RA CAPITAL MANAGEMENT, L.P.

SEC CIK
0001346824

Holdings, Q2 2026

Positions as of Jun 30, 2026, filed Aug 14, 2026.SEC

Positions
84
−1 vs. Q1 2026
Total value
$11.51B
+$2.07B (+21.9%) vs. Q1 2026

Compare with Q1 2026: new, added, reduced and sold out

Positions

Long positions only. Changes compare share counts with Q1 2026.

RA CAPITAL MANAGEMENT, L.P. holdings in Q2 2026
SecurityClassSharesValue% of portfolioChange in sharesActionHistory
ASNDASCENDIS PHARMA A/SORD SHS10,281,496$2.74B23.83%+10,281,496NewView
PBLSPARABILIS MEDICINES INC COMStock28,933,371$791.91M6.88%+28,933,371NewView
RYTMRHYTHM PHARMACEUTICALS INCCOM6,666,837$740.22M6.43%00.0%UnchangedView
PCVXVAXCYTE INCCOM11,474,599$667.02M5.80%00.0%UnchangedView
SIONSIONNA THERAPEUTICS INCCOM9,905,045$435.72M3.79%00.0%UnchangedView
TYRATYRA BIOSCIENCES INCCOM12,198,625$389.62M3.39%00.0%UnchangedView
EWTXEDGEWISE THERAPEUTICS INCCOM8,392,730$341M2.96%−2,035,707−19.5%ReducedView
NAMSNEWAMSTERDAM PHARMA COMPANYORDINARY SHARES9,550,191$323.66M2.81%00.0%UnchangedView
COAGHEMAB THERAPEUTICS HLDGS INCCOM SHS7,808,627$286.81M2.49%+7,808,627NewView
SEPNSEPTERNA INCCOM6,995,858$234.29M2.04%00.0%UnchangedView
BCAXBICARA THERAPEUTICS INCCOM7,255,993$215.43M1.87%00.0%UnchangedView
MLYSMINERALYS THERAPEUTICS INCCOM7,692,750$207.55M1.80%00.0%UnchangedView
GHRSGH RESEARCH PLCORDINARY SHARES7,636,813$205.28M1.78%−39,884−0.5%ReducedView
IRONDISC MEDICINE INCCOM2,450,221$179.21M1.56%00.0%UnchangedView
SGPSPYGLASS PHARMA INCCOM SHS8,021,117$178.55M1.55%00.0%UnchangedView
ARTVARTIVA BIOTHERAPEUTICS INCCOM17,955,642$174.17M1.51%+8,102,340+82.2%AddedView
JANXJANUX THERAPEUTICS INCCOM11,189,693$171.87M1.49%00.0%UnchangedView
TSHATAYSHA GENE THERAPIES INCCOM SHS23,555,648$160.41M1.39%00.0%UnchangedView
BCRXBIOCRYST PHARMACEUTICALS INCCOM15,827,186$158.27M1.38%00.0%UnchangedView
WVEWAVE LIFE SCIENCES LTDSHS26,975,505$156.73M1.36%00.0%UnchangedView
NUVALENT INC670703107COM1,246,456$153.94M1.34%−1,287,689−50.8%Reduced–
ABVXABIVAX SASPONSORED ADS1,132,557$150.92M1.31%+1,132,557NewView
ORKAORUKA THERAPEUTICS INCCOM1,554,597$147.95M1.29%+1,554,597NewView
CLYMCLIMB BIO INCCOM11,300,939$147.36M1.28%00.0%UnchangedView
SLDBSOLID BIOSCIENCES INCCOM NEW12,036,126$120.24M1.04%+2,696,148+28.9%AddedView
ZLABZAI LAB LTDADR5,743,533$109.13M0.95%+36,271+0.6%AddedView
SPRYARS PHARMACEUTICALS INCCOM10,860,977$87M0.76%00.0%UnchangedView
XNCRXENCOR INCCOM5,274,274$84.92M0.74%+377,037+7.7%AddedView
JBIOJADE BIOSCIENCES INCCOM NEW3,671,083$81.57M0.71%00.0%UnchangedView
NTLAINTELLIA THERAPEUTICS INCCOM4,526,926$76.6M0.67%+4,526,926NewView
LBRXLB PHARMACEUTICALS INCCOM SHS2,208,604$71.68M0.62%00.0%UnchangedView
DFTXDEFINIUM THERAPEUTICS INCCOM SHS1,500,000$70.56M0.61%+1,500,000NewView
ACRSACLARIS THERAPEUTICS INCCOM12,723,026$67.3M0.58%+5,918,954+87.0%AddedView
FDMT4D MOLECULAR THERAPEUTICS INCOM5,049,779$67.16M0.58%00.0%UnchangedView
SANASANA BIOTECHNOLOGY INCCOM18,750,000$65.44M0.57%+18,750,000NewView
DMRADAMORA THERAPEUTICS INCCOM NEW2,399,702$62.42M0.54%+3920.0%AddedView
MNPRMONOPAR THERAPEUTICS INCCOM NEW667,207$61.78M0.54%00.0%UnchangedView
ABOSACUMEN PHARMACEUTICALS INCCOM20,992,669$56.05M0.49%00.0%UnchangedView
GERNGERON CORPCOM42,809,751$54.8M0.48%−20,961,615−32.9%ReducedView
