Tyra Biosciences, Inc.
TYRA- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001863127
In the last 90 days, Tyra Biosciences, Inc. insiders filed 1 open-market purchase and 0 sales; 168 institutions reported holding it in 13F filings for Q2 2026, worth $2.22B in total; no superinvestor holds it.
13F holders, Q1 2025
Institutional positions in Tyra Biosciences, Inc. as of Mar 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 117
- +6 vs. Q4 2024
- Shares held
- 53.6M
- +9.07M (+20.4%) vs. Q4 2024
- Total value
- $499.5M
- −$119.2M (−19.3%) vs. Q4 2024
- New holders
- 22
- 42 more added
- Sold out
- 16
- 31 more reduced
2 institutions that held it in Q4 2024 haven't filed for Q1 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting TYRA on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 168 | $2.22B |
| Q1 2026 | 164 | $2.52B |
| Q4 2025 | 133 | $1.49B |
| Q3 2025 | 116 | $778.4M |
| Q2 2025 | 121 | $541.5M |
| Q1 2025 | 117 | $499.5M |
| Q4 2024 | 113 | $675.8M |
| Q3 2024 | 95 | $1.11B |
| Q2 2024 | 79 | $748.6M |
| Q1 2024 | 77 | $768.4M |
| Q4 2023 | 62 | $495.2M |
| Q3 2023 | 59 | $502.1M |
| Q2 2023 | 59 | $616.7M |
| Q1 2023 | 51 | $573.0M |
| Q4 2022 | 46 | $267.8M |
| Q3 2022 | 49 | $313.8M |
| Q2 2022 | 48 | $255.6M |
| Q1 2022 | 46 | $386.6M |
| Q4 2021 | 45 | $494.2M |
| Q3 2021 | 26 | $456.8M |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q1 2025
Shares, value and share of portfolio for each institution holding Tyra Biosciences, Inc.; share changes are against Q4 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Ra Capital Management, L.P. | 10,637,290 | $98.9M | 1.65% | 00.0% | Unchanged |
| Canaan Partners XI LLC | 4,144,590 | $38.5M | 58.09% | −35,267−0.8% | Reduced |
| Alta Partners Management Company, L.P. | 4,080,296 | $37.9M | 90.83% | 00.0% | Unchanged |
| Nextech Invest, Ltd. | 4,055,861 | $37.7M | 8.77% | +4,055,861 | New |
| BVF Inc | 3,944,194 | $36.7M | 1.50% | 00.0% | Unchanged |
| TCG Crossover Management, LLC | 2,898,103 | $27.0M | 3.68% | +909,000+45.7% | Added |
| Vestal Point Capital, LP | 2,879,829 | $26.8M | 1.91% | +1,889,829+190.9% | Added |
| Janus Henderson Group PLC | 2,693,237 | $26.3M | 0.01% | +946,917+54.2% | Added |
| Kynam Capital Management, LP | 2,406,067 | $22.4M | 1.91% | +1,875,589+353.6% | Added |
| OrbiMed Advisors LLC | 1,752,831 | $16.3M | 0.39% | +282,745+19.2% | Added |
| FMR LLC | 1,707,148 | $15.9M | 0.00% | −1,400,822−45.1% | Reduced |
| BlackRock, Inc. | 1,695,917 | $15.8M | 0.00% | −22,587−1.3% | Reduced |
| Vanguard Group Inc | 1,218,371 | $11.3M | 0.00% | +10,606+0.9% | Added |
| Farallon Capital Management, L.L.C. | 1,143,818 | $10.6M | 0.06% | +142,837+14.3% | Added |
| Commodore Capital LP | 950,000 | $8.84M | 0.65% | +950,000 | New |
| 5AM Venture Management, LLC | 939,298 | $8.74M | 3.30% | 00.0% | Unchanged |
| Geode Capital Management, LLC | 516,290 | $4.80M | 0.00% | −1,288−0.2% | Reduced |
| Pictet Asset Management Holding SA | 459,113 | $4.27M | 0.00% | +105,101+29.7% | Added |
| Sio Capital Management, LLC | 416,617 | $3.87M | 1.17% | +175,747+73.0% | Added |
| State Street Corp | 413,988 | $3.85M | 0.00% | +6,415+1.6% | Added |
