Karyopharm Therapeutics Inc.
KPTI- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001503802
In the last 90 days, Karyopharm Therapeutics Inc. insiders filed 0 open-market purchases and 2 sales; 96 institutions reported holding it in 13F filings for Q2 2026, worth $206.8M in total; no superinvestor holds it.
13F holders, Q1 2024
Institutional positions in Karyopharm Therapeutics Inc. as of Mar 31, 2024. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 114
- −4 vs. Q4 2023
- Shares held
- 74.8M
- +1.38M (+1.9%) vs. Q4 2023
- Total value
- $113.0M
- +$49.6M (+78.2%) vs. Q4 2023
- New holders
- 18
- 38 more added
- Sold out
- 22
- 31 more reduced
2 institutions that held it in Q4 2023 haven't filed for Q1 2024 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2023: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting KPTI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 96 | $206.8M |
| Q1 2026 | 77 | $98.4M |
| Q4 2025 | 68 | $69.6M |
| Q3 2025 | 52 | $19.5M |
| Q2 2025 | 50 | $19.0M |
| Q1 2025 | 50 | $13.7M |
| Q4 2024 | 87 | $41.2M |
| Q3 2024 | 91 | $49.2M |
| Q2 2024 | 114 | $58.6M |
| Q1 2024 | 114 | $113.0M |
| Q4 2023 | 120 | $63.5M |
| Q3 2023 | 120 | $102.8M |
| Q2 2023 | 138 | $145.0M |
| Q1 2023 | 132 | $340.1M |
| Q4 2022 | 155 | $334.4M |
| Q3 2022 | 147 | $364.1M |
| Q2 2022 | 150 | $302.8M |
| Q1 2022 | 139 | $501.8M |
| Q4 2021 | 143 | $347.5M |
| Q3 2021 | 134 | $334.4M |
| Q2 2021 | 154 | $608.7M |
| Q1 2021 | 171 | $637.1M |
Institutions, Q1 2024
Shares, value and share of portfolio for each institution holding Karyopharm Therapeutics Inc.; share changes are against Q4 2023.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| CWM, LLC | 12 | $0 | 0.00% | +9+300.0% | Added |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 6 | $9 | 0.00% | 00.0% | Unchanged |
| Farther Finance Advisors, LLC | 13 | $21 | 0.00% | +13 | New |
| JJJ Advisors Inc. | 17 | $26 | 0.00% | 00.0% | Unchanged |
| Nelson, Van Denburg & Campbell Wealth Management Group, LLC | 22 | $33 | 0.00% | +22 | New |
| West Branch Capital LLC | 48 | $73 | 0.00% | 00.0% | Unchanged |
| CIBC Private Wealth Group, LLC | 50 | $79 | 0.00% | +50 | New |
| Sofos Investments, Inc. | 147 | $220 | 0.00% | +145+7,250.0% | Added |
| AdvisorNet Financial, Inc | 200 | $302 | 0.00% | −500−71.4% | Reduced |
| Nisa Investment Advisors, LLC | 202 | $305 | 0.00% | +202 | New |
| Kelly Financial Services LLC | 250 | $378 | 0.00% | 00.0% | Unchanged |
| Providence Capital Advisors, LLC | 312 | $471 | 0.00% | +312 | New |
| Allworth Financial LP | 500 | $755 | 0.00% | 00.0% | Unchanged |
| Bruce G. Allen Investments, LLC | 507 | $766 | 0.00% | 00.0% | Unchanged |
| Headlands Technologies LLC | 1,242 | $1.88K | 0.00% | +1,242 | New |
| Harbour Investments, Inc. | 1,300 | $1.96K | 0.00% | 00.0% | Unchanged |
| ADAR1 Capital Management, LLC | 1,479 | $2.23K | 0.00% | +1,479 | New |
| MB, Levis & Associates, LLC | 1,500 | $2.27K | 0.00% | 00.0% | Unchanged |
| Tower Research Capital LLC (TRC) | 1,637 | $2.47K | 0.00% | −9,979−85.9% | Reduced |
| Founders Capital Management | 2,000 | $3.02K | 0.00% | 00.0% | Unchanged |
