Tyra Biosciences, Inc.
TYRA- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001863127
In the last 90 days, Tyra Biosciences, Inc. insiders filed 1 open-market purchase and 0 sales; 168 institutions reported holding it in 13F filings for Q2 2026, worth $2.22B in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Tyra Biosciences, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 133
- +19 vs. Q3 2025
- Shares held
- 56.8M
- +1.36M (+2.4%) vs. Q3 2025
- Total value
- $1.49B
- +$717.9M (+92.5%) vs. Q3 2025
- New holders
- 29
- 43 more added
- Sold out
- 10
- 38 more reduced
2 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting TYRA on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 168 | $2.22B |
| Q1 2026 | 164 | $2.52B |
| Q4 2025 | 133 | $1.49B |
| Q3 2025 | 116 | $778.4M |
| Q2 2025 | 121 | $541.5M |
| Q1 2025 | 117 | $499.5M |
| Q4 2024 | 113 | $675.8M |
| Q3 2024 | 95 | $1.11B |
| Q2 2024 | 79 | $748.6M |
| Q1 2024 | 77 | $768.4M |
| Q4 2023 | 62 | $495.2M |
| Q3 2023 | 59 | $502.1M |
| Q2 2023 | 59 | $616.7M |
| Q1 2023 | 51 | $573.0M |
| Q4 2022 | 46 | $267.8M |
| Q3 2022 | 49 | $313.8M |
| Q2 2022 | 48 | $255.6M |
| Q1 2022 | 46 | $386.6M |
| Q4 2021 | 45 | $494.2M |
| Q3 2021 | 26 | $456.8M |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Tyra Biosciences, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Ra Capital Management, L.P. | 12,198,625 | $320.7M | 3.29% | 00.0% | Unchanged |
| Nextech Invest, Ltd. | 4,055,861 | $106.6M | 10.31% | 00.0% | Unchanged |
| Alta Partners Management Company, L.P. | 3,823,425 | $100.5M | 97.03% | −256,871−6.3% | Reduced |
| Commodore Capital LP | 3,375,000 | $88.7M | 5.91% | 00.0% | Unchanged |
| Canaan Partners XI LLC | 3,374,329 | $88.7M | 64.85% | −233,780−6.5% | Reduced |
| Janus Henderson Group PLC | 2,935,442 | $77.1M | 0.03% | +60,638+2.1% | Added |
| TCG Crossover Management, LLC | 2,898,103 | $76.2M | 2.52% | 00.0% | Unchanged |
| Vestal Point Capital, LP | 2,425,000 | $63.8M | 2.34% | 00.0% | Unchanged |
| BVF Inc | 2,127,665 | $55.9M | 1.88% | −1,522,129−41.7% | Reduced |
| BlackRock, Inc. | 2,086,423 | $54.9M | 0.00% | +216,949+11.6% | Added |
| Farallon Capital Management, L.L.C. | 2,066,818 | $54.3M | 0.28% | +923,000+80.7% | Added |
| Vanguard Group Inc | 1,572,785 | $41.3M | 0.00% | +52,600+3.5% | Added |
| Kynam Capital Management, LP | 1,564,492 | $41.1M | 2.68% | −765,506−32.9% | Reduced |
| 5AM Venture Management, LLC | 1,029,298 | $27.1M | 8.51% | +90,000+9.6% | Added |
| Caligan Partners LP | 944,257 | $24.8M | 2.27% | +247,432+35.5% | Added |
| Point72 Asset Management, L.P. | 874,192 | $23.0M | 0.04% | +592,160+210.0% | Added |
| Balyasny Asset Management LLC | 818,326 | $21.5M | 0.04% | −28,259−3.3% | Reduced |
| State Street Corp | 749,463 | $19.7M | 0.00% | +320,991+74.9% | Added |
| Marshall Wace, LLP | 711,891 | $18.7M | 0.02% | +109,876+18.3% | Added |
| Trails Edge Capital Partners, LP | 700,000 | $18.4M | 4.55% | +700,000 | New |
| Geode Capital Management, LLC | 657,756 | $17.3M | 0.00% | +60,302+10.1% | Added |
