Tyra Biosciences, Inc.
TYRA- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001863127
In the last 90 days, Tyra Biosciences, Inc. insiders filed 1 open-market purchase and 0 sales; 168 institutions reported holding it in 13F filings for Q2 2026, worth $2.22B in total; no superinvestor holds it.
13F holders, Q2 2026
Institutional positions in Tyra Biosciences, Inc. as of Jun 30, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 168
- +6 vs. Q1 2026
- Shares held
- 69.4M
- +7.10M (+11.4%) vs. Q1 2026
- Total value
- $2.22B
- −$168.5M (−7.1%) vs. Q1 2026
- New holders
- 32
- 73 more added
- Sold out
- 26
- 44 more reduced
2 institutions that held it in Q1 2026 haven't filed for Q2 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2026: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting TYRA on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 168 | $2.22B |
| Q1 2026 | 164 | $2.54B |
| Q4 2025 | 133 | $1.49B |
| Q3 2025 | 116 | $779.4M |
| Q2 2025 | 121 | $541.7M |
| Q1 2025 | 117 | $499.5M |
| Q4 2024 | 113 | $675.8M |
| Q3 2024 | 95 | $1.11B |
| Q2 2024 | 79 | $754.4M |
| Q1 2024 | 77 | $775.8M |
| Q4 2023 | 62 | $501.2M |
| Q3 2023 | 59 | $502.1M |
| Q2 2023 | 59 | $616.7M |
| Q1 2023 | 51 | $623.6M |
| Q4 2022 | 46 | $267.8M |
| Q3 2022 | 49 | $319.8M |
| Q2 2022 | 48 | $255.6M |
| Q1 2022 | 46 | $386.6M |
| Q4 2021 | 45 | $503.6M |
| Q3 2021 | 26 | $456.8M |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q2 2026
Shares, value and share of portfolio for each institution holding Tyra Biosciences, Inc.; share changes are against Q1 2026.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Ra Capital Management, L.P. | 12,198,625 | $389.6M | 3.39% | 00.0% | Unchanged |
| FMR LLC | 8,920,513 | $284.9M | 0.01% | +1,172,865+15.1% | Added |
| Jupiter Topco LLC | 4,352,448 | $139.2M | 0.06% | +4,352,448 | New |
| Alta Partners Management Company, L.P. | 3,823,425 | $122.1M | 95.92% | 00.0% | Unchanged |
| Nextech Invest, Ltd. | 3,553,585 | $113.5M | 5.39% | −502,276−12.4% | Reduced |
| TCG Crossover Management, LLC | 3,248,980 | $103.8M | 2.49% | 00.0% | Unchanged |
| BlackRock, Inc. | 3,031,972 | $96.8M | 0.00% | +814,043+36.7% | Added |
| Price T Rowe Associates Inc | 2,782,567 | $88.9M | 0.01% | +1,796,506+182.2% | Added |
| State Street Corp | 2,140,368 | $68.4M | 0.00% | +924,290+76.0% | Added |
| Commodore Capital LP | 1,875,000 | $59.9M | 3.57% | −600,000−24.2% | Reduced |
| Paradigm Biocapital Advisors LP | 1,828,607 | $58.4M | 1.09% | −226,384−11.0% | Reduced |
| Vanguard Capital Management LLC | 1,508,447 | $48.2M | 0.00% | +382,477+34.0% | Added |
| BVF Inc | 1,476,196 | $47.1M | 1.21% | −500,000−25.3% | Reduced |
| 5AM Venture Management, LLC | 1,029,298 | $32.9M | 11.42% | 00.0% | Unchanged |
| Deerfield Management Company, L.P. (Series C) | 1,017,000 | $32.5M | 0.34% | +468,000+85.2% | Added |
| Hood River Capital Management LLC | 1,016,775 | $32.5M | 0.24% | +1,016,775 | New |
| Geode Capital Management, LLC | 970,734 | $31.0M | 0.00% | +312,252+47.4% | Added |
| Caligan Partners LP | 806,986 | $25.8M | 1.24% | −469,982−36.8% | Reduced |
| Canaan Partners XI LLC | 750,000 | $24.0M | 18.82% | 00.0% | Unchanged |
