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Sionna Therapeutics, Inc.

SION
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0002036042

In the last 90 days, Sionna Therapeutics, Inc. insiders filed 0 open-market purchases and 1 sale; 146 institutions reported holding it in 13F filings for Q2 2026, worth $2.11B in total; Viking Global Investors is the only superinvestor holding it.

Key figures

Market capClose on Nov 10, 2026
$167.3M
Insider buysOpen market, last 90 days
0
Insider sellsLast 90 days, $21.8M in total
1
13F holdersQ2 2026, +25 vs. previous quarter
146
13F valueReported value at the end of Q2 2026
$2.11B
Superinvestors holdingAt the end of Q2 2026
1

Price chart

From SEC filings, in USD.

Revenue, FY2025
–
No comparable prior period
Net income, FY2025
-$75.3M
No comparable prior period
Free cash flow, FY2025
-$66.7M
No comparable prior period
Revenue, Q2 FY2026
–
No comparable prior period

Short interest

See short data

From FINRA, settlement date Oct 15, 2026.

Short interest
3.68M
Shares sold short
Change
−121.2K
−3.2% vs. previous
Days to cover
3.74
At average daily volume

Superinvestors holding SION, Q2 2026

Go to the superinvestors tab

1 superinvestor reports holding Sionna Therapeutics, Inc. on Form 13F. Percentages are the stock's share of each portfolio.

Viking Global Investors

Andreas Halvorsen

0.4%

Sionna Therapeutics, Inc.'s share of the portfolio

Shares
3,195,181
Value
$140.6M

Latest insider trades

See all insider trades

Open-market purchases and sales by Sionna Therapeutics, Inc. insiders from Form 4, newest first.

Insider trades
Filed (ET)Trade dateFiling delayInsiderTransactionSharesAvg priceValueHolding changeFlags
Sep 21, 2026 (view filing)6:56 PM ETSep 174 daysRA Capital Healthcare Fund LP and 5 othersDirectorSSale−3.45M$6.33−$21.8M−50.0%3.45M after2 lots
Jul 9, 2026 (view filing)4:47 PM ETJul 72 daysThompson Peter A.DirectorSSale−85.9K$44.86−$3.85M−3.4%2.47M after10b5-1Duplicate filing
Jul 9, 2026 (view filing)4:44 PM ETJul 72 daysOrbiMed Advisors LLC and 1 otherDirectorSSale−85.9K$44.86−$3.85M−3.4%2.47M after10b5-1
Jul 7, 2026 (view filing)4:38 PM ETJul 61 dayFitzpatrick JenniferChief Legal OfficerSSale−10.3K$43.60−$446.9K−100.0%0 after10b5-1
Jul 2, 2026 (view filing)4:45 PM ETJun 302 daysThompson Peter A.DirectorSSale−115.8K$45.50−$5.27M−4.3%2.56M after10b5-1Duplicate filing
Jul 2, 2026 (view filing)4:42 PM ETJun 302 daysOrbiMed Advisors LLC and 1 otherDirectorSSale−115.8K$45.50−$5.27M−4.3%2.56M after10b5-1
May 29, 2026 (view filing)8:57 PM ETMay 272 daysOrbiMed Advisors LLC and 1 otherDirectorSSale−101$44.49−$4.49K0.0%2.67M after10b5-1Duplicate filing
May 29, 2026 (view filing)May 272 daysThompson Peter A.DirectorSSale−101$44.49−$4.49K0.0%2.67M after10b5-1
May 11, 2026 (view filing)6:58 PM ETMay 7-114 daysOrbiMed Advisors LLC and 1 otherDirectorSSale−293.0K$45.62−$13.4M−9.9%2.67M after3 lots10b5-1Duplicate filing
May 11, 2026 (view filing)May 7-114 daysThompson Peter A.DirectorSSale−293.0K$45.62−$13.4M−9.9%2.67M after3 lots10b5-1

Top 10 13F holders, Q2 2026

See all 146 holders

The largest institutional positions in Sionna Therapeutics, Inc. at the end of Q2 2026; share changes are against Q1 2026.

Institutions holding SION in Q2 2026
InstitutionSharesValue% of portfolioChange in sharesAction
Ra Capital Management, L.P.9,905,045$435.7M3.79%00.0%Unchanged
TPG GP A, LLC6,494,962$285.7M5.71%00.0%Unchanged
Viking Global Investors LPSuperinvestorViking Global Investors3,195,181$140.6M0.40%00.0%Unchanged
Atlas Venture Life Science Advisors, LLC2,995,602$131.8M14.95%00.0%Unchanged
OrbiMed Advisors LLC2,555,877$112.4M2.13%−974,825−27.6%Reduced
Enavate Sciences GP, LLC2,478,030$109.0M31.56%00.0%Unchanged
Adage Capital Partners GP, L.L.C.1,600,000$70.4M0.10%+1,450,000+966.7%Added
BlackRock, Inc.1,474,769$64.9M0.00%+178,902+13.8%Added
JPMorgan Chase & Co1,490,508$64.1M0.00%+25,494+1.7%Added
Jennison Associates LLC1,172,133$51.6M0.03%−279,087−19.2%Reduced

Holders of 5% or more of SION

See all 7 holders and filings

Holders whose latest Schedule 13D or 13G filing reports 5% or more of Sionna Therapeutics, Inc..

Largest holders of SION from 13D and 13G filings
HolderLatest formStakeChangeFirst filedLatest filingFiling
TPG GP A, LLC13D15.20%6.68M sharesNewFeb 18, 20251 filingFeb 18, 2025SEC
Ra Capital Management, L.P.13D/A14.30%6.48M shares−8.30 ppfrom 22.60%Feb 18, 20253 filingsSep 21, 2026SEC
Viking Global Investors LPSuperinvestorViking Global Investors13G/A7.10%3.20M shares+0.40 ppfrom 6.70%Feb 14, 20252 filingsMay 15, 2026SEC
OrbiMed Advisors LLC13D/A6.60%2.97M shares−1.80 ppfrom 8.40%Feb 13, 20252 filingsApr 20, 2026SEC
Goldman Sachs Group Inc13G5.80%2.64M sharesNewNov 9, 20261 filingNov 9, 2026SEC