Karyopharm Therapeutics Inc.
KPTI- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001503802
In the last 90 days, Karyopharm Therapeutics Inc. insiders filed 0 open-market purchases and 2 sales; 96 institutions reported holding it in 13F filings for Q2 2026, worth $206.8M in total; no superinvestor holds it.
13F holders, Q4 2022
Institutional positions in Karyopharm Therapeutics Inc. as of Dec 31, 2022. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 155
- +9 vs. Q3 2022
- Shares held
- 98.4M
- +31.8M (+47.7%) vs. Q3 2022
- Total value
- $334.4M
- −$29.2M (−8.0%) vs. Q3 2022
- New holders
- 32
- 63 more added
- Sold out
- 23
- 40 more reduced
1 institution that held it in Q3 2022 haven't filed for Q4 2022 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2022: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting KPTI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 96 | $206.8M |
| Q1 2026 | 77 | $98.4M |
| Q4 2025 | 68 | $69.6M |
| Q3 2025 | 52 | $19.5M |
| Q2 2025 | 50 | $19.0M |
| Q1 2025 | 50 | $13.7M |
| Q4 2024 | 87 | $41.2M |
| Q3 2024 | 91 | $49.2M |
| Q2 2024 | 114 | $58.6M |
| Q1 2024 | 114 | $113.0M |
| Q4 2023 | 120 | $63.5M |
| Q3 2023 | 120 | $102.8M |
| Q2 2023 | 138 | $145.0M |
| Q1 2023 | 132 | $340.1M |
| Q4 2022 | 155 | $334.4M |
| Q3 2022 | 147 | $364.1M |
| Q2 2022 | 150 | $302.8M |
| Q1 2022 | 139 | $501.8M |
| Q4 2021 | 143 | $347.5M |
| Q3 2021 | 134 | $334.4M |
| Q2 2021 | 154 | $608.7M |
| Q1 2021 | 171 | $637.1M |
Institutions, Q4 2022
Shares, value and share of portfolio for each institution holding Karyopharm Therapeutics Inc.; share changes are against Q3 2022.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Daiwa Securities Group Inc. | 138 | $0 | 0.00% | 00.0% | Unchanged |
| Sofos Investments, Inc. | 3 | $16 | 0.00% | −12−80.0% | Reduced |
| Wells Fargo & Company | 122 | $415 | 0.00% | −5,526−97.8% | Reduced |
| Key Financial Inc | 150 | $819 | 0.00% | 00.0% | Unchanged |
| Kelly Financial Services LLC | 250 | $850 | 0.00% | 00.0% | Unchanged |
| CWM, LLC | 177 | $1.00K | 0.00% | +177 | New |
| Quent Capital, LLC | 386 | $1.31K | 0.00% | +356+1,186.7% | Added |
| Allworth Financial LP | 500 | $1.70K | 0.00% | +400+400.0% | Added |
| Advisory Services Network, LLC | 600 | $2.04K | 0.00% | +600 | New |
| AdvisorNet Financial, Inc | 700 | $2.38K | 0.00% | 00.0% | Unchanged |
| Money Concepts Capital Corp | 800 | $2.72K | 0.00% | 00.0% | Unchanged |
| Harbour Investments, Inc. | 800 | $2.72K | 0.00% | 00.0% | Unchanged |
| China Universal Asset Management Co., Ltd. | 825 | $2.81K | 0.00% | +78+10.4% | Added |
| Nisa Investment Advisors, LLC | 800 | $3.00K | 0.00% | −4,900−86.0% | Reduced |
| Lazard Asset Management LLC | 1,000 | $3.00K | 0.00% | 00.0% | Unchanged |
| DT Investment Partners, LLC | 1,000 | $3.40K | 0.00% | 00.0% | Unchanged |
| Belpointe Asset Management LLC | 1,000 | $3.40K | 0.00% | +1,000 | New |
| TD Waterhouse Canada Inc. | 1,060 | $3.44K | 0.00% | 00.0% | Unchanged |
| MB, Levis & Associates, LLC | 1,500 | $5.10K | 0.00% | +1,500 | New |
| Founders Capital Management | 2,000 | $7.00K | 0.01% | 00.0% | Unchanged |
| Great West Life Assurance Co | 3,017 | $10.0K | 0.00% | −14,838−83.1% | Reduced |
