Karyopharm Therapeutics Inc.
KPTI- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001503802
In the last 90 days, Karyopharm Therapeutics Inc. insiders filed 0 open-market purchases and 2 sales; 96 institutions reported holding it in 13F filings for Q2 2026, worth $206.8M in total; no superinvestor holds it.
13F holders, Q1 2022
Institutional positions in Karyopharm Therapeutics Inc. as of Mar 31, 2022. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 139
- −2 vs. Q4 2021
- Shares held
- 68.3M
- +14.3M (+26.4%) vs. Q4 2021
- Total value
- $501.8M
- +$155.2M (+44.8%) vs. Q4 2021
- New holders
- 26
- 43 more added
- Sold out
- 28
- 46 more reduced
2 institutions that held it in Q4 2021 haven't filed for Q1 2022 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2021: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting KPTI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 96 | $206.8M |
| Q1 2026 | 77 | $98.4M |
| Q4 2025 | 68 | $69.6M |
| Q3 2025 | 52 | $19.5M |
| Q2 2025 | 50 | $19.0M |
| Q1 2025 | 50 | $13.7M |
| Q4 2024 | 87 | $41.2M |
| Q3 2024 | 91 | $49.2M |
| Q2 2024 | 114 | $58.6M |
| Q1 2024 | 114 | $113.0M |
| Q4 2023 | 120 | $63.5M |
| Q3 2023 | 120 | $102.8M |
| Q2 2023 | 138 | $145.0M |
| Q1 2023 | 132 | $340.1M |
| Q4 2022 | 155 | $334.4M |
| Q3 2022 | 147 | $364.1M |
| Q2 2022 | 150 | $302.8M |
| Q1 2022 | 139 | $501.8M |
| Q4 2021 | 143 | $347.5M |
| Q3 2021 | 134 | $334.4M |
| Q2 2021 | 154 | $608.7M |
| Q1 2021 | 171 | $637.1M |
Institutions, Q1 2022
Shares, value and share of portfolio for each institution holding Karyopharm Therapeutics Inc.; share changes are against Q4 2021.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Ellevest, Inc. | 27 | $0 | 0.00% | +27 | New |
| Quent Capital, LLC | 30 | $0 | 0.00% | +30 | New |
| American Portfolios Advisors | 83 | $612 | 0.00% | −917−91.7% | Reduced |
| Jefferies Group LLC | 100 | $737 | 0.00% | +100 | New |
| Quadrant Capital Group LLC | 90 | $1.00K | 0.00% | −346−79.4% | Reduced |
| Daiwa Securities Group Inc. | 138 | $1.00K | 0.00% | 00.0% | Unchanged |
| Allworth Financial LP | 100 | $1.00K | 0.00% | 00.0% | Unchanged |
| Kelly Financial Services LLC | 250 | $1.84K | 0.00% | 00.0% | Unchanged |
| Point72 Hong Kong Ltd | 471 | $3.00K | 0.00% | −787−62.6% | Reduced |
| AdvisorNet Financial, Inc | 700 | $5.00K | 0.00% | 00.0% | Unchanged |
| Nisa Investment Advisors, LLC | 800 | $6.00K | 0.00% | 00.0% | Unchanged |
| Ikarian Capital, LLC | 830 | $6.00K | 0.00% | +45+5.7% | Added |
| Money Concepts Capital Corp | 870 | $6.00K | 0.00% | +870 | New |
| Captrust Financial Advisors | 1,000 | $7.00K | 0.00% | 00.0% | Unchanged |
| Future Financial Wealth Managment LLC | 900 | $7.00K | 0.01% | 00.0% | Unchanged |
| Signaturefd, LLC | 1,076 | $8.00K | 0.00% | −692−39.1% | Reduced |
| TD Waterhouse Canada Inc. | 1,060 | $8.54K | 0.00% | 00.0% | Unchanged |
| Founders Capital Management | 3,000 | $19.0K | 0.01% | 00.0% | Unchanged |
| Great West Life Assurance Co | 3,017 | $24.0K | 0.00% | 00.0% | Unchanged |
| US Bancorp | 3,229 | $24.0K | 0.00% | +471+17.1% | Added |
| Rockefeller Capital Management L.P. | 3,400 | $25.0K | 0.00% | −700−17.1% | Reduced |
