Karyopharm Therapeutics Inc.
KPTI- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001503802
In the last 90 days, Karyopharm Therapeutics Inc. insiders filed 0 open-market purchases and 2 sales; 96 institutions reported holding it in 13F filings for Q2 2026, worth $206.8M in total; no superinvestor holds it.
13F holders, Q2 2026
Institutional positions in Karyopharm Therapeutics Inc. as of Jun 30, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 96
- +19 vs. Q1 2026
- Shares held
- 21.2M
- +3.49M (+19.8%) vs. Q1 2026
- Total value
- $206.8M
- +$108.4M (+110.1%) vs. Q1 2026
- New holders
- 33
- 31 more added
- Sold out
- 14
- 14 more reduced
Compare with Q1 2026: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting KPTI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 96 | $206.8M |
| Q1 2026 | 77 | $98.4M |
| Q4 2025 | 68 | $69.6M |
| Q3 2025 | 52 | $19.5M |
| Q2 2025 | 50 | $19.0M |
| Q1 2025 | 50 | $13.7M |
| Q4 2024 | 87 | $41.2M |
| Q3 2024 | 91 | $49.2M |
| Q2 2024 | 114 | $58.6M |
| Q1 2024 | 114 | $113.0M |
| Q4 2023 | 120 | $63.5M |
| Q3 2023 | 120 | $102.8M |
| Q2 2023 | 138 | $145.0M |
| Q1 2023 | 132 | $340.1M |
| Q4 2022 | 155 | $334.4M |
| Q3 2022 | 147 | $364.1M |
| Q2 2022 | 150 | $302.8M |
| Q1 2022 | 139 | $501.8M |
| Q4 2021 | 143 | $347.5M |
| Q3 2021 | 134 | $334.4M |
| Q2 2021 | 154 | $608.7M |
| Q1 2021 | 171 | $637.1M |
Institutions, Q2 2026
Shares, value and share of portfolio for each institution holding Karyopharm Therapeutics Inc.; share changes are against Q1 2026.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| PlanVest Financial, Inc | 1 | $10 | 0.00% | 00.0% | Unchanged |
| West Branch Capital LLC | 3 | $30 | 0.00% | 00.0% | Unchanged |
| Caitong International Asset Management Co., Ltd | 14 | $137 | 0.00% | +14 | New |
| Allworth Financial LP | 26 | $255 | 0.00% | 00.0% | Unchanged |
| Activest Wealth Management | 66 | $645 | 0.00% | 00.0% | Unchanged |
| SBI Securities Co., Ltd. | 67 | $655 | 0.00% | 00.0% | Unchanged |
| MB, Levis & Associates, LLC | 100 | $977 | 0.00% | 00.0% | Unchanged |
| Quent Capital, LLC | 166 | $1.62K | 0.00% | −69−29.4% | Reduced |
| California State Teachers Retirement System | 274 | $2.68K | 0.00% | +274 | New |
| Harbour Investments, Inc. | 285 | $2.78K | 0.00% | 00.0% | Unchanged |
| Sterling Capital Management LLC | 352 | $3.44K | 0.00% | +352 | New |
| Advisor Group Holdings, Inc. | 402 | $3.93K | 0.00% | 00.0% | Unchanged |
| Tower Research Capital LLC (TRC) | 1,259 | $12.3K | 0.00% | +1,259 | New |
| Russell Investments Group, Ltd. | 1,592 | $15.6K | 0.00% | +1,592 | New |
| Ameritas Investment Partners, Inc. | 1,808 | $17.7K | 0.00% | +1,808 | New |
| Legal & General Group Plc | 1,935 | $18.9K | 0.00% | +1,935 | New |
| TD Waterhouse Canada Inc. | 5,707 | $54.5K | 0.00% | +2,504+78.2% | Added |
| New York State Common Retirement Fund | 5,600 | $54.7K | 0.00% | +5,600 | New |
| Police & Firemen's Retirement System of New Jersey | 5,874 | $57.4K | 0.00% | +5,874 | New |
| Vanguard Global Advisers, LLC | 8,207 | $80.2K | 0.00% | 00.0% | Unchanged |
| FMR LLC | 8,936 | $87.3K | 0.00% | +8,271+1,243.8% | Added |