| Sio Capital Management, LLC | 526,002 | $13.8M | 2.29% | +11,055+2.1% | Added |
| Boone Capital Management LLC | 398,482 | $10.5M | 3.29% | +398,482 | New |
| Elmind Capital, LP | 350,000 | $9.20M | 2.72% | +350,000 | New |
| Eversept Partners, LP | 278,564 | $7.32M | 0.41% | +5,858+2.1% | Added |
| Boothbay Fund Management, LLC | 221,177 | $5.81M | 0.15% | +34,507+18.5% | Added |
| Logos Global Management LP | 210,000 | $5.52M | 0.37% | +210,000 | New |
| Northern Trust Corp | 200,956 | $5.28M | 0.00% | −7,530−3.6% | Reduced |
| Charles Schwab Investment Management Inc | 199,426 | $5.24M | 0.00% | −2,161−1.1% | Reduced |
| Goldman Sachs Group Inc | 182,387 | $4.79M | 0.00% | +82,237+82.1% | Added |
| Raymond James Financial Inc | 170,032 | $4.47M | 0.00% | +43,658+34.5% | Added |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 129,779 | $3.41M | 0.00% | +129,779 | New |
| Jacobs Levy Equity Management, Inc | 129,753 | $3.41M | 0.01% | −121,809−48.4% | Reduced |
| Invesco Ltd. | 129,435 | $3.40M | 0.00% | +113,925+734.5% | Added |
| Soleus Capital Management, L.P. | 125,000 | $3.29M | 0.14% | +125,000 | New |
| BNP Paribas Arbitrage, SA | 120,278 | $3.16M | 0.00% | −8,603−6.7% | Reduced |
| Morgan Stanley | 118,898 | $3.13M | 0.00% | −203,245−63.1% | Reduced |
| Millennium Management LLC | 114,388 | $3.01M | 0.00% | −29,628−20.6% | Reduced |
| Two Sigma Investments, LP | 107,023 | $2.81M | 0.00% | −92,415−46.3% | Reduced |
| Wellington Management Group LLP | 104,305 | $2.74M | 0.00% | +21,434+25.9% | Added |
| Dimensional Fund Advisors LP | 95,640 | $2.51M | 0.00% | +55,961+141.0% | Added |
| Investment Counsel Co of Nevada | 85,020 | $2.24M | 4.80% | 00.0% | Unchanged |
| Oppenheimer & Co Inc | 84,726 | $2.23M | 0.03% | +2,488+3.0% | Added |
| Seven Fleet Capital Management LP | 79,560 | $2.09M | 1.42% | +79,560 | New |
| Barclays PLC | 76,309 | $2.01M | 0.00% | +19,183+33.6% | Added |
| Kalehua Capital Management LLC | 74,465 | $1.96M | 1.94% | +74,465 | New |
| JPMorgan Chase & Co | 71,175 | $1.87M | 0.00% | −3,054−4.1% | Reduced |
| Bank of New York Mellon Corp | 60,901 | $1.60M | 0.00% | +3,739+6.5% | Added |
| Two Sigma Advisers, LP | 58,900 | $1.55M | 0.00% | −54,300−48.0% | Reduced |
| UBS Group AG | 58,856 | $1.55M | 0.00% | −288−0.5% | Reduced |
| Superstring Capital Management LP | 58,677 | $1.54M | 0.83% | +58,677 | New |
| Susquehanna International Group, LLP | 55,135 | $1.45M | 0.00% | +55,135 | New |
| Ameriprise Financial Inc | 54,625 | $1.44M | 0.00% | −32,482−37.3% | Reduced |
| Squarepoint Ops LLC | 54,424 | $1.43M | 0.00% | +42,210+345.6% | Added |
| Susquehanna Portfolio Strategies, LLC | 48,644 | $1.28M | 0.02% | 00.0% | Unchanged |
| Nuveen, LLC | 47,349 | $1.24M | 0.00% | −33,092−41.1% | Reduced |
| Algert Global LLC | 46,870 | $1.23M | 0.02% | +46,870 | New |
| American Century Companies Inc | 46,227 | $1.22M | 0.00% | +7,815+20.3% | Added |
| Y-Intercept (Hong Kong) Ltd | 45,942 | $1.21M | 0.03% | +45,942 | New |
| Alps Advisors Inc | 43,827 | $1.15M | 0.01% | +19,127+77.4% | Added |
| ExodusPoint Capital Management, LP | 42,791 | $1.12M | 0.01% | +42,791 | New |
