Karyopharm Therapeutics Inc.
KPTI- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001503802
In the last 90 days, Karyopharm Therapeutics Inc. insiders filed 0 open-market purchases and 2 sales; 96 institutions reported holding it in 13F filings for Q2 2026, worth $206.8M in total; no superinvestor holds it.
13F holders, Q1 2022
Institutional positions in Karyopharm Therapeutics Inc. as of Mar 31, 2022. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 139
- −2 vs. Q4 2021
- Shares held
- 68.3M
- +14.3M (+26.4%) vs. Q4 2021
- Total value
- $501.8M
- +$155.2M (+44.8%) vs. Q4 2021
- New holders
- 26
- 43 more added
- Sold out
- 28
- 46 more reduced
2 institutions that held it in Q4 2021 haven't filed for Q1 2022 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2021: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting KPTI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 96 | $206.8M |
| Q1 2026 | 77 | $98.4M |
| Q4 2025 | 68 | $69.6M |
| Q3 2025 | 52 | $19.5M |
| Q2 2025 | 50 | $19.0M |
| Q1 2025 | 50 | $13.7M |
| Q4 2024 | 87 | $41.2M |
| Q3 2024 | 91 | $49.2M |
| Q2 2024 | 114 | $58.6M |
| Q1 2024 | 114 | $113.0M |
| Q4 2023 | 120 | $63.5M |
| Q3 2023 | 120 | $102.8M |
| Q2 2023 | 138 | $145.0M |
| Q1 2023 | 132 | $340.1M |
| Q4 2022 | 155 | $334.4M |
| Q3 2022 | 147 | $364.1M |
| Q2 2022 | 150 | $302.8M |
| Q1 2022 | 139 | $501.8M |
| Q4 2021 | 143 | $347.5M |
| Q3 2021 | 134 | $334.4M |
| Q2 2021 | 154 | $608.7M |
| Q1 2021 | 171 | $637.1M |
Institutions, Q1 2022
Shares, value and share of portfolio for each institution holding Karyopharm Therapeutics Inc.; share changes are against Q4 2021.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| State Street Corp | 10,966,701 | $80.8M | 0.00% | +5,453,021+98.9% | Added |
| BlackRock Inc. | 7,927,618 | $58.4M | 0.00% | −990,588−11.1% | Reduced |
| Palo Alto Investors LP | 5,621,533 | $41.4M | 3.20% | +151,081+2.8% | Added |
| Vanguard Group Inc | 3,960,708 | $29.2M | 0.00% | +601,901+17.9% | Added |
| Rubric Capital Management LP | 3,607,443 | $26.6M | 1.24% | +825,000+29.7% | Added |
| Commodore Capital LP | 3,561,052 | $26.2M | 5.86% | +3,561,052 | New |
| Morgan Stanley | 2,812,563 | $20.7M | 0.00% | +1,746,944+163.9% | Added |
| Iron Triangle Partners LP | 2,000,000 | $14.7M | 1.75% | +2,000,000 | New |
| Nuveen Asset Management, LLC | 1,819,048 | $11.9M | 0.00% | +634,738+53.6% | Added |
| C WorldWide Group Holding A/S | 1,500,000 | $11.1M | 0.12% | 00.0% | Unchanged |
| Rice Hall James & Associates, LLC | 1,344,929 | $9.91M | 0.39% | +68,295+5.3% | Added |
| Geode Capital Management, LLC | 1,337,888 | $9.86M | 0.00% | −104,843−7.3% | Reduced |
| Candriam Luxembourg S.C.A. | 1,335,026 | $9.84M | 0.07% | +457,358+52.1% | Added |
| Frontier Capital Management Co LLC | 1,279,295 | $9.43M | 0.09% | −406,110−24.1% | Reduced |
| Millennium Management LLC | 1,252,873 | $9.23M | 0.01% | −267,351−17.6% | Reduced |
| Two Sigma Investments, LP | 1,117,925 | $8.24M | 0.02% | +128,894+13.0% | Added |
| Bank of America Corp | 1,116,230 | $8.23M | 0.00% | +861,362+338.0% | Added |
| Goldman Sachs Group Inc | 898,906 | $6.63M | 0.00% | −129,976−12.6% | Reduced |
| Citadel Advisors LLC | 854,517 | $6.30M | 0.01% | +625,634+273.3% | Added |