| Mirae Asset Global ETFs Holdings Ltd. | 9,171 | $89.6K | 0.00% | +9,171 | New |
| Quadrature Capital Ltd | 10,296 | $100.6K | 0.00% | +10,296 | New |
| Y-Intercept (Hong Kong) Ltd | 10,375 | $101.4K | 0.00% | +10,375 | New |
| Virtu Financial LLC | 10,728 | $105.0K | 0.00% | +10,728 | New |
| MetLife Investment Management | 12,017 | $117.4K | 0.00% | +12,017 | New |
| Headlands Technologies LLC | 12,113 | $118.3K | 0.01% | +12,113 | New |
| HSBC Holdings PLC | 13,750 | $137.4K | 0.00% | +2,255+19.6% | Added |
| SEI Investments Co | 15,083 | $147.4K | 0.00% | +15,083 | New |
| Wells Fargo & Company | 16,903 | $165.1K | 0.00% | +16,903 | New |
| Deutsche Bank AG | 19,425 | $189.8K | 0.00% | +19,425 | New |
| Velan Capital Investment Management LP | 20,000 | $195.4K | 0.12% | +5,000+33.3% | Added |
| Susquehanna Fundamental Investments, LLC | 23,265 | $227.3K | 0.00% | +23,265 | New |
| Rhumbline Advisers | 23,467 | $229.3K | 0.00% | +23,467 | New |
| Simplex Trading, LLC | 24,086 | $235.3K | 0.01% | +24,086 | New |
| China Universal Asset Management Co., Ltd. | 25,000 | $244.3K | 0.01% | −5,000−16.7% | Reduced |
| ExodusPoint Capital Management, LP | 26,582 | $259.7K | 0.00% | +26,582 | New |
| Price T Rowe Associates Inc | 27,225 | $266.0K | 0.00% | +16,339+150.1% | Added |
| Baird Financial Group, Inc. | 29,791 | $291.1K | 0.00% | 00.0% | Unchanged |
| Silverback Asset Management LLC | 30,000 | $293.1K | 0.04% | −35,000−53.8% | Reduced |
| Toronto Dominion Bank | 30,930 | $302.2K | 0.00% | +30,930 | New |
| Jane Street Group, LLC | 33,173 | $324.1K | 0.00% | −72,728−68.7% | Reduced |
| Nomura Asset Management International Inc. | 33,333 | $326.0K | 0.00% | +33,333 | New |
| Engineers Gate Manager LP | 33,966 | $331.8K | 0.00% | −78,466−69.8% | Reduced |
| Nuveen, LLC | 37,868 | $370.0K | 0.00% | +37,868 | New |
| Citigroup Inc | 37,917 | $370.4K | 0.00% | +32,976+667.4% | Added |
| Birchview Capital, LP | 42,952 | $419.6K | 0.20% | −41,000−48.8% | Reduced |
| Bank of America Corp | 49,924 | $487.8K | 0.00% | +30,452+156.4% | Added |
| Citadel Advisors LLC | 52,069 | $508.7K | 0.00% | +52,069 | New |
| XTX Topco Ltd | 53,272 | $520.5K | 0.01% | −111,171−67.6% | Reduced |
| Susquehanna Portfolio Strategies, LLC | 54,545 | $532.9K | 0.01% | +29,524+118.0% | Added |
| Bank of New York Mellon Corp | 57,262 | $559.4K | 0.00% | +45,863+402.3% | Added |
| Royal Bank of Canada | 60,430 | $590.0K | 0.00% | +31+0.1% | Added |
| Charles Schwab Investment Management Inc | 61,943 | $605.2K | 0.00% | +48,514+361.3% | Added |
| Squarepoint Ops LLC | 63,801 | $623.3K | 0.00% | +63,801 | New |
| J. Goldman & Co LP | 67,500 | $659.5K | 0.02% | +67,500 | New |
| Bridgeway Capital Management, LLC | 71,873 | $702.2K | 0.01% | 00.0% | Unchanged |
| Connor, Clark & Lunn Investment Management Ltd. | 76,397 | $746.4K | 0.00% | −2,684−3.4% | Reduced |
| Invesco Ltd. | 90,304 | $882.3K | 0.00% | +73,566+439.5% | Added |
| Jump Financial, LLC | 94,000 | $918.4K | 0.01% | −168,146−64.1% | Reduced |
| C WorldWide Group Holding A/S | 100,000 | $977.0K | 0.02% | 00.0% | Unchanged |