RZLTREZOLUTE INCCOM NEW9,445,039$49.11M0.43%+265,039+2.9%AddedView
EVMNEVOMMUNE INCCOM SHS3,494,638$46.44M0.40%00.0%UnchangedView
VORVOR BIOPHARMA INCCOM NEW2,402,095$44.22M0.38%−3,002,903−55.6%ReducedView
IPSCCENTURY THERAPEUTICS INCCOM17,754,430$43.5M0.38%00.0%UnchangedView
AKTSAKTIS ONCOLOGY INCCOM1,314,405$42.36M0.37%−188,679−12.6%ReducedView
BIOABIOAGE LABS INCCOM1,671,648$40.97M0.36%+21,000+1.3%AddedView
CCCCC4 THERAPEUTICS INCCOM STK8,000,000$37.36M0.32%00.0%UnchangedView
MIRMMIRUM PHARMACEUTICALS INCCOM318,554$37.29M0.32%00.0%UnchangedView
CAPRCAPRICOR THERAPEUTICS INCCOM NEW1,507,844$36.31M0.32%00.0%UnchangedView
PEPGPEPGEN INCCOM20,064,545$36.12M0.31%00.0%UnchangedView
PRLDPRELUDE THERAPEUTICS INCCOM6,475,882$34.52M0.30%+6,475,882NewView
NKTXNKARTA INCCOM10,805,129$30.58M0.27%00.0%UnchangedView
QTTBQ32 BIO INCCOM2,332,457$29.72M0.26%+2,332,457NewView
AVRANTERIS TECHNOLOGIES GLOBALCOM3,000,000$29.55M0.26%00.0%UnchangedView
EDITEDITAS MEDICINE INCCOM8,889,000$28.8M0.25%+8,889,000NewView
OVIDOVID THERAPEUTICS INCCOM10,500,968$28.25M0.25%−213,032−2.0%ReducedView
ASMBASSEMBLY BIOSCIENCES INCCOM NEW1,020,410$28.04M0.24%00.0%UnchangedView
ALXOALX ONCOLOGY HLDGS INCCOM13,011,849$26.93M0.23%00.0%UnchangedView
BNTCBENITEC BIOPHARMA INCCOM NEW1,850,000$24.75M0.22%00.0%UnchangedView
LENZLENZ THERAPEUTICS INCCOM4,178,823$23.74M0.21%00.0%UnchangedView
LXEOLEXEO THERAPEUTICS INCCOM5,000,000$23.28M0.20%00.0%UnchangedView
ACRVACRIVON THERAPEUTICS INCCOMMON STOCK12,229,396$21.77M0.19%+3,888,888+46.6%AddedView
ALTALTIMMUNE INCCOM NEW6,500,000$19.76M0.17%+6,500,000NewView
KPTIKARYOPHARM THERAPEUTICS INCCOM NEW1,917,354$18.73M0.16%00.0%UnchangedView
DRUGBRIGHT MINDS BIOSCIENCES INCCOM NEW265,000$18.6M0.16%00.0%UnchangedView
AVTXAVALO THERAPEUTICS INCCOM NEW1,000,000$18.48M0.16%+337,032+50.8%AddedView
OKURONKURE THERAPEUTICS INCCOM CL A3,998,333$18.23M0.16%00.0%UnchangedView
FTHSENSEI BIOTHERAPEUTICS INCCOM NEW722,020$18.05M0.16%+722,020NewView
AURAAURA BIOSCIENCES INCCOM2,500,000$17.75M0.15%+2,500,000NewView
SABSSAB BIOTHERAPEUTICS INCCOM NEW4,401,500$17.17M0.15%00.0%UnchangedView
SPTXSEAPORT THERAPEUTICS INCCOMMON STOCK700,000$15.2M0.13%+700,000NewView
PALIPALISADE BIO INCCOM7,124,116$14.89M0.13%00.0%UnchangedView
HLXCHELIX ACQUISITION CORP IIIUSD CL A ORD SHS1,250,000$13.3M0.12%00.0%UnchangedView
WAYWAYSTAR HLDG CORPCOM529,400$10.87M0.09%00.0%UnchangedView
EQEQUILLIUM INCCOM3,096,336$9.91M0.09%00.0%UnchangedView
MGNXMACROGENICS INCCOM1,864,176$8.61M0.07%00.0%UnchangedView
FRNMPERCEPTIVE CAP SOLUTIONS CORCL A ORD SHS750,000$8.16M0.07%00.0%UnchangedView
ACETADICET BIO INCCOM NEW932,624$8.06M0.07%−250,000−21.1%ReducedView
NAMSWNEWAMSTERDAM PHARMA COMPANY*W EXP 11/22/202333,333$7.12M0.06%00.0%UnchangedView
CRVSCORVUS PHARMACEUTICALS INCCOM450,000$6.72M0.06%00.0%UnchangedView
RANIRANI THERAPEUTICS HLDGS INCCOM CL A8,500,000$6.46M0.06%00.0%UnchangedView
JATTJATT II ACQUISITION CORPORD SHS500,000$5.68M0.05%+500,000NewView
AMANAMANAT ACQUISITION CORPCL A ORD375,000$3.81M0.03%+375,000NewView
HOWLWEREWOLF THERAPEUTICS INCCOM2,387,744$859.35K0.01%−4,293,563−64.3%ReducedView
PTNPALATIN TECHNOLOGIES INCCOM NEW62,124$670.32K0.01%−7,876−11.3%ReducedView

