Karyopharm Therapeutics Inc.
KPTI- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001503802
In the last 90 days, Karyopharm Therapeutics Inc. insiders filed 0 open-market purchases and 2 sales; 96 institutions reported holding it in 13F filings for Q2 2026, worth $206.8M in total; no superinvestor holds it.
13F holders, Q4 2023
Institutional positions in Karyopharm Therapeutics Inc. as of Dec 31, 2023. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 120
- 0 vs. Q3 2023
- Shares held
- 73.5M
- −3.74M (−4.8%) vs. Q3 2023
- Total value
- $63.5M
- −$39.3M (−38.2%) vs. Q3 2023
- New holders
- 23
- 24 more added
- Sold out
- 23
- 42 more reduced
Compare with Q3 2023: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting KPTI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 96 | $206.8M |
| Q1 2026 | 77 | $98.4M |
| Q4 2025 | 68 | $69.6M |
| Q3 2025 | 52 | $19.5M |
| Q2 2025 | 50 | $19.0M |
| Q1 2025 | 50 | $13.7M |
| Q4 2024 | 87 | $41.2M |
| Q3 2024 | 91 | $49.2M |
| Q2 2024 | 114 | $58.6M |
| Q1 2024 | 114 | $113.0M |
| Q4 2023 | 120 | $63.5M |
| Q3 2023 | 120 | $102.8M |
| Q2 2023 | 138 | $145.0M |
| Q1 2023 | 132 | $340.1M |
| Q4 2022 | 155 | $334.4M |
| Q3 2022 | 147 | $364.1M |
| Q2 2022 | 150 | $302.8M |
| Q1 2022 | 139 | $501.8M |
| Q4 2021 | 143 | $347.5M |
| Q3 2021 | 134 | $334.4M |
| Q2 2021 | 154 | $608.7M |
| Q1 2021 | 171 | $637.1M |
Institutions, Q4 2023
Shares, value and share of portfolio for each institution holding Karyopharm Therapeutics Inc.; share changes are against Q3 2023.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| CWM, LLC | 3 | $0 | 0.00% | +3 | New |
| Sofos Investments, Inc. | 2 | $2 | 0.00% | 00.0% | Unchanged |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 6 | $5 | 0.00% | 00.0% | Unchanged |
| JJJ Advisors Inc. | 17 | $15 | 0.00% | +17 | New |
| West Branch Capital LLC | 48 | $42 | 0.00% | +48 | New |
| Kelly Financial Services LLC | 250 | $216 | 0.00% | 00.0% | Unchanged |
| Allworth Financial LP | 500 | $433 | 0.00% | 00.0% | Unchanged |
| Advisory Services Network, LLC | 500 | $433 | 0.00% | +500 | New |
| Bruce G. Allen Investments, LLC | 507 | $439 | 0.00% | +507 | New |
| AdvisorNet Financial, Inc | 700 | $606 | 0.00% | 00.0% | Unchanged |
| Harbour Investments, Inc. | 1,300 | $1.13K | 0.00% | 00.0% | Unchanged |
| MB, Levis & Associates, LLC | 1,500 | $1.30K | 0.00% | 00.0% | Unchanged |
| TD Waterhouse Canada Inc. | 2,060 | $1.70K | 0.00% | 00.0% | Unchanged |
| Founders Capital Management | 2,000 | $1.73K | 0.00% | 00.0% | Unchanged |
| The PNC Financial Services Group, Inc. | 3,000 | $2.60K | 0.00% | 00.0% | Unchanged |
| Cubist Systematic Strategies, LLC | 4,684 | $4.05K | 0.00% | +4,684 | New |
| Ameritas Investment Partners, Inc. | 6,194 | $5.36K | 0.00% | 00.0% | Unchanged |
| Advisor Group Holdings, Inc. | 6,444 | $5.57K | 0.00% | −500−7.2% | Reduced |
| Russell Investments Group, Ltd. | 6,519 | $5.64K | 0.00% | −88,339−93.1% | Reduced |
| Janney Montgomery Scott LLC | 10,000 | $9.00K | 0.00% | 00.0% | Unchanged |
| Virtu Financial LLC | 10,007 | $9.00K | 0.00% | +10,007 | New |