| Siren, L.L.C. | 725,000 | $23.2M | 0.47% | +725,000 | New |
| Sio Capital Management, LLC | 695,315 | $22.2M | 3.81% | +89,876+14.8% | Added |
| StemPoint Capital LP | 632,754 | $20.2M | 3.50% | +246,400+63.8% | Added |
| Marshall Wace, LLP | 583,133 | $18.6M | 0.02% | +385,385+194.9% | Added |
| Goldman Sachs Group Inc | 463,477 | $14.8M | 0.00% | −86,857−15.8% | Reduced |
| Jennison Associates LLC | 450,964 | $14.4M | 0.01% | −181,468−28.7% | Reduced |
| Two Sigma Investments, LP | 449,808 | $14.4M | 0.01% | +348,190+342.6% | Added |
| Vanguard Portfolio Management LLC | 403,019 | $12.9M | 0.00% | +155,749+63.0% | Added |
| Defilade Capital Management, L.P. | 376,870 | $12.0M | 1.61% | +376,870 | New |
| Bank of America Corp | 349,732 | $11.2M | 0.00% | +139,810+66.6% | Added |
| Walleye Capital LLC | 347,898 | $11.1M | 0.05% | +329,183+1,758.9% | Added |
| Woodline Partners LP | 320,040 | $10.2M | 0.03% | +19,000+6.3% | Added |
| Northern Trust Corp | 310,084 | $9.90M | 0.00% | +91,576+41.9% | Added |
| Morgan Stanley | 300,322 | $9.59M | 0.00% | +179,837+149.3% | Added |
| Citadel Advisors LLC | 278,307 | $8.89M | 0.01% | +262,911+1,707.7% | Added |
| Charles Schwab Investment Management Inc | 267,699 | $8.55M | 0.00% | +68,588+34.4% | Added |
| Qube Research & Technologies Ltd | 266,934 | $8.53M | 0.01% | +266,934 | New |
| BNP Paribas Arbitrage, SA | 240,227 | $7.67M | 0.00% | +50,188+26.4% | Added |
| Algert Global LLC | 239,120 | $7.64M | 0.09% | +51,110+27.2% | Added |
| Vanguard Fiduciary Trust Co | 224,805 | $7.18M | 0.00% | +67,014+42.5% | Added |
| Dimensional Fund Advisors LP | 217,078 | $6.93M | 0.00% | +125,252+136.4% | Added |
| Affinity Asset Advisors, LLC | 200,012 | $6.39M | 0.31% | −57,500−22.3% | Reduced |
| Franklin Resources Inc | 192,340 | $6.14M | 0.00% | +179,370+1,383.0% | Added |
| HighVista Strategies LLC | 184,774 | $5.90M | 1.35% | +53,470+40.7% | Added |
| Raymond James Financial Inc | 180,881 | $5.78M | 0.00% | −66,217−26.8% | Reduced |
| JPMorgan Chase & Co | 178,263 | $5.74M | 0.00% | +111,474+166.9% | Added |
| Millennium Management LLC | 177,672 | $5.67M | 0.00% | −43,909−19.8% | Reduced |
| Boothbay Fund Management, LLC | 173,559 | $5.54M | 0.10% | −99,715−36.5% | Reduced |
| Adage Capital Partners GP, L.L.C. | 162,000 | $5.17M | 0.01% | +162,000 | New |
| Jump Financial, LLC | 157,000 | $5.01M | 0.04% | +115,625+279.5% | Added |
| Victory Capital Management Inc | 152,585 | $4.87M | 0.00% | +137,355+901.9% | Added |
| Kalehua Capital Management LLC | 148,930 | $4.76M | 1.52% | 00.0% | Unchanged |
| Ensign Peak Advisors, Inc | 146,537 | $4.68M | 0.01% | +72,473+97.9% | Added |
| Trexquant Investment LP | 132,740 | $4.24M | 0.03% | −14,577−9.9% | Reduced |
| UBS Group AG | 129,945 | $4.15M | 0.00% | +68,384+111.1% | Added |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 123,420 | $3.94M | 0.00% | −5,440−4.2% | Reduced |
| Lord, Abbett & Co. LLC | 121,833 | $3.89M | 0.01% | +121,833 | New |
| Bank of New York Mellon Corp | 103,720 | $3.31M | 0.00% | +31,507+43.6% | Added |
| Russell Investments Group, Ltd. | 102,703 | $3.28M | 0.00% | +32,281+45.8% | Added |
| OrbiMed Advisors LLC | 102,000 | $3.26M | 0.06% | +102,000 | New |