| PDT Partners, LLC | 42,284 | $1.11M | 0.07% | −1,026−2.4% | Reduced |
| State of Wisconsin Investment Board | 39,023 | $1.03M | 0.00% | +9,375+31.6% | Added |
| Rhumbline Advisers | 38,790 | $1.02M | 0.00% | −1,846−4.5% | Reduced |
| Bank of America Corp | 38,310 | $1.01M | 0.00% | −96,009−71.5% | Reduced |
| HighVista Strategies LLC | 35,086 | $922.4K | 0.24% | −30,726−46.7% | Reduced |
| Alliancebernstein L.P. | 31,990 | $841.0K | 0.00% | −1,270−3.8% | Reduced |
| XTX Topco Ltd | 30,414 | $799.6K | 0.02% | −3,286−9.8% | Reduced |
| Voya Investment Management LLC | 29,887 | $785.7K | 0.00% | +29,887 | New |
| Wells Fargo & Company | 29,049 | $763.7K | 0.00% | +10,579+57.3% | Added |
| Canada Pension Plan Investment Board | 28,900 | $759.8K | 0.00% | +28,900 | New |
| Fisher Asset Management, LLC | 28,800 | $757.2K | 0.00% | +28,800 | New |
| AQR Capital Management LLC | 28,631 | $752.7K | 0.00% | +562+2.0% | Added |
| PSP Research LLC | 21,853 | $574.5K | 0.50% | +21,853 | New |
| Auour Investments LLC | 21,020 | $552.6K | 0.18% | 00.0% | Unchanged |
| Creative Planning | 19,603 | $515.4K | 0.00% | +19,603 | New |
| Victory Capital Management Inc | 18,790 | $494.0K | 0.00% | 00.0% | Unchanged |
| Public Employees Retirement System of Ohio | 18,542 | $487.5K | 0.00% | −6,420−25.7% | Reduced |
| Deutsche Bank AG | 16,377 | $430.6K | 0.00% | +894+5.8% | Added |
| Rafferty Asset Management, LLC | 15,455 | $406.3K | 0.00% | +15,455 | New |
| MetLife Investment Management | 15,356 | $403.7K | 0.00% | +725+5.0% | Added |
| Price T Rowe Associates Inc | 14,432 | $380.0K | 0.00% | +1,631+12.7% | Added |
| Russell Investments Group, Ltd. | 12,996 | $341.7K | 0.00% | +255+2.0% | Added |
| Franklin Resources Inc | 12,970 | $341.0K | 0.00% | +12,970 | New |
| Mirae Asset Global ETFs Holdings Ltd. | 12,908 | $338.6K | 0.00% | +1,591+14.1% | Added |
| FMR LLC | 12,563 | $330.3K | 0.00% | +34+0.3% | Added |
| Virtus Investment Advisers, Inc. | 11,756 | $309.1K | 0.08% | +741+6.7% | Added |
| Bank of Nova Scotia | 11,100 | $291.8K | 0.00% | +11,100 | New |
| Baker Bros. Advisors LP | 10,607 | $278.9K | 0.00% | 00.0% | Unchanged |
| Intech Investment Management LLC | 9,801 | $257.7K | 0.00% | −1,601−14.0% | Reduced |
| VARCOV Co. | 9,708 | $255.2K | 0.10% | +9,708 | New |
| China Universal Asset Management Co., Ltd. | 8,697 | $228.6K | 0.02% | −645−6.9% | Reduced |
| Manufacturers Life Insurance Company, The | 8,357 | $219.7K | 0.00% | +8,357 | New |
| New York State Common Retirement Fund | 7,423 | $195.2K | 0.00% | 00.0% | Unchanged |
| Police & Firemen's Retirement System of New Jersey | 6,440 | $169.3K | 0.00% | 00.0% | Unchanged |
| Citigroup Inc | 3,817 | $100.3K | 0.00% | +2,110+123.6% | Added |
| Bellevue Group AG | 3,143 | $82.6K | 0.00% | +3,143 | New |
| Caitong International Asset Management Co., Ltd | 2,997 | $78.8K | 0.02% | +2,997 | New |
| Mirae Asset Global Investments Co., Ltd. | 2,594 | $68.2K | 0.00% | +534+25.9% | Added |
| Legal & General Group Plc | 2,367 | $62.2K | 0.00% | +175+8.0% | Added |