| The PNC Financial Services Group, Inc. | 3,000 | $10.2K | 0.00% | 00.0% | Unchanged |
| Metropolitan Life Insurance Co | 4,622 | $15.7K | 0.00% | 00.0% | Unchanged |
| Cutler Group LP | 4,819 | $16.0K | 0.00% | +4,400+1,050.1% | Added |
| Banque Cantonale Vaudoise | 5,000 | $17.0K | 0.00% | 00.0% | Unchanged |
| Ameritas Investment Partners, Inc. | 6,194 | $20.1K | 0.00% | 00.0% | Unchanged |
| Advisor Group Holdings, Inc. | 8,906 | $30.0K | 0.00% | +5,105+134.3% | Added |
| Running Point Capital Advisors, LLC | 10,000 | $34.0K | 0.02% | 00.0% | Unchanged |
| Janney Montgomery Scott LLC | 10,000 | $34.0K | 0.00% | +10,000 | New |
| State of Wisconsin Investment Board | 10,048 | $34.2K | 0.00% | −59,682−85.6% | Reduced |
| Creative Planning | 11,600 | $39.4K | 0.00% | 00.0% | Unchanged |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 12,018 | $40.9K | 0.00% | +1,628+15.7% | Added |
| Amalgamated Bank | 12,012 | $41.0K | 0.00% | 00.0% | Unchanged |
| Moors & Cabot, Inc. | 12,200 | $41.5K | 0.00% | −8,950−42.3% | Reduced |
| Janus Henderson Group PLC | 12,194 | $41.5K | 0.00% | −10.0% | Reduced |
| Balyasny Asset Management LLC | 12,249 | $41.6K | 0.00% | −583,309−97.9% | Reduced |
| Mercer Global Advisors Inc | 12,221 | $42.0K | 0.00% | +796+7.0% | Added |
| Ergoteles LLC | 13,321 | $45.3K | 0.00% | +13,321 | New |
| Prudential Financial Inc | 13,800 | $46.9K | 0.00% | −17,900−56.5% | Reduced |
| Snowden Capital Advisors LLC | 14,233 | $48.4K | 0.00% | +2,033+16.7% | Added |
| Ashton Thomas Private Wealth, LLC | 14,500 | $49.3K | 0.00% | +14,500 | New |
| Y-Intercept (Hong Kong) Ltd | 15,087 | $51.3K | 0.01% | +4,723+45.6% | Added |
| Mackenzie Financial Corp | 15,817 | $53.8K | 0.00% | +2,011+14.6% | Added |
| ProShare Advisors LLC | 16,730 | $56.9K | 0.00% | +1,619+10.7% | Added |
| Alpine Global Management, LLC | 17,081 | $58.0K | 0.02% | +17,081 | New |
| State of Wyoming | 17,082 | $58.1K | 0.02% | +11,168+188.8% | Added |
| Simplex Trading, LLC | 17,405 | $59.0K | 0.00% | +11,591+199.4% | Added |
| Baird Financial Group, Inc. | 19,101 | $65.0K | 0.00% | +910+5.0% | Added |
| Arizona State Retirement System | 20,267 | $68.9K | 0.00% | +844+4.3% | Added |
| Tower Research Capital LLC (TRC) | 20,122 | $69.0K | 0.00% | −14,275−41.5% | Reduced |
| Franklin Resources Inc | 20,647 | $70.2K | 0.00% | 00.0% | Unchanged |
| DuPont Capital Management Corp | 22,957 | $78.1K | 0.00% | +22,957 | New |
| Weiss Multi-Strategy Advisers LLC | 24,129 | $82.0K | 0.00% | −596−2.4% | Reduced |
| Aquatic Capital Management LLC | 25,400 | $86.0K | 0.01% | −19,700−43.7% | Reduced |
| Allspring Global Investments Holdings, LLC | 26,599 | $90.4K | 0.00% | −9,930−27.2% | Reduced |
| State Board of Administration of Florida Retirement System | 27,015 | $91.9K | 0.00% | −26,060−49.1% | Reduced |
| Teacher Retirement System of Texas | 28,597 | $97.0K | 0.00% | +5,224+22.4% | Added |
| Manufacturers Life Insurance Company, The | 28,760 | $97.8K | 0.00% | −260−0.9% | Reduced |
| Fox Run Management, L.L.C. | 28,823 | $98.0K | 0.04% | +28,823 | New |
| Voya Investment Management LLC | 28,866 | $98.1K | 0.00% | −142,755−83.2% | Reduced |
