Tyra Biosciences, Inc.
TYRA- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001863127
In the last 90 days, Tyra Biosciences, Inc. insiders filed 1 open-market purchase and 0 sales; 168 institutions reported holding it in 13F filings for Q2 2026, worth $2.22B in total; no superinvestor holds it.
13F holders, Q3 2025
Institutional positions in Tyra Biosciences, Inc. as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 116
- −5 vs. Q2 2025
- Shares held
- 55.6M
- −950.0K (−1.7%) vs. Q2 2025
- Total value
- $778.4M
- +$236.9M (+43.7%) vs. Q2 2025
- New holders
- 9
- 40 more added
- Sold out
- 14
- 38 more reduced
Compare with Q2 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting TYRA on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 168 | $2.22B |
| Q1 2026 | 164 | $2.52B |
| Q4 2025 | 133 | $1.49B |
| Q3 2025 | 116 | $778.4M |
| Q2 2025 | 121 | $541.5M |
| Q1 2025 | 117 | $499.5M |
| Q4 2024 | 113 | $675.8M |
| Q3 2024 | 95 | $1.11B |
| Q2 2024 | 79 | $748.6M |
| Q1 2024 | 77 | $768.4M |
| Q4 2023 | 62 | $495.2M |
| Q3 2023 | 59 | $502.1M |
| Q2 2023 | 59 | $616.7M |
| Q1 2023 | 51 | $573.0M |
| Q4 2022 | 46 | $267.8M |
| Q3 2022 | 49 | $313.8M |
| Q2 2022 | 48 | $255.6M |
| Q1 2022 | 46 | $386.6M |
| Q4 2021 | 45 | $494.2M |
| Q3 2021 | 26 | $456.8M |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q3 2025
Shares, value and share of portfolio for each institution holding Tyra Biosciences, Inc.; share changes are against Q2 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Ra Capital Management, L.P. | 12,198,625 | $170.7M | 2.10% | 00.0% | Unchanged |
| Alta Partners Management Company, L.P. | 4,080,296 | $57.1M | 95.15% | 00.0% | Unchanged |
| Nextech Invest, Ltd. | 4,055,861 | $56.7M | 8.64% | 00.0% | Unchanged |
| BVF Inc | 3,649,794 | $51.1M | 2.07% | −294,400−7.5% | Reduced |
| Canaan Partners XI LLC | 3,608,109 | $50.5M | 49.07% | 00.0% | Unchanged |
| Commodore Capital LP | 3,375,000 | $47.2M | 2.30% | +275,000+8.9% | Added |
| TCG Crossover Management, LLC | 2,898,103 | $40.5M | 1.99% | 00.0% | Unchanged |
| Janus Henderson Group PLC | 2,874,804 | $40.2M | 0.02% | +18,514+0.6% | Added |
| Vestal Point Capital, LP | 2,425,000 | $33.9M | 1.54% | −230,000−8.7% | Reduced |
| Kynam Capital Management, LP | 2,329,998 | $32.6M | 2.43% | 00.0% | Unchanged |
| BlackRock, Inc. | 1,869,474 | $26.2M | 0.00% | −23,854−1.3% | Reduced |
| Vanguard Group Inc | 1,520,185 | $21.3M | 0.00% | +118,492+8.5% | Added |
| Farallon Capital Management, L.L.C. | 1,143,818 | $16.0M | 0.09% | 00.0% | Unchanged |
| 5AM Venture Management, LLC | 939,298 | $13.1M | 4.81% | 00.0% | Unchanged |
| Balyasny Asset Management LLC | 846,585 | $11.8M | 0.02% | +263,199+45.1% | Added |
| Caligan Partners LP | 696,825 | $9.75M | 1.35% | +506,875+266.8% | Added |
| Marshall Wace, LLP | 602,015 | $8.42M | 0.01% | +173,907+40.6% | Added |
| Geode Capital Management, LLC | 597,454 | $8.36M | 0.00% | +30,328+5.3% | Added |
| Sio Capital Management, LLC | 514,947 | $7.20M | 1.82% | −295,327−36.4% | Reduced |
| State Street Corp | 428,472 | $5.99M | 0.00% | +9,488+2.3% | Added |
