Tyra Biosciences, Inc.
TYRA- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001863127
In the last 90 days, Tyra Biosciences, Inc. insiders filed 1 open-market purchase and 0 sales; 168 institutions reported holding it in 13F filings for Q2 2026, worth $2.22B in total; no superinvestor holds it.
13F holders, Q2 2025
Institutional positions in Tyra Biosciences, Inc. as of Jun 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 121
- +4 vs. Q1 2025
- Shares held
- 56.6M
- +3.02M (+5.6%) vs. Q1 2025
- Total value
- $541.5M
- +$42.0M (+8.4%) vs. Q1 2025
- New holders
- 18
- 62 more added
- Sold out
- 14
- 20 more reduced
Compare with Q1 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting TYRA on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 168 | $2.22B |
| Q1 2026 | 164 | $2.52B |
| Q4 2025 | 133 | $1.49B |
| Q3 2025 | 116 | $778.4M |
| Q2 2025 | 121 | $541.5M |
| Q1 2025 | 117 | $499.5M |
| Q4 2024 | 113 | $675.8M |
| Q3 2024 | 95 | $1.11B |
| Q2 2024 | 79 | $748.6M |
| Q1 2024 | 77 | $768.4M |
| Q4 2023 | 62 | $495.2M |
| Q3 2023 | 59 | $502.1M |
| Q2 2023 | 59 | $616.7M |
| Q1 2023 | 51 | $573.0M |
| Q4 2022 | 46 | $267.8M |
| Q3 2022 | 49 | $313.8M |
| Q2 2022 | 48 | $255.6M |
| Q1 2022 | 46 | $386.6M |
| Q4 2021 | 45 | $494.2M |
| Q3 2021 | 26 | $456.8M |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q2 2025
Shares, value and share of portfolio for each institution holding Tyra Biosciences, Inc.; share changes are against Q1 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Ra Capital Management, L.P. | 12,198,625 | $116.7M | 1.97% | +1,561,335+14.7% | Added |
| Alta Partners Management Company, L.P. | 4,080,296 | $39.0M | 93.82% | 00.0% | Unchanged |
| Nextech Invest, Ltd. | 4,055,861 | $38.8M | 7.35% | 00.0% | Unchanged |
| BVF Inc | 3,944,194 | $37.7M | 1.35% | 00.0% | Unchanged |
| Canaan Partners XI LLC | 3,608,109 | $34.5M | 20.10% | −536,481−12.9% | Reduced |
| Commodore Capital LP | 3,100,000 | $29.7M | 2.09% | +2,150,000+226.3% | Added |
| TCG Crossover Management, LLC | 2,898,103 | $27.7M | 3.17% | 00.0% | Unchanged |
| Janus Henderson Group PLC | 2,856,290 | $27.3M | 0.01% | +163,053+6.1% | Added |
| Vestal Point Capital, LP | 2,655,000 | $25.4M | 1.34% | −224,829−7.8% | Reduced |
| Kynam Capital Management, LP | 2,329,998 | $22.3M | 2.40% | −76,069−3.2% | Reduced |
| BlackRock, Inc. | 1,893,328 | $18.1M | 0.00% | +197,411+11.6% | Added |
| Vanguard Group Inc | 1,401,693 | $13.4M | 0.00% | +183,322+15.0% | Added |
| Farallon Capital Management, L.L.C. | 1,143,818 | $10.9M | 0.05% | 00.0% | Unchanged |
| 5AM Venture Management, LLC | 939,298 | $8.99M | 3.46% | 00.0% | Unchanged |
| Sio Capital Management, LLC | 810,274 | $7.75M | 3.11% | +393,657+94.5% | Added |
| OrbiMed Advisors LLC | 804,603 | $7.70M | 0.19% | −948,228−54.1% | Reduced |
| Balyasny Asset Management LLC | 583,386 | $5.58M | 0.01% | +340,142+139.8% | Added |
| Geode Capital Management, LLC | 567,126 | $5.43M | 0.00% | +50,836+9.8% | Added |
| Marshall Wace, LLP | 428,108 | $4.10M | 0.00% | +47,408+12.5% | Added |
| State Street Corp | 418,984 | $4.01M | 0.00% | +4,996+1.2% | Added |
| Millennium Management LLC | 407,464 | $3.90M | 0.00% | +3,299+0.8% | Added |
| Jacobs Levy Equity Management, Inc | 395,299 | $3.78M | 0.01% | +93,498+31.0% | Added |
| Morgan Stanley | 378,402 | $3.62M | 0.00% | +197,812+109.5% | Added |
| Bank of America Corp | 372,967 | $3.57M | 0.00% | +289,446+346.6% | Added |
| Walleye Capital LLC | 370,408 | $3.54M | 0.03% | +229,666+163.2% | Added |
| Point72 Asset Management, L.P. | 224,700 | $2.15M | 0.01% | +175,100+353.0% | Added |
| Citadel Advisors LLC | 216,136 | $2.07M | 0.00% | +119,854+124.5% | Added |
| Northern Trust Corp | 205,308 | $1.96M | 0.00% | −11,139−5.1% | Reduced |
| Caligan Partners LP | 189,950 | $1.82M | 0.35% | +164,950+659.8% | Added |
| Charles Schwab Investment Management Inc | 178,104 | $1.70M | 0.00% | +13,996+8.5% | Added |
| Renaissance Technologies LLC | 135,100 | $1.29M | 0.00% | +83,700+162.8% | Added |
| AXA S.A. | 128,400 | $1.23M | 0.00% | +211+0.2% | Added |
| Cubist Systematic Strategies, LLC | 122,036 | $1.17M | 0.01% | +30,192+32.9% | Added |
| Two Sigma Investments, LP | 105,825 | $1.01M | 0.00% | +41,007+63.3% | Added |
| Goldman Sachs Group Inc | 105,595 | $1.01M | 0.00% | +27,589+35.4% | Added |
| Wellington Management Group LLP | 103,078 | $986.5K | 0.00% | −1,009−1.0% | Reduced |
| JPMorgan Chase & Co | 102,917 | $984.9K | 0.00% | +17,427+20.4% | Added |
| Woodline Partners LP | 100,108 | $958.0K | 0.01% | 00.0% | Unchanged |
| BNP Paribas Arbitrage, SA | 97,736 | $935.3K | 0.00% | +28,786+41.7% | Added |
| Two Sigma Advisers, LP | 87,000 | $832.6K | 0.00% | +36,900+73.7% | Added |
| Investment Counsel Co of Nevada | 85,020 | $813.6K | 1.67% | 00.0% | Unchanged |
| Ameriprise Financial Inc | 80,602 | $771.4K | 0.00% | +80,602 | New |
| Nuveen, LLC | 80,441 | $769.8K | 0.00% | +30,443+60.9% | Added |
| State of Wisconsin Investment Board | 76,449 | $731.6K | 0.00% | +17,737+30.2% | Added |
| Oppenheimer & Co Inc | 74,033 | $708.5K | 0.01% | −772−1.0% | Reduced |
| Quest Partners LLC | 73,073 | $699.3K | 0.07% | +43,451+146.7% | Added |
| Jump Financial, LLC | 71,119 | $680.6K | 0.01% | +43,170+154.5% | Added |
| ExodusPoint Capital Management, LP | 67,442 | $645.0K | 0.01% | +37,207+123.1% | Added |
| Raymond James Financial Inc | 63,187 | $604.7K | 0.00% | +8,843+16.3% | Added |
| Barclays PLC | 61,555 | $589.1K | 0.00% | +19,044+44.8% | Added |
| Jane Street Group, LLC | 58,168 | $556.7K | 0.00% | +23,355+67.1% | Added |
| Bank of New York Mellon Corp | 54,039 | $517.2K | 0.00% | +12,956+31.5% | Added |
| Susquehanna Portfolio Strategies, LLC | 48,644 | $465.5K | 0.01% | +48,644 | New |
| UBS Group AG | 46,268 | $442.8K | 0.00% | −180.0% | Reduced |
| Trexquant Investment LP | 44,681 | $427.6K | 0.00% | +44,681 | New |
| Victory Capital Management Inc | 44,190 | $422.9K | 0.00% | −11,960−21.3% | Reduced |
| PDT Partners, LLC | 43,310 | $414.5K | 0.02% | +43,310 | New |
| Dimensional Fund Advisors LP | 41,681 | $398.9K | 0.00% | +6,969+20.1% | Added |
| Verition Fund Management LLC | 40,939 | $391.8K | 0.00% | −1,235−2.9% | Reduced |
| Rhumbline Advisers | 40,685 | $389.3K | 0.00% | +12,604+44.9% | Added |
| Susquehanna International Group, LLP | 37,782 | $361.6K | 0.00% | +14,256+60.6% | Added |
| Brevan Howard Capital Management LP | 36,594 | $350.2K | 0.00% | −9,777−21.1% | Reduced |
| Alliancebernstein L.P. | 35,640 | $341.1K | 0.00% | +18,070+102.8% | Added |
| XTX Topco Ltd | 34,601 | $331.1K | 0.01% | +34,601 | New |
| Dynamic Technology Lab Private Ltd | 34,115 | $326.0K | 0.04% | +34,115 | New |
| Squarepoint Ops LLC | 31,408 | $300.6K | 0.00% | +31,408 | New |
| American Century Companies Inc | 28,854 | $276.1K | 0.00% | +5,423+23.1% | Added |
| Alps Advisors Inc | 28,729 | $274.9K | 0.00% | +28,729 | New |
| AQR Capital Management LLC | 28,712 | $274.8K | 0.00% | +28,712 | New |
| Tudor Investment Corp Et Al | 26,265 | $251.4K | 0.00% | +14,172+117.2% | Added |
| HighVista Strategies LLC | 24,962 | $238.9K | 0.09% | +1,021+4.3% | Added |
| Corton Capital Inc. | 24,346 | $233.0K | 0.27% | +24,346 | New |
| Auour Investments LLC | 21,020 | $201.2K | 0.07% | 00.0% | Unchanged |
| Intech Investment Management LLC | 19,919 | $190.6K | 0.00% | +6,322+46.5% | Added |
| Public Employees Retirement System of Ohio | 18,512 | $177.2K | 0.00% | +18,512 | New |
| Royal Bank of Canada | 16,213 | $156.0K | 0.00% | +15,536+2,294.8% | Added |
| Wells Fargo & Company | 15,457 | $147.9K | 0.00% | +6,104+65.3% | Added |
| MetLife Investment Management | 14,631 | $140.0K | 0.00% | +2,424+19.9% | Added |
| Aquatic Capital Management LLC | 13,744 | $131.5K | 0.00% | +1,963+16.7% | Added |
| Deutsche Bank AG | 13,300 | $127.3K | 0.00% | −3,679−21.7% | Reduced |
| Mirae Asset Global ETFs Holdings Ltd. | 13,182 | $126.2K | 0.00% | +1,668+14.5% | Added |
| Axq Capital, LP | 12,350 | $118.2K | 0.04% | +2,048+19.9% | Added |
| FMR LLC | 12,202 | $116.8K | 0.00% | −1,694,946−99.3% | Reduced |
| Price T Rowe Associates Inc | 12,022 | $116.0K | 0.00% | +12,022 | New |
| China Universal Asset Management Co., Ltd. | 10,681 | $102.2K | 0.01% | +531+5.2% | Added |
| Baker Bros. Advisors LP | 10,607 | $101.5K | 0.00% | 00.0% | Unchanged |
| Russell Investments Group, Ltd. | 9,975 | $95.5K | 0.00% | −264−2.6% | Reduced |
| Citigroup Inc | 9,497 | $90.9K | 0.00% | −6,010−38.8% | Reduced |
| Virtus Investment Advisers, Inc. | 9,103 | $87.1K | 0.03% | −1,715−15.9% | Reduced |
| US Bancorp | 7,561 | $72.4K | 0.00% | +2,126+39.1% | Added |
| New York State Common Retirement Fund | 7,423 | $71.0K | 0.00% | 00.0% | Unchanged |
| Police & Firemen's Retirement System of New Jersey | 5,049 | $48.3K | 0.00% | 00.0% | Unchanged |
| Point72 Asia (Singapore) Pte. Ltd. | 3,490 | $33.4K | 0.01% | +2,698+340.7% | Added |
| Tower Research Capital LLC (TRC) | 2,840 | $27.2K | 0.00% | +757+36.3% | Added |
| Point72 (DIFC) Ltd | 2,330 | $22.3K | 0.00% | +57+2.5% | Added |
| Legal & General Group Plc | 2,192 | $21.0K | 0.00% | −7,069−76.3% | Reduced |
| Mirae Asset Global Investments Co., Ltd. | 2,054 | $19.7K | 0.00% | +361+21.3% | Added |
| Ameritas Investment Partners, Inc. | 1,991 | $19.1K | 0.00% | 00.0% | Unchanged |
| CWM, LLC | 1,541 | $15.0K | 0.00% | +1,158+302.3% | Added |
| California State Teachers Retirement System | 1,472 | $14.1K | 0.00% | −9,098−86.1% | Reduced |