Karyopharm Therapeutics Inc.
KPTI- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001503802
In the last 90 days, Karyopharm Therapeutics Inc. insiders filed 0 open-market purchases and 2 sales; 96 institutions reported holding it in 13F filings for Q2 2026, worth $206.8M in total; no superinvestor holds it.
13F holders, Q2 2021
Institutional positions in Karyopharm Therapeutics Inc. as of Jun 30, 2021. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 154
- −16 vs. Q1 2021
- Shares held
- 59.0M
- −1.17M (−1.9%) vs. Q1 2021
- Total value
- $608.7M
- −$28.3M (−4.4%) vs. Q1 2021
- New holders
- 21
- 54 more added
- Sold out
- 37
- 57 more reduced
1 institution that held it in Q1 2021 haven't filed for Q2 2021 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2021: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting KPTI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 96 | $206.8M |
| Q1 2026 | 77 | $98.4M |
| Q4 2025 | 68 | $69.6M |
| Q3 2025 | 52 | $19.5M |
| Q2 2025 | 50 | $19.0M |
| Q1 2025 | 50 | $13.7M |
| Q4 2024 | 87 | $41.2M |
| Q3 2024 | 91 | $49.2M |
| Q2 2024 | 114 | $58.6M |
| Q1 2024 | 114 | $113.0M |
| Q4 2023 | 120 | $63.5M |
| Q3 2023 | 120 | $102.8M |
| Q2 2023 | 138 | $145.0M |
| Q1 2023 | 132 | $340.1M |
| Q4 2022 | 155 | $334.4M |
| Q3 2022 | 147 | $364.1M |
| Q2 2022 | 150 | $302.8M |
| Q1 2022 | 139 | $501.8M |
| Q4 2021 | 143 | $347.5M |
| Q3 2021 | 134 | $334.4M |
| Q2 2021 | 154 | $608.7M |
| Q1 2021 | 171 | $637.1M |
Institutions, Q2 2021
Shares, value and share of portfolio for each institution holding Karyopharm Therapeutics Inc.; share changes are against Q1 2021.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Arizona State Retirement System | 16,230 | $167.0K | 0.00% | +1,232+8.2% | Added |
| Creative Planning | 16,100 | $166.0K | 0.00% | −18,692−53.7% | Reduced |
| Engineers Gate Manager LP | 14,980 | $155.0K | 0.01% | −53,332−78.1% | Reduced |
| State of Wyoming | 14,403 | $149.0K | 0.09% | +14,403 | New |
| ACT Capital Management, LLC | 14,000 | $145.0K | 0.07% | +14,000 | New |
| Amalgamated Bank | 13,596 | $140.0K | 0.00% | +3,522+35.0% | Added |
| Parametrica Management Ltd | 13,466 | $139.0K | 0.10% | −79,422−85.5% | Reduced |
| Advisor Group Holdings, Inc. | 12,705 | $131.0K | 0.00% | −546−4.1% | Reduced |
| Altfest L J & Co Inc | 12,374 | $128.0K | 0.03% | +161+1.3% | Added |
| Silvant Capital Management LLC | 11,386 | $118.0K | 0.02% | 00.0% | Unchanged |
| LPL Financial LLC | 10,558 | $109.0K | 0.00% | +10,558 | New |
| Cambridge Investment Research Advisors, Inc. | 10,431 | $108.0K | 0.00% | +10,431 | New |
| Handelsbanken Fonder AB | 10,400 | $107.0K | 0.00% | −3,000−22.4% | Reduced |
| First Mercantile Trust Co | 9,852 | $102.0K | 0.01% | −6,244−38.8% | Reduced |
| Altshuler Shaham Ltd | 9,739 | $101.0K | 0.00% | +9,739 | New |