| Morgan Stanley | 322,143 | $4.51M | 0.00% | −56,259−14.9% | Reduced |
| Walleye Capital LLC | 297,808 | $4.17M | 0.03% | −72,600−19.6% | Reduced |
| Point72 Asset Management, L.P. | 282,032 | $3.95M | 0.01% | +57,332+25.5% | Added |
| Eversept Partners, LP | 272,706 | $3.82M | 0.29% | +272,706 | New |
| Jacobs Levy Equity Management, Inc | 251,562 | $3.52M | 0.01% | −143,737−36.4% | Reduced |
| Northern Trust Corp | 208,486 | $2.92M | 0.00% | +3,178+1.5% | Added |
| Charles Schwab Investment Management Inc | 201,587 | $2.82M | 0.00% | +23,483+13.2% | Added |
| Two Sigma Investments, LP | 199,438 | $2.79M | 0.00% | +93,613+88.5% | Added |
| Boothbay Fund Management, LLC | 186,670 | $2.61M | 0.07% | +186,670 | New |
| Renaissance Technologies LLC | 170,100 | $2.38M | 0.00% | +35,000+25.9% | Added |
| Millennium Management LLC | 144,016 | $2.01M | 0.00% | −263,448−64.7% | Reduced |
| Bank of America Corp | 134,319 | $1.88M | 0.00% | −238,648−64.0% | Reduced |
| BNP Paribas Arbitrage, SA | 128,881 | $1.80M | 0.00% | +31,145+31.9% | Added |
| AXA Investment Managers S.A. | 128,789 | $1.80M | 0.00% | +128,789 | New |
| Raymond James Financial Inc | 126,374 | $1.77M | 0.00% | +63,187+100.0% | Added |
| Two Sigma Advisers, LP | 113,200 | $1.58M | 0.00% | +26,200+30.1% | Added |
| Citadel Advisors LLC | 111,293 | $1.56M | 0.00% | −104,843−48.5% | Reduced |
| Goldman Sachs Group Inc | 100,150 | $1.40M | 0.00% | −5,445−5.2% | Reduced |
| Ameriprise Financial Inc | 87,107 | $1.22M | 0.00% | +6,505+8.1% | Added |
| Investment Counsel Co of Nevada | 85,020 | $1.19M | 2.42% | 00.0% | Unchanged |
| Wellington Management Group LLP | 82,871 | $1.16M | 0.00% | −20,207−19.6% | Reduced |
| Oppenheimer & Co Inc | 82,238 | $1.15M | 0.01% | +8,205+11.1% | Added |
| Nuveen, LLC | 80,441 | $1.13M | 0.00% | 00.0% | Unchanged |
| JPMorgan Chase & Co | 74,229 | $1.04M | 0.00% | −28,688−27.9% | Reduced |
| HighVista Strategies LLC | 65,812 | $920.7K | 0.23% | +40,850+163.6% | Added |
| Jump Financial, LLC | 62,000 | $867.4K | 0.01% | −9,119−12.8% | Reduced |
| UBS Group AG | 59,144 | $827.4K | 0.00% | +12,876+27.8% | Added |
| Bank of New York Mellon Corp | 57,162 | $799.7K | 0.00% | +3,123+5.8% | Added |
| Barclays PLC | 57,126 | $799.2K | 0.00% | −4,429−7.2% | Reduced |
| Susquehanna Portfolio Strategies, LLC | 48,644 | $680.5K | 0.01% | 00.0% | Unchanged |
| Jane Street Group, LLC | 44,680 | $625.1K | 0.00% | −13,488−23.2% | Reduced |
| PDT Partners, LLC | 43,310 | $605.9K | 0.04% | 00.0% | Unchanged |
| Rhumbline Advisers | 40,636 | $568.5K | 0.00% | −49−0.1% | Reduced |
| Dimensional Fund Advisors LP | 39,679 | $555.1K | 0.00% | −2,002−4.8% | Reduced |
| Cubist Systematic Strategies, LLC | 39,310 | $549.9K | 0.01% | −82,726−67.8% | Reduced |
| American Century Companies Inc | 38,412 | $537.4K | 0.00% | +9,558+33.1% | Added |
| XTX Topco Ltd | 33,700 | $471.5K | 0.02% | −901−2.6% | Reduced |
| Alliancebernstein L.P. | 33,260 | $465.3K | 0.00% | −2,380−6.7% | Reduced |
| Brevan Howard Capital Management LP | 31,101 | $435.1K | 0.01% | −5,493−15.0% | Reduced |
| Quest Partners LLC | 30,060 | $420.5K | 0.03% | −43,013−58.9% | Reduced |
