Karyopharm Therapeutics Inc.
KPTI- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001503802
In the last 90 days, Karyopharm Therapeutics Inc. insiders filed 0 open-market purchases and 2 sales; 96 institutions reported holding it in 13F filings for Q2 2026, worth $206.8M in total; no superinvestor holds it.
13F holders, Q4 2024
Institutional positions in Karyopharm Therapeutics Inc. as of Dec 31, 2024. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 87
- −4 vs. Q3 2024
- Shares held
- 60.9M
- +1.50M (+2.5%) vs. Q3 2024
- Total value
- $41.2M
- −$8.02M (−16.3%) vs. Q3 2024
- New holders
- 14
- 22 more added
- Sold out
- 18
- 23 more reduced
Compare with Q3 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting KPTI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 96 | $206.8M |
| Q1 2026 | 77 | $98.4M |
| Q4 2025 | 68 | $69.6M |
| Q3 2025 | 52 | $19.5M |
| Q2 2025 | 50 | $19.0M |
| Q1 2025 | 50 | $13.7M |
| Q4 2024 | 87 | $41.2M |
| Q3 2024 | 91 | $49.2M |
| Q2 2024 | 114 | $58.6M |
| Q1 2024 | 114 | $113.0M |
| Q4 2023 | 120 | $63.5M |
| Q3 2023 | 120 | $102.8M |
| Q2 2023 | 138 | $145.0M |
| Q1 2023 | 132 | $340.1M |
| Q4 2022 | 155 | $334.4M |
| Q3 2022 | 147 | $364.1M |
| Q2 2022 | 150 | $302.8M |
| Q1 2022 | 139 | $501.8M |
| Q4 2021 | 143 | $347.5M |
| Q3 2021 | 134 | $334.4M |
| Q2 2021 | 154 | $608.7M |
| Q1 2021 | 171 | $637.1M |
Institutions, Q4 2024
Shares, value and share of portfolio for each institution holding Karyopharm Therapeutics Inc.; share changes are against Q3 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| West Branch Capital LLC | 48 | $33 | 0.00% | 00.0% | Unchanged |
| CIBC Private Wealth Group, LLC | 50 | $36 | 0.00% | 00.0% | Unchanged |
| Bruce G. Allen Investments, LLC | 338 | $229 | 0.00% | 00.0% | Unchanged |
| Allworth Financial LP | 500 | $334 | 0.00% | 00.0% | Unchanged |
| Wells Fargo & Company | 666 | $450 | 0.00% | 00.0% | Unchanged |
| SBI Securities Co., Ltd. | 717 | $485 | 0.00% | +717 | New |
| Activest Wealth Management | 1,000 | $676 | 0.00% | 00.0% | Unchanged |
| Harbour Investments, Inc. | 1,300 | $879 | 0.00% | 00.0% | Unchanged |
| MB, Levis & Associates, LLC | 1,500 | $1.01K | 0.00% | 00.0% | Unchanged |
| VSM Wealth Advisory, LLC | 2,000 | $1.35K | 0.00% | +2,000 | New |
| Quent Capital, LLC | 3,489 | $2.36K | 0.00% | 00.0% | Unchanged |
| Advisor Group Holdings, Inc. | 5,390 | $3.66K | 0.00% | +1,000+22.8% | Added |
| Royal Bank of Canada | 6,500 | $4.00K | 0.00% | −1,450−18.2% | Reduced |
| Tower Research Capital LLC (TRC) | 7,696 | $5.20K | 0.00% | +7,696 | New |
| BLB&B Advisors, LLC | 10,150 | $6.86K | 0.00% | 00.0% | Unchanged |
| Janney Montgomery Scott LLC | 10,000 | $7.00K | 0.00% | 00.0% | Unchanged |
| Walleye Capital LLC | 10,451 | $7.07K | 0.00% | +10,451 | New |
| Wolverine Trading, LLC | 10,273 | $7.19K | 0.00% | −3,462−25.2% | Reduced |
| Snowden Capital Advisors LLC | 11,000 | $7.44K | 0.00% | 00.0% | Unchanged |
| CAPROCK Group, Inc. | 11,600 | $7.84K | 0.00% | +11,600 | New |
| Winthrop Advisory Group LLC | 15,000 | $10.1K | 0.00% | 00.0% | Unchanged |
