Tyra Biosciences, Inc.
TYRA- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001863127
In the last 90 days, Tyra Biosciences, Inc. insiders filed 1 open-market purchase and 0 sales; 168 institutions reported holding it in 13F filings for Q2 2026, worth $2.22B in total; no superinvestor holds it.
Holders of 5% or more of TYRA
Holders whose latest Schedule 13D or 13G filing reports 5% or more of Tyra Biosciences, Inc., largest stake first. The change is against the holder's previous filing.
| Holder | Latest form | Stake | Change | First filed | Latest filing | Filing |
|---|---|---|---|---|---|---|
| Ra Capital Management, L.P. | 13D/A | 19.90%14.1M shares | −1.30 ppfrom 21.20% | Sep 27, 20218 filings | Sep 17, 2026 | SEC |
| FMR LLC | 13G | 14.40%7.75M shares | +11.20 ppfrom 3.20% | Feb 9, 20227 filings | Apr 7, 2026 | SEC |
| Janus Henderson Group PLC | 13G/A | 7.20%3.89M shares | +1.80 ppfrom 5.40% | May 14, 20253 filings | May 15, 2026 | SEC |
| Farallon Capital Partners, L.P. | 13G/A | 6.60%3.58M shares | +1.00 ppfrom 5.60% | Feb 20, 20262 filings | May 12, 2026 | SEC |
| Biotechnology Value Fund L P | 13G | 6.10%4.22M shares | +2.10 ppfrom 4.00% | Mar 24, 20226 filings | Sep 21, 2026 | SEC |
| Nextech VI Oncology SCSP | 13G/A | 6.00%3.55M shares | – | Sep 27, 20213 filings | Aug 14, 2026 | SEC |
| Paradigm Biocapital Advisors LP | 13G | 5.80%3.47M shares | New | Sep 17, 20261 filing | Sep 17, 2026 | SEC |
| TCG Crossover GP I, LLC | 13G | 5.70%2.90M shares | New | Mar 6, 20251 filing | Mar 6, 2025 | SEC |
Stakes are as of each holder's latest filing. Holders whose last filing was in the old format (before December 18, 2024) have no stake on record and are not listed, and after an acquisition or delisting holders usually stop filing.
13D and 13G filings
56 Schedule 13D and 13G filings on Tyra Biosciences, Inc., newest first, including old-format filings without a stake.
| Filed (ET) | Filer | Form | Stake | Change | Event date | Filing |
|---|---|---|---|---|---|---|
| Oct 27, 20265:25 PM ET | BlackRock, Inc. | 13G/A | 4.80%3.30M shares | −0.20 ppfrom 5.00%Below 5% | Sep 30, 2026 | SEC |
| Sep 21, 20265:21 PM ET | Biotechnology Value Fund L Pand 9 others | 13G | 6.10%4.22M shares | +2.10 ppfrom 4.00% | Sep 14, 2026 | SEC |
| Sep 17, 20264:32 PM ET | Ra Capital Management, L.P.and 3 others | 13D/A | 19.90%14.1M shares | −1.30 ppfrom 21.20% | Sep 15, 2026 | SEC |
| Sep 17, 20264:06 PM ET | Paradigm Biocapital Advisors LPand 3 others | 13G | 5.80%3.47M shares | New | Sep 10, 2026 | SEC |