| State of Wisconsin Investment Board | 29,648 | $414.8K | 0.00% | −46,801−61.2% | Reduced |
| AQR Capital Management LLC | 28,069 | $392.7K | 0.00% | −643−2.2% | Reduced |
| Public Employees Retirement System of Ohio | 24,962 | $349.2K | 0.00% | +6,450+34.8% | Added |
| Alps Advisors Inc | 24,700 | $345.6K | 0.00% | −4,029−14.0% | Reduced |
| Auour Investments LLC | 21,020 | $294.1K | 0.10% | 00.0% | Unchanged |
| Victory Capital Management Inc | 18,790 | $262.9K | 0.00% | −25,400−57.5% | Reduced |
| Wells Fargo & Company | 18,470 | $258.4K | 0.00% | +3,013+19.5% | Added |
| Trexquant Investment LP | 15,758 | $220.5K | 0.00% | −28,923−64.7% | Reduced |
| Invesco Ltd. | 15,510 | $217.0K | 0.00% | +15,510 | New |
| Deutsche Bank AG | 15,483 | $216.6K | 0.00% | +2,183+16.4% | Added |
| MetLife Investment Management | 14,631 | $204.7K | 0.00% | 00.0% | Unchanged |
| Price T Rowe Associates Inc | 12,801 | $180.0K | 0.00% | +779+6.5% | Added |
| Russell Investments Group, Ltd. | 12,741 | $178.2K | 0.00% | +2,766+27.7% | Added |
| FMR LLC | 12,529 | $175.3K | 0.00% | +327+2.7% | Added |
| Squarepoint Ops LLC | 12,214 | $170.9K | 0.00% | −19,194−61.1% | Reduced |
| Intech Investment Management LLC | 11,402 | $159.5K | 0.00% | −8,517−42.8% | Reduced |
| Mirae Asset Global ETFs Holdings Ltd. | 11,317 | $158.3K | 0.00% | −1,865−14.1% | Reduced |
| Virtus Investment Advisers, Inc. | 11,015 | $154.1K | 0.04% | +1,912+21.0% | Added |
| Tudor Investment Corp Et Al | 10,761 | $150.5K | 0.00% | −15,504−59.0% | Reduced |
| Baker Bros. Advisors LP | 10,607 | $148.4K | 0.00% | 00.0% | Unchanged |
| SG Americas Securities, LLC | 9,542 | $133.0K | 0.00% | +9,542 | New |
| China Universal Asset Management Co., Ltd. | 9,342 | $130.7K | 0.01% | −1,339−12.5% | Reduced |
| New York State Common Retirement Fund | 7,423 | $103.8K | 0.00% | 00.0% | Unchanged |
| Police & Firemen's Retirement System of New Jersey | 6,440 | $90.1K | 0.00% | +1,391+27.6% | Added |
| Legal & General Group Plc | 2,192 | $30.7K | 0.00% | 00.0% | Unchanged |
| Federated Hermes, Inc. | 2,155 | $30.1K | 0.00% | +1,841+586.3% | Added |
| Mirae Asset Global Investments Co., Ltd. | 2,060 | $28.8K | 0.00% | +6+0.3% | Added |
| Ameritas Investment Partners, Inc. | 1,991 | $27.9K | 0.00% | 00.0% | Unchanged |
| Citigroup Inc | 1,707 | $23.9K | 0.00% | −7,790−82.0% | Reduced |
| Sterling Capital Management LLC | 1,662 | $23.3K | 0.00% | +1,012+155.7% | Added |
| CWM, LLC | 1,529 | $21.0K | 0.00% | −12−0.8% | Reduced |
| California State Teachers Retirement System | 1,473 | $20.6K | 0.00% | +1+0.1% | Added |
| Advisor Group Holdings, Inc. | 1,192 | $16.1K | 0.00% | +183+18.1% | Added |
| GF Fund Management Co. Ltd. | 1,147 | $16.0K | 0.00% | −149−11.5% | Reduced |
| Royal Bank of Canada | 1,156 | $16.0K | 0.00% | −15,057−92.9% | Reduced |
| Tower Research Capital LLC (TRC) | 874 | $12.2K | 0.00% | −1,966−69.2% | Reduced |
| Versant Capital Management, Inc | 819 | $11.5K | 0.00% | 00.0% | Unchanged |
| Amalgamated Bank | 701 | $10.0K | 0.00% | 00.0% | Unchanged |
| STRS Ohio | 700 | $9.79K | 0.00% | 00.0% | Unchanged |
| Optiver Holding B.V. | 368 | $5.15K | 0.00% | +368 | New |