Karyopharm Therapeutics Inc.
KPTI- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001503802
In the last 90 days, Karyopharm Therapeutics Inc. insiders filed 0 open-market purchases and 3 sales; 96 institutions reported holding it in 13F filings for Q2 2026, worth $206.8M in total; no superinvestor holds it.
13F holders, Q4 2022
Institutional positions in Karyopharm Therapeutics Inc. as of Dec 31, 2022. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 155
- +9 vs. Q3 2022
- Shares held
- 98.4M
- +31.8M (+47.7%) vs. Q3 2022
- Total value
- $334.4M
- −$29.2M (−8.0%) vs. Q3 2022
- New holders
- 32
- 63 more added
- Sold out
- 23
- 40 more reduced
1 institution that held it in Q3 2022 haven't filed for Q4 2022 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2022: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting KPTI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 96 | $206.8M |
| Q1 2026 | 77 | $98.4M |
| Q4 2025 | 68 | $69.6M |
| Q3 2025 | 52 | $19.5M |
| Q2 2025 | 50 | $19.0M |
| Q1 2025 | 50 | $13.7M |
| Q4 2024 | 87 | $41.2M |
| Q3 2024 | 91 | $49.2M |
| Q2 2024 | 114 | $58.6M |
| Q1 2024 | 114 | $113.0M |
| Q4 2023 | 120 | $63.5M |
| Q3 2023 | 120 | $102.8M |
| Q2 2023 | 138 | $145.0M |
| Q1 2023 | 132 | $340.1M |
| Q4 2022 | 155 | $334.4M |
| Q3 2022 | 147 | $364.1M |
| Q2 2022 | 150 | $302.8M |
| Q1 2022 | 139 | $501.8M |
| Q4 2021 | 143 | $347.5M |
| Q3 2021 | 134 | $334.4M |
| Q2 2021 | 154 | $608.7M |
| Q1 2021 | 171 | $637.1M |
Institutions, Q4 2022
Shares, value and share of portfolio for each institution holding Karyopharm Therapeutics Inc.; share changes are against Q3 2022.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Allspring Global Investments Holdings, LLC | 26,599 | $90.4K | 0.00% | −9,930−27.2% | Reduced |
| Aquatic Capital Management LLC | 25,400 | $86.0K | 0.01% | −19,700−43.7% | Reduced |
| Weiss Multi-Strategy Advisers LLC | 24,129 | $82.0K | 0.00% | −596−2.4% | Reduced |
| DuPont Capital Management Corp | 22,957 | $78.1K | 0.00% | +22,957 | New |
| Franklin Resources Inc | 20,647 | $70.2K | 0.00% | 00.0% | Unchanged |
| Tower Research Capital LLC (TRC) | 20,122 | $69.0K | 0.00% | −14,275−41.5% | Reduced |
| Arizona State Retirement System | 20,267 | $68.9K | 0.00% | +844+4.3% | Added |
| Baird Financial Group, Inc. | 19,101 | $65.0K | 0.00% | +910+5.0% | Added |
| Simplex Trading, LLC | 17,405 | $59.0K | 0.00% | +11,591+199.4% | Added |
| State of Wyoming | 17,082 | $58.1K | 0.02% | +11,168+188.8% | Added |
| Alpine Global Management, LLC | 17,081 | $58.0K | 0.02% | +17,081 | New |
| ProShare Advisors LLC | 16,730 | $56.9K | 0.00% | +1,619+10.7% | Added |
| Mackenzie Financial Corp | 15,817 | $53.8K | 0.00% | +2,011+14.6% | Added |
| Y-Intercept (Hong Kong) Ltd | 15,087 | $51.3K | 0.01% | +4,723+45.6% | Added |
| Ashton Thomas Private Wealth, LLC | 14,500 | $49.3K | 0.00% | +14,500 | New |
| Snowden Capital Advisors LLC | 14,233 | $48.4K | 0.00% | +2,033+16.7% | Added |
| Prudential Financial Inc | 13,800 | $46.9K | 0.00% | −17,900−56.5% | Reduced |
| Ergoteles LLC | 13,321 | $45.3K | 0.00% | +13,321 | New |
| Mercer Global Advisors Inc | 12,221 | $42.0K | 0.00% | +796+7.0% | Added |
| Balyasny Asset Management LLC | 12,249 | $41.6K | 0.00% | −583,309−97.9% | Reduced |
| Janus Henderson Group PLC | 12,194 | $41.5K | 0.00% | −10.0% | Reduced |
| Moors & Cabot, Inc. | 12,200 | $41.5K | 0.00% | −8,950−42.3% | Reduced |
| Amalgamated Bank | 12,012 | $41.0K | 0.00% | 00.0% | Unchanged |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 12,018 | $40.9K | 0.00% | +1,628+15.7% | Added |
| Creative Planning | 11,600 | $39.4K | 0.00% | 00.0% | Unchanged |
| State of Wisconsin Investment Board | 10,048 | $34.2K | 0.00% | −59,682−85.6% | Reduced |
| Running Point Capital Advisors, LLC | 10,000 | $34.0K | 0.02% | 00.0% | Unchanged |