| Renaissance Technologies LLC | 108,214 | $1.06M | 0.00% | +2,800+2.7% | Added |
| Marshall Wace, LLP | 128,451 | $1.25M | 0.00% | 00.0% | Unchanged |
| Vanguard Portfolio Management LLC | 134,818 | $1.32M | 0.00% | +134,818 | New |
| Vanguard Fiduciary Trust Co | 145,401 | $1.42M | 0.00% | +30,467+26.5% | Added |
| Northern Trust Corp | 160,006 | $1.56M | 0.00% | +121,450+315.0% | Added |
| Barclays PLC | 165,904 | $1.62M | 0.00% | +158,480+2,134.7% | Added |
| BNP Paribas Arbitrage, SA | 188,038 | $1.84M | 0.00% | +187,954+223,754.8% | Added |
| Trexquant Investment LP | 188,368 | $1.84M | 0.01% | −69,535−27.0% | Reduced |
| Morgan Stanley | 202,506 | $1.98M | 0.00% | +183,936+990.5% | Added |
| JPMorgan Chase & Co | 207,609 | $2.09M | 0.00% | +207,138+43,978.3% | Added |
| Eversept Partners, LP | 276,174 | $2.70M | 0.15% | 00.0% | Unchanged |
| Silverarc Capital Management, LLC | 297,460 | $2.91M | 0.32% | +297,460 | New |
| Acadian Asset Management LLC | 298,997 | $2.92M | 0.00% | +50,040+20.1% | Added |
| Davidson Kempner Capital Management LP | 300,000 | $2.93M | 0.05% | 00.0% | Unchanged |
| Boxer Capital Management, LLC | 302,536 | $2.96M | 0.22% | 00.0% | Unchanged |
| Millennium Management LLC | 305,676 | $2.99M | 0.00% | −114,895−27.3% | Reduced |
| Brevan Howard Capital Management LP | 309,817 | $3.03M | 0.04% | +97,450+45.9% | Added |
| Affinity Asset Advisors, LLC | 312,500 | $3.05M | 0.15% | −187,500−37.5% | Reduced |
| State Street Corp | 325,991 | $3.18M | 0.00% | +245,249+303.7% | Added |
| UBS Group AG | 353,545 | $3.45M | 0.00% | +159,528+82.2% | Added |
| Soleus Capital Management, L.P. | 440,000 | $4.30M | 0.15% | 00.0% | Unchanged |
| Ghisallo Capital Management LLC | 500,000 | $4.88M | 0.10% | +500,000 | New |
| Geode Capital Management, LLC | 531,231 | $5.19M | 0.00% | +325,098+157.7% | Added |
| NEA Management Company, LLC | 576,780 | $5.64M | 0.35% | +576,780 | New |
| Kalehua Capital Management LLC | 685,644 | $6.70M | 3.85% | +685,644 | New |
| Two Sigma Investments, LP | 695,264 | $6.79M | 0.01% | +544,032+359.7% | Added |
| T. Rowe Price Investment Management, Inc. | 786,309 | $7.68M | 0.01% | −755,781−49.0% | Reduced |
| Avidity Partners Management LP | 924,487 | $9.03M | 1.45% | +460,746+99.4% | Added |
| Catalio Capital Management, LP | 940,855 | $9.19M | 1.73% | +43,146+4.8% | Added |
| Vanguard Capital Management LLC | 958,979 | $9.37M | 0.00% | +219,234+29.6% | Added |
| BlackRock, Inc. | 1,418,799 | $13.9M | 0.00% | +1,173,900+479.3% | Added |
| Goldman Sachs Group Inc | 1,424,658 | $13.9M | 0.00% | +477,079+50.3% | Added |
| Acorn Capital Advisors, LLC | 1,518,113 | $14.8M | 4.05% | +1,230,287+427.4% | Added |
| Adage Capital Partners GP, L.L.C. | 1,521,322 | $14.9M | 0.02% | −285,000−15.8% | Reduced |
| Ra Capital Management, L.P. | 1,917,354 | $18.7M | 0.16% | 00.0% | Unchanged |
| Commodore Capital LP | 0 | $0 | 0.00% | −1,950,000−100.0% | Sold out |
| Ikarian Capital, LLC | 0 | $0 | 0.00% | −733,435−100.0% | Sold out |
| Boothbay Fund Management, LLC | 0 | $0 | 0.00% | −213,810−100.0% | Sold out |
| Group One Trading, L.P. | 0 | $0 | 0.00% | −191,527−100.0% | Sold out |