| Snowden Capital Advisors LLC | 11,000 | $9.52K | 0.00% | +11,000 | New |
| Bayesian Capital Management, LP | 11,100 | $9.60K | 0.00% | +11,100 | New |
| Creative Planning | 11,600 | $10.0K | 0.00% | 00.0% | Unchanged |
| Tower Research Capital LLC (TRC) | 11,616 | $10.0K | 0.00% | −10,528−47.5% | Reduced |
| Brinker Capital Investments, LLC | 10,965 | $10.1K | 0.00% | −2,074−15.9% | Reduced |
| Orion Portfolio Solutions, LLC | 10,965 | $10.1K | 0.00% | −2,074−15.9% | Reduced |
| Neuberger Berman Group LLC | 13,317 | $11.5K | 0.00% | +2,083+18.5% | Added |
| Legal & General Group Plc | 13,735 | $11.9K | 0.00% | 00.0% | Unchanged |
| Baird Financial Group, Inc. | 13,800 | $11.9K | 0.00% | 00.0% | Unchanged |
| CI Private Wealth, LLC | 14,000 | $12.1K | 0.00% | +14,000 | New |
| Amalgamated Bank | 14,694 | $13.0K | 0.00% | −737−4.8% | Reduced |
| Citigroup Inc | 16,432 | $14.2K | 0.00% | +14,827+923.8% | Added |
| Diversified Trust Co | 18,580 | $16.1K | 0.00% | +18,580 | New |
| California State Teachers Retirement System | 18,642 | $16.1K | 0.00% | −6,348−25.4% | Reduced |
| ProShare Advisors LLC | 18,746 | $16.2K | 0.00% | −3,445−15.5% | Reduced |
| New York State Common Retirement Fund | 19,373 | $16.8K | 0.00% | −290−1.5% | Reduced |
| Two Sigma Securities, LLC | 19,586 | $16.9K | 0.00% | +19,586 | New |
| Simplex Trading, LLC | 21,001 | $18.0K | 0.00% | −505−2.3% | Reduced |
| Point72 Middle East FZE | 22,028 | $19.1K | 0.00% | −73,110−76.8% | Reduced |
| ELCO Management Co., LLC | 22,561 | $19.5K | 0.01% | 00.0% | Unchanged |
| Prudential Financial Inc | 24,815 | $21.5K | 0.00% | +5,400+27.8% | Added |
| Banque Cantonale Vaudoise | 25,000 | $22.0K | 0.00% | +10,000+66.7% | Added |
| Weiss Multi-Strategy Advisers LLC | 27,043 | $23.0K | 0.00% | −4,771−15.0% | Reduced |
| Wexford Capital LP | 27,280 | $23.6K | 0.01% | +27,280 | New |
| State of Wyoming | 28,431 | $24.6K | 0.00% | −12,310−30.2% | Reduced |
| Invesco Ltd. | 28,471 | $24.6K | 0.00% | −35,341−55.4% | Reduced |
| Engineers Gate Manager LP | 28,700 | $24.8K | 0.00% | −10,262−26.3% | Reduced |
| Wells Fargo & Company | 29,365 | $25.4K | 0.00% | +6,682+29.5% | Added |
| State Board of Administration of Florida Retirement System | 29,422 | $25.4K | 0.00% | +29,422 | New |
| Redwood Wealth Management Group, LLC | 29,730 | $25.7K | 0.03% | −3,000−9.2% | Reduced |
| Group One Trading, L.P. | 30,473 | $26.4K | 0.00% | −24,040−44.1% | Reduced |
| Principal Financial Group Inc | 31,442 | $27.2K | 0.00% | −1,396−4.3% | Reduced |
| Kennedy Investment Group | 35,000 | $30.3K | 0.02% | 00.0% | Unchanged |
| Sawtooth Solutions, LLC | 37,938 | $32.8K | 0.00% | +37,938 | New |
| Bleakley Financial Group, LLC | 37,938 | $32.8K | 0.00% | +37,938 | New |
| Monashee Investment Management LLC | 132,435 | $34.9K | 0.01% | +132,435 | New |
| HSBC Holdings PLC | 45,290 | $38.9K | 0.00% | +362+0.8% | Added |
| Wade G W & Inc | 45,140 | $39.0K | 0.00% | 00.0% | Unchanged |
| Voya Investment Management LLC | 45,471 | $39.3K | 0.00% | 00.0% | Unchanged |
| XTX Topco Ltd | 49,122 | $42.5K | 0.01% | −260,943−84.2% | Reduced |