| Aug 14, 20264:44 PM ET | Nextech VI Oncology SCSPand 4 others | 13G/A | 6.00%3.55M shares | – | Jun 30, 2026 | SEC |
| Aug 14, 20268:24 AM ET | Farallon Capital Management, L.L.C.and 28 others | 13G/A | 0.00%6.00K shares | –Below 5% | Jun 30, 2026 | SEC |
| Jul 30, 202611:18 AM ET | BlackRock, Inc. | 13G | 5.00%2.98M shares | New | Jun 30, 2026 | SEC |
| May 15, 20264:19 PM ET | Commodore Capital LPand 3 others | 13G/A | 4.20%2.48M shares | −2.10 ppfrom 6.30%Below 5% | Mar 31, 2026 | SEC |
| May 15, 202612:50 PM ET | Janus Henderson Group PLC | 13G/A | 7.20%3.89M shares | +1.80 ppfrom 5.40% | Mar 31, 2026 | SEC |
| May 14, 20264:56 PM ET | Harris Todd | 13G/A | 4.80%2.91M shares | −0.30 ppfrom 5.10%Below 5% | Mar 31, 2026 | SEC |
| May 12, 20268:54 AM ET | Farallon Capital Partners, L.P.and 27 others | 13G/A | 6.60%3.58M shares | +1.00 ppfrom 5.60% | Mar 31, 2026 | SEC |
| Apr 24, 20264:15 PM ET | Canaan XI L.P.and 3 others | 13G/A | 1.40%750.0K shares | −4.10 ppfrom 5.50%Below 5% | Mar 31, 2026 | SEC |
| Apr 7, 20261:33 PM ET | FMR LLCand 1 other | 13G | 14.40%7.75M shares | +11.20 ppfrom 3.20% | Mar 31, 2026 | SEC |
| Mar 6, 20264:28 PM ET | Ra Capital Management, L.P.and 3 others | 13D/A | 21.20%12.3M shares | −1.20 ppfrom 22.40% | Mar 4, 2026 | SEC |
| Feb 20, 20268:14 AM ET | Farallon Capital Partners, L.P.and 25 others | 13G | 5.60%2.98M shares | New | Feb 12, 2026 | SEC |
| Feb 17, 20264:28 PM ET | Biotechnology Value Fund L Pand 9 others | 13G/A | 4.00%2.13M shares | −3.80 ppfrom 7.80%Below 5% | Dec 31, 2025 | SEC |
| Feb 13, 20264:30 PM ET | Harris Todd | 13G | 5.10%2.81M shares | New | Dec 31, 2025 | SEC |
| Feb 13, 20264:15 PM ET | Canaan XI L.P.and 3 others | 13G/A | 5.50%2.93M shares | −1.90 ppfrom 7.40% | Dec 31, 2025 | SEC |
| Nov 14, 20254:35 PM ET | Commodore Capital LPand 3 others | 13G/A | 6.30%3.38M shares | +1.10 ppfrom 5.20% | Sep 30, 2025 | SEC |
| Nov 14, 20254:02 PM ET | Vestal Point Capital, LPand 1 other | 13G/A | 4.50%2.42M shares | −0.90 ppfrom 5.40%Below 5% | Sep 30, 2025 | SEC |
| Aug 14, 202511:44 AM ET | Janus Henderson Group PLC | 13G/A | 5.40%2.86M shares | +0.30 ppfrom 5.10% | Jun 30, 2025 | SEC |
| Jun 6, 20254:50 PM ET | Ra Capital Management, L.P.and 3 others | 13D/A | 22.40%11.9M shares | +2.30 ppfrom 20.10% | Jun 4, 2025 | SEC |
| May 15, 20254:14 PM ET | Vestal Point Capital, LPand 1 other | 13G | 5.40%2.88M shares | New | Mar 31, 2025 | SEC |