| ELCO Management Co., LLC | 16,177 | $10.9K | 0.01% | 00.0% | Unchanged |
| ADAR1 Capital Management, LLC | 20,000 | $13.5K | 0.00% | +20,000 | New |
| CI Private Wealth, LLC | 20,500 | $13.9K | 0.00% | −584−2.8% | Reduced |
| Squarepoint Ops LLC | 20,786 | $14.1K | 0.00% | +20,786 | New |
| Commonwealth Equity Services, LLC | 22,288 | $15.0K | 0.00% | +82+0.4% | Added |
| Engineers Gate Manager LP | 28,699 | $19.4K | 0.00% | −19,434−40.4% | Reduced |
| R Squared Ltd | 29,670 | $20.1K | 0.02% | +29,670 | New |
| Kennedy Investment Group | 35,000 | $23.7K | 0.01% | 00.0% | Unchanged |
| Eqis Capital Management, Inc. | 38,684 | $26.2K | 0.00% | +1,483+4.0% | Added |
| HSBC Holdings PLC | 40,301 | $26.5K | 0.00% | 00.0% | Unchanged |
| Velan Capital Investment Management LP | 40,000 | $27.1K | 0.02% | +40,000 | New |
| Baird Financial Group, Inc. | 44,800 | $30.3K | 0.00% | +7,000+18.5% | Added |
| Colony Group, LLC | 45,818 | $31.0K | 0.00% | +45,818 | New |
| TD Waterhouse Canada Inc. | 48,049 | $32.2K | 0.00% | +48,049 | New |
| Charles Schwab Investment Management Inc | 51,173 | $34.6K | 0.00% | +173+0.3% | Added |
| Price T Rowe Associates Inc | 64,300 | $44.0K | 0.00% | −70,400−52.3% | Reduced |
| Prudential Financial Inc | 74,600 | $50.5K | 0.00% | 00.0% | Unchanged |
| Two Sigma Advisers, LP | 76,600 | $51.8K | 0.00% | +45,400+145.5% | Added |
| Point72 Asia (Singapore) Pte. Ltd. | 84,698 | $57.3K | 0.02% | +2,252+2.7% | Added |
| Boothbay Fund Management, LLC | 90,635 | $61.3K | 0.00% | −456−0.5% | Reduced |
| Barclays PLC | 95,611 | $64.7K | 0.00% | −156−0.2% | Reduced |
| Citigroup Inc | 105,679 | $71.5K | 0.00% | −140.0% | Reduced |
| Opti Capital Management, LP | 125,000 | $84.5K | 0.00% | +125,000 | New |
| Woodline Partners LP | 134,112 | $90.7K | 0.00% | 00.0% | Unchanged |
| Two Sigma Investments, LP | 137,786 | $93.2K | 0.00% | +51,856+60.3% | Added |
| UBS Group AG | 145,791 | $98.6K | 0.00% | +11,313+8.4% | Added |
| Bank of America Corp | 161,708 | $109.3K | 0.00% | −67,233−29.4% | Reduced |
| Bank of New York Mellon Corp | 166,317 | $112.5K | 0.00% | +10.0% | Added |
| Shay Capital LLC | 172,153 | $116.4K | 0.03% | +172,153 | New |
| Exchange Traded Concepts, LLC | 218,791 | $148.0K | 0.00% | 00.0% | Unchanged |
| D. E. Shaw & Co., Inc. | 229,685 | $155.3K | 0.00% | −817,711−78.1% | Reduced |
| Bridgeway Capital Management, LLC | 239,500 | $162.0K | 0.00% | 00.0% | Unchanged |
| Atom Investors LP | 259,824 | $175.7K | 0.02% | 00.0% | Unchanged |
| JPMorgan Chase & Co | 276,208 | $186.8K | 0.00% | −1,109,516−80.1% | Reduced |
| Northern Trust Corp | 283,729 | $191.9K | 0.00% | +54,061+23.5% | Added |
| Cubist Systematic Strategies, LLC | 328,807 | $222.4K | 0.00% | −167,429−33.7% | Reduced |
| Acadian Asset Management LLC | 342,847 | $230.0K | 0.00% | −25,664−7.0% | Reduced |
| Ikarian Capital, LLC | 408,899 | $276.5K | 0.08% | −456−0.1% | Reduced |
| FMR LLC | 412,456 | $278.9K | 0.00% | +42,733+11.6% | Added |
| Birchview Capital, LP | 419,832 | $283.9K | 0.23% | −50,000−10.6% | Reduced |
