COMMODORE CAPITAL LP

SEC CIK
0001831942

Holdings, Q2 2026

Positions as of Jun 30, 2026, filed Aug 14, 2026.SEC

Positions
33
−3 vs. Q1 2026
Total value
$1.68B
−$49.49M (−2.9%) vs. Q1 2026

Compare with Q1 2026: new, added, reduced and sold out

Positions

Long positions only. Changes compare share counts with Q1 2026.

COMMODORE CAPITAL LP holdings in Q2 2026
SecurityClassSharesValue% of portfolioChange in sharesActionHistory
RLAYRELAY THERAPEUTICS INCCOM12,000,000$224.52M13.37%−5,000,000−29.4%ReducedView
ELVNENLIVEN THERAPEUTICS INCCOM3,275,000$166.21M9.90%00.0%UnchangedView
ALKSALKERMES PLCSHS3,000,000$157.19M9.36%−1,200,000−28.6%ReducedView
COGTCOGENT BIOSCIENCES INCCOM3,050,000$118.04M7.03%+161,993+5.6%AddedView
AMLXAMYLYX PHARMACEUTICALS INCCOM5,650,000$101.47M6.04%00.0%UnchangedView
DFTXDEFINIUM THERAPEUTICS INCCOM SHS2,000,000$94.08M5.60%00.0%UnchangedView
SYRESPYRE THERAPEUTICS INCCOM NEW846,786$75.18M4.48%−1,065,594−55.7%ReducedView
ANROALTO NEUROSCIENCE INCCOM SHS2,723,196$71.87M4.28%00.0%UnchangedView
TNGXTANGO THERAPEUTICS INCCOM2,250,000$70.34M4.19%+2,250,000NewView
EYPTEYEPOINT INCCOM NEW4,600,000$65.78M3.92%+1,775,000+62.8%AddedView
TYRATYRA BIOSCIENCES INCCOM1,875,000$59.89M3.57%−600,000−24.2%ReducedView
DMRADAMORA THERAPEUTICS INCCOM NEW1,939,000$50.43M3.00%00.0%UnchangedView
CLDXCELLDEX THERAPEUTICS INC NEWCOM NEW1,350,000$50.23M2.99%−1,346,616−49.9%ReducedView
PHVSPHARVARIS N VCOM1,425,000$49.28M2.93%−493,970−25.7%ReducedView
LBRXLB PHARMACEUTICALS INCCOM SHS1,500,000$48.68M2.90%00.0%UnchangedView
ASMBASSEMBLY BIOSCIENCES INCCOM NEW1,415,000$38.88M2.32%+415,000+41.5%AddedView
EDITEDITAS MEDICINE INCCOM8,889,000$28.8M1.72%+8,889,000NewView
KYMRKYMERA THERAPEUTICS INCCOM250,000$28.67M1.71%−500,000−66.7%ReducedView
CATXPERSPECTIVE THERAPEUTICS INCCOM NEW6,336,782$21.61M1.29%00.0%UnchangedView
IPSCCENTURY THERAPEUTICS INCCOM8,695,652$21.3M1.27%00.0%UnchangedView
ZURAZURA BIO LTDCLASS A ORD SHS3,250,000$19.18M1.14%00.0%UnchangedView
AVTXAVALO THERAPEUTICS INCCOM NEW1,018,319$18.82M1.12%+535,319+110.8%AddedView
IFRXINFLARX NVCOM7,300,000$16.35M0.97%+7,300,000NewView
ANTXAN2 THERAPEUTICS INCCOM2,933,680$14.2M0.85%+599,967+25.7%AddedView
NUVALENT INC670703107COM100,000$12.35M0.74%−733,600−88.0%Reduced–
SABSSAB BIOTHERAPEUTICS INCCOM NEW2,870,000$11.19M0.67%−1,531,500−34.8%ReducedView
IKTINHIBIKASE THERAPEUTICS INCCOM NEW5,397,488$10.96M0.65%00.0%UnchangedView
RLMDRELMADA THERAPEUTICS INCCOM1,425,000$9.86M0.59%+791,099+124.8%AddedView
PEPGPEPGEN INCCOM4,475,000$8.06M0.48%00.0%UnchangedView
RACCRESEARCH ALLIANCE CORP IIIORD SHS CL A500,000$5.35M0.32%+500,000NewView
HLXCHELIX ACQUISITION CORP IIIUSD CL A ORD SHS500,000$5.32M0.32%00.0%UnchangedView
LONALEONABIO INCCOM464,398$4.27M0.25%00.0%UnchangedView
VTGNVISTAGEN THERAPEUTICS INCCOM2,788,620$630.23K0.04%+2,788,620NewView

Sold out since Q1 2026 (8)

Positions held at the end of Q1 2026 that are no longer in this filing.

COMMODORE CAPITAL LP positions sold out since Q1 2026
SecurityClassShares, Q1 2026Value, Q1 2026% of portfolio, Q1 2026
ERASERASCA INCCOM3,175,000$51.37M2.97%
XENEXENON PHARMACEUTICALS INCCOM825,000$47.97M2.78%
NRIXNURIX THERAPEUTICS INCCOM2,275,000$35.26M2.04%
CRVSCORVUS PHARMACEUTICALS INCCOM2,258,735$33.05M1.91%
SOLENO THERAPEUTICS INC834203309COM652,432$21.84M1.26%
OCULOCULAR THERAPEUTIX INCCOM2,575,000$21.81M1.26%
PALIPALISADE BIO INCCOM7,181,062$12.57M0.73%
KPTIKARYOPHARM THERAPEUTICS INCCOM NEW1,950,000$10.86M0.63%

13F filings by quarter

COMMODORE CAPITAL LP 13F filings by quarter
QuarterFiledPositionsTotal valueChangesFiling
Q2 2026Aug 14, 202633$1.68Bvs. Q1 2026SEC
Q1 2026May 15, 202636$1.73Bvs. Q4 2025SEC
Q4 2025Feb 17, 202633$1.5Bvs. Q3 2025SEC
Q3 2025Nov 14, 202537$2.05Bvs. Q2 2025SEC
Q2 2025Aug 14, 202533$1.42Bvs. Q1 2025SEC
Q1 2025May 15, 202531$1.36Bvs. Q4 2024SEC
Q4 2024Feb 14, 202531$1.36Bvs. Q3 2024SEC
Q3 2024Nov 14, 202436$1.6Bvs. Q2 2024SEC
Q2 2024Aug 14, 202435$1.47Bvs. Q1 2024SEC
Q1 2024May 15, 202439$1.5Bvs. Q4 2023SEC
Q4 2023Feb 14, 2024Amended32$1.14Bvs. Q3 2023SEC
Q3 2023Nov 14, 202330$855.51Mvs. Q2 2023SEC
Q2 2023Aug 14, 202326$889.84Mvs. Q1 2023SEC
Q1 2023May 15, 202332$656.83Mvs. Q4 2022SEC
Q4 2022Feb 14, 202335$663.54Mvs. Q3 2022SEC
Q3 2022Nov 14, 202230$621.89Mvs. Q2 2022SEC
Q2 2022Aug 15, 202224$472.97Mvs. Q1 2022SEC
Q1 2022May 16, 202227$447.72Mvs. Q4 2021SEC
Q4 2021Feb 14, 202225$431.77Mvs. Q3 2021SEC
Q3 2021Nov 15, 202129$379.29Mvs. Q2 2021SEC
Q2 2021Oct 14, 2021Amended29$287.02Mvs. Q1 2021SEC
Q1 2021Oct 14, 2021Amended31$251.03M–SEC