| Ameritas Investment Partners, Inc. | 6,194 | $64.0K | 0.00% | 00.0% | Unchanged |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 5,977 | $62.0K | 0.00% | 00.0% | Unchanged |
| Lazard Asset Management LLC | 5,726 | $59.0K | 0.00% | −1,730−23.2% | Reduced |
| Atlas Private Wealth Advisors | 5,500 | $57.0K | 0.03% | −8,280−60.1% | Reduced |
| Tower Research Capital LLC (TRC) | 5,377 | $55.0K | 0.00% | −24,655−82.1% | Reduced |
| Group One Trading, L.P. | 4,783 | $49.0K | 0.00% | −48,466−91.0% | Reduced |
| Captrust Financial Advisors | 4,436 | $46.0K | 0.00% | +936+26.7% | Added |
| The PNC Financial Services Group, Inc. | 3,800 | $39.0K | 0.00% | −13,210−77.7% | Reduced |
| Rockefeller Capital Management L.P. | 3,400 | $35.0K | 0.00% | 00.0% | Unchanged |
| Patriot Financial Group Insurance Agency, LLC | 3,400 | $35.0K | 0.01% | +1,200+54.5% | Added |
| Great West Life Assurance Co | 3,017 | $31.0K | 0.00% | 00.0% | Unchanged |
| Tarbox Family Office, Inc. | 3,000 | $31.0K | 0.01% | +3,000 | New |
| Harbour Investments, Inc. | 2,505 | $26.0K | 0.00% | −2,600−50.9% | Reduced |
| Tortoise Investment Management, LLC | 2,200 | $23.0K | 0.00% | 00.0% | Unchanged |
| Penserra Capital Management LLC | 1,710 | $17.0K | 0.00% | +15+0.9% | Added |
| Signaturefd, LLC | 1,551 | $16.0K | 0.00% | +97+6.7% | Added |
| Thomas J. Herzfeld Advisors, Inc. | 1,500 | $15.0K | 0.01% | 00.0% | Unchanged |
| US Bancorp | 1,171 | $12.0K | 0.00% | +994+561.6% | Added |
| American Portfolios Advisors | 1,000 | $10.3K | 0.00% | +1,000 | New |
| Private Capital Group, LLC | 1,000 | $10.0K | 0.00% | 00.0% | Unchanged |
| Founders Capital Management | 1,000 | $10.0K | 0.01% | +1,000 | New |
| Advisory Services Network, LLC | 900 | $9.00K | 0.00% | +900 | New |
| Nisa Investment Advisors, LLC | 800 | $8.00K | 0.00% | −3,250−80.2% | Reduced |
| AdvisorNet Financial, Inc | 800 | $8.00K | 0.00% | 00.0% | Unchanged |
| O'Shaughnessy Asset Management, LLC | 753 | $8.00K | 0.00% | 00.0% | Unchanged |
| Glen Eagle Advisors, LLC | 700 | $7.22K | 0.00% | −110−13.6% | Reduced |
| Bank of Montreal | 536 | $6.00K | 0.00% | −1,498−73.6% | Reduced |
| Sargent Bickham Lagudis LLC | 606 | $6.00K | 0.00% | 00.0% | Unchanged |
| Lindbrook Capital, LLC | 575 | $6.00K | 0.00% | +575 | New |
| Trust Co of Vermont | 400 | $4.00K | 0.00% | −1,000−71.4% | Reduced |
| TCI Wealth Advisors, Inc. | 298 | $3.00K | 0.00% | +298 | New |
| Simplex Trading, LLC | 284 | $2.00K | 0.00% | −2,826−90.9% | Reduced |
| Allworth Financial LP | 100 | $1.00K | 0.00% | −330−76.7% | Reduced |
| Daiwa Securities Group Inc. | 138 | $1.00K | 0.00% | 00.0% | Unchanged |
| Gemmer Asset Management LLC | 140 | $1.00K | 0.00% | 00.0% | Unchanged |
| Cypress Capital Management LLC (WY) | 50 | $1.00K | 0.00% | 00.0% | Unchanged |
| Kelly Financial Services LLC | 2,580 | $250 | 0.01% | +2,330+932.0% | Added |
| FMR LLC | 2 | $0 | 0.00% | −79,208−100.0% | Reduced |
| Quadrant Capital Group LLC | 25 | $0 | 0.00% | +25 | New |