| Rafferty Asset Management, LLC | 808,939 | $5.96M | 0.04% | +428,371+112.6% | Added |
| Lombard Odier Asset Management (Switzerland) SA | 776,053 | $5.72M | 0.45% | −881,994−53.2% | Reduced |
| Two Sigma Advisers, LP | 775,300 | $5.71M | 0.02% | +347,700+81.3% | Added |
| Northern Trust Corp | 764,335 | $5.63M | 0.00% | −11,216−1.4% | Reduced |
| JPMorgan Chase & Co | 718,640 | $5.30M | 0.00% | −24,760−3.3% | Reduced |
| Voloridge Investment Management, LLC | 676,834 | $4.99M | 0.03% | +479,443+242.9% | Added |
| Jacobs Levy Equity Management, Inc | 663,512 | $4.89M | 0.03% | +663,512 | New |
| Altium Capital Management LP | 645,000 | $4.75M | 1.66% | +645,000 | New |
| Deutsche Bank AG | 599,436 | $4.42M | 0.00% | +551,470+1,149.7% | Added |
| UBS Group AG | 518,460 | $3.82M | 0.00% | +251,465+94.2% | Added |
| Acadian Asset Management LLC | 498,922 | $3.67M | 0.02% | +498,922 | New |
| Jane Street Group, LLC | 416,843 | $3.07M | 0.01% | +209,700+101.2% | Added |
| Hennion & Walsh Asset Management, Inc. | 385,837 | $2.84M | 0.15% | −7,855−2.0% | Reduced |
| Macquarie Group Ltd | 382,041 | $2.82M | 0.00% | 00.0% | Unchanged |
| Balyasny Asset Management LLC | 342,484 | $2.52M | 0.01% | +342,484 | New |
| Bank of New York Mellon Corp | 296,900 | $2.19M | 0.00% | −641−0.2% | Reduced |
| Susquehanna International Group, LLP | 281,129 | $2.07M | 0.00% | −321,697−53.4% | Reduced |
| Birchview Capital, LP | 269,332 | $1.99M | 1.43% | +23,332+9.5% | Added |
| Parametric Portfolio Associates LLC | 256,291 | $1.89M | 0.00% | −21,228−7.6% | Reduced |
| Renaissance Technologies LLC | 215,100 | $1.58M | 0.00% | +129,200+150.4% | Added |
| Victory Capital Management Inc | 197,570 | $1.46M | 0.00% | +197,570 | New |
| Wellington Management Group LLP | 196,342 | $1.45M | 0.00% | −5,208−2.6% | Reduced |
| Charles Schwab Investment Management Inc | 194,197 | $1.43M | 0.00% | +6,048+3.2% | Added |
| Allianz Asset Management GmbH | 163,985 | $1.21M | 0.00% | −23,116−12.4% | Reduced |
| Cubist Systematic Strategies, LLC | 161,483 | $1.19M | 0.01% | −402,047−71.3% | Reduced |
| Swiss National Bank | 160,750 | $1.19M | 0.00% | +11,300+7.6% | Added |
| Credit Suisse AG | 138,158 | $1.02M | 0.00% | +76,015+122.3% | Added |
| Citigroup Inc | 127,780 | $942.0K | 0.00% | −176,318−58.0% | Reduced |
| Alliancebernstein L.P. | 116,030 | $855.0K | 0.00% | +200+0.2% | Added |
| FMR LLC | 113,972 | $840.0K | 0.00% | +113,972 | New |
| State of Wisconsin Investment Board | 95,800 | $706.0K | 0.00% | 00.0% | Unchanged |
| California State Teachers Retirement System | 89,741 | $661.0K | 0.00% | −6,957−7.2% | Reduced |
| Barclays PLC | 87,724 | $646.0K | 0.00% | −94,028−51.7% | Reduced |
| Walleye Capital LLC | 83,078 | $612.0K | 0.02% | +69,175+497.6% | Added |
| Rhumbline Advisers | 79,123 | $583.0K | 0.00% | −15,587−16.5% | Reduced |
| Susquehanna Fundamental Investments, LLC | 62,544 | $461.0K | 0.01% | 00.0% | Unchanged |
| UBS Asset Management Americas Inc | 62,120 | $457.8K | 0.00% | −29,601−32.3% | Reduced |
| Russell Investments Group, Ltd. | 60,746 | $447.0K | 0.00% | +60,041+8,516.5% | Added |
| ClariVest Asset Management LLC | 59,600 | $440.0K | 0.02% | +59,600 | New |
| IndexIQ Advisors LLC | 53,438 | $394.0K | 0.01% | +53,438 | New |