| Amalgamated Bank | 2,478 | $4.00K | 0.00% | −12,216−83.1% | Reduced |
| The PNC Financial Services Group, Inc. | 3,000 | $4.53K | 0.00% | 00.0% | Unchanged |
| Ameritas Investment Partners, Inc. | 6,194 | $9.35K | 0.00% | 00.0% | Unchanged |
| Metropolitan Life Insurance Co | 6,231 | $9.41K | 0.00% | +6,231 | New |
| Advisor Group Holdings, Inc. | 8,595 | $13.0K | 0.00% | +2,151+33.4% | Added |
| Janney Montgomery Scott LLC | 10,000 | $15.0K | 0.00% | 00.0% | Unchanged |
| Two Sigma Securities, LLC | 10,208 | $15.4K | 0.00% | −9,378−47.9% | Reduced |
| Snowden Capital Advisors LLC | 11,000 | $16.6K | 0.00% | 00.0% | Unchanged |
| California State Teachers Retirement System | 11,387 | $17.2K | 0.00% | −7,255−38.9% | Reduced |
| Two Sigma Investments, LP | 13,691 | $20.7K | 0.00% | −128,583−90.4% | Reduced |
| Legal & General Group Plc | 13,735 | $20.7K | 0.00% | 00.0% | Unchanged |
| CI Private Wealth, LLC | 13,900 | $21.0K | 0.00% | −100−0.7% | Reduced |
| Winthrop Advisory Group LLC | 15,000 | $22.6K | 0.00% | +15,000 | New |
| Diversified Trust Co | 18,580 | $28.1K | 0.00% | 00.0% | Unchanged |
| Citigroup Inc | 18,924 | $28.6K | 0.00% | +2,492+15.2% | Added |
| Prudential Financial Inc | 19,615 | $29.6K | 0.00% | −5,200−21.0% | Reduced |
| ProShare Advisors LLC | 20,348 | $30.7K | 0.00% | +1,602+8.5% | Added |
| Baird Financial Group, Inc. | 20,800 | $31.4K | 0.00% | +7,000+50.7% | Added |
| New York State Common Retirement Fund | 21,150 | $31.9K | 0.00% | +1,777+9.2% | Added |
| Prelude Capital Management, LLC | 23,500 | $35.5K | 0.00% | +23,500 | New |
| Banque Cantonale Vaudoise | 25,000 | $38.0K | 0.00% | 00.0% | Unchanged |
| Commonwealth Equity Services, LLC | 25,406 | $38.0K | 0.00% | +25,406 | New |
| Invesco Ltd. | 27,969 | $42.2K | 0.00% | −502−1.8% | Reduced |
| Engineers Gate Manager LP | 28,700 | $43.3K | 0.00% | 00.0% | Unchanged |
| Eqis Capital Management, Inc. | 29,197 | $44.1K | 0.00% | +29,197 | New |
| ELCO Management Co., LLC | 31,901 | $48.2K | 0.03% | +9,340+41.4% | Added |
| Colony Group, LLC | 45,930 | $50.0K | 0.00% | +45,930 | New |
| Principal Financial Group Inc | 33,165 | $50.1K | 0.00% | +1,723+5.5% | Added |
| Wells Fargo & Company | 33,898 | $51.2K | 0.00% | +4,533+15.4% | Added |
| Kennedy Investment Group | 35,000 | $52.9K | 0.03% | 00.0% | Unchanged |
| Manufacturers Life Insurance Company, The | 35,868 | $54.2K | 0.00% | +35,868 | New |
| Group One Trading, L.P. | 37,132 | $56.1K | 0.00% | +6,659+21.9% | Added |
| Voya Investment Management LLC | 38,802 | $58.6K | 0.00% | −6,669−14.7% | Reduced |
| SEI Investments Co | 40,000 | $60.4K | 0.00% | +40,000 | New |
| Bleakley Financial Group, LLC | 44,011 | $66.5K | 0.00% | +6,073+16.0% | Added |
| Simplicity Wealth,LLC | 44,011 | $66.5K | 0.00% | +44,011 | New |
| State of Wyoming | 47,307 | $71.4K | 0.01% | +18,876+66.4% | Added |
| HSBC Holdings PLC | 53,563 | $80.9K | 0.00% | +8,273+18.3% | Added |
| Simplex Trading, LLC | 55,985 | $84.0K | 0.00% | +34,984+166.6% | Added |
| American International Group, Inc. | 55,816 | $84.3K | 0.00% | −479−0.9% | Reduced |
| MetLife Investment Management | 60,551 | $91.4K | 0.00% | +60,551 | New |