| May 14, 20254:05 PM ET | Commodore Capital LPand 1 other | 13G | 5.20%2.75M shares | New | May 7, 2025 | SEC |
| May 14, 202511:47 AM ET | Janus Henderson Group PLC | 13G | 5.10%2.69M shares | New | Mar 31, 2025 | SEC |
| May 12, 202510:43 AM ET | FMR LLCand 1 other | 13G/A | 3.20%1.71M shares | –Below 5% | Mar 31, 2025 | SEC |
| Mar 31, 20254:54 PM ET | Ra Capital Management, L.P.and 3 others | 13D/A | 20.10%10.7M shares | – | Mar 27, 2025 | SEC |
| Mar 6, 20256:02 PM ET | TCG Crossover GP I, LLCand 2 others | 13G | 5.70%2.90M shares | New | Feb 27, 2025 | SEC |
| Feb 14, 20254:24 PM ET | Biotechnology Value Fund L Pand 9 others | 13G/A | 7.80%3.94M shares | – | Dec 31, 2024 | SEC |
| Jan 21, 20254:30 PM ET | Canaan XI L.P.and 3 others | 13G/A | 7.40%3.73M shares | – | Dec 31, 2024 | SEC |
| Dec 6, 2024 | Boxer Capital Management, LLC | 13D/AOld format | – | – | – | SEC |
| Nov 19, 2024 | Boxer Capital Management, LLC | 13D/AOld format | – | – | – | SEC |
| Nov 14, 2024 | Nextech VI Oncology SCSP | 13G/AOld format | – | – | – | SEC |
| Nov 14, 2024 | Biotechnology Value Fund L P | 13G/AOld format | – | – | – | SEC |
| Nov 13, 2024 | Ra Capital Management, L.P. | 13D/AOld format | – | – | – | SEC |
| Nov 12, 2024 | FMR LLC | 13G/AOld format | – | – | – | SEC |
| Oct 22, 2024 | Ra Capital Management, L.P. | 13D/AOld format | – | – | – | SEC |
| Oct 22, 2024 | Boxer Capital Management, LLC | 13D/AOld format | – | – | – | SEC |
| Oct 15, 2024 | Boxer Capital, LLC | 13D/AOld format | – | – | – | SEC |
| Oct 15, 2024 | Boxer Asset Management Inc. | 13D/AOld format | – | – | – | SEC |
| Mar 11, 2024 | FMR LLC | 13G/AOld format | – | – | – | SEC |
| Feb 14, 2024 | Biotechnology Value Fund L P | 13G/AOld format | – | – | – | SEC |
| Feb 9, 2024 | FMR LLC | 13G/AOld format | – | – | – | SEC |
| Feb 8, 2024 | Boxer Capital, LLC | 13D/AOld format | – | – | – | SEC |
| Feb 6, 2024 | Ra Capital Management, L.P. | 13D/AOld format | – | – | – | SEC |
| Feb 9, 2023 | FMR LLC | 13G/AOld format | – | – | – | SEC |
| Jun 16, 2022 | Boxer Capital, LLC | 13D/AOld format | – | – | – | SEC |
| Mar 24, 2022 | Biotechnology Value Fund L P | 13GOld format | – | New | – | SEC |
| Feb 9, 2022 | FMR LLC | 13GOld format | – | New | – | SEC |
| Feb 8, 2022 | Canaan XI L.P. | 13GOld format | – | New | – | SEC |
Form 144: proposed insider sales
49 notices from officers, directors and other affiliates planning to sell Tyra Biosciences, Inc. shares, newest first.