| American International Group, Inc. | 56,295 | $48.7K | 0.00% | −228−0.4% | Reduced |
| Two Sigma Advisers, LP | 63,200 | $54.7K | 0.00% | +28,000+79.5% | Added |
| Connor, Clark & Lunn Investment Management Ltd. | 71,224 | $61.6K | 0.00% | +35,945+101.9% | Added |
| SG Americas Securities, LLC | 73,430 | $64.0K | 0.00% | +54,839+295.0% | Added |
| Royal Bank of Canada | 76,320 | $66.0K | 0.00% | −961−1.2% | Reduced |
| Susquehanna International Group, LLP | 78,596 | $68.0K | 0.00% | −59,213−43.0% | Reduced |
| Boothbay Fund Management, LLC | 81,736 | $70.7K | 0.00% | 00.0% | Unchanged |
| Price T Rowe Associates Inc | 87,113 | $76.0K | 0.00% | 00.0% | Unchanged |
| Exchange Traded Concepts, LLC | 115,864 | $100.2K | 0.00% | +29,380+34.0% | Added |
| Woodline Partners LP | 116,718 | $101.0K | 0.00% | −17,394−13.0% | Reduced |
| Rhumbline Advisers | 138,107 | $119.5K | 0.00% | −500.0% | Reduced |
| Two Sigma Investments, LP | 142,274 | $123.1K | 0.00% | +142,274 | New |
| DAFNA Capital Management LLC | 192,678 | $166.7K | 0.04% | 00.0% | Unchanged |
| Alliancebernstein L.P. | 192,810 | $166.8K | 0.00% | 00.0% | Unchanged |
| Atom Investors LP | 216,690 | $187.4K | 0.03% | +25,865+13.6% | Added |
| Panagora Asset Management Inc | 227,445 | $196.7K | 0.00% | +227,445 | New |
| FMR LLC | 268,286 | $232.1K | 0.00% | +1,839+0.7% | Added |
| Acadian Asset Management LLC | 275,059 | $237.0K | 0.00% | +275,059 | New |
| Jane Street Group, LLC | 275,460 | $238.3K | 0.00% | +275,460 | New |
| Jacobs Levy Equity Management, Inc | 284,457 | $246.1K | 0.00% | −2,069,071−87.9% | Reduced |
| Bridgeway Capital Management, LLC | 289,500 | $250.4K | 0.01% | 00.0% | Unchanged |
| Bank of America Corp | 306,455 | $265.1K | 0.00% | −46,167−13.1% | Reduced |
| Charles Schwab Investment Management Inc | 309,909 | $268.1K | 0.00% | +51,000+19.7% | Added |
| Ameriprise Financial Inc | 309,967 | $268.1K | 0.00% | −47,011−13.2% | Reduced |
| Macquarie Group Ltd | 380,000 | $329.0K | 0.00% | 00.0% | Unchanged |
| Los Angeles Capital Management LLC | 391,540 | $338.7K | 0.00% | +391,540 | New |
| Ikarian Capital, LLC | 400,000 | $346.0K | 0.09% | 00.0% | Unchanged |
| Nuveen Asset Management, LLC | 454,302 | $393.0K | 0.00% | +1,896+0.4% | Added |
| UBS Group AG | 457,185 | $395.5K | 0.00% | −449,460−49.6% | Reduced |
| Birchview Capital, LP | 469,832 | $406.4K | 0.32% | −102,000−17.8% | Reduced |
| Bank of New York Mellon Corp | 497,202 | $430.1K | 0.00% | −156,448−23.9% | Reduced |
| Candriam Luxembourg S.C.A. | 530,694 | $459.1K | 0.00% | −610,000−53.5% | Reduced |
| Silverarc Capital Management, LLC | 561,955 | $486.1K | 0.15% | 00.0% | Unchanged |
| AQR Capital Management LLC | 598,142 | $517.4K | 0.00% | +96,343+19.2% | Added |
| D. E. Shaw & Co., Inc. | 617,216 | $533.9K | 0.00% | −5,639−0.9% | Reduced |
| Altium Capital Management LP | 740,000 | $640.1K | 0.44% | 00.0% | Unchanged |
| UBS Oconnor LLC | 802,327 | $694.0K | 0.02% | −74,383−8.5% | Reduced |
| Morgan Stanley | 845,151 | $731.1K | 0.00% | −199,320−19.1% | Reduced |
| Barclays PLC | 970,062 | $839.1K | 0.00% | −182,236−15.8% | Reduced |