Tyra Biosciences, Inc.
TYRA- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001863127
In the last 90 days, Tyra Biosciences, Inc. insiders filed 1 open-market purchase and 0 sales; 168 institutions reported holding it in 13F filings for Q2 2026, worth $2.22B in total; no superinvestor holds it.
13F holders, Q1 2026
Institutional positions in Tyra Biosciences, Inc. as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 164
- +32 vs. Q4 2025
- Shares held
- 65.9M
- +10.7M (+19.3%) vs. Q4 2025
- Total value
- $2.52B
- +$1.07B (+73.8%) vs. Q4 2025
- New holders
- 46
- 59 more added
- Sold out
- 14
- 35 more reduced
1 institution that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting TYRA on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 168 | $2.22B |
| Q1 2026 | 164 | $2.52B |
| Q4 2025 | 133 | $1.49B |
| Q3 2025 | 116 | $778.4M |
| Q2 2025 | 121 | $541.5M |
| Q1 2025 | 117 | $499.5M |
| Q4 2024 | 113 | $675.8M |
| Q3 2024 | 95 | $1.11B |
| Q2 2024 | 79 | $748.6M |
| Q1 2024 | 77 | $768.4M |
| Q4 2023 | 62 | $495.2M |
| Q3 2023 | 59 | $502.1M |
| Q2 2023 | 59 | $616.7M |
| Q1 2023 | 51 | $573.0M |
| Q4 2022 | 46 | $267.8M |
| Q3 2022 | 49 | $313.8M |
| Q2 2022 | 48 | $255.6M |
| Q1 2022 | 46 | $386.6M |
| Q4 2021 | 45 | $494.2M |
| Q3 2021 | 26 | $456.8M |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q1 2026
Shares, value and share of portfolio for each institution holding Tyra Biosciences, Inc.; share changes are against Q4 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Ra Capital Management, L.P. | 12,198,625 | $467.2M | 4.95% | 00.0% | Unchanged |
| FMR LLC | 7,747,648 | $296.7M | 0.02% | +7,735,085+61,570.4% | Added |
| Nextech Invest, Ltd. | 4,055,861 | $155.3M | 10.93% | 00.0% | Unchanged |
| Janus Henderson Group PLC | 3,890,589 | $148.9M | 0.07% | +955,147+32.5% | Added |
| Alta Partners Management Company, L.P. | 3,823,425 | $146.4M | 96.97% | 00.0% | Unchanged |
| Farallon Capital Management, L.L.C. | 3,580,818 | $137.1M | 0.81% | +1,514,000+73.3% | Added |
| TCG Crossover Management, LLC | 3,248,980 | $124.4M | 3.56% | +350,877+12.1% | Added |
| Commodore Capital LP | 2,475,000 | $94.8M | 5.48% | −900,000−26.7% | Reduced |
| BlackRock, Inc. | 2,217,929 | $84.9M | 0.00% | +131,506+6.3% | Added |
| Paradigm Biocapital Advisors LP | 2,054,991 | $78.7M | 1.61% | +2,054,991 | New |
| BVF Inc | 1,976,196 | $75.7M | 2.41% | −151,469−7.1% | Reduced |
| Caligan Partners LP | 1,276,968 | $48.9M | 3.46% | +332,711+35.2% | Added |
| State Street Corp | 1,216,078 | $46.6M | 0.00% | +466,615+62.3% | Added |
| Vanguard Capital Management LLC | 1,125,970 | $43.1M | 0.00% | +1,125,970 | New |
| 5AM Venture Management, LLC | 1,029,298 | $39.4M | 10.94% | 00.0% | Unchanged |
| Price T Rowe Associates Inc | 986,061 | $37.8M | 0.00% | +971,629+6,732.5% | Added |
| Logos Global Management LP | 850,000 | $32.6M | 1.68% | +640,000+304.8% | Added |
| Barclays PLC | 833,399 | $31.9M | 0.01% | +757,090+992.1% | Added |
| Canaan Partners XI LLC | 750,000 | $28.7M | 37.76% | −2,624,329−77.8% | Reduced |
| Geode Capital Management, LLC | 658,482 | $25.2M | 0.00% | +726+0.1% | Added |