Sold out since Q1 2026 (18)

Positions held at the end of Q1 2026 that are no longer in this filing.

RA CAPITAL MANAGEMENT, L.P. positions sold out since Q1 2026
SecurityClassShares, Q1 2026Value, Q1 2026% of portfolio, Q1 2026
ASNDASCENDIS PHARMA A/SSPONSORED ADR10,281,496$2.35B24.92%
DNTHDIANTHUS THERAPEUTICS INCCOM2,611,733$219.18M2.32%
PRAXPRAXIS PRECISION MEDICINES ICOM NEW373,787$120.43M1.28%
SRPTSAREPTA THERAPEUTICS INCCOM3,902,596$84.92M0.90%
SYRESPYRE THERAPEUTICS INCCOM NEW1,621,620$81.79M0.87%
FULCFULCRUM THERAPEUTICS INCCOM6,053,960$46.43M0.49%
OLMAOLEMA PHARMACEUTICALS INCCOM2,600,000$38.77M0.41%
DSGNDESIGN THERAPEUTICS INCCOM2,972,973$31.63M0.34%
TVTXTRAVERE THERAPEUTICS INCCOM746,841$22.19M0.24%
GRALGRAIL INCCOM428,266$22.13M0.23%
RLMDRELMADA THERAPEUTICS INCCOM2,947,369$20.51M0.22%
STROSUTRO BIOPHARMA INCCOM SHS715,307$17.82M0.19%
CTNMCONTINEUM THERAPEUTICS INCCL A1,296,012$16.93M0.18%
INSPINSPIRE MED SYS INCCOM325,663$16.8M0.18%
HNGEHINGE HEALTH INCCL A364,613$14.06M0.15%
WGSGENEDX HOLDINGS CORPCOM CL A209,887$13.48M0.14%
RNAATRIUM THERAPEUTICS INCCOM864,102$11.55M0.12%
MPLTMAPLIGHT THERAPEUTICS INCCOM248,294$5.05M0.05%

13F filings by quarter

RA CAPITAL MANAGEMENT, L.P. 13F filings by quarter
QuarterFiledPositionsTotal valueChangesFiling
Q2 2026Aug 14, 202684$11.51Bvs. Q1 2026SEC
Q1 2026May 15, 202685$9.44Bvs. Q4 2025SEC
Q4 2025Feb 17, 202671$9.76Bvs. Q3 2025SEC
Q3 2025Nov 14, 202567$8.12Bvs. Q2 2025SEC
Q2 2025Aug 14, 202563$5.94Bvs. Q1 2025SEC
Q1 2025May 15, 202585$5.99Bvs. Q4 2024SEC
Q4 2024Feb 14, 202589$7.51Bvs. Q3 2024SEC
Q3 2024Nov 14, 202481$8.67Bvs. Q2 2024SEC
Q2 2024Aug 14, 202478$7.56Bvs. Q1 2024SEC
Q1 2024May 17, 2024Amended76$7.86Bvs. Q4 2023SECSEC
Q4 2023Feb 14, 202462$6.4Bvs. Q3 2023SEC
Q3 2023Nov 15, 2023Amended66$5.08Bvs. Q2 2023SECSEC
Q2 2023Aug 14, 202354$5.3Bvs. Q1 2023SEC
Q1 2023May 15, 202359$4.42Bvs. Q4 2022SEC
Q4 2022Feb 14, 202370$4.93Bvs. Q3 2022SEC
Q3 2022Nov 14, 202281$4.69Bvs. Q2 2022SEC
Q2 2022Aug 15, 202288$3.75Bvs. Q1 2022SEC
Q1 2022May 16, 202296$4.58Bvs. Q4 2021SEC
Q4 2021Feb 14, 202297$5.67Bvs. Q3 2021SEC
Q3 2021Nov 15, 202195$7.22Bvs. Q2 2021SEC
Q2 2021Aug 16, 202192$6.23Bvs. Q1 2021SEC
Q1 2021May 17, 202182$6.63B–SEC