| MetLife Investment Management | 29,394 | $99.9K | 0.00% | −12,015−29.0% | Reduced |
| Occudo Quantitative Strategies LP | 29,817 | $101.4K | 0.01% | +29,817 | New |
| Redwood Wealth Management Group, LLC | 33,230 | $113.0K | 0.14% | +33,230 | New |
| Invesco Ltd. | 36,126 | $122.8K | 0.00% | +1,225+3.5% | Added |
| E Fund Management Co., Ltd. | 36,504 | $124.0K | 0.01% | −9,420−20.5% | Reduced |
| American International Group, Inc. | 36,828 | $125.2K | 0.00% | +657+1.8% | Added |
| Federated Hermes, Inc. | 38,605 | $131.3K | 0.00% | +38,605 | New |
| Bayesian Capital Management, LP | 43,638 | $148.4K | 0.02% | +43,638 | New |
| Martingale Asset Management L P | 45,315 | $154.1K | 0.00% | +45,315 | New |
| Legal & General Group Plc | 45,819 | $156.0K | 0.00% | +8,000+21.2% | Added |
| Point72 Middle East FZE | 47,257 | $160.7K | 0.01% | +47,257 | New |
| New York State Common Retirement Fund | 49,074 | $166.9K | 0.00% | −18,332−27.2% | Reduced |
| Engineers Gate Manager LP | 49,552 | $168.5K | 0.01% | +18,762+60.9% | Added |
| Squarepoint Ops LLC | 52,283 | $177.8K | 0.00% | +52,283 | New |
| Principal Financial Group Inc | 56,805 | $193.1K | 0.00% | +36,978+186.5% | Added |
| Price T Rowe Associates Inc | 57,955 | $197.0K | 0.00% | +5,423+10.3% | Added |
| Jump Financial, LLC | 58,472 | $198.8K | 0.01% | +58,472 | New |
| Prelude Capital Management, LLC | 58,534 | $199.0K | 0.01% | +45,043+333.9% | Added |
| AQR Capital Management LLC | 61,647 | $209.6K | 0.00% | −51,029−45.3% | Reduced |
| Royal Bank of Canada | 64,229 | $218.0K | 0.00% | +53,054+474.8% | Added |
| Caxton Associates LP | 75,926 | $258.1K | 0.02% | +4,023+5.6% | Added |
| New York Life Investment Management LLC | 76,968 | $261.7K | 0.00% | +8,675+12.7% | Added |
| Gsa Capital Partners LLP | 82,162 | $279.0K | 0.03% | +82,162 | New |
| Algert Global LLC | 82,668 | $281.1K | 0.02% | −13,290−13.8% | Reduced |
| UBS Asset Management Americas Inc | 82,875 | $281.8K | 0.00% | +10,853+15.1% | Added |
| Virginia Retirement Systems Et Al | 91,300 | $310.4K | 0.00% | +70,200+332.7% | Added |
| Jane Street Group, LLC | 97,336 | $330.9K | 0.00% | +82,568+559.1% | Added |
| Rhumbline Advisers | 98,740 | $336.0K | 0.00% | −1,002−1.0% | Reduced |
| Los Angeles Capital Management LLC | 101,917 | $346.5K | 0.00% | +23,260+29.6% | Added |
| FMR LLC | 110,921 | $377.1K | 0.00% | −1,173−1.0% | Reduced |
| Tudor Investment Corp Et Al | 119,755 | $407.0K | 0.01% | +59,691+99.4% | Added |
| California State Teachers Retirement System | 124,306 | $422.6K | 0.00% | +32,726+35.7% | Added |
| XTX Topco Ltd | 130,817 | $444.8K | 0.09% | +90,276+222.7% | Added |
| Credit Suisse AG | 141,924 | $482.5K | 0.00% | +2,783+2.0% | Added |
| Hennion & Walsh Asset Management, Inc. | 144,353 | $491.0K | 0.03% | −132,069−47.8% | Reduced |
| Russell Investments Group, Ltd. | 146,160 | $496.9K | 0.00% | +16,745+12.9% | Added |
| Alliancebernstein L.P. | 158,030 | $537.3K | 0.00% | +19,900+14.4% | Added |
| Walleye Capital LLC | 160,107 | $544.4K | 0.01% | −513,565−76.2% | Reduced |
| Ameriprise Financial Inc | 164,989 | $560.0K | 0.00% | −5,040−3.0% | Reduced |
| Renaissance Technologies LLC | 189,300 | $644.0K | 0.00% | −119,000−38.6% | Reduced |