| Quantbot Technologies LP | 53,300 | $392.0K | 0.03% | +47,200+773.8% | Added |
| State Board of Administration of Florida Retirement System | 53,075 | $391.0K | 0.00% | 00.0% | Unchanged |
| New York State Common Retirement Fund | 52,425 | $386.0K | 0.00% | +9,831+23.1% | Added |
| Allspring Global Investments Holdings, LLC | 48,718 | $359.0K | 0.00% | +10,174+26.4% | Added |
| Capital Fund Management S.A. | 44,154 | $325.4K | 0.01% | +44,154 | New |
| Ensign Peak Advisors, Inc | 43,380 | $320.0K | 0.00% | 00.0% | Unchanged |
| Golden State Equity Partners | 41,850 | $308.0K | 0.16% | 00.0% | Unchanged |
| MetLife Investment Management | 41,772 | $307.9K | 0.00% | +14,765+54.7% | Added |
| GFG Capital, LLC | 41,400 | $305.0K | 0.09% | 00.0% | Unchanged |
| Wells Fargo & Company | 40,876 | $302.0K | 0.00% | −24,992−37.9% | Reduced |
| E Fund Management Co., Ltd. | 40,582 | $299.0K | 0.01% | +28,191+227.5% | Added |
| American International Group, Inc. | 35,745 | $263.0K | 0.00% | −2,517−6.6% | Reduced |
| D. E. Shaw & Co., Inc. | 34,113 | $251.0K | 0.00% | −141,938−80.6% | Reduced |
| Legal & General Group Plc | 31,845 | $234.0K | 0.00% | 00.0% | Unchanged |
| Invesco Ltd. | 31,546 | $232.0K | 0.00% | −22−0.1% | Reduced |
| Voya Investment Management LLC | 30,763 | $227.0K | 0.00% | +1,897+6.6% | Added |
| PDT Partners, LLC | 30,778 | $227.0K | 0.02% | +30,778 | New |
| Manufacturers Life Insurance Company, The | 29,498 | $217.4K | 0.00% | −8,803−23.0% | Reduced |
| Trexquant Investment LP | 29,108 | $215.0K | 0.01% | −191,767−86.8% | Reduced |
| Weiss Multi-Strategy Advisers LLC | 27,878 | $205.0K | 0.00% | −2,005−6.7% | Reduced |
| AQR Capital Management LLC | 27,830 | $205.0K | 0.00% | +27,830 | New |
| Walleye Trading LLC | 26,482 | $195.0K | 0.00% | +17,384+191.1% | Added |
| Price T Rowe Associates Inc | 26,298 | $194.0K | 0.00% | +5,886+28.8% | Added |
| Lazard Asset Management LLC | 24,729 | $182.0K | 0.00% | −6,814−21.6% | Reduced |
| Dimensional Fund Advisors LP | 23,570 | $174.0K | 0.00% | 00.0% | Unchanged |
| CSS LLC | 23,428 | $173.0K | 0.01% | +23,428 | New |
| DuPont Capital Management Corp | 22,727 | $167.0K | 0.01% | −29,675−56.6% | Reduced |
| Blueshift Asset Management, LLC | 22,229 | $164.0K | 0.01% | +22,229 | New |
| Moors & Cabot, Inc. | 21,550 | $159.0K | 0.01% | 00.0% | Unchanged |
| ProShare Advisors LLC | 21,299 | $158.0K | 0.00% | −5,072−19.2% | Reduced |
| ExodusPoint Capital Management, LP | 19,487 | $144.0K | 0.00% | −89,409−82.1% | Reduced |
| Los Angeles Capital Management LLC | 18,680 | $138.0K | 0.00% | +18,680 | New |
| Arizona State Retirement System | 18,379 | $135.0K | 0.00% | +91+0.5% | Added |
| Baird Financial Group, Inc. | 17,037 | $126.0K | 0.00% | −2,780−14.0% | Reduced |
| Royal Bank of Canada | 16,567 | $123.0K | 0.00% | −14,510−46.7% | Reduced |
| Man Group plc | 15,266 | $113.0K | 0.00% | +15,266 | New |
| State of Wyoming | 15,116 | $111.0K | 0.06% | +689+4.8% | Added |
| XTX Topco Ltd | 14,429 | $106.0K | 0.05% | +1,378+10.6% | Added |
| Teacher Retirement System of Texas | 13,977 | $103.0K | 0.00% | +870+6.6% | Added |
| Creative Planning | 13,100 | $97.0K | 0.00% | 00.0% | Unchanged |
| Principal Financial Group Inc | 13,104 | $97.0K | 0.00% | +932+7.7% | Added |