| Filed (ET) | Seller | Shares to sell | Market value | Planned sale | Broker | Filing |
|---|---|---|---|---|---|---|
| Jun 26, 20264:59 PM ET | Nextech VI Oncology SCSPShareholder | 308.4K | $9.54M | Jun 26, 202610b5-1 | Merrill Lynch | SEC |
| Jun 1, 20264:16 PM ET | Nextech VI Oncology SCSPShareholder | 300.0K | $10.0M | Jun 1, 202610b5-1 | Merrill Lynch | SEC |
| May 12, 20265:33 PM ET | Daniel BensenOfficer | 8.00K | $274.0K | May 12, 202610b5-1 | Merrill Lynch | SEC |
| Apr 13, 20264:44 PM ET | Daniel BensenOfficer | 8.00K | $285.0K | Apr 13, 202610b5-1 | Merrill Lynch | SEC |
| Mar 26, 20264:04 PM ET | Gilla KaplanDirector | 53.2K | $2.01M | Mar 26, 2026 | Morgan Stanley Smith Barney LLC Executive Financial Services | SEC |
| Mar 25, 20265:36 PM ET | Gilla KaplanDirector | 14.3K | $528.5K | Mar 25, 2026 | Morgan Stanley Smith Barney LLC Executive Financial Services | SEC |
| Mar 12, 20265:42 PM ET | Daniel BensenOfficer | 8.00K | $283.0K | Mar 12, 202610b5-1 | Merrill Lynch | SEC |
| Feb 12, 20264:52 PM ET | Daniel BensenOfficer | 8.00K | $262.0K | Feb 12, 202610b5-1 | Merrill Lynch | SEC |
| Jan 12, 20265:38 PM ET | Daniel BensenOfficer | 8.00K | $232.0K | Jan 12, 202610b5-1 | Merrill Lynch | SEC |
| Dec 12, 20254:21 PM ET | Daniel BensenOfficer | 8.00K | $180.0K | Dec 12, 2025 | Merrill Lynch | SEC |
| Nov 21, 20254:26 PM ET | Alta Partners NextGen Fund II, L.P.Affiliate | 256.9K | $5.39M | Nov 21, 202510b5-1 | Merrill Lynch | SEC |
| Nov 18, 20255:04 PM ET | Daniel BensenOfficer | 124.6K | $2.00M | Nov 18, 202510b5-1 | Merrill Lynch | SEC |
| Nov 17, 20254:28 PM ET | Daniel BensenOfficer | 20.1K | $320.0K | Nov 17, 2025 | Merrill Lynch | SEC |
| Nov 14, 20254:29 PM ET | Daniel BensenOfficer | 86.3K | $1.38M | Nov 14, 202510b5-1 | Merrill Lynch | SEC |
| Nov 13, 20255:40 PM ET | Daniel BensenOfficer | 25.0K | $400.0K | Nov 13, 202510b5-1 | Merrill Lynch | SEC |
| Jun 18, 20254:03 PM ET | Gilla KaplanDirector | 9.57K | $93.6K | Jun 18, 2025 | Morgan Stanley Smith Barney LLC Executive Financial Services | SEC |
| Jun 17, 20254:21 PM ET | Gilla KaplanDirector | 10 | $103.5 | Jun 17, 2025 | Morgan Stanley Smith Barney LLC Executive Financial Services | SEC |
| Jun 16, 20254:14 PM ET | Gilla KaplanDirector | 6.81K | $70.7K | Jun 16, 2025 | Morgan Stanley Smith Barney LLC Executive Financial Services | SEC |
| Jun 13, 20254:22 PM ET | Gilla KaplanDirector | 15.0K | $154.6K | Jun 13, 2025 | Morgan Stanley Smith Barney LLC Executive Financial Services | SEC |
| Jun 12, 20254:28 PM ET | Gilla KaplanDirector | 30.0K | $309.3K | Jun 12, 2025 | Morgan Stanley Smith Barney LLC Executive Financial Services | SEC |
| Feb 5, 20255:42 PM ET | Canaan XI, LPDirector | 120.0K | $1.65M | Feb 5, 2025 | UBS Financial Services Inc | SEC |
| Feb 5, 20254:41 PM ET | Canaan 2020 Plus Co-Investment LP - Series 7Director | 112.5K | $1.55M | Feb 5, 2025 | UBS Financial Services Inc | SEC |
| Jan 22, 20256:00 PM ET | Subramony SiddarthDirector | 18.6K | $292.2K | Jan 22, 2025 | MORGAN STANLEY SMITH BARNEY LLC EXECUTIVE SERVICES | SEC |
| Dec 9, 20245:42 PM ET | Tada HiroomiOfficer | 10.0K | $159.0K | Dec 9, 2024 | Morgan Stanley Smith Barney LLC Executive Services | SEC |
| Dec 5, 20244:21 PM ET | Tada HiroomiOfficer | 5.00K | $75.0K | Dec 5, 2024 | Morgan Stanley Smith Barney LLC Executive Services | SEC |
Showing the latest 25. See the TYRA notices from the last 12 months