Taysha Gene Therapies, Inc.
TSHA- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001806310
In the last 90 days, Taysha Gene Therapies, Inc. insiders filed 0 open-market purchases and 1 sale; 208 institutions reported holding it in 13F filings for Q2 2026, worth $2.03B in total; no superinvestor holds it.
Holders of 5% or more of TSHA
Holders whose latest Schedule 13D or 13G filing reports 5% or more of Taysha Gene Therapies, Inc., largest stake first. The change is against the holder's previous filing.
| Holder | Latest form | Stake | Change | First filed | Latest filing | Filing |
|---|---|---|---|---|---|---|
| Ra Capital Management, L.P. | 13G/A | 9.90%27.7M shares | 0.00 ppfrom 9.90% | Aug 14, 20252 filings | Nov 14, 2025 | SEC |
| RTW Investments, LP | 13G/A | 9.90%25.2M shares | −0.09 ppfrom 9.99% | Feb 14, 20253 filings | Aug 14, 2025 | SEC |
| Manning Paul B | 13D/A | 9.80%25.6M shares | – | Jun 3, 20251 filing | Jun 3, 2025 | SEC |
| Morgan Stanley | 13G/A | 6.70%16.9M shares | −1.90 ppfrom 8.60% | Feb 5, 20252 filings | Aug 6, 2025 | SEC |
| FMR LLC | 13G/A | 6.20%15.6M shares | −1.80 ppfrom 8.00% | Feb 12, 20252 filings | Aug 6, 2025 | SEC |
| BlackRock, Inc. | 13G/A | 5.20%13.2M shares | – | Jul 16, 20251 filing | Jul 16, 2025 | SEC |
| Goldman Sachs Group Inc | 13G | 5.10%12.7M shares | New | Jul 3, 20251 filing | Jul 3, 2025 | SEC |
Stakes are as of each holder's latest filing. Holders whose last filing was in the old format (before December 18, 2024) have no stake on record and are not listed, and after an acquisition or delisting holders usually stop filing.
13D and 13G filings
14 Schedule 13D and 13G filings on Taysha Gene Therapies, Inc., newest first, including old-format filings without a stake.
| Filed (ET) | Filer | Form | Stake | Change | Event date | Filing |
|---|---|---|---|---|---|---|
| Nov 14, 20254:46 PM ET | Octagon Capital Advisors LPand 2 others | 13G/A | 3.30%9.07M shares | −1.80 ppfrom 5.10%Below 5% | Sep 30, 2025 | SEC |
| Nov 14, 20254:18 PM ET | Ra Capital Management, L.P.and 3 others | 13G/A | 9.90%27.7M shares | 0.00 ppfrom 9.90% | Sep 30, 2025 | SEC |
| Aug 14, 20256:11 PM ET | Ra Capital Management, L.P.and 3 others | 13G/A | 9.90%25.3M shares | – | Jun 30, 2025 | SEC |
| Aug 14, 20258:10 AM ET | RTW Investments, LPand 1 other | 13G/A | 9.90%25.2M shares | −0.09 ppfrom 9.99% | Jun 30, 2025 | SEC |
| Aug 6, 20252:13 PM ET | Morgan Stanleyand 1 other | 13G/A | 6.70%16.9M shares | −1.90 ppfrom 8.60% | Jun 30, 2025 | SEC |
| Aug 6, 202512:14 PM ET | FMR LLCand 1 other | 13G/A | 6.20%15.6M shares | −1.80 ppfrom 8.00% | Jun 30, 2025 | SEC |
| Jul 16, 20257:02 PM ET | BlackRock, Inc. | 13G/A | 5.20%13.2M shares | – | Jun 30, 2025 | SEC |
| Jul 3, 202512:23 PM ET | Goldman Sachs Group Incand 1 other | 13G | 5.10%12.7M shares | New | Jun 26, 2025 | SEC |
| Jun 3, 20259:54 PM ET | Manning Paul Band 5 others | 13D/A | 9.80%25.6M shares | – | May 30, 2025 | SEC |
| May 15, 20258:00 AM ET | RTW Investments, LPand 1 other | 13G/A | 9.99%20.7M shares | +4.09 ppfrom 5.90% | Mar 31, 2025 | SEC |
| Feb 14, 20259:00 AM ET | RTW Investments, LPand 1 other | 13G/A | 5.90%12.4M shares | – | Dec 31, 2024 | SEC |
| Feb 12, 20259:22 AM ET | FMR LLCand 1 other | 13G/A | 8.00%16.4M shares | – | Dec 31, 2024 | SEC |
| Feb 5, 20256:05 PM ET | Octagon Capital Advisors LPand 2 others | 13G | 5.10%10.4M shares | New | Dec 31, 2024 | SEC |
| Feb 5, 202510:43 AM ET | Morgan Stanleyand 1 other | 13G | 8.60%17.6M shares | New | Dec 31, 2024 | SEC |
Form 144: proposed insider sales
Notices from officers, directors and other affiliates planning to sell Taysha Gene Therapies, Inc. shares.
No Form 144 notices for Taysha Gene Therapies, Inc. are on file.