| State Board of Administration of Florida Retirement System | 27,015 | $105.1K | 0.00% | −2,407−8.2% | Reduced |
| Connor, Clark & Lunn Investment Management Ltd. | 76,317 | $115.2K | 0.00% | +5,093+7.2% | Added |
| Susquehanna International Group, LLP | 76,599 | $115.7K | 0.00% | −1,997−2.5% | Reduced |
| Boothbay Fund Management, LLC | 91,091 | $137.5K | 0.00% | +9,355+11.4% | Added |
| Price T Rowe Associates Inc | 95,091 | $144.0K | 0.00% | +7,978+9.2% | Added |
| AQR Capital Management LLC | 125,826 | $190.0K | 0.00% | −472,316−79.0% | Reduced |
| Woodline Partners LP | 134,112 | $202.5K | 0.00% | +17,394+14.9% | Added |
| Royal Bank of Canada | 137,012 | $207.0K | 0.00% | +60,692+79.5% | Added |
| Rhumbline Advisers | 144,028 | $217.5K | 0.00% | +5,921+4.3% | Added |
| Bank of America Corp | 157,915 | $238.4K | 0.00% | −148,540−48.5% | Reduced |
| Jane Street Group, LLC | 171,650 | $259.2K | 0.00% | −103,810−37.7% | Reduced |
| Bridgeway Capital Management, LLC | 189,500 | $286.1K | 0.01% | −100,000−34.5% | Reduced |
| DAFNA Capital Management LLC | 192,678 | $290.9K | 0.07% | 00.0% | Unchanged |
| Alliancebernstein L.P. | 192,810 | $291.1K | 0.00% | 00.0% | Unchanged |
| Exchange Traded Concepts, LLC | 212,638 | $321.1K | 0.01% | +96,774+83.5% | Added |
| Panagora Asset Management Inc | 229,924 | $347.2K | 0.00% | +2,479+1.1% | Added |
| XTX Topco Ltd | 242,841 | $366.7K | 0.05% | +193,719+394.4% | Added |
| Atom Investors LP | 244,397 | $369.0K | 0.05% | +27,707+12.8% | Added |
| UBS Group AG | 254,933 | $384.9K | 0.00% | −202,252−44.2% | Reduced |
| FMR LLC | 273,808 | $413.4K | 0.00% | +5,522+2.1% | Added |
| Morgan Stanley | 294,787 | $445.1K | 0.00% | −550,364−65.1% | Reduced |
| Charles Schwab Investment Management Inc | 309,909 | $468.0K | 0.00% | 00.0% | Unchanged |
| Los Angeles Capital Management LLC | 387,520 | $585.2K | 0.00% | −4,020−1.0% | Reduced |
| Ikarian Capital, LLC | 409,355 | $618.1K | 0.17% | +9,355+2.3% | Added |
| Birchview Capital, LP | 469,832 | $709.4K | 0.58% | 00.0% | Unchanged |
| Bank of New York Mellon Corp | 487,060 | $735.5K | 0.00% | −10,142−2.0% | Reduced |
| Nuveen Asset Management, LLC | 492,365 | $743.5K | 0.00% | +38,063+8.4% | Added |
| Macquarie Group Ltd | 500,000 | $755.0K | 0.00% | +120,000+31.6% | Added |
| Silverarc Capital Management, LLC | 558,466 | $843.3K | 0.24% | −3,489−0.6% | Reduced |
| UBS Oconnor LLC | 722,327 | $1.09M | 0.03% | −80,000−10.0% | Reduced |
| Altium Capital Management LP | 740,000 | $1.12M | 0.50% | 00.0% | Unchanged |
| Barclays PLC | 892,815 | $1.35M | 0.00% | −77,247−8.0% | Reduced |
| Renaissance Technologies LLC | 906,800 | $1.37M | 0.00% | −1,057,577−53.8% | Reduced |
| Northern Trust Corp | 958,805 | $1.45M | 0.00% | −37,342−3.7% | Reduced |
| D. E. Shaw & Co., Inc. | 962,825 | $1.45M | 0.00% | +345,609+56.0% | Added |
| AlphaCentric Advisors LLC | 1,125,000 | $1.70M | 1.02% | 00.0% | Unchanged |
| Millennium Management LLC | 1,185,879 | $1.79M | 0.00% | −348,385−22.7% | Reduced |
| Gsa Capital Partners LLP | 1,299,151 | $1.96M | 0.16% | −1,038,834−44.4% | Reduced |
| Deutsche Bank AG | 1,324,977 | $2.00M | 0.00% | −2,031−0.2% | Reduced |