| Millennium Management LLC | 404,165 | $3.76M | 0.00% | +89,024+28.2% | Added |
| Marshall Wace, LLP | 380,700 | $3.54M | 0.00% | +326,623+604.0% | Added |
| Jacobs Levy Equity Management, Inc | 301,801 | $2.81M | 0.01% | +57,556+23.6% | Added |
| Balyasny Asset Management LLC | 243,244 | $2.26M | 0.01% | +243,244 | New |
| Northern Trust Corp | 216,447 | $2.01M | 0.00% | −6,317−2.8% | Reduced |
| Morgan Stanley | 180,590 | $1.68M | 0.00% | +106,441+143.6% | Added |
| Charles Schwab Investment Management Inc | 164,108 | $1.53M | 0.00% | −6,492−3.8% | Reduced |
| Polar Asset Management Partners Inc. | 141,241 | $1.31M | 0.04% | +30,134+27.1% | Added |
| Walleye Capital LLC | 140,742 | $1.31M | 0.01% | +77,762+123.5% | Added |
| AXA S.A. | 128,189 | $1.19M | 0.00% | +128,189 | New |
| Ally Bridge Group (NY) LLC | 107,244 | $997.4K | 0.90% | −67,819−38.7% | Reduced |
| Wellington Management Group LLP | 104,087 | $968.0K | 0.00% | +9,228+9.7% | Added |
| Woodline Partners LP | 100,108 | $931.0K | 0.01% | +100,108 | New |
| Citadel Advisors LLC | 96,282 | $895.4K | 0.00% | +40,695+73.2% | Added |
| Cubist Systematic Strategies, LLC | 91,844 | $854.1K | 0.01% | −17,904−16.3% | Reduced |
| JPMorgan Chase & Co | 85,490 | $795.1K | 0.00% | −5,625−6.2% | Reduced |
| Investment Counsel Co of Nevada | 85,020 | $790.7K | 1.80% | 00.0% | Unchanged |
| Bank of America Corp | 83,521 | $776.7K | 0.00% | +17,364+26.2% | Added |
| Goldman Sachs Group Inc | 78,006 | $725.5K | 0.00% | +13,896+21.7% | Added |
| Oppenheimer & Co Inc | 74,805 | $695.7K | 0.01% | −634−0.8% | Reduced |
| BNP Paribas Arbitrage, SA | 68,950 | $641.2K | 0.00% | +64,632+1,496.8% | Added |
| Two Sigma Investments, LP | 64,818 | $602.8K | 0.00% | +18,549+40.1% | Added |
| State of Wisconsin Investment Board | 58,712 | $546.0K | 0.00% | −6,327−9.7% | Reduced |
| Victory Capital Management Inc | 56,150 | $522.2K | 0.00% | −490−0.9% | Reduced |
| Raymond James Financial Inc | 54,344 | $505.4K | 0.00% | −439−0.8% | Reduced |
| Renaissance Technologies LLC | 51,400 | $478.0K | 0.00% | +22,300+76.6% | Added |
| Two Sigma Advisers, LP | 50,100 | $465.9K | 0.00% | +37,800+307.3% | Added |
| Nuveen, LLC | 49,998 | $465.0K | 0.00% | +49,998 | New |
| Point72 Asset Management, L.P. | 49,600 | $461.3K | 0.00% | +36,817+288.0% | Added |
| Brevan Howard Capital Management LP | 46,371 | $431.3K | 0.01% | +46,371 | New |
| UBS Group AG | 46,286 | $430.5K | 0.00% | −1,565−3.3% | Reduced |
| Barclays PLC | 42,511 | $395.4K | 0.00% | −559−1.3% | Reduced |
| Verition Fund Management LLC | 42,174 | $392.2K | 0.00% | +42,174 | New |
| Bank of New York Mellon Corp | 41,083 | $382.1K | 0.00% | −3,924−8.7% | Reduced |
| UBS Asset Management Americas Inc | 35,635 | $331.4K | 0.00% | 00.0% | Unchanged |
| Ikarian Capital, LLC | 35,000 | $325.5K | 0.11% | −25,000−41.7% | Reduced |
| Jane Street Group, LLC | 34,813 | $323.8K | 0.00% | +34,813 | New |
| Dimensional Fund Advisors LP | 34,712 | $322.8K | 0.00% | −3,269−8.6% | Reduced |
| ExodusPoint Capital Management, LP | 30,235 | $281.0K | 0.00% | +30,235 | New |
| Quest Partners LLC | 29,622 | $275.5K | 0.03% | +24,599+489.7% | Added |
