Karyopharm Therapeutics Inc.
KPTI- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001503802
In the last 90 days, Karyopharm Therapeutics Inc. insiders filed 0 open-market purchases and 2 sales; 96 institutions reported holding it in 13F filings for Q2 2026, worth $206.8M in total; no superinvestor holds it.
13F holders, Q4 2022
Institutional positions in Karyopharm Therapeutics Inc. as of Dec 31, 2022. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 155
- +9 vs. Q3 2022
- Shares held
- 98.4M
- +31.8M (+47.7%) vs. Q3 2022
- Total value
- $334.4M
- −$29.2M (−8.0%) vs. Q3 2022
- New holders
- 32
- 63 more added
- Sold out
- 23
- 40 more reduced
1 institution that held it in Q3 2022 haven't filed for Q4 2022 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2022: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting KPTI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 96 | $206.8M |
| Q1 2026 | 77 | $98.4M |
| Q4 2025 | 68 | $69.6M |
| Q3 2025 | 52 | $19.5M |
| Q2 2025 | 50 | $19.0M |
| Q1 2025 | 50 | $13.7M |
| Q4 2024 | 87 | $41.2M |
| Q3 2024 | 91 | $49.2M |
| Q2 2024 | 114 | $58.6M |
| Q1 2024 | 114 | $113.0M |
| Q4 2023 | 120 | $63.5M |
| Q3 2023 | 120 | $102.8M |
| Q2 2023 | 138 | $145.0M |
| Q1 2023 | 132 | $340.1M |
| Q4 2022 | 155 | $334.4M |
| Q3 2022 | 147 | $364.1M |
| Q2 2022 | 150 | $302.8M |
| Q1 2022 | 139 | $501.8M |
| Q4 2021 | 143 | $347.5M |
| Q3 2021 | 134 | $334.4M |
| Q2 2021 | 154 | $608.7M |
| Q1 2021 | 171 | $637.1M |
Institutions, Q4 2022
Shares, value and share of portfolio for each institution holding Karyopharm Therapeutics Inc.; share changes are against Q3 2022.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Avidity Partners Management LP | 9,633,911 | $32.8M | 0.77% | +9,633,911 | New |
| BlackRock Inc. | 8,508,237 | $28.9M | 0.00% | +595,283+7.5% | Added |
| Rubric Capital Management LP | 8,294,621 | $28.2M | 1.23% | +4,304,495+107.9% | Added |
| State Street Corp | 8,287,036 | $28.2M | 0.00% | −723,303−8.0% | Reduced |
| Palo Alto Investors LP | 5,655,676 | $19.2M | 1.64% | +34,143+0.6% | Added |
| Vanguard Group Inc | 5,197,502 | $17.7M | 0.00% | +384,103+8.0% | Added |
| Armistice Capital, LLC | 3,853,565 | $13.1M | 0.35% | +3,853,565 | New |
| Citadel Advisors LLC | 3,713,153 | $12.3M | 0.01% | +1,903,507+105.2% | Added |
| Jacobs Levy Equity Management, Inc | 2,249,399 | $7.65M | 0.05% | +666,875+42.1% | Added |
| Marshall Wace, LLP | 2,210,223 | $7.51M | 0.02% | +2,051,086+1,288.9% | Added |
| Point72 Asset Management, L.P. | 1,991,613 | $6.77M | 0.03% | +1,988,113+56,803.2% | Added |
| Commodore Capital LP | 1,935,609 | $6.58M | 0.99% | 00.0% | Unchanged |
| Iron Triangle Partners LP | 1,926,782 | $6.55M | 1.17% | +1,926,782 | New |
| Nuveen Asset Management, LLC | 1,593,710 | $5.42M | 0.00% | −377,338−19.1% | Reduced |
| Candriam Luxembourg S.C.A. | 1,535,026 | $5.22M | 0.04% | +200,000+15.0% | Added |
| Bank of America Corp | 1,511,166 | $5.14M | 0.00% | +779,302+106.5% | Added |
| C WorldWide Group Holding A/S | 1,500,000 | $5.10M | 0.07% | 00.0% | Unchanged |
| JPMorgan Chase & Co | 1,482,164 | $5.04M | 0.00% | +1,302,937+727.0% | Added |
| Geode Capital Management, LLC | 1,377,128 | $4.68M | 0.00% | +46,693+3.5% | Added |