| Advisor Group Holdings, Inc. | 3,642 | $27.0K | 0.00% | −1,490−29.0% | Reduced |
| The PNC Financial Services Group, Inc. | 3,800 | $28.0K | 0.00% | 00.0% | Unchanged |
| Metropolitan Life Insurance Co | 4,812 | $35.5K | 0.00% | −8,168−62.9% | Reduced |
| Banque Cantonale Vaudoise | 5,000 | $37.0K | 0.00% | +5,000 | New |
| Ameritas Investment Partners, Inc. | 6,194 | $46.0K | 0.00% | 00.0% | Unchanged |
| Tower Research Capital LLC (TRC) | 6,520 | $48.0K | 0.00% | −13,218−67.0% | Reduced |
| BNP Paribas Arbitrage, SA | 8,550 | $63.0K | 0.00% | −5,874−40.7% | Reduced |
| Running Point Capital Advisors, LLC | 10,000 | $74.0K | 0.04% | +10,000 | New |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 10,641 | $78.0K | 0.00% | +4,664+78.0% | Added |
| Amalgamated Bank | 11,722 | $86.0K | 0.00% | −990−7.8% | Reduced |
| Amalgamated Financial Corp. | 11,722 | $86.0K | 0.00% | +11,722 | New |
| Janus Henderson Group PLC | 12,163 | $90.0K | 0.00% | +10.0% | Added |
| Snowden Capital Advisors LLC | 12,293 | $90.0K | 0.00% | +8,200+200.3% | Added |
| American Trust | 12,388 | $91.0K | 0.01% | −166−1.3% | Reduced |
| First Republic Investment Management, Inc. | 12,833 | $95.0K | 0.00% | −3,851−23.1% | Reduced |
| BIT Capital GmbH | 13,000 | $95.8K | 0.01% | +13,000 | New |
| Commonwealth Equity Services, LLC | 13,090 | $96.0K | 0.00% | −600−4.4% | Reduced |
| Creative Planning | 13,100 | $97.0K | 0.00% | 00.0% | Unchanged |
| Principal Financial Group Inc | 13,104 | $97.0K | 0.00% | +932+7.7% | Added |
| Teacher Retirement System of Texas | 13,977 | $103.0K | 0.00% | +870+6.6% | Added |
| XTX Topco Ltd | 14,429 | $106.0K | 0.05% | +1,378+10.6% | Added |
| State of Wyoming | 15,116 | $111.0K | 0.06% | +689+4.8% | Added |
| Man Group plc | 15,266 | $113.0K | 0.00% | +15,266 | New |
| Royal Bank of Canada | 16,567 | $123.0K | 0.00% | −14,510−46.7% | Reduced |
| Baird Financial Group, Inc. | 17,037 | $126.0K | 0.00% | −2,780−14.0% | Reduced |
| Arizona State Retirement System | 18,379 | $135.0K | 0.00% | +91+0.5% | Added |
| Los Angeles Capital Management LLC | 18,680 | $138.0K | 0.00% | +18,680 | New |
| ExodusPoint Capital Management, LP | 19,487 | $144.0K | 0.00% | −89,409−82.1% | Reduced |
| ProShare Advisors LLC | 21,299 | $158.0K | 0.00% | −5,072−19.2% | Reduced |
| Moors & Cabot, Inc. | 21,550 | $159.0K | 0.01% | 00.0% | Unchanged |
| Blueshift Asset Management, LLC | 22,229 | $164.0K | 0.01% | +22,229 | New |
| DuPont Capital Management Corp | 22,727 | $167.0K | 0.01% | −29,675−56.6% | Reduced |
| CSS LLC | 23,428 | $173.0K | 0.01% | +23,428 | New |
| Dimensional Fund Advisors LP | 23,570 | $174.0K | 0.00% | 00.0% | Unchanged |
| Lazard Asset Management LLC | 24,729 | $182.0K | 0.00% | −6,814−21.6% | Reduced |
| Price T Rowe Associates Inc | 26,298 | $194.0K | 0.00% | +5,886+28.8% | Added |
| Walleye Trading LLC | 26,482 | $195.0K | 0.00% | +17,384+191.1% | Added |
| Weiss Multi-Strategy Advisers LLC | 27,878 | $205.0K | 0.00% | −2,005−6.7% | Reduced |
| AQR Capital Management LLC | 27,830 | $205.0K | 0.00% | +27,830 | New |
| Trexquant Investment LP | 29,108 | $215.0K | 0.01% | −191,767−86.8% | Reduced |