| Janney Montgomery Scott LLC | 10,000 | $34.0K | 0.00% | +10,000 | New |
| Advisor Group Holdings, Inc. | 8,906 | $30.0K | 0.00% | +5,105+134.3% | Added |
| Ameritas Investment Partners, Inc. | 6,194 | $20.1K | 0.00% | 00.0% | Unchanged |
| Banque Cantonale Vaudoise | 5,000 | $17.0K | 0.00% | 00.0% | Unchanged |
| Cutler Group LP | 4,819 | $16.0K | 0.00% | +4,400+1,050.1% | Added |
| Metropolitan Life Insurance Co | 4,622 | $15.7K | 0.00% | 00.0% | Unchanged |
| The PNC Financial Services Group, Inc. | 3,000 | $10.2K | 0.00% | 00.0% | Unchanged |
| Great West Life Assurance Co | 3,017 | $10.0K | 0.00% | −14,838−83.1% | Reduced |
| Founders Capital Management | 2,000 | $7.00K | 0.01% | 00.0% | Unchanged |
| MB, Levis & Associates, LLC | 1,500 | $5.10K | 0.00% | +1,500 | New |
| TD Waterhouse Canada Inc. | 1,060 | $3.44K | 0.00% | 00.0% | Unchanged |
| DT Investment Partners, LLC | 1,000 | $3.40K | 0.00% | 00.0% | Unchanged |
| Belpointe Asset Management LLC | 1,000 | $3.40K | 0.00% | +1,000 | New |
| Nisa Investment Advisors, LLC | 800 | $3.00K | 0.00% | −4,900−86.0% | Reduced |
| Lazard Asset Management LLC | 1,000 | $3.00K | 0.00% | 00.0% | Unchanged |
| China Universal Asset Management Co., Ltd. | 825 | $2.81K | 0.00% | +78+10.4% | Added |
| Money Concepts Capital Corp | 800 | $2.72K | 0.00% | 00.0% | Unchanged |
| Harbour Investments, Inc. | 800 | $2.72K | 0.00% | 00.0% | Unchanged |
| AdvisorNet Financial, Inc | 700 | $2.38K | 0.00% | 00.0% | Unchanged |
| Advisory Services Network, LLC | 600 | $2.04K | 0.00% | +600 | New |
| Allworth Financial LP | 500 | $1.70K | 0.00% | +400+400.0% | Added |
| Quent Capital, LLC | 386 | $1.31K | 0.00% | +356+1,186.7% | Added |
| CWM, LLC | 177 | $1.00K | 0.00% | +177 | New |
| Kelly Financial Services LLC | 250 | $850 | 0.00% | 00.0% | Unchanged |
| Key Financial Inc | 150 | $819 | 0.00% | 00.0% | Unchanged |
| Wells Fargo & Company | 122 | $415 | 0.00% | −5,526−97.8% | Reduced |
| Sofos Investments, Inc. | 3 | $16 | 0.00% | −12−80.0% | Reduced |
| Daiwa Securities Group Inc. | 138 | $0 | 0.00% | 00.0% | Unchanged |
| Rice Hall James & Associates, LLC | 0 | $0 | 0.00% | −909,083−100.0% | Sold out |
| Altium Capital Management LP | 0 | $0 | 0.00% | −750,000−100.0% | Sold out |
| Frontier Capital Management Co LLC | 0 | $0 | 0.00% | −629,154−100.0% | Sold out |
| Lombard Odier Asset Management (Switzerland) SA | 0 | $0 | 0.00% | −479,124−100.0% | Sold out |
| UBS Oconnor LLC | 0 | $0 | 0.00% | −271,219−100.0% | Sold out |
| Trexquant Investment LP | 0 | $0 | 0.00% | −119,526−100.0% | Sold out |
| Walleye Trading LLC | 0 | $0 | 0.00% | −59,480−100.0% | Sold out |
| Ensign Peak Advisors, Inc | 0 | $0 | 0.00% | −43,380−100.0% | Sold out |
| GFG Capital, LLC | 0 | $0 | 0.00% | −41,400−100.0% | Sold out |
| CSS LLC | 0 | $0 | 0.00% | −33,128−100.0% | Sold out |
| Mirae Asset Global Investments Co., Ltd. | 0 | $0 | 0.00% | −32,197−100.0% | Sold out |
| Dynamic Technology Lab Private Ltd | 0 | $0 | 0.00% | −22,469−100.0% | Sold out |
| Schonfeld Strategic Advisors LLC | 0 | $0 | 0.00% | −18,857−100.0% | Sold out |
| Qtron Investments LLC | 0 | $0 | 0.00% | −18,330−100.0% | Sold out |
| Mariner, LLC | 0 | $0 | 0.00% | −16,705−100.0% | Sold out |
| SG Americas Securities, LLC | 0 | $0 | 0.00% | −15,214−100.0% | Sold out |
| First Republic Investment Management, Inc. | 0 | $0 | 0.00% | −12,012−100.0% | Sold out |
| American Trust | 0 | $0 | 0.00% | −11,715−100.0% | Sold out |
| Commonwealth Equity Services, LLC | 0 | $0 | 0.00% | −10,165−100.0% | Sold out |
| US Bancorp | 0 | $0 | 0.00% | −3,989−100.0% | Sold out |
| Dark Forest Capital Management LP | 0 | $0 | 0.00% | −761−100.0% | Sold out |
| Signaturefd, LLC | 0 | $0 | 0.00% | −607−100.0% | Sold out |
| Lindbrook Capital, LLC | 0 | $0 | 0.00% | −48−100.0% | Sold out |
| Jefferies Group LLC | – | – | – | – | Not filed |