| Swiss National Bank | 29,400 | $273.4K | 0.00% | +8,700+42.0% | Added |
| Rhumbline Advisers | 28,081 | $261.1K | 0.00% | +1,879+7.2% | Added |
| Jump Financial, LLC | 27,949 | $259.9K | 0.00% | +12,789+84.4% | Added |
| Caligan Partners LP | 25,000 | $232.5K | 0.05% | +25,000 | New |
| HighVista Strategies LLC | 23,941 | $222.7K | 0.09% | 00.0% | Unchanged |
| Susquehanna International Group, LLP | 23,526 | $218.8K | 0.00% | +23,526 | New |
| American Century Companies Inc | 23,431 | $217.9K | 0.00% | +1,289+5.8% | Added |
| Auour Investments LLC | 21,020 | $216.5K | 0.08% | 00.0% | Unchanged |
| Alliancebernstein L.P. | 17,570 | $163.4K | 0.00% | 00.0% | Unchanged |
| Deutsche Bank AG | 16,979 | $157.9K | 0.00% | −1,930−10.2% | Reduced |
| Citigroup Inc | 15,507 | $144.2K | 0.00% | −1,296−7.7% | Reduced |
| SG Americas Securities, LLC | 15,120 | $141.0K | 0.00% | +5,449+56.3% | Added |
| EntryPoint Capital, LLC | 14,892 | $138.5K | 0.06% | −3,317−18.2% | Reduced |
| Intech Investment Management LLC | 13,597 | $126.5K | 0.00% | +13,597 | New |
| MetLife Investment Management | 12,207 | $113.5K | 0.00% | 00.0% | Unchanged |
| Tudor Investment Corp Et Al | 12,093 | $112.5K | 0.00% | −3,484−22.4% | Reduced |
| Exchange Traded Concepts, LLC | 11,861 | $110.3K | 0.00% | +3,550+42.7% | Added |
| Aquatic Capital Management LLC | 11,781 | $109.6K | 0.00% | +7,195+156.9% | Added |
| Mirae Asset Global ETFs Holdings Ltd. | 11,514 | $107.1K | 0.00% | −127−1.1% | Reduced |
| Virtus Investment Advisers, Inc. | 10,818 | $100.6K | 0.03% | +10,818 | New |
| Baker Bros. Advisors LP | 10,607 | $98.6K | 0.00% | 00.0% | Unchanged |
| California State Teachers Retirement System | 10,570 | $98.3K | 0.00% | 00.0% | Unchanged |
| Axq Capital, LP | 10,302 | $95.8K | 0.04% | +10,302 | New |
| Russell Investments Group, Ltd. | 10,239 | $95.2K | 0.00% | −216−2.1% | Reduced |
| China Universal Asset Management Co., Ltd. | 10,150 | $94.4K | 0.01% | −580−5.4% | Reduced |
| Corebridge Financial, Inc. | 9,590 | $89.2K | 0.00% | −512−5.1% | Reduced |
| Wells Fargo & Company | 9,353 | $87.0K | 0.00% | −140−1.5% | Reduced |
| Legal & General Group Plc | 9,261 | $86.1K | 0.00% | −79−0.8% | Reduced |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 9,047 | $84.1K | 0.00% | +9,047 | New |
| New York State Common Retirement Fund | 7,423 | $69.0K | 0.00% | 00.0% | Unchanged |
| US Bancorp | 5,435 | $50.5K | 0.00% | +1,823+50.5% | Added |
| Police & Firemen's Retirement System of New Jersey | 5,049 | $47.0K | 0.00% | 00.0% | Unchanged |
| Point72 (DIFC) Ltd | 2,273 | $21.1K | 0.00% | +1,712+305.2% | Added |
| KLP Kapitalforvaltning AS | 2,200 | $20.5K | 0.00% | 00.0% | Unchanged |
| Tower Research Capital LLC (TRC) | 2,083 | $19.4K | 0.00% | +666+47.0% | Added |
| Ameritas Investment Partners, Inc. | 1,991 | $18.5K | 0.00% | 00.0% | Unchanged |
| Mirae Asset Global Investments Co., Ltd. | 1,693 | $16.5K | 0.00% | +7+0.4% | Added |
| GF Fund Management Co. Ltd. | 1,296 | $12.1K | 0.00% | +233+21.9% | Added |
| Advisor Group Holdings, Inc. | 835 | $7.76K | 0.00% | +813+3,695.5% | Added |
| Point72 Asia (Singapore) Pte. Ltd. | 792 | $7.37K | 0.00% | +792 | New |