,244−38.8% | Reduced |
| Handelsbanken Fonder AB | 10,400 | $107.0K | 0.00% | −3,000−22.4% | Reduced |
| Cambridge Investment Research Advisors, Inc. | 10,431 | $108.0K | 0.00% | +10,431 | New |
| LPL Financial LLC | 10,558 | $109.0K | 0.00% | +10,558 | New |
| Silvant Capital Management LLC | 11,386 | $118.0K | 0.02% | 00.0% | Unchanged |
| Altfest L J & Co Inc | 12,374 | $128.0K | 0.03% | +161+1.3% | Added |
| Advisor Group Holdings, Inc. | 12,705 | $131.0K | 0.00% | −546−4.1% | Reduced |
| Parametrica Management Ltd | 13,466 | $139.0K | 0.10% | −79,422−85.5% | Reduced |
| Amalgamated Bank | 13,596 | $140.0K | 0.00% | +3,522+35.0% | Added |
| ACT Capital Management, LLC | 14,000 | $145.0K | 0.07% | +14,000 | New |
| State of Wyoming | 14,403 | $149.0K | 0.09% | +14,403 | New |
| Engineers Gate Manager LP | 14,980 | $155.0K | 0.01% | −53,332−78.1% | Reduced |
| Creative Planning | 16,100 | $166.0K | 0.00% | −18,692−53.7% | Reduced |
| Arizona State Retirement System | 16,230 | $167.0K | 0.00% | +1,232+8.2% | Added |
| Baird Financial Group, Inc. | 16,966 | $175.0K | 0.00% | +1,348+8.6% | Added |
| Virtu Financial LLC | 18,229 | $188.0K | 0.02% | −28,825−61.3% | Reduced |
| Legal & General Group Plc | 18,334 | $190.0K | 0.00% | −829−4.3% | Reduced |
| Renaissance Technologies LLC | 18,472 | $191.0K | 0.00% | +18,472 | New |
| Moors & Cabot, Inc. | 18,650 | $192.0K | 0.01% | −300−1.6% | Reduced |
| Centiva Capital, LP | 20,405 | $211.0K | 0.02% | +20,405 | New |
| Prelude Capital Management, LLC | 21,000 | $217.0K | 0.01% | 00.0% | Unchanged |
| Royal Bank of Canada | 21,700 | $224.0K | 0.00% | +10,356+91.3% | Added |
| Symons Capital Management Inc | 21,766 | $225.0K | 0.13% | −112−0.5% | Reduced |
| Golden State Equity Partners | 22,103 | $228.0K | 0.09% | +11,406+106.6% | Added |
| Metropolitan Life Insurance Co | 22,247 | $229.6K | 0.00% | +2,881+14.9% | Added |
| First Republic Investment Management, Inc. | 22,451 | $232.0K | 0.00% | +4,800+27.2% | Added |
| Boothbay Fund Management, LLC | 23,067 | $238.0K | 0.01% | +23,067 | New |
| Virginia Retirement Systems Et Al | 23,500 | $243.0K | 0.00% | +23,500 | New |
| MetLife Investment Management | 23,713 | $244.7K | 0.00% | 00.0% | Unchanged |
| Dimensional Fund Advisors LP | 24,084 | $249.0K | 0.00% | −122,519−83.6% | Reduced |
| Trexquant Investment LP | 24,542 | $253.0K | 0.02% | −9,609−28.1% | Reduced |
| Jane Street Group, LLC | 26,942 | $278.0K | 0.00% | −46,383−63.3% | Reduced |
| ExodusPoint Capital Management, LP | 27,120 | $280.0K | 0.00% | +1,209+4.7% | Added |
| Invesco Ltd. | 28,606 | $295.0K | 0.00% | +10,426+57.3% | Added |
| Principal Financial Group Inc | 28,742 | $297.0K | 0.00% | −3,211−10.0% | Reduced |
| Gsa Capital Partners LLP | 29,138 | $301.0K | 0.03% | −1,454−4.8% | Reduced |
| Voya Investment Management LLC | 29,450 | $304.0K | 0.00% | −2,400−7.5% | Reduced |
| Vontobel Holding Ltd. | 30,000 | $310.0K | 0.00% | 00.0% | Unchanged |
| SEI Investments Co | 30,807 | $314.0K | 0.00% | −2,492−7.5% | Reduced |
| Wells Fargo & Company | 30,656 | $316.0K | 0.00% | −73,922−70.7% | Reduced |
| ProShare Advisors LLC | 32,172 | $332.0K | 0.00% | +2,904+9.9% | Added |
| State Board of Administration of Florida Retirement System | 33,171 | $342.0K | 0.00% | +6,825+25.9% | Added |
| Weiss Multi-Strategy Advisers LLC | 33,337 | $344.0K | 0.01% | +1,194+3.7% | Added |
| Spearhead Capital Advisors, LLC | 34,029 | $351.0K | 0.05% | +7,006+25.9% | Added |
| Squarepoint Ops LLC | 34,409 | $355.0K | 0.00% | +34,409 | New |
| DekaBank Deutsche Girozentrale | 36,200 | $364.0K | 0.00% | 00.0% | Unchanged |
| Algert Global LLC | 36,320 | $375.0K | 0.13% | +36,320 | New |
| Manufacturers Life Insurance Company, The | 40,167 | $415.0K | 0.00% | −665−1.6% | Reduced |
| American International Group, Inc. | 40,342 | $416.0K | 0.00% | −973−2.4% | Reduced |
| Cubist Systematic Strategies, LLC | 47,013 | $485.0K | 0.01% | +17,031+56.8% | Added |
| Virtus ETF Advisers LLC | 48,428 | $500.0K | 0.21% | +8,241+20.5% | Added |
| Balyasny Asset Management LLC | 49,649 | $512.0K | 0.00% | −241,538−82.9% | Reduced |
| Russell Investments Group, Ltd. | 52,669 | $542.0K | 0.00% | +9,244+21.3% | Added |
| New York State Common Retirement Fund | 59,300 | $612.0K | 0.00% | −15,575−20.8% | Reduced |
| M&G Investment Management Ltd | 62,183 | $622.0K | 0.00% | +62,183 | New |
| Laurion Capital Management LP | 60,786 | $627.0K | 0.01% | −919,678−93.8% | Reduced |
| Jump Financial, LLC | 70,285 | $725.0K | 0.07% | +7,785+12.5% | Added |
| Tudor Investment Corp Et Al | 80,772 | $834.0K | 0.02% | −2,600−3.1% | Reduced |
| Jacobs Levy Equity Management, Inc | 81,257 | $839.0K | 0.01% | +81,257 | New |
| AlphaCentric Advisors LLC | 81,500 | $841.0K | 0.23% | +29,500+56.7% | Added |