| Jennison Associates LLC | 632,432 | $24.2M | 0.02% | +632,432 | New |
| Sio Capital Management, LLC | 605,439 | $23.2M | 3.34% | +79,437+15.1% | Added |
| Goldman Sachs Group Inc | 550,334 | $21.1M | 0.00% | +367,947+201.7% | Added |
| Deerfield Management Company, L.P. (Series C) | 549,000 | $21.0M | 0.25% | +549,000 | New |
| Balyasny Asset Management LLC | 351,479 | $13.5M | 0.03% | −466,847−57.0% | Reduced |
| Elmind Capital, LP | 350,000 | $13.4M | 3.81% | 00.0% | Unchanged |
| Woodline Partners LP | 301,040 | $11.5M | 0.04% | +301,040 | New |
| Boothbay Fund Management, LLC | 273,274 | $10.5M | 0.25% | +52,097+23.6% | Added |
| Affinity Asset Advisors, LLC | 257,512 | $9.86M | 0.58% | +257,512 | New |
| Vanguard Portfolio Management LLC | 247,270 | $9.47M | 0.00% | +247,270 | New |
| Raymond James Financial Inc | 247,098 | $9.46M | 0.00% | +77,066+45.3% | Added |
| Millennium Management LLC | 221,581 | $8.49M | 0.01% | +107,193+93.7% | Added |
| Northern Trust Corp | 218,508 | $8.37M | 0.00% | +17,552+8.7% | Added |
| Bank of America Corp | 209,922 | $8.04M | 0.00% | +171,612+448.0% | Added |
| Sofinnova Investments, Inc. | 204,015 | $7.81M | 0.39% | +204,015 | New |
| Charles Schwab Investment Management Inc | 199,111 | $7.63M | 0.00% | −315−0.2% | Reduced |
| Seven Fleet Capital Management LP | 198,585 | $7.61M | 2.39% | +119,025+149.6% | Added |
| Marshall Wace, LLP | 197,748 | $7.57M | 0.01% | −514,143−72.2% | Reduced |
| StemPoint Capital LP | 193,177 | $7.40M | 1.42% | +193,177 | New |
| BNP Paribas Arbitrage, SA | 190,039 | $7.28M | 0.00% | +69,761+58.0% | Added |
| Algert Global LLC | 188,010 | $7.20M | 0.11% | +141,140+301.1% | Added |
| Jacobs Levy Equity Management, Inc | 162,204 | $6.21M | 0.03% | +32,451+25.0% | Added |
| Vanguard Fiduciary Trust Co | 157,791 | $6.04M | 0.00% | +157,791 | New |
| Trexquant Investment LP | 147,317 | $5.64M | 0.04% | +147,317 | New |
| Ameriprise Financial Inc | 144,900 | $5.55M | 0.00% | +90,275+165.3% | Added |
| HighVista Strategies LLC | 131,304 | $5.03M | 1.39% | +96,218+274.2% | Added |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 128,860 | $4.94M | 0.01% | −919−0.7% | Reduced |
| Morgan Stanley | 120,485 | $4.61M | 0.00% | +1,587+1.3% | Added |
| Invesco Ltd. | 109,052 | $4.18M | 0.00% | −20,383−15.7% | Reduced |
| Two Sigma Investments, LP | 101,618 | $3.89M | 0.00% | −5,405−5.1% | Reduced |
| Dimensional Fund Advisors LP | 91,826 | $3.52M | 0.00% | −3,814−4.0% | Reduced |
| Oppenheimer & Co Inc | 84,192 | $3.22M | 0.04% | −534−0.6% | Reduced |
| XTX Topco Ltd | 83,896 | $3.21M | 0.06% | +53,482+175.8% | Added |
| Schonfeld Strategic Advisors LLC | 79,592 | $3.05M | 0.02% | +79,592 | New |
| Cinctive Capital Management LP | 78,018 | $2.99M | 0.20% | +78,018 | New |
| Wellington Management Group LLP | 77,169 | $2.96M | 0.00% | −27,136−26.0% | Reduced |
| Kalehua Capital Management LLC | 74,465 | $2.85M | 2.02% | 00.0% | Unchanged |
| Ensign Peak Advisors, Inc | 74,064 | $2.84M | 0.01% | +74,064 | New |
| Bank of New York Mellon Corp | 72,213 | $2.77M | 0.00% | +11,312+18.6% | Added |