| State Street Corp | 442,510 | $299.3K | 0.00% | +33,000+8.1% | Added |
| Macquarie Group Ltd | 500,000 | $338.0K | 0.00% | 00.0% | Unchanged |
| Silverarc Capital Management, LLC | 595,990 | $403.1K | 0.09% | +37,524+6.7% | Added |
| Susquehanna International Group, LLP | 664,145 | $449.2K | 0.00% | +361,597+119.5% | Added |
| Altium Capital Management LP | 740,000 | $500.5K | 0.16% | 00.0% | Unchanged |
| Jane Street Group, LLC | 748,306 | $506.1K | 0.00% | +543,556+265.5% | Added |
| Millennium Management LLC | 1,154,414 | $780.7K | 0.00% | −100,850−8.0% | Reduced |
| Kennedy Capital Management, Inc. | 1,195,293 | $808.4K | 0.02% | −8,716−0.7% | Reduced |
| Renaissance Technologies LLC | 1,202,590 | $813.3K | 0.00% | −38,817−3.1% | Reduced |
| Deutsche Bank AG | 1,268,777 | $862.8K | 0.00% | 00.0% | Unchanged |
| BNP Paribas Arbitrage, SA | 1,313,893 | $888.6K | 0.00% | −668,461−33.7% | Reduced |
| Goldman Sachs Group Inc | 1,335,771 | $903.4K | 0.00% | −944−0.1% | Reduced |
| Geode Capital Management, LLC | 1,392,314 | $941.9K | 0.00% | +36,922+2.7% | Added |
| UBS Oconnor LLC | 1,483,727 | $1.00M | 0.03% | +287,553+24.0% | Added |
| C WorldWide Group Holding A/S | 1,500,000 | $1.01M | 0.01% | 00.0% | Unchanged |
| Gsa Capital Partners LLP | 1,598,435 | $1.08M | 0.08% | −177,265−10.0% | Reduced |
| Avidity Partners Management LP | 2,018,500 | $1.37M | 0.14% | 00.0% | Unchanged |
| Eversept Partners, LP | 2,088,757 | $1.41M | 0.15% | −3,459,123−62.4% | Reduced |
| Catalio Capital Management, LP | 2,334,375 | $1.58M | 0.35% | +2,334,375 | New |
| Marshall Wace, LLP | 2,401,413 | $1.63M | 0.00% | +319,187+15.3% | Added |
| Citadel Advisors LLC | 3,103,669 | $2.10M | 0.00% | 00.0% | Unchanged |
| Morgan Stanley | 3,513,188 | $2.38M | 0.00% | +3,389,541+2,741.3% | Added |
| BlackRock, Inc. | 3,768,875 | $2.55M | 0.00% | +130,497+3.6% | Added |
| Palo Alto Investors LP | 4,907,001 | $3.32M | 0.51% | −195,192−3.8% | Reduced |
| Adage Capital Partners GP, L.L.C. | 6,319,842 | $4.27M | 0.01% | +2,000,000+46.3% | Added |
| Vanguard Group Inc | 7,654,482 | $5.17M | 0.00% | 00.0% | Unchanged |
| AlphaCentric Advisors LLC | 0 | $0 | 0.00% | −1,125,000−100.0% | Sold out |
| DAFNA Capital Management LLC | 0 | $0 | 0.00% | −192,678−100.0% | Sold out |
| Qube Research & Technologies Ltd | 0 | $0 | 0.00% | −62,026−100.0% | Sold out |
| Invesco Ltd. | 0 | $0 | 0.00% | −58,152−100.0% | Sold out |
| Cerity Partners LLC | 0 | $0 | 0.00% | −51,533−100.0% | Sold out |
| Monashee Investment Management LLC | 0 | $0 | 0.00% | −132,435−100.0% | Sold out |
| Catalyst Funds Management Pty Ltd | 0 | $0 | 0.00% | −28,600−100.0% | Sold out |
| XTX Topco Ltd | 0 | $0 | 0.00% | −25,905−100.0% | Sold out |
| JustInvest LLC | 0 | $0 | 0.00% | −17,188−100.0% | Sold out |
| Victory Capital Management Inc | 0 | $0 | 0.00% | −14,496−100.0% | Sold out |
| AQR Capital Management LLC | 0 | $0 | 0.00% | −12,221−100.0% | Sold out |
| Avidian Wealth Solutions, LLC | 0 | $0 | 0.00% | −10,100−100.0% | Sold out |
| The PNC Financial Services Group, Inc. | 0 | $0 | 0.00% | −3,000−100.0% | Sold out |