| Woodline Partners LP | 1,324,884 | $4.50M | 0.06% | −188,375−12.4% | Reduced |
| Morgan Stanley | 1,289,437 | $4.38M | 0.00% | +209,556+19.4% | Added |
| Opaleye Management Inc. | 1,206,841 | $4.28M | 1.49% | +1,206,841 | New |
| CVI Holdings, LLC | 1,252,408 | $4.26M | 0.54% | +1,252,408 | New |
| ExodusPoint Capital Management, LP | 1,106,132 | $3.76M | 0.06% | +398,852+56.4% | Added |
| Goldman Sachs Group Inc | 1,056,633 | $3.59M | 0.00% | −298,543−22.0% | Reduced |
| Barclays PLC | 1,046,712 | $3.56M | 0.00% | +591,248+129.8% | Added |
| Ally Bridge Group (NY) LLC | 896,618 | $3.05M | 2.97% | −631,962−41.3% | Reduced |
| Acadian Asset Management LLC | 845,744 | $2.87M | 0.01% | −4,832−0.6% | Reduced |
| Adage Capital Partners GP, L.L.C. | 770,713 | $2.62M | 0.01% | +770,713 | New |
| Northern Trust Corp | 745,733 | $2.54M | 0.00% | −8,046−1.1% | Reduced |
| Two Sigma Advisers, LP | 703,200 | $2.39M | 0.01% | −128,100−15.4% | Reduced |
| Rafferty Asset Management, LLC | 696,666 | $2.37M | 0.02% | +28,662+4.3% | Added |
| Affinity Asset Advisors, LLC | 661,264 | $2.25M | 1.03% | +661,264 | New |
| Deutsche Bank AG | 594,326 | $2.02M | 0.00% | +509+0.1% | Added |
| Qube Research & Technologies Ltd | 523,788 | $1.78M | 0.01% | +523,788 | New |
| UBS Group AG | 523,259 | $1.78M | 0.00% | +410,713+364.9% | Added |
| Citigroup Inc | 508,593 | $1.73M | 0.00% | −98,803−16.3% | Reduced |
| Tejara Capital Ltd | 501,562 | $1.71M | 0.99% | +501,562 | New |
| Cubist Systematic Strategies, LLC | 490,010 | $1.67M | 0.01% | +401,646+454.5% | Added |
| Alyeska Investment Group, L.P. | 481,696 | $1.64M | 0.02% | +481,696 | New |
| Monashee Investment Management LLC | 481,696 | $1.64M | 0.70% | +481,696 | New |
| Bank of New York Mellon Corp | 432,881 | $1.47M | 0.00% | +133,890+44.8% | Added |
| Connor, Clark & Lunn Investment Management Ltd. | 432,278 | $1.47M | 0.01% | +276,845+178.1% | Added |
| BNP Paribas Arbitrage, SA | 423,620 | $1.44M | 0.00% | −338,900−44.4% | Reduced |
| Macquarie Group Ltd | 380,000 | $1.29M | 0.00% | −1,465−0.4% | Reduced |
| Millennium Management LLC | 351,543 | $1.20M | 0.00% | +88,857+33.8% | Added |
| D. E. Shaw & Co., Inc. | 307,959 | $1.05M | 0.00% | +164,153+114.1% | Added |
| Birchview Capital, LP | 291,332 | $991.0K | 0.70% | +22,000+8.2% | Added |
| Two Sigma Investments, LP | 265,308 | $902.0K | 0.00% | +36,973+16.2% | Added |
| Swiss National Bank | 259,150 | $881.1K | 0.00% | +89,700+52.9% | Added |
| Susquehanna International Group, LLP | 255,193 | $867.7K | 0.00% | −136,724−34.9% | Reduced |
| Putnam Investments LLC | 242,620 | $824.9K | 0.00% | +242,620 | New |
| Wellington Management Group LLP | 228,619 | $777.3K | 0.00% | −16,515−6.7% | Reduced |
| Charles Schwab Investment Management Inc | 206,831 | $703.2K | 0.00% | +6,330+3.2% | Added |
| DAFNA Capital Management LLC | 192,678 | $655.1K | 0.18% | +192,678 | New |
| Renaissance Technologies LLC | 189,300 | $644.0K | 0.00% | −119,000−38.6% | Reduced |
| Ameriprise Financial Inc | 164,989 | $560.0K | 0.00% | −5,040−3.0% | Reduced |
| Walleye Capital LLC | 160,107 | $544.4K | 0.01% | −513,565−76.2% | Reduced |
| Alliancebernstein L.P. | 158,030 | $537.3K | 0.00% | +19,900+14.4% | Added |
| Russell Investments Group, Ltd. | 146,160 | $496.9K | 0.00% | +16,745+12.9% | Added |