| Manufacturers Life Insurance Company, The | 29,498 | $217.4K | 0.00% | −8,803−23.0% | Reduced |
| Voya Investment Management LLC | 30,763 | $227.0K | 0.00% | +1,897+6.6% | Added |
| PDT Partners, LLC | 30,778 | $227.0K | 0.02% | +30,778 | New |
| Invesco Ltd. | 31,546 | $232.0K | 0.00% | −22−0.1% | Reduced |
| Legal & General Group Plc | 31,845 | $234.0K | 0.00% | 00.0% | Unchanged |
| D. E. Shaw & Co., Inc. | 34,113 | $251.0K | 0.00% | −141,938−80.6% | Reduced |
| American International Group, Inc. | 35,745 | $263.0K | 0.00% | −2,517−6.6% | Reduced |
| E Fund Management Co., Ltd. | 40,582 | $299.0K | 0.01% | +28,191+227.5% | Added |
| Wells Fargo & Company | 40,876 | $302.0K | 0.00% | −24,992−37.9% | Reduced |
| GFG Capital, LLC | 41,400 | $305.0K | 0.09% | 00.0% | Unchanged |
| MetLife Investment Management | 41,772 | $307.9K | 0.00% | +14,765+54.7% | Added |
| Golden State Equity Partners | 41,850 | $308.0K | 0.16% | 00.0% | Unchanged |
| Ensign Peak Advisors, Inc | 43,380 | $320.0K | 0.00% | 00.0% | Unchanged |
| Capital Fund Management S.A. | 44,154 | $325.4K | 0.01% | +44,154 | New |
| Allspring Global Investments Holdings, LLC | 48,718 | $359.0K | 0.00% | +10,174+26.4% | Added |
| New York State Common Retirement Fund | 52,425 | $386.0K | 0.00% | +9,831+23.1% | Added |
| State Board of Administration of Florida Retirement System | 53,075 | $391.0K | 0.00% | 00.0% | Unchanged |
| Quantbot Technologies LP | 53,300 | $392.0K | 0.03% | +47,200+773.8% | Added |
| IndexIQ Advisors LLC | 53,438 | $394.0K | 0.01% | +53,438 | New |
| ClariVest Asset Management LLC | 59,600 | $440.0K | 0.02% | +59,600 | New |
| Russell Investments Group, Ltd. | 60,746 | $447.0K | 0.00% | +60,041+8,516.5% | Added |
| UBS Asset Management Americas Inc | 62,120 | $457.8K | 0.00% | −29,601−32.3% | Reduced |
| Susquehanna Fundamental Investments, LLC | 62,544 | $461.0K | 0.01% | 00.0% | Unchanged |
| Rhumbline Advisers | 79,123 | $583.0K | 0.00% | −15,587−16.5% | Reduced |
| Walleye Capital LLC | 83,078 | $612.0K | 0.02% | +69,175+497.6% | Added |
| Barclays PLC | 87,724 | $646.0K | 0.00% | −94,028−51.7% | Reduced |
| California State Teachers Retirement System | 89,741 | $661.0K | 0.00% | −6,957−7.2% | Reduced |
| State of Wisconsin Investment Board | 95,800 | $706.0K | 0.00% | 00.0% | Unchanged |
| FMR LLC | 113,972 | $840.0K | 0.00% | +113,972 | New |
| Alliancebernstein L.P. | 116,030 | $855.0K | 0.00% | +200+0.2% | Added |
| Citigroup Inc | 127,780 | $942.0K | 0.00% | −176,318−58.0% | Reduced |
| Credit Suisse AG | 138,158 | $1.02M | 0.00% | +76,015+122.3% | Added |
| Swiss National Bank | 160,750 | $1.19M | 0.00% | +11,300+7.6% | Added |
| Cubist Systematic Strategies, LLC | 161,483 | $1.19M | 0.01% | −402,047−71.3% | Reduced |
| Allianz Asset Management GmbH | 163,985 | $1.21M | 0.00% | −23,116−12.4% | Reduced |
| Charles Schwab Investment Management Inc | 194,197 | $1.43M | 0.00% | +6,048+3.2% | Added |
| Wellington Management Group LLP | 196,342 | $1.45M | 0.00% | −5,208−2.6% | Reduced |
| Victory Capital Management Inc | 197,570 | $1.46M | 0.00% | +197,570 | New |
| Renaissance Technologies LLC | 215,100 | $1.58M | 0.00% | +129,200+150.4% | Added |