| Jacobs Levy Equity Management, Inc | 89,205 | $2.85M | 0.01% | −72,999−45.0% | Reduced |
| Oppenheimer & Co Inc | 83,783 | $2.68M | 0.03% | −409−0.5% | Reduced |
| XTX Topco Ltd | 81,320 | $2.60M | 0.03% | −2,576−3.1% | Reduced |
| Nuveen, LLC | 78,829 | $2.52M | 0.00% | +27,989+55.1% | Added |
| SEI Investments Co | 66,607 | $2.13M | 0.00% | +66,607 | New |
| Squarepoint Ops LLC | 63,805 | $2.04M | 0.00% | +43,311+211.3% | Added |
| Citigroup Inc | 62,279 | $1.99M | 0.00% | +56,288+939.5% | Added |
| Fisher Asset Management, LLC | 60,230 | $1.92M | 0.00% | +31,430+109.1% | Added |
| Alps Advisors Inc | 60,159 | $1.92M | 0.01% | +16,303+37.2% | Added |
| Wellington Management Group LLP | 59,601 | $1.90M | 0.00% | −17,568−22.8% | Reduced |
| Alliancebernstein L.P. | 48,420 | $1.85M | 0.00% | +16,430+51.4% | Added |
| Rhumbline Advisers | 52,039 | $1.66M | 0.00% | +12,379+31.2% | Added |
| TD Asset Management Inc | 50,000 | $1.60M | 0.00% | 00.0% | Unchanged |
| Arkadios Wealth Advisors | 49,336 | $1.58M | 0.02% | +1,769+3.7% | Added |
| State of Wisconsin Investment Board | 46,697 | $1.49M | 0.00% | +13,439+40.4% | Added |
| Susquehanna Portfolio Strategies, LLC | 44,878 | $1.43M | 0.02% | −2,147−4.6% | Reduced |
| Swiss National Bank | 44,700 | $1.43M | 0.00% | +18,300+69.3% | Added |
| Manufacturers Life Insurance Company, The | 44,327 | $1.42M | 0.00% | +4,103+10.2% | Added |
| ExodusPoint Capital Management, LP | 41,026 | $1.31M | 0.01% | +26,960+191.7% | Added |
| Rafferty Asset Management, LLC | 38,702 | $1.24M | 0.00% | +3,846+11.0% | Added |
| Deutsche Bank AG | 36,935 | $1.18M | 0.00% | +16,440+80.2% | Added |
| Verdad Advisers, LP | 36,003 | $1.15M | 1.10% | +36,003 | New |
| Wells Fargo & Company | 33,561 | $1.07M | 0.00% | +21,889+187.5% | Added |
| Sofinnova Investments, Inc. | 32,267 | $1.03M | 0.06% | −171,748−84.2% | Reduced |
| Engineers Gate Manager LP | 31,958 | $1.02M | 0.01% | +31,958 | New |
| AQR Capital Management LLC | 29,853 | $953.5K | 0.00% | +430+1.5% | Added |
| Toroso Investments, LLC | 29,519 | $942.8K | 0.00% | +29,519 | New |
| Tema ETFs LLC | 29,519 | $942.8K | 0.03% | +29,519 | New |
| SG Americas Securities, LLC | 29,444 | $940.0K | 0.00% | +22,229+308.1% | Added |
| PDT Partners, LLC | 25,684 | $820.3K | 0.04% | −16,600−39.3% | Reduced |
| Invesco Ltd. | 24,893 | $795.1K | 0.00% | −84,159−77.2% | Reduced |
| California State Teachers Retirement System | 24,544 | $783.9K | 0.00% | +23,142+1,650.6% | Added |
| STRS Ohio | 22,100 | $705.9K | 0.00% | +4,000+22.1% | Added |
| Creative Planning | 21,803 | $696.4K | 0.00% | −2,145−9.0% | Reduced |
| MetLife Investment Management | 21,723 | $693.8K | 0.00% | +7,730+55.2% | Added |
| Mirae Asset Global ETFs Holdings Ltd. | 21,364 | $683.1K | 0.00% | +6,738+46.1% | Added |
| LMR Partners LLP | 21,151 | $675.6K | 0.00% | +21,151 | New |
| Auour Investments LLC | 21,020 | $671.4K | 0.19% | 00.0% | Unchanged |
| Voya Investment Management LLC | 20,282 | $647.8K | 0.00% | −18,076−47.1% | Reduced |
| Barclays PLC | 20,275 | $647.6K | 0.00% | −813,124−97.6% | Reduced |
| D. E. Shaw & Co., Inc. | 20,189 | $644.8K | 0.00% | +20,189 | New |