| Hennion & Walsh Asset Management, Inc. | 144,353 | $491.0K | 0.03% | −132,069−47.8% | Reduced |
| Credit Suisse AG | 141,924 | $482.5K | 0.00% | +2,783+2.0% | Added |
| XTX Topco Ltd | 130,817 | $444.8K | 0.09% | +90,276+222.7% | Added |
| California State Teachers Retirement System | 124,306 | $422.6K | 0.00% | +32,726+35.7% | Added |
| Tudor Investment Corp Et Al | 119,755 | $407.0K | 0.01% | +59,691+99.4% | Added |
| FMR LLC | 110,921 | $377.1K | 0.00% | −1,173−1.0% | Reduced |
| Los Angeles Capital Management LLC | 101,917 | $346.5K | 0.00% | +23,260+29.6% | Added |
| Rhumbline Advisers | 98,740 | $336.0K | 0.00% | −1,002−1.0% | Reduced |
| Jane Street Group, LLC | 97,336 | $330.9K | 0.00% | +82,568+559.1% | Added |
| Virginia Retirement Systems Et Al | 91,300 | $310.4K | 0.00% | +70,200+332.7% | Added |
| UBS Asset Management Americas Inc | 82,875 | $281.8K | 0.00% | +10,853+15.1% | Added |
| Algert Global LLC | 82,668 | $281.1K | 0.02% | −13,290−13.8% | Reduced |
| Gsa Capital Partners LLP | 82,162 | $279.0K | 0.03% | +82,162 | New |
| New York Life Investment Management LLC | 76,968 | $261.7K | 0.00% | +8,675+12.7% | Added |
| Caxton Associates LP | 75,926 | $258.1K | 0.02% | +4,023+5.6% | Added |
| Royal Bank of Canada | 64,229 | $218.0K | 0.00% | +53,054+474.8% | Added |
| AQR Capital Management LLC | 61,647 | $209.6K | 0.00% | −51,029−45.3% | Reduced |
| Prelude Capital Management, LLC | 58,534 | $199.0K | 0.01% | +45,043+333.9% | Added |
| Jump Financial, LLC | 58,472 | $198.8K | 0.01% | +58,472 | New |
| Price T Rowe Associates Inc | 57,955 | $197.0K | 0.00% | +5,423+10.3% | Added |
| Principal Financial Group Inc | 56,805 | $193.1K | 0.00% | +36,978+186.5% | Added |
| Squarepoint Ops LLC | 52,283 | $177.8K | 0.00% | +52,283 | New |
| Engineers Gate Manager LP | 49,552 | $168.5K | 0.01% | +18,762+60.9% | Added |
| New York State Common Retirement Fund | 49,074 | $166.9K | 0.00% | −18,332−27.2% | Reduced |
| Point72 Middle East FZE | 47,257 | $160.7K | 0.01% | +47,257 | New |
| Legal & General Group Plc | 45,819 | $156.0K | 0.00% | +8,000+21.2% | Added |
| Martingale Asset Management L P | 45,315 | $154.1K | 0.00% | +45,315 | New |
| Bayesian Capital Management, LP | 43,638 | $148.4K | 0.02% | +43,638 | New |
| Federated Hermes, Inc. | 38,605 | $131.3K | 0.00% | +38,605 | New |
| American International Group, Inc. | 36,828 | $125.2K | 0.00% | +657+1.8% | Added |
| E Fund Management Co., Ltd. | 36,504 | $124.0K | 0.01% | −9,420−20.5% | Reduced |
| Invesco Ltd. | 36,126 | $122.8K | 0.00% | +1,225+3.5% | Added |
| Redwood Wealth Management Group, LLC | 33,230 | $113.0K | 0.14% | +33,230 | New |
| Occudo Quantitative Strategies LP | 29,817 | $101.4K | 0.01% | +29,817 | New |
| MetLife Investment Management | 29,394 | $99.9K | 0.00% | −12,015−29.0% | Reduced |
| Voya Investment Management LLC | 28,866 | $98.1K | 0.00% | −142,755−83.2% | Reduced |
| Fox Run Management, L.L.C. | 28,823 | $98.0K | 0.04% | +28,823 | New |
| Manufacturers Life Insurance Company, The | 28,760 | $97.8K | 0.00% | −260−0.9% | Reduced |
| Teacher Retirement System of Texas | 28,597 | $97.0K | 0.00% | +5,224+22.4% | Added |
| State Board of Administration of Florida Retirement System | 27,015 | $91.9K | 0.00% | −26,060−49.1% | Reduced |