| Adage Capital Partners GP, L.L.C. | 0 | $0 | 0.00% | −1,349,800−100.0% | Sold out |
| Compagnie Lombard Odier SCmA | 0 | $0 | 0.00% | −829,681−100.0% | Sold out |
| Schonfeld Strategic Advisors LLC | 0 | $0 | 0.00% | −178,704−100.0% | Sold out |
| Junson Asset Management (Hong Kong) Ltd | 0 | $0 | 0.00% | −150,000−100.0% | Sold out |
| Qube Research & Technologies Ltd | 0 | $0 | 0.00% | −146,442−100.0% | Sold out |
| California Public Employees Retirement System | 0 | $0 | 0.00% | −143,000−100.0% | Sold out |
| Phocas Financial Corp. | 0 | $0 | 0.00% | −135,816−100.0% | Sold out |
| Knights of Columbus Asset Advisors LLC | 0 | $0 | 0.00% | −72,343−100.0% | Sold out |
| PDT Partners, LLC | 0 | $0 | 0.00% | −71,026−100.0% | Sold out |
| Seven Eight Capital, LP | 0 | $0 | 0.00% | −46,600−100.0% | Sold out |
| Dynamic Technology Lab Private Ltd | 0 | $0 | 0.00% | −61,002−100.0% | Sold out |
| First Trust Advisors LP | 0 | $0 | 0.00% | −58,053−100.0% | Sold out |
| Teachers Retirement System of the State of Kentucky | 0 | $0 | 0.00% | −46,472−100.0% | Sold out |
| Emerald Advisers, LLC | 0 | $0 | 0.00% | −46,470−100.0% | Sold out |
| D.A. Davidson & Co. | 0 | $0 | 0.00% | −41,000−100.0% | Sold out |
| Bridgefront Capital, LLC | 0 | $0 | 0.00% | −37,381−100.0% | Sold out |
| Insight Advisors, LLC | 0 | $0 | 0.00% | −32,765−100.0% | Sold out |
| Bayesian Capital Management, LP | 0 | $0 | 0.00% | −27,000−100.0% | Sold out |
| AlphaCrest Capital Management LLC | 0 | $0 | 0.00% | −26,000−100.0% | Sold out |
| Mesirow Financial Investment Management, Inc. | 0 | $0 | 0.00% | −21,712−100.0% | Sold out |
| SG Americas Securities, LLC | 0 | $0 | 0.00% | −16,269−100.0% | Sold out |
| Twinbeech Capital LP | 0 | $0 | 0.00% | −15,988−100.0% | Sold out |
| D. E. Shaw & Co., Inc. | 0 | $0 | 0.00% | −14,865−100.0% | Sold out |
| HSBC Holdings PLC | 0 | $0 | 0.00% | −14,239−100.0% | Sold out |
| Man Group plc | 0 | $0 | 0.00% | −11,646−100.0% | Sold out |
| Victory Capital Management Inc | 0 | $0 | 0.00% | −11,432−100.0% | Sold out |
| Emerald Mutual Fund Advisers Trust | 0 | $0 | 0.00% | −11,145−100.0% | Sold out |
| Private Advisor Group, LLC | 0 | $0 | 0.00% | −11,070−100.0% | Sold out |
| CSS LLC | 0 | $0 | 0.00% | −10,127−100.0% | Sold out |
| Pacer Advisors, Inc. | 0 | $0 | 0.00% | −6,328−100.0% | Sold out |
| Valeo Financial Advisors, LLC | 0 | $0 | 0.00% | −2,107−100.0% | Sold out |
| Sowell Financial Services LLC | 0 | $0 | 0.00% | −1,255−100.0% | Sold out |
| Ikarian Capital, LLC | 0 | $0 | 0.00% | −791−100.0% | Sold out |
| Point72 Hong Kong Ltd | 0 | $0 | 0.00% | −299−100.0% | Sold out |
| International Assets Investment Management, LLC | 0 | $0 | 0.00% | −100−100.0% | Sold out |
| Parallel Advisors, LLC | 0 | $0 | 0.00% | −102−100.0% | Sold out |
| Certified Advisory Corp | 0 | $0 | 0.00% | −95−100.0% | Sold out |
| E Fund Management Co., Ltd. | – | – | – | – | Not filed |