| Russell Investments Group, Ltd. | 70,422 | $2.70M | 0.00% | +57,426+441.9% | Added |
| Catalio Capital Management, LP | 67,285 | $2.58M | 0.54% | +67,285 | New |
| UBS Group AG | 61,561 | $2.36M | 0.00% | +2,705+4.6% | Added |
| JPMorgan Chase & Co | 66,789 | $2.31M | 0.00% | −4,386−6.2% | Reduced |
| Vestal Point Capital, LP | 54,000 | $2.07M | 0.06% | −2,371,000−97.8% | Reduced |
| Nuveen, LLC | 50,840 | $1.95M | 0.00% | +3,491+7.4% | Added |
| TD Asset Management Inc | 50,000 | $1.92M | 0.00% | +50,000 | New |
| American Century Companies Inc | 47,929 | $1.84M | 0.00% | +1,702+3.7% | Added |
| Arkadios Wealth Advisors | 47,567 | $1.82M | 0.03% | +47,567 | New |
| Susquehanna Portfolio Strategies, LLC | 47,025 | $1.80M | 0.03% | −1,619−3.3% | Reduced |
| Alps Advisors Inc | 43,856 | $1.68M | 0.01% | +29+0.1% | Added |
| PDT Partners, LLC | 42,284 | $1.62M | 0.10% | 00.0% | Unchanged |
| Jump Financial, LLC | 41,375 | $1.58M | 0.02% | +41,375 | New |
| Manufacturers Life Insurance Company, The | 40,224 | $1.54M | 0.00% | +31,867+381.3% | Added |
| Rhumbline Advisers | 39,660 | $1.52M | 0.00% | +870+2.2% | Added |
| Point72 Asset Management, L.P. | 38,850 | $1.49M | 0.00% | −835,342−95.6% | Reduced |
| Voya Investment Management LLC | 38,358 | $1.47M | 0.00% | +8,471+28.3% | Added |
| Brevan Howard Capital Management LP | 38,606 | $1.46M | 0.02% | +38,606 | New |
| Rafferty Asset Management, LLC | 34,856 | $1.33M | 0.01% | +19,401+125.5% | Added |
| State of Wisconsin Investment Board | 33,258 | $1.27M | 0.00% | −5,765−14.8% | Reduced |
| AQR Capital Management LLC | 29,423 | $1.13M | 0.00% | +792+2.8% | Added |
| Fisher Asset Management, LLC | 28,800 | $1.10M | 0.00% | 00.0% | Unchanged |
| Eversept Partners, LP | 27,055 | $1.04M | 0.07% | −251,509−90.3% | Reduced |
| Swiss National Bank | 26,400 | $1.01M | 0.00% | +26,400 | New |
| Creative Planning | 23,948 | $917.2K | 0.00% | +4,345+22.2% | Added |
| Alliancebernstein L.P. | 31,990 | $841.0K | 0.00% | 00.0% | Unchanged |
| Auour Investments LLC | 21,020 | $805.1K | 0.25% | 00.0% | Unchanged |
| Public Employees Retirement System of Ohio | 20,522 | $786.0K | 0.00% | +1,980+10.7% | Added |
| Deutsche Bank AG | 20,495 | $785.0K | 0.00% | +4,118+25.1% | Added |
| Squarepoint Ops LLC | 20,494 | $784.9K | 0.00% | −33,930−62.3% | Reduced |
| Walleye Capital LLC | 18,715 | $716.8K | 0.00% | +18,715 | New |
| Quadrature Capital Ltd | 18,203 | $697.2K | 0.01% | +18,203 | New |
| STRS Ohio | 18,100 | $693.2K | 0.00% | +17,400+2,485.7% | Added |
| Tudor Investment Corp Et Al | 16,284 | $623.7K | 0.00% | +16,284 | New |
| PSP Research LLC | 16,000 | $612.8K | 0.43% | −5,853−26.8% | Reduced |
| Profund Advisors LLC | 15,656 | $599.6K | 0.02% | +15,656 | New |
| Susquehanna International Group, LLP | 15,543 | $595.3K | 0.00% | −39,592−71.8% | Reduced |
| Vanguard Global Advisers, LLC | 15,480 | $592.9K | 0.00% | +15,480 | New |
| Citadel Advisors LLC | 15,396 | $589.7K | 0.00% | +15,396 | New |
| Victory Capital Management Inc | 15,230 | $583.3K | 0.00% | −3,560−18.9% | Reduced |
| Mirae Asset Global ETFs Holdings Ltd. | 14,626 | $551.0K | 0.00